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Items: 27


Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease.

Rosenblad C, Li Q, Pioli EY, Dovero S, Antunes AS, Agúndez L, Bardelli M, Linden RM, Henckaerts E, Björklund A, Bezard E, Björklund T.

Brain. 2019 Aug 1;142(8):2402-2416. doi: 10.1093/brain/awz176.


An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA.

Gray AL, O'Leary C, Liao A, Agúndez L, Youshani AS, Gleitz HF, Parker H, Taylor JT, Danos O, Hocquemiller M, Palomar N, Linden RM, Henckaerts E, Holley RJ, Bigger BW.

Hum Gene Ther. 2019 Jun 4. doi: 10.1089/hum.2018.189. [Epub ahead of print]


Exchange of functional domains between a bacterial conjugative relaxase and the integrase of the human adeno-associated virus.

Agúndez L, Zárate-Pérez F, Meier AF, Bardelli M, Llosa M, Escalante CR, Linden RM, Henckaerts E.

PLoS One. 2018 Jul 17;13(7):e0200841. doi: 10.1371/journal.pone.0200841. eCollection 2018.


Inhibition of somatosensory mechanotransduction by annexin A6.

Raouf R, Lolignier S, Sexton JE, Millet Q, Santana-Varela S, Biller A, Fuller AM, Pereira V, Choudhary JS, Collins MO, Moss SE, Lewis R, Tordo J, Henckaerts E, Linden M, Wood JN.

Sci Signal. 2018 Jun 19;11(535). pii: eaao2060. doi: 10.1126/scisignal.aao2060.


AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease.

Hughes MP, Smith DA, Morris L, Fletcher C, Colaco A, Huebecker M, Tordo J, Palomar N, Massaro G, Henckaerts E, Waddington SN, Platt FM, Rahim AA.

Hum Mol Genet. 2018 Sep 1;27(17):3079-3098. doi: 10.1093/hmg/ddy212.


A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.

Tordo J, O'Leary C, Antunes ASLM, Palomar N, Aldrin-Kirk P, Basche M, Bennett A, D'Souza Z, Gleitz H, Godwin A, Holley RJ, Parker H, Liao AY, Rouse P, Youshani AS, Dridi L, Martins C, Levade T, Stacey KB, Davis DM, Dyer A, Clément N, Björklund T, Ali RR, Agbandje-McKenna M, Rahim AA, Pshezhetsky A, Waddington SN, Linden RM, Bigger BW, Henckaerts E.

Brain. 2018 Jul 1;141(7):2014-2031. doi: 10.1093/brain/awy126.


Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome.

Smith-Moore S, Neil SJD, Fraefel C, Linden RM, Bollen M, Rowe HM, Henckaerts E.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3529-E3538. doi: 10.1073/pnas.1721883115. Epub 2018 Mar 26.


Analysis of Replicative Intermediates of Adeno-associated Virus through Hirt Extraction and Southern Blotting.

Bardelli M, Zarate-Perez F, Agundez L, Jolinon N, Michael Linden R, Escalante CR, Henckaerts E.

Bio Protoc. 2017 May 5;7(9). pii: e2271. doi: 10.21769/BioProtoc.2271.


Determination of Adeno-associated Virus Rep DNA Binding Using Fluorescence Anisotropy.

Zarate-Perez F, Santosh V, Bardelli M, Agundez L, Linden RM, Henckaerts E, Escalante CR.

Bio Protoc. 2017 Mar 20;7(6). pii: e2194.


Identification of a Functionally Relevant Adeno-Associated Virus Rep68 Oligomeric Interface.

Bardelli M, Zárate-Pérez F, Agúndez L, Linden RM, Escalante CR, Henckaerts E.

J Virol. 2016 Jul 11;90(15):6612-6624. doi: 10.1128/JVI.00356-16. Print 2016 Aug 1.


Structural Studies of AAV2 Rep68 Reveal a Partially Structured Linker and Compact Domain Conformation.

Musayev FN, Zarate-Perez F, Bardelli M, Bishop C, Saniev EF, Linden RM, Henckaerts E, Escalante CR.

Biochemistry. 2015 Sep 29;54(38):5907-19. doi: 10.1021/acs.biochem.5b00610. Epub 2015 Sep 14.


Presence of a trs-Like Motif Promotes Rep-Mediated Wild-Type Adeno-Associated Virus Type 2 Integration.

Petri K, Gabriel R, Agundez L, Fronza R, Afzal S, Kaeppel C, Linden RM, Henckaerts E, Schmidt M.

J Virol. 2015 Jul;89(14):7428-32. doi: 10.1128/JVI.00426-15. Epub 2015 May 13.


Adeno-associated virus Rep represses the human integration site promoter by two pathways that are similar to those required for the regulation of the viral p5 promoter.

Dutheil N, Smith SC, Agúndez L, Vincent-Mistiaen ZI, Escalante CR, Linden RM, Henckaerts E.

J Virol. 2014 Aug;88(15):8227-41. doi: 10.1128/JVI.00412-14. Epub 2014 May 14.


Comparative next-generation sequencing of adeno-associated virus inverted terminal repeats.

Petri K, Fronza R, Gabriel R, Käppel C, Nowrouzi A, Linden RM, Henckaerts E, Schmidt M.

Biotechniques. 2014 May 1;56(5):269-73. doi: 10.2144/000114170. eCollection 2014 May.


Brief report: self-organizing neuroepithelium from human pluripotent stem cells facilitates derivation of photoreceptors.

Boucherie C, Mukherjee S, Henckaerts E, Thrasher AJ, Sowden JC, Ali RR.

Stem Cells. 2013 Feb;31(2):408-14. doi: 10.1002/stem.1268.


Quantification of AAV particle titers by infrared fluorescence scanning of coomassie-stained sodium dodecyl sulfate-polyacrylamide gels.

Kohlbrenner E, Henckaerts E, Rapti K, Gordon RE, Linden RM, Hajjar RJ, Weber T.

Hum Gene Ther Methods. 2012 Jun;23(3):198-203. doi: 10.1089/hgtb.2012.049. Epub 2012 Jul 20.


Adeno-associated virus: a key to the human genome?

Henckaerts E, Linden RM.

Future Virol. 2010 Sep 1;5(5):555-574.


Transcriptional analysis of the adeno-associated virus integration site.

Dutheil N, Henckaerts E, Kohlbrenner E, Linden RM.

J Virol. 2009 Dec;83(23):12512-25. doi: 10.1128/JVI.01754-09. Epub 2009 Sep 16.


Site-specific integration of adeno-associated virus involves partial duplication of the target locus.

Henckaerts E, Dutheil N, Zeltner N, Kattman S, Kohlbrenner E, Ward P, Clément N, Rebollo P, Kennedy M, Keller GM, Linden RM.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7571-6. doi: 10.1073/pnas.0806821106. Epub 2009 Apr 16.


Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.

Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM.

Nature. 2008 May 22;453(7194):524-8. doi: 10.1038/nature06894. Epub 2008 Apr 23.


Characterization of the mouse adeno-associated virus AAVS1 ortholog.

Dutheil N, Yoon-Robarts M, Ward P, Henckaerts E, Skrabanek L, Berns KI, Campagne F, Linden RM.

J Virol. 2004 Aug;78(16):8917-21.


Generation of dendritic cells from bone marrow progenitors using GM-CSF, TNF-alpha, and additional cytokines: antagonistic effects of IL-4 and IFN-gamma and selective involvement of TNF-alpha receptor-1.

Lardon F, Snoeck HW, Berneman ZN, Van Tendeloo VF, Nijs G, Lenjou M, Henckaerts E, Boeckxtaens CJ, Vandenabeele P, Kestens LL, Van Bockstaele DR, Vanham GL.

Immunology. 1997 Aug;91(4):553-9.

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