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A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.

Minutti CM, Modak RV, Macdonald F, Li F, Smyth DJ, Dorward DA, Blair N, Husovsky C, Muir A, Giampazolias E, Dobie R, Maizels RM, Kendall TJ, Griggs DW, Kopf M, Henderson NC, Zaiss DM.

Immunity. 2019 Feb 6. pii: S1074-7613(19)30031-7. doi: 10.1016/j.immuni.2019.01.008. [Epub ahead of print]


An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade.

Vuong L, Kouverianou E, Rooney CM, McHugh BJ, Howie SE, Gregory CD, Forbes SJ, Henderson NC, Zetterberg FR, Nilsson UJ, Leffler H, Ford P, Pederson A, Gravelle L, Tantawi S, Schambye H, Sethi T, Mackinnon AC.

Cancer Res. 2019 Jan 23. pii: canres.2244.2018. doi: 10.1158/0008-5472.CAN-18-2244. [Epub ahead of print]


Fibroblast-specific integrin-alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis.

Sciurba JC, Gieseck RL, Jiwrajka N, White SD, Karmele EP, Redes J, Vannella KM, Henderson NC, Wynn TA, Hart KM.

J Pathol. 2018 Dec 7. doi: 10.1002/path.5215. [Epub ahead of print]


Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.

Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC.

Am J Pathol. 2019 Feb;189(2):258-271. doi: 10.1016/j.ajpath.2018.10.007. Epub 2018 Nov 16.


Unravelling atherosclerotic heterogeneity by single cell RNA sequencing.

McCracken IR, Taylor RS, Henderson NC, Sluimer JC, Baker AH.

Curr Opin Lipidol. 2018 Dec;29(6):488-489. doi: 10.1097/MOL.0000000000000559. No abstract available.


AR(1) latent class models for longitudinal count data.

Henderson NC, Rathouz PJ.

Stat Med. 2018 Dec 20;37(29):4441-4456. doi: 10.1002/sim.7931. Epub 2018 Aug 21.


Individualized treatment effects with censored data via fully nonparametric Bayesian accelerated failure time models.

Henderson NC, Louis TA, Rosner GL, Varadhan R.

Biostatistics. 2018 Jul 19. doi: 10.1093/biostatistics/kxy028. [Epub ahead of print]


Considerations when assessing heterogeneity of treatment effect in patient-centered outcomes research.

Lesko CR, Henderson NC, Varadhan R.

J Clin Epidemiol. 2018 Aug;100:22-31. doi: 10.1016/j.jclinepi.2018.04.005. Epub 2018 Apr 11. Review.


A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation.

Mair I, Zandee SEJ, Toor IS, Saul L, McPherson RC, Leech MD, Smyth DJ, O'Connor RA, Henderson NC, Anderton SM.

Front Immunol. 2018 Feb 26;9:264. doi: 10.3389/fimmu.2018.00264. eCollection 2018.


The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury.

Campana L, Starkey Lewis PJ, Pellicoro A, Aucott RL, Man J, O'Duibhir E, Mok SE, Ferreira-Gonzalez S, Livingstone E, Greenhalgh SN, Hull KL, Kendall TJ, Vernimmen D, Henderson NC, Boulter L, Gregory CD, Feng Y, Anderton SM, Forbes SJ, Iredale JP.

J Immunol. 2018 Feb 1;200(3):1169-1187. doi: 10.4049/jimmunol.1701247. Epub 2017 Dec 20.


11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis.

Zou X, Ramachandran P, Kendall TJ, Pellicoro A, Dora E, Aucott RL, Manwani K, Man TY, Chapman KE, Henderson NC, Forbes SJ, Webster SP, Iredale JP, Walker BR, Michailidou Z.

Hepatology. 2018 Jun;67(6):2167-2181. doi: 10.1002/hep.29734. Epub 2018 Feb 22.


αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis.

Murray IR, Gonzalez ZN, Baily J, Dobie R, Wallace RJ, Mackinnon AC, Smith JR, Greenhalgh SN, Thompson AI, Conroy KP, Griggs DW, Ruminski PG, Gray GA, Singh M, Campbell MA, Kendall TJ, Dai J, Li Y, Iredale JP, Simpson H, Huard J, Péault B, Henderson NC.

Nat Commun. 2017 Oct 24;8(1):1118. doi: 10.1038/s41467-017-01097-z.


Antifibrotics in chronic liver disease: tractable targets and translational challenges.

Ramachandran P, Henderson NC.

Lancet Gastroenterol Hepatol. 2016 Dec;1(4):328-340. doi: 10.1016/S2468-1253(16)30110-8. Epub 2016 Nov 10. Review.


Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.

King A, Houlihan DD, Kavanagh D, Haldar D, Luu N, Owen A, Suresh S, Than NN, Reynolds G, Penny J, Sumption H, Ramachandran P, Henderson NC, Kalia N, Frampton J, Adams DH, Newsome PN.

Gastroenterology. 2017 Jul;153(1):233-248.e16. doi: 10.1053/j.gastro.2017.03.022. Epub 2017 Mar 28.


Logistic Regression Likelihood Ratio Test Analysis for Detecting Signals of Adverse Events in Post-market Safety Surveillance.

Nam K, Henderson NC, Rohan P, Woo EJ, Russek-Cohen E.

J Biopharm Stat. 2017;27(6):990-1008. doi: 10.1080/10543406.2017.1295250. Epub 2017 Mar 27.


Galectin-3, histone deacetylases, and Hedgehog signaling: Possible convergent targets in schistosomiasis-induced liver fibrosis.

de Oliveira FL, Carneiro K, Brito JM, Cabanel M, Pereira JX, Paiva LA, Syn W, Henderson NC, El-Cheikh MC.

PLoS Negl Trop Dis. 2017 Feb 23;11(2):e0005137. doi: 10.1371/journal.pntd.0005137. eCollection 2017 Feb. Review.


Longitudinal in vivo bioimaging of hepatocyte transcription factor activity following cholestatic liver injury in mice.

Delhove JM, Buckley SM, Perocheau DP, Karda R, Arbuthnot P, Henderson NC, Waddington SN, McKay TR.

Sci Rep. 2017 Feb 3;7:41874. doi: 10.1038/srep41874.


Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver.

Gamal W, Treskes P, Samuel K, Sullivan GJ, Siller R, Srsen V, Morgan K, Bryans A, Kozlowska A, Koulovasilopoulos A, Underwood I, Smith S, Del-Pozo J, Moss S, Thompson AI, Henderson NC, Hayes PC, Plevris JN, Bagnaninchi PO, Nelson LJ.

Sci Rep. 2017 Jan 30;7:37541. doi: 10.1038/srep37541.


Bayesian analysis of heterogeneous treatment effects for patient-centered outcomes research.

Henderson NC, Louis TA, Wang C, Varadhan R.

Health Serv Outcomes Res Methodol. 2016;16(4):213-233. Epub 2016 Sep 20.


Mesenchymal stromal cells and liver fibrosis: a complicated relationship.

Haldar D, Henderson NC, Hirschfield G, Newsome PN.

FASEB J. 2016 Dec;30(12):3905-3928. Epub 2016 Sep 6. Review.


Skeletal and cardiac muscle pericytes: Functions and therapeutic potential.

Murray IR, Baily JE, Chen WCW, Dar A, Gonzalez ZN, Jensen AR, Petrigliano FA, Deb A, Henderson NC.

Pharmacol Ther. 2017 Mar;171:65-74. doi: 10.1016/j.pharmthera.2016.09.005. Epub 2016 Sep 2. Review.


Making the cut: improved ranking and selection for large-scale inference.

Henderson NC, Newton MA.

J R Stat Soc Series B Stat Methodol. 2016 Sep;78(4):781-804. Epub 2015 Nov 8.


PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis.

Martin K, Pritchett J, Llewellyn J, Mullan AF, Athwal VS, Dobie R, Harvey E, Zeef L, Farrow S, Streuli C, Henderson NC, Friedman SL, Hanley NA, Piper Hanley K.

Nat Commun. 2016 Aug 18;7:12502. doi: 10.1038/ncomms12502.


Homing in on the hepatic scar: recent advances in cell-specific targeting of liver fibrosis.

Dobie R, Henderson NC.

F1000Res. 2016 Jul 19;5. pii: F1000 Faculty Rev-1749. doi: 10.12688/f1000research.8822.1. eCollection 2016. Review.


Recent progress on targeting the αvβ1 integrin for the treatment of tissue fibrosis.

Smith JR, Henderson NC.

Expert Opin Drug Discov. 2016 Aug;11(8):749-51. doi: 10.1080/17460441.2016.1193486. Epub 2016 Jun 7. No abstract available.


αv integrins: key regulators of tissue fibrosis.

Conroy KP, Kitto LJ, Henderson NC.

Cell Tissue Res. 2016 Sep;365(3):511-9. doi: 10.1007/s00441-016-2407-9. Epub 2016 May 2. Review.


Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury.

Vliegenthart AD, Shaffer JM, Clarke JI, Peeters LE, Caporali A, Bateman DN, Wood DM, Dargan PI, Craig DG, Moore JK, Thompson AI, Henderson NC, Webb DJ, Sharkey J, Antoine DJ, Park BK, Bailey MA, Lader E, Simpson KJ, Dear JW.

Sci Rep. 2015 Oct 22;5:15501. doi: 10.1038/srep15501.


Acute Liver Injury Is Independent of B Cells or Immunoglobulin M.

Richards JA, Bucsaiova M, Hesketh EE, Ventre C, Henderson NC, Simpson K, Bellamy CO, Howie SE, Anderton SM, Hughes J, Wigmore SJ.

PLoS One. 2015 Sep 25;10(9):e0138688. doi: 10.1371/journal.pone.0138688. eCollection 2015.


CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism.

Wilhelm A, Aldridge V, Haldar D, Naylor AJ, Weston CJ, Hedegaard D, Garg A, Fear J, Reynolds GM, Croft AP, Henderson NC, Buckley CD, Newsome PN.

Gut. 2016 Jul;65(7):1175-85. doi: 10.1136/gutjnl-2014-308325. Epub 2015 Jun 15.


Hepatic stellate cells: central modulators of hepatic carcinogenesis.

Thompson AI, Conroy KP, Henderson NC.

BMC Gastroenterol. 2015 May 27;15:63. doi: 10.1186/s12876-015-0291-5. Review.


Cre-ativity in the liver: transgenic approaches to targeting hepatic nonparenchymal cells.

Greenhalgh SN, Conroy KP, Henderson NC.

Hepatology. 2015 Jun;61(6):2091-9. doi: 10.1002/hep.27606. Epub 2015 Apr 13. Review.


Galectin-3 regulates hepatic progenitor cell expansion during liver injury.

Hsieh WC, Mackinnon AC, Lu WY, Jung J, Boulter L, Henderson NC, Simpson KJ, Schotanus B, Wojtacha D, Bird TG, Medine CN, Hay DC, Sethi T, Iredale JP, Forbes SJ.

Gut. 2015 Feb;64(2):312-21. doi: 10.1136/gutjnl-2013-306290. Epub 2014 May 16.


Healing scars: targeting pericytes to treat fibrosis.

Greenhalgh SN, Conroy KP, Henderson NC.

QJM. 2015 Jan;108(1):3-7. doi: 10.1093/qjmed/hcu067. Epub 2014 Mar 22. Review.


Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D.

Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10.


Origins of fibrosis: pericytes take centre stage.

Greenhalgh SN, Iredale JP, Henderson NC.

F1000Prime Rep. 2013 Sep 2;5:37. doi: 10.12703/P5-37. Review.


Fast Pure R Implementation of GEE: Application of the Matrix Package.

McDaniel LS, Henderson NC, Rathouz PJ.

R J. 2013 Jun;5(1):181-187.


Eosinophils secrete IL-4 to facilitate liver regeneration.

Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9914-9. doi: 10.1073/pnas.1304046110. Epub 2013 May 28.


Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation.

Iredale JP, Thompson A, Henderson NC.

Biochim Biophys Acta. 2013 Jul;1832(7):876-83. doi: 10.1016/j.bbadis.2012.11.002. Epub 2012 Nov 10. Review.


Integrin-mediated regulation of TGFβ in fibrosis.

Henderson NC, Sheppard D.

Biochim Biophys Acta. 2013 Jul;1832(7):891-6. doi: 10.1016/j.bbadis.2012.10.005. Epub 2012 Oct 6. Review.


Standing down the guard: stellate cells leave quietly.

Henderson NC, Iredale JP.

Gastroenterology. 2012 Oct;143(4):890-2. doi: 10.1053/j.gastro.2012.08.014. Epub 2012 Aug 20. No abstract available.


Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure.

Dabos KJ, Whalen HR, Newsome PN, Parkinson JA, Henderson NC, Sadler IH, Hayes PC, Plevris JN.

World J Gastroenterol. 2011 Mar 21;17(11):1457-61. doi: 10.3748/wjg.v17.i11.1457.


Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure.

Newsome PN, Henderson NC, Nelson LJ, Dabos C, Filippi C, Bellamy C, Howie F, Clutton RE, King T, Lee A, Hayes PC, Plevris JN.

BMC Gastroenterol. 2010 Mar 30;10:34. doi: 10.1186/1471-230X-10-34.


The regulation of inflammation by galectin-3.

Henderson NC, Sethi T.

Immunol Rev. 2009 Jul;230(1):160-71. doi: 10.1111/j.1600-065X.2009.00794.x. Review.


The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies.

Simpson KJ, Bates CM, Henderson NC, Wigmore SJ, Garden OJ, Lee A, Pollok A, Masterton G, Hayes PC.

Liver Transpl. 2009 Jun;15(6):600-9. doi: 10.1002/lt.21681.


Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells.

Eksteen B, Mora JR, Haughton EL, Henderson NC, Lee-Turner L, Villablanca EJ, Curbishley SM, Aspinall AI, von Andrian UH, Adams DH.

Gastroenterology. 2009 Jul;137(1):320-9. doi: 10.1053/j.gastro.2009.02.046. Epub 2009 Feb 21.


Hepatic fibrogenesis: from within and outwith.

Henderson NC, Forbes SJ.

Toxicology. 2008 Dec 30;254(3):130-5. doi: 10.1016/j.tox.2008.08.017. Epub 2008 Sep 7. Review.


Regulation of alternative macrophage activation by galectin-3.

MacKinnon AC, Farnworth SL, Hodkinson PS, Henderson NC, Atkinson KM, Leffler H, Nilsson UJ, Haslett C, Forbes SJ, Sethi T.

J Immunol. 2008 Feb 15;180(4):2650-8.


Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function.

Farnworth SL, Henderson NC, Mackinnon AC, Atkinson KM, Wilkinson T, Dhaliwal K, Hayashi K, Simpson AJ, Rossi AG, Haslett C, Sethi T.

Am J Pathol. 2008 Feb;172(2):395-405. doi: 10.2353/ajpath.2008.070870. Epub 2008 Jan 17.


Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis.

Henderson NC, Mackinnon AC, Farnworth SL, Kipari T, Haslett C, Iredale JP, Liu FT, Hughes J, Sethi T.

Am J Pathol. 2008 Feb;172(2):288-98. doi: 10.2353/ajpath.2008.070726. Epub 2008 Jan 17.


Liver fibrosis: cellular mechanisms of progression and resolution.

Henderson NC, Iredale JP.

Clin Sci (Lond). 2007 Mar;112(5):265-80. Review.


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