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Items: 1 to 50 of 168

1.

Short-chain diamines are the physiological substrates of PACE family efflux pumps.

Hassan KA, Naidu V, Edgerton JR, Mettrick KA, Liu Q, Fahmy L, Li L, Jackson SM, Ahmad I, Sharples D, Henderson PJF, Paulsen IT.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):18015-18020. doi: 10.1073/pnas.1901591116. Epub 2019 Aug 15.

2.

"Obstruction Alternans": A Rare Presentation of Mechanical Mitral Valve Obstruction.

Henderson PJ, Harrison TJ, Wildes DE Jr.

CASE (Phila). 2018 Aug 28;2(6):244-247. doi: 10.1016/j.case.2018.06.001. eCollection 2018 Dec. No abstract available.

3.

Screening of candidate substrates and coupling ions of transporters by thermostability shift assays.

Majd H, King MS, Palmer SM, Smith AC, Elbourne LD, Paulsen IT, Sharples D, Henderson PJ, Kunji ER.

Elife. 2018 Oct 15;7. pii: e38821. doi: 10.7554/eLife.38821.

4.

Production of membrane proteins for characterisation of their pheromone-sensing and antimicrobial resistance functions.

Azam AA, Kinder JM, Khan GN, Alase A, Ma P, Liu Y, Ault JR, Henderson PJF, Chowdhry BZ, Alexander BD, Harding SE, Phillips-Jones MK.

Eur Biophys J. 2018 Oct;47(7):723-737. doi: 10.1007/s00249-018-1325-z. Epub 2018 Jul 31.

5.

A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3.

Southam HM, Smith TW, Lyon RL, Liao C, Trevitt CR, Middlemiss LA, Cox FL, Chapman JA, El-Khamisy SF, Hippler M, Williamson MP, Henderson PJF, Poole RK.

Redox Biol. 2018 Sep;18:114-123. doi: 10.1016/j.redox.2018.06.008. Epub 2018 Jun 30.

6.

Microbial expression systems for membrane proteins.

Dilworth MV, Piel MS, Bettaney KE, Ma P, Luo J, Sharples D, Poyner DR, Gross SR, Moncoq K, Henderson PJF, Miroux B, Bill RM.

Methods. 2018 Sep 1;147:3-39. doi: 10.1016/j.ymeth.2018.04.009. Epub 2018 Apr 12. Review.

7.

Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens.

Hassan KA, Liu Q, Elbourne LDH, Ahmad I, Sharples D, Naidu V, Chan CL, Li L, Harborne SPD, Pokhrel A, Postis VLG, Goldman A, Henderson PJF, Paulsen IT.

Res Microbiol. 2018 Sep - Oct;169(7-8):450-454. doi: 10.1016/j.resmic.2018.01.001. Epub 2018 Feb 2. Review.

8.

Topological Dissection of the Membrane Transport Protein Mhp1 Derived from Cysteine Accessibility and Mass Spectrometry.

Calabrese AN, Jackson SM, Jones LN, Beckstein O, Heinkel F, Gsponer J, Sharples D, Sans M, Kokkinidou M, Pearson AR, Radford SE, Ashcroft AE, Henderson PJF.

Anal Chem. 2017 Sep 5;89(17):8844-8852. doi: 10.1021/acs.analchem.7b01310. Epub 2017 Aug 9.

9.

The putative drug efflux systems of the Bacillus cereus group.

Hassan KA, Fagerlund A, Elbourne LDH, Vörös A, Kroeger JK, Simm R, Tourasse NJ, Finke S, Henderson PJF, Økstad OA, Paulsen IT, Kolstø AB.

PLoS One. 2017 May 4;12(5):e0176188. doi: 10.1371/journal.pone.0176188. eCollection 2017.

10.

Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions.

Hussain R, Harding SE, Hughes CS, Ma P, Patching SG, Edara S, Siligardi G, Henderson PJ, Phillips-Jones MK.

Biochem Soc Trans. 2016 Jun 15;44(3):810-23. doi: 10.1042/BST20160023. Review.

11.

Allantoin transport protein, PucI, from Bacillus subtilis: evolutionary relationships, amplified expression, activity and specificity.

Ma P, Patching SG, Ivanova E, Baldwin JM, Sharples D, Baldwin SA, Henderson PJ.

Microbiology. 2016 May;162(5):823-36. doi: 10.1099/mic.0.000266. Epub 2016 Mar 11.

12.

Bacillus cereus efflux protein BC3310 - a multidrug transporter of the unknown major facilitator family, UMF-2.

Kroeger JK, Hassan K, Vörös A, Simm R, Saidijam M, Bettaney KE, Bechthold A, Paulsen IT, Henderson PJ, Kolstø AB.

Front Microbiol. 2015 Oct 12;6:1063. doi: 10.3389/fmicb.2015.01063. eCollection 2015.

13.

An ace up their sleeve: a transcriptomic approach exposes the AceI efflux protein of Acinetobacter baumannii and reveals the drug efflux potential hidden in many microbial pathogens.

Hassan KA, Elbourne LD, Li L, Gamage HK, Liu Q, Jackson SM, Sharples D, Kolstø AB, Henderson PJ, Paulsen IT.

Front Microbiol. 2015 Apr 22;6:333. doi: 10.3389/fmicb.2015.00333. eCollection 2015.

14.

Homologs of the Acinetobacter baumannii AceI transporter represent a new family of bacterial multidrug efflux systems.

Hassan KA, Liu Q, Henderson PJ, Paulsen IT.

MBio. 2015 Feb 10;6(1). pii: e01982-14. doi: 10.1128/mBio.01982-14.

15.

Amphipols outperform dodecylmaltoside micelles in stabilizing membrane protein structure in the gas phase.

Calabrese AN, Watkinson TG, Henderson PJ, Radford SE, Ashcroft AE.

Anal Chem. 2015 Jan 20;87(2):1118-26. doi: 10.1021/ac5037022. Epub 2014 Dec 30.

16.

Synthesis of uniformly deuterated n-dodecyl-β-D-maltoside (d39-DDM) for solubilization of membrane proteins in TROSY NMR experiments.

Hiruma-Shimizu K, Kalverda AP, Henderson PJ, Homans SW, Patching SG.

J Labelled Comp Radiopharm. 2014 Dec;57(14):737-43. doi: 10.1002/jlcr.3249. Epub 2014 Dec 9.

PMID:
25491565
17.

Molecular mechanism of ligand recognition by membrane transport protein, Mhp1.

Simmons KJ, Jackson SM, Brueckner F, Patching SG, Beckstein O, Ivanova E, Geng T, Weyand S, Drew D, Lanigan J, Sharples DJ, Sansom MS, Iwata S, Fishwick CW, Johnson AP, Cameron AD, Henderson PJ.

EMBO J. 2014 Aug 18;33(16):1831-44. doi: 10.15252/embj.201387557. Epub 2014 Jun 21.

18.

TROSY NMR with a 52 kDa sugar transport protein and the binding of a small-molecule inhibitor.

Kalverda AP, Gowdy J, Thompson GS, Homans SW, Henderson PJ, Patching SG.

Mol Membr Biol. 2014 Jun;31(4):131-40. doi: 10.3109/09687688.2014.911980. Epub 2014 May 7.

PMID:
24804563
19.

An efficient strategy for small-scale screening and production of archaeal membrane transport proteins in Escherichia coli.

Ma P, Varela F, Magoch M, Silva AR, Rosário AL, Brito J, Oliveira TF, Nogly P, Pessanha M, Stelter M, Kletzin A, Henderson PJ, Archer M.

PLoS One. 2013 Oct 7;8(10):e76913. doi: 10.1371/journal.pone.0076913. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/ba41a7db-2c22-4ffc-b603-526534594a51.

20.

Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins.

Hassan KA, Jackson SM, Penesyan A, Patching SG, Tetu SG, Eijkelkamp BA, Brown MH, Henderson PJ, Paulsen IT.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20254-9. doi: 10.1073/pnas.1317052110. Epub 2013 Nov 25.

21.

This is about the in and the out.

Henderson PJ, Baldwin SA.

Nat Struct Mol Biol. 2013 Jun;20(6):654-5. doi: 10.1038/nsmb.2604. No abstract available.

PMID:
23739167
22.

Probing the contacts of a low-affinity substrate with a membrane-embedded transport protein using 1H-13C cross-polarisation magic-angle spinning solid-state NMR.

Patching SG, Henderson PJ, Sharples DJ, Middleton DA.

Mol Membr Biol. 2013 Mar;30(2):129-37. doi: 10.3109/09687688.2012.743193. Epub 2012 Nov 23.

PMID:
23173920
23.

A systematic approach to the amplified expression, functional characterization and purification of inositol transporters from Bacillus subtilis.

Bettaney KE, Sukumar P, Hussain R, Siligardi G, Henderson PJ, Patching SG.

Mol Membr Biol. 2013 Feb;30(1):3-14. doi: 10.3109/09687688.2012.729093. Epub 2012 Oct 18.

PMID:
23078035
24.

Structural biology: Bundles of insights into sugar transporters.

Henderson PJ, Baldwin SA.

Nature. 2012 Oct 18;490(7420):348-50. doi: 10.1038/490348a. No abstract available.

PMID:
23075980
25.

BC4707 is a major facilitator superfamily multidrug resistance transport protein from Bacillus cereus implicated in fluoroquinolone tolerance.

Simm R, Vörös A, Ekman JV, Sødring M, Nes I, Kroeger JK, Saidijam M, Bettaney KE, Henderson PJ, Salkinoja-Salonen M, Kolstø AB.

PLoS One. 2012;7(5):e36720. doi: 10.1371/journal.pone.0036720. Epub 2012 May 16.

26.

The MFS efflux proteins of gram-positive and gram-negative bacteria.

Saidijam M, Bettaney KE, Leng D, Ma P, Xu Z, Keen JN, Rutherford NG, Ward A, Henderson PJ, Szakonyi G, Ren Q, Paulsen IT, Nes I, Kroeger JK, Kolsto AB.

Adv Enzymol Relat Areas Mol Biol. 2011;77:147-66. Review. No abstract available.

PMID:
21692369
27.

Overcoming barriers to membrane protein structure determination.

Bill RM, Henderson PJ, Iwata S, Kunji ER, Michel H, Neutze R, Newstead S, Poolman B, Tate CG, Vogel H.

Nat Biotechnol. 2011 Apr;29(4):335-40. doi: 10.1038/nbt.1833. Review.

PMID:
21478852
28.

Determinants of ligand binding affinity and cooperativity at the GLUT1 endofacial site.

Robichaud T, Appleyard AN, Herbert RB, Henderson PJ, Carruthers A.

Biochemistry. 2011 Apr 19;50(15):3137-48. doi: 10.1021/bi1020327. Epub 2011 Mar 25.

29.

The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1.

Weyand S, Shimamura T, Beckstein O, Sansom MS, Iwata S, Henderson PJ, Cameron AD.

J Synchrotron Radiat. 2011 Jan;18(1):20-3. doi: 10.1107/S0909049510032449. Epub 2010 Nov 5.

30.

"4D Biology for health and disease" workshop report.

Abrahams JP, Apweiler R, Balling R, Bertero MG, Bujnicki JM, Chayen NE, Chène P, Corthals GL, Dyląg T, Förster F, Heck AJ, Henderson PJ, Herwig R, Jehenson P, Kokalj SJ, Laue E, Legrain P, Martens L, Migliorini C, Musacchio A, Podobnik M, Schertler GF, Schreiber G, Sixma TK, Smit AB, Stuart D, Svergun DI, Taussig MJ.

N Biotechnol. 2011 Jul;28(4):291-3. doi: 10.1016/j.nbt.2010.10.003. Epub 2010 Oct 15.

PMID:
20951846
31.

Unfolding free energy of a two-domain transmembrane sugar transport protein.

Findlay HE, Rutherford NG, Henderson PJ, Booth PJ.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18451-6. doi: 10.1073/pnas.1005729107. Epub 2010 Oct 11.

32.

Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).

Miller K, Dunsmore CJ, Leeds JA, Patching SG, Sachdeva M, Blake KL, Stubbings WJ, Simmons KJ, Henderson PJ, De Los Angeles J, Fishwick CW, Chopra I.

J Antimicrob Chemother. 2010 Dec;65(12):2566-73. doi: 10.1093/jac/dkq349. Epub 2010 Sep 22.

PMID:
20861142
33.

Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1.

Shimamura T, Weyand S, Beckstein O, Rutherford NG, Hadden JM, Sharples D, Sansom MS, Iwata S, Henderson PJ, Cameron AD.

Science. 2010 Apr 23;328(5977):470-3. doi: 10.1126/science.1186303.

34.

Defining topological features of membrane proteins by nanoelectrospray ionisation mass spectrometry.

Jones LN, Baldwin SA, Henderson PJ, Ashcroft AE.

Rapid Commun Mass Spectrom. 2010 Feb;24(3):276-84. doi: 10.1002/rcm.4387.

PMID:
20058234
35.

Impedance spectroscopy of bacterial membranes: coenzyme-Q diffusion in a finite diffusion layer.

Jeuken LJ, Weiss SA, Henderson PJ, Evans SD, Bushby RJ.

Anal Chem. 2008 Dec 1;80(23):9084-90. doi: 10.1021/ac8015856.

36.

The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors.

Blake KL, O'Neill AJ, Mengin-Lecreulx D, Henderson PJ, Bostock JM, Dunsmore CJ, Simmons KJ, Fishwick CW, Leeds JA, Chopra I.

Mol Microbiol. 2009 Apr;72(2):335-43. doi: 10.1111/j.1365-2958.2009.06648.x. Epub 2009 Mar 3.

37.

The multidrug resistance efflux complex, EmrAB from Escherichia coli forms a dimer in vitro.

Tanabe M, Szakonyi G, Brown KA, Henderson PJ, Nield J, Byrne B.

Biochem Biophys Res Commun. 2009 Mar 6;380(2):338-42. doi: 10.1016/j.bbrc.2009.01.081. Epub 2009 Jan 24.

PMID:
19171121
38.

The sodium-dependent D-glucose transport protein of Helicobacter pylori.

Psakis G, Saidijam M, Shibayama K, Polaczek J, Bettaney KE, Baldwin JM, Baldwin SA, Hope R, Essen LO, Essenberg RC, Henderson PJ.

Mol Microbiol. 2009 Jan;71(2):391-403. doi: 10.1111/j.1365-2958.2008.06535.x.

39.

Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens.

Shimamura T, Yajima S, Suzuki S, Rutherford NG, O'Reilly J, Henderson PJ, Iwata S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Dec 1;64(Pt 12):1172-4. doi: 10.1107/S1744309108036920. Epub 2008 Nov 28.

40.

Investigation of the structure and function of a Shewanella oneidensis arsenical-resistance family transporter.

Xia X, Postis VL, Rahman M, Wright GS, Roach PC, Deacon SE, Ingram JC, Henderson PJ, Findlay JB, Phillips SE, McPherson MJ, Baldwin SA.

Mol Membr Biol. 2008 Dec;25(8):691-705. doi: 10.1080/09687680802535930.

PMID:
19039703
41.

Probing metal ion substrate-binding to the E. coli ZitB exporter in native membranes by solid state NMR.

Rahman M, Patching SG, Ismat F, Henderson PJ, Herbert RB, Baldwin SA, McPherson MJ.

Mol Membr Biol. 2008 Dec;25(8):683-90. doi: 10.1080/09687680802495267.

PMID:
19039702
42.

Reliable scale-up of membrane protein over-expression by bacterial auto-induction: from microwell plates to pilot scale fermentations.

Deacon SE, Roach PC, Postis VL, Wright GS, Xia X, Phillips SE, Knox JP, Henderson PJ, McPherson MJ, Baldwin SA.

Mol Membr Biol. 2008 Dec;25(8):588-98. doi: 10.1080/09687680802511774.

PMID:
19023695
43.

A high-throughput assay of membrane protein stability.

Postis VL, Deacon SE, Roach PC, Wright GS, Xia X, Ingram JC, Hadden JM, Henderson PJ, Phillips SE, McPherson MJ, Baldwin SA.

Mol Membr Biol. 2008 Dec;25(8):617-24. doi: 10.1080/09687680802530469.

PMID:
19016381
44.

Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter.

Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD.

Science. 2008 Oct 31;322(5902):709-13. doi: 10.1126/science.1164440. Epub 2008 Oct 16.

45.

Characterization of cytochrome bo3 activity in a native-like surface-tethered membrane.

Weiss SA, Bushby RJ, Evans SD, Henderson PJ, Jeuken LJ.

Biochem J. 2009 Jan 15;417(2):555-60. doi: 10.1042/BJ20081345.

46.

Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR.

Patching SG, Psakis G, Baldwin SA, Baldwin J, Henderson PJ, Middleton DA.

Mol Membr Biol. 2008 Sep;25(6-7):474-84. doi: 10.1080/09687680802371963.

PMID:
18798051
47.

Expression, purification and activities of the entire family of intact membrane sensor kinases from Enterococcus faecalis.

Ma P, Yuille HM, Blessie V, Göhring N, Iglói Z, Nishiguchi K, Nakayama J, Henderson PJ, Phillips-Jones MK.

Mol Membr Biol. 2008 Sep;25(6-7):449-73. doi: 10.1080/09687680802359885.

PMID:
18785057
48.

Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients.

Lutgendorf SK, Weinrib AZ, Penedo F, Russell D, DeGeest K, Costanzo ES, Henderson PJ, Sephton SE, Rohleder N, Lucci JA 3rd, Cole S, Sood AK, Lubaroff DM.

J Clin Oncol. 2008 Oct 10;26(29):4820-7. doi: 10.1200/JCO.2007.14.1978. Epub 2008 Sep 8.

49.
50.

2-Aminotetralones: novel inhibitors of MurA and MurZ.

Dunsmore CJ, Miller K, Blake KL, Patching SG, Henderson PJ, Garnett JA, Stubbings WJ, Phillips SE, Palestrant DJ, Angeles Jde L, Leeds JA, Chopra I, Fishwick CW.

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1730-4. doi: 10.1016/j.bmcl.2008.01.089. Epub 2008 Jan 30.

PMID:
18261901

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