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Low redundancy and complementarity shape ecosystem functioning in a low-diversity ecosystem.

Henderson CJ, Gilby BL, Schlacher TA, Connolly RM, Sheaves M, Maxwell PS, Flint N, Borland HP, Martin TSH, Olds AD.

J Anim Ecol. 2019 Nov 23. doi: 10.1111/1365-2656.13148. [Epub ahead of print]


Correlation between 3-MCPD-induced organ toxicity and oxidative stress response in male mice.

Schultrich K, Henderson CJ, Braeuning A, Buhrke T.

Food Chem Toxicol. 2020 Feb;136:110957. doi: 10.1016/j.fct.2019.110957. Epub 2019 Nov 8.


The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice.

Hessel-Pras S, Braeuning A, Guenther G, Adawy A, Enge AM, Ebmeyer J, Henderson CJ, Hengstler JG, Lampen A, Reif R.

Arch Toxicol. 2019 Oct 12. doi: 10.1007/s00204-019-02582-8. [Epub ahead of print]


Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice.

Kapelyukh Y, Henderson CJ, Scheer N, Rode A, Wolf CR.

Drug Metab Dispos. 2019 Aug;47(8):907-918. doi: 10.1124/dmd.119.087718. Epub 2019 May 30.


Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo.

Stock V, Böhmert L, Lisicki E, Block R, Cara-Carmona J, Pack LK, Selb R, Lichtenstein D, Voss L, Henderson CJ, Zabinsky E, Sieg H, Braeuning A, Lampen A.

Arch Toxicol. 2019 Jul;93(7):1817-1833. doi: 10.1007/s00204-019-02478-7. Epub 2019 May 28.


An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.

Henderson CJ, Kapelyukh Y, Scheer N, Rode A, McLaren AW, MacLeod AK, Lin D, Wright J, Stanley LA, Wolf CR.

Drug Metab Dispos. 2019 Jun;47(6):601-615. doi: 10.1124/dmd.119.086397. Epub 2019 Mar 25.


Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.

Reed L, Indra R, Mrizova I, Moserova M, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM.

Toxicol Appl Pharmacol. 2019 Mar 1;366:64-74. doi: 10.1016/j.taap.2019.01.020. Epub 2019 Jan 25.


Gene to diagnostic: Self immobilizing protein for silica microparticle biosensor, modelled with sarcosine oxidase.

Henderson CJ, Pumford E, Seevaratnam DJ, Daly R, Hall EAH.

Biomaterials. 2019 Feb;193:58-70. doi: 10.1016/j.biomaterials.2018.12.003. Epub 2018 Dec 8.


Cobalt Administration Causes Reduced Contractility with Parallel Increases in TRPC6 and TRPM7 Transporter Protein Expression in Adult Rat Hearts.

Laovitthayanggoon S, Henderson CJ, McCluskey C, MacDonald M, Tate RJ, Grant MH, Currie S.

Cardiovasc Toxicol. 2019 Jun;19(3):276-286. doi: 10.1007/s12012-018-9498-3.


Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes.

McMahon M, Ding S, Jimenez LA, Terranova R, Gerard MA, Vitobello A, Moggs J, Henderson CJ, Wolf CR.

Mol Pharmacol. 2019 Jan;95(1):97-105. doi: 10.1124/mol.118.113555. Epub 2018 Oct 25.


Effects of seascape connectivity on reserve performance along exposed coastlines.

Ortodossi NL, Gilby BL, Schlacher TA, Connolly RM, Yabsley NA, Henderson CJ, Olds AD.

Conserv Biol. 2019 Jun;33(3):580-589. doi: 10.1111/cobi.13237. Epub 2018 Dec 18.


Reactivity and properties of bis(chlorodifluoroacetyl) peroxide generated in situ from chlorodifluoroacetic anhydride for chlorodifluoromethylation reactions.

Kawamura S, Henderson CJ, Aoki Y, Sekine D, Kobayashi S, Sodeoka M.

Chem Commun (Camb). 2018 Oct 4;54(80):11276-11279. doi: 10.1039/c8cc05905e.


Functional plasticity in vertebrate scavenger assemblages in the presence of introduced competitors.

Bingham EL, Gilby BL, Olds AD, Weston MA, Connolly RM, Henderson CJ, Maslo B, Peterson CF, Voss CM, Schlacher TA.

Oecologia. 2018 Oct;188(2):583-593. doi: 10.1007/s00442-018-4217-0. Epub 2018 Jul 6.


Suppurative cribriform ulcers in one leg.

Chan L, Henderson CJ, Weller PA, Tong PL.

Int J Dermatol. 2018 Nov;57(11):1301-1303. doi: 10.1111/ijd.14024. Epub 2018 May 11. No abstract available.


Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy.

MacLeod AK, Lin, Huang JT, McLaughlin LA, Henderson CJ, Wolf CR.

Clin Cancer Res. 2018 May 1;24(9):2138-2147. doi: 10.1158/1078-0432.CCR-17-3555. Epub 2018 Feb 6.


Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice.

Reed L, Mrizova I, Barta F, Indra R, Moserova M, Kopka K, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM.

Arch Toxicol. 2018 Apr;92(4):1625-1638. doi: 10.1007/s00204-018-2162-7. Epub 2018 Jan 24.


Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function.

Pandey AV, Henderson CJ, Ishii Y, Kranendonk M, Backes WL, Zanger UM.

Front Pharmacol. 2017 Nov 27;8:881. doi: 10.3389/fphar.2017.00881. eCollection 2017. No abstract available.


Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse.

McMahon M, Ding S, Acosta-Jimenez LP, Frangova TG, Henderson CJ, Wolf CR.

J Physiol. 2018 Jan 1;596(1):105-127. doi: 10.1113/JP274915. Epub 2017 Nov 23.


Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites.

Lin, Kostov R, Huang JT, Henderson CJ, Wolf CR.

J Pharmacol Exp Ther. 2017 Oct;363(1):12-19. doi: 10.1124/jpet.117.243246.


Xenobiotic CAR Activators Induce Dlk1-Dio3 Locus Noncoding RNA Expression in Mouse Liver.

Pouché L, Vitobello A, Römer M, Glogovac M, MacLeod AK, Ellinger-Ziegelbauer H, Westphal M, Dubost V, Stiehl DP, Dumotier B, Fekete A, Moulin P, Zell A, Schwarz M, Moreno R, Huang JTJ, Elcombe CR, Henderson CJ, Roland Wolf C, Moggs JG, Terranova R.

Toxicol Sci. 2017 Aug 1;158(2):367-378. doi: 10.1093/toxsci/kfx104.


Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

MacLeod AK, Acosta-Jimenez L, Coates PJ, McMahon M, Carey FA, Honda T, Hayes JD, Henderson CJ, Wolf CR.

Br J Cancer. 2017 Aug 22;117(5):e1. doi: 10.1038/bjc.2017.80. Epub 2017 Mar 21.


Feedback control of AHR signalling regulates intestinal immunity.

Schiering C, Wincent E, Metidji A, Iseppon A, Li Y, Potocnik AJ, Omenetti S, Henderson CJ, Wolf CR, Nebert DW, Stockinger B.

Nature. 2017 Feb 9;542(7640):242-245. doi: 10.1038/nature21080. Epub 2017 Feb 1.


MRE11 and ATM Expression Levels Predict Rectal Cancer Survival and Their Association with Radiotherapy Response.

Ho V, Chung L, Revoltar M, Lim SH, Tut TG, Abubakar A, Henderson CJ, Chua W, Ng W, Lee M, De Souza P, Morgan M, Lee CS, Shin JS.

PLoS One. 2016 Dec 8;11(12):e0167675. doi: 10.1371/journal.pone.0167675. eCollection 2016.


Aryl hydrocarbon receptor is required for optimal B-cell proliferation.

Villa M, Gialitakis M, Tolaini M, Ahlfors H, Henderson CJ, Wolf CR, Brink R, Stockinger B.

EMBO J. 2017 Jan 4;36(1):116-128. doi: 10.15252/embj.201695027. Epub 2016 Nov 14.


Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

MacLeod AK, Acosta-Jimenez L, Coates PJ, McMahon M, Carey FA, Honda T, Henderson CJ, Wolf CR.

Br J Cancer. 2016 Dec 6;115(12):1530-1539. doi: 10.1038/bjc.2016.363. Epub 2016 Nov 8. Erratum in: Br J Cancer. 2017 Aug 22;117(5):e1.


Optimising Land-Sea Management for Inshore Coral Reefs.

Gilby BL, Olds AD, Connolly RM, Stevens T, Henderson CJ, Maxwell PS, Tibbetts IR, Schoeman DS, Rissik D, Schlacher TA.

PLoS One. 2016 Oct 20;11(10):e0164934. doi: 10.1371/journal.pone.0164934. eCollection 2016.


Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants.

MacLeod AK, McLaughlin LA, Henderson CJ, Wolf CR.

Drug Metab Dispos. 2017 Jan;45(1):17-22. Epub 2016 Oct 18.


Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.

Takahashi S, Fukami T, Masuo Y, Brocker CN, Xie C, Krausz KW, Wolf CR, Henderson CJ, Gonzalez FJ.

J Lipid Res. 2016 Dec;57(12):2130-2137. Epub 2016 Sep 16.


Ulnar-Sided Wrist Pain in the Athlete.

Henderson CJ, Kobayashi KM.

Orthop Clin North Am. 2016 Oct;47(4):789-98. doi: 10.1016/j.ocl.2016.05.017. Review.


Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse.

McMahon M, Frangova TG, Henderson CJ, Wolf CR.

Mol Cancer Res. 2016 Dec;14(12):1195-1203. Epub 2016 Sep 7.


Quantifying the influence of small omnivorous fishes on seagrass epiphyte load.

Gilby BL, Henderson CJ, Tibbetts IR, Burfeind DD.

J Fish Biol. 2016 Sep;89(3):1905-12. doi: 10.1111/jfb.13096. Epub 2016 Jul 26.


Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, Townsend DM, Henderson CJ, Wolf CR, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, van der Vliet A, Flemer S, Anathy V, Janssen-Heininger YM.

JCI Insight. 2016 Jun 2;1(8). pii: 85717. doi: 10.1172/jci.insight.85717.


An evaluation of Minor Groove Binders as anti-lung cancer therapeutics.

Scott FJ, Puig-Sellart M, Khalaf AI, Henderson CJ, Westrop G, Watson DG, Carter K, Grant MH, Suckling CJ.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3478-86. doi: 10.1016/j.bmcl.2016.06.040. Epub 2016 Jun 16.


Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications.

Nelson LJ, Morgan K, Treskes P, Samuel K, Henderson CJ, LeBled C, Homer N, Grant MH, Hayes PC, Plevris JN.

Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):30-37. doi: 10.1111/bcpt.12631. Epub 2016 Jul 15.


Automatic effects of illness schema activation on behavioral manifestations of illness.

Orbell S, Henderson CJ.

Health Psychol. 2016 Oct;35(10):1144-53. doi: 10.1037/hea0000375. Epub 2016 Jun 2.


Assessing the suitability of a non-lethal biopsy punch for sampling fish muscle tissue.

Henderson CJ, Stevens TF, Lee SY.

Fish Physiol Biochem. 2016 Dec;42(6):1521-1526. Epub 2016 May 13.


The early bird and the worm: a case of cercarial dermatitis.

Frew JW, Henderson CJ, McCrossin ID.

Med J Aust. 2016 Feb 15;204(3):122-3.e1. No abstract available.


The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function.

Scott EE, Wolf CR, Otyepka M, Humphreys SC, Reed JR, Henderson CJ, McLaughlin LA, Paloncýová M, Navrátilová V, Berka K, Anzenbacher P, Dahal UP, Barnaba C, Brozik JA, Jones JP, Estrada DF, Laurence JS, Park JW, Backes WL.

Drug Metab Dispos. 2016 Apr;44(4):576-90. doi: 10.1124/dmd.115.068569. Epub 2016 Feb 5. Review.


Model Systems for Understanding Mechanisms of Nongenotoxic Carcinogenesis: Response.

Braeuning A, Henderson CJ, Wolf CR, Schwarz M.

Toxicol Sci. 2015 Oct;147(2):299-300. No abstract available.


Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.

MacLeod AK, McLaughlin LA, Henderson CJ, Wolf CR.

Cancer Res. 2015 Nov 1;75(21):4573-81. doi: 10.1158/0008-5472.CAN-15-1454. Epub 2015 Sep 11.


Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity.

McGarry DJ, Chakravarty P, Wolf CR, Henderson CJ.

J Pharmacol Exp Ther. 2015 Nov;355(2):137-44. doi: 10.1124/jpet.115.227389. Epub 2015 Aug 26.


Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model.

Scheer N, Kapelyukh Y, Rode A, Oswald S, Busch D, McLaughlin LA, Lin D, Henderson CJ, Wolf CR.

Drug Metab Dispos. 2015 Nov;43(11):1679-90. doi: 10.1124/dmd.115.065656. Epub 2015 Aug 11.


Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.

Kostov RV, Knatko EV, McLaughlin LA, Henderson CJ, Zheng S, Huang JT, Honda T, Dinkova-Kostova AT.

Biochem Biophys Res Commun. 2015 Sep 25;465(3):402-7. doi: 10.1016/j.bbrc.2015.08.016. Epub 2015 Aug 8.


Illness Schema Activation and the Effects of Illness Seasonality on Accessibility of Implicit Illness-Related Information.

Orbell S, Henderson CJ, Hagger MS.

Ann Behav Med. 2015 Dec;49(6):918-23. doi: 10.1007/s12160-015-9719-y. No abstract available.


Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver.

McGarry DJ, Chen W, Chakravarty P, Lamont DL, Wolf CR, Henderson CJ.

Biochem J. 2015 Jul 1;469(1):25-32. doi: 10.1042/BJ20141256. Epub 2015 Apr 20.


Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.

Henderson CJ, Cameron AR, Chatham L, Stanley LA, Wolf CR.

Toxicol Sci. 2015 May;145(1):138-48. doi: 10.1093/toxsci/kfv039. Epub 2015 Feb 17.


Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

Henderson CJ, McLaughlin LA, Scheer N, Stanley LA, Wolf CR.

Mol Pharmacol. 2015 Apr;87(4):733-9. doi: 10.1124/mol.114.097394. Epub 2015 Feb 5.


Value of an Additional Review for Eosinophil Quantification in Esophageal Biopsies.

Stucke EM, Clarridge KE, Collins MH, Henderson CJ, Martin LJ, Rothenberg ME.

J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):65-8. doi: 10.1097/MPG.0000000000000740.


An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.

MacLeod AK, Fallon PG, Sharp S, Henderson CJ, Wolf CR, Huang JT.

Mol Cell Proteomics. 2015 Mar;14(3):750-60. doi: 10.1074/mcp.M114.043661. Epub 2015 Jan 5.


HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents.

McMahon M, Campbell KH, MacLeod AK, McLaughlin LA, Henderson CJ, Wolf CR.

PLoS One. 2014 Nov 26;9(11):e114055. doi: 10.1371/journal.pone.0114055. eCollection 2014.

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