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Editorial: Long Non-coding RNAs and Immunity.

Kwon GJ, Henao-Mejia J, Williams A.

Front Immunol. 2019 Oct 9;10:2378. doi: 10.3389/fimmu.2019.02378. eCollection 2019. No abstract available.


Efficient and flexible tagging of endogenous genes by homology-independent intron targeting.

Serebrenik YV, Sansbury SE, Kumar SS, Henao-Mejia J, Shalem O.

Genome Res. 2019 Aug;29(8):1322-1328. doi: 10.1101/gr.246413.118. Epub 2019 Jun 25.


The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs.

Virtue AT, McCright SJ, Wright JM, Jimenez MT, Mowel WK, Kotzin JJ, Joannas L, Basavappa MG, Spencer SP, Clark ML, Eisennagel SH, Williams A, Levy M, Manne S, Henrickson SE, Wherry EJ, Thaiss CA, Elinav E, Henao-Mejia J.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaav1892. doi: 10.1126/scitranslmed.aav1892.


The long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection.

Kotzin JJ, Iseka F, Wright J, Basavappa MG, Clark ML, Ali MA, Abdel-Hakeem MS, Robertson TF, Mowel WK, Joannas L, Neal VD, Spencer SP, Syrett CM, Anguera MC, Williams A, Wherry EJ, Henao-Mejia J.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11916-11925. doi: 10.1073/pnas.1819457116. Epub 2019 May 28.


Preemptive ECMO Cannulation in a Patient with Severe Left Ventricular Systolic Dysfunction Undergoing Cesarean Delivery.

Bui P, Mascaro PG, Henao-Mejia J, Patel S.

Case Rep Anesthesiol. 2019 Apr 8;2019:2623608. doi: 10.1155/2019/2623608. eCollection 2019.


miR-181a/b downregulation exerts a protective action on mitochondrial disease models.

Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez-Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao-Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S, Franco B.

EMBO Mol Med. 2019 May;11(5). pii: e8734. doi: 10.15252/emmm.201708734.


Long noncoding RNAs and the regulation of innate immunity and host-virus interactions.

Basavappa M, Cherry S, Henao-Mejia J.

J Leukoc Biol. 2019 Jul;106(1):83-93. doi: 10.1002/JLB.3MIR0918-354R. Epub 2019 Feb 28. Review.


TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.

Sarute N, Ibrahim N, Medegan Fagla B, Lavanya M, Cuevas C, Stavrou S, Otkiran-Clare G, Tyynismaa H, Henao-Mejia J, Ross SR.

PLoS Biol. 2019 Feb 6;17(2):e3000137. doi: 10.1371/journal.pbio.3000137. eCollection 2019 Feb.


Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis.

Cai Z, Kotzin JJ, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali RS, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R.

Cell Stem Cell. 2018 Dec 6;23(6):833-849.e5. doi: 10.1016/j.stem.2018.10.013.


Radiotherapy and CD40 Activation Separately Augment Immunity to Checkpoint Blockade in Cancer.

Rech AJ, Dada H, Kotzin JJ, Henao-Mejia J, Minn AJ, Twyman-Saint Victor C, Vonderheide RH.

Cancer Res. 2018 Aug 1;78(15):4282-4291. doi: 10.1158/0008-5472.CAN-17-3821. Epub 2018 May 29.


CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes.

Ma Z, Taruno A, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff H, Payne R, Demuro A, Parker I, Mitchell CH, Henao-Mejia J, Tanis JE, Matsumoto I, Tordoff MG, Foskett JK.

Neuron. 2018 May 2;98(3):547-561.e10. doi: 10.1016/j.neuron.2018.03.043. Epub 2018 Apr 19.


NLRP6 and Dysbiosis: Avoiding the Luring Attraction of Over-Simplification.

Elinav E, Henao-Mejia J, Strowig T, Flavell R.

Immunity. 2018 Apr 17;48(4):603-604. doi: 10.1016/j.immuni.2018.04.002. No abstract available.


ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates.

Guan T, Dominguez CX, Amezquita RA, Laidlaw BJ, Cheng J, Henao-Mejia J, Williams A, Flavell RA, Lu J, Kaech SM.

J Exp Med. 2018 Apr 2;215(4):1153-1168. doi: 10.1084/jem.20171352. Epub 2018 Feb 15.


Viruses hijack a host lncRNA to replicate.

Kotzin JJ, Mowel WK, Henao-Mejia J.

Science. 2017 Nov 24;358(6366):993-994. doi: 10.1126/science.aar2300. No abstract available.


Immune System: An Emerging Player in Mediating Effects of Endocrine Disruptors on Metabolic Health.

Bansal A, Henao-Mejia J, Simmons RA.

Endocrinology. 2018 Jan 1;159(1):32-45. doi: 10.1210/en.2017-00882. Review.


Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.

Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, DeLaney A, Spencer SP, Virtue AT, Yang E, Villarino A, Kurachi M, Dunagin MC, Pritchard GH, Stein J, Hughes C, Fonseca-Pereira D, Veiga-Fernandes H, Raj A, Kambayashi T, Brodsky IE, O'Shea JJ, Wherry EJ, Goff LA, Rinn JL, Williams A, Flavell RA, Henao-Mejia J.

Immunity. 2017 Sep 19;47(3):435-449.e8. doi: 10.1016/j.immuni.2017.08.012.


Control of Immune Cell Homeostasis and Function by lncRNAs.

Mowel WK, Kotzin JJ, McCright SJ, Neal VD, Henao-Mejia J.

Trends Immunol. 2018 Jan;39(1):55-69. doi: 10.1016/ Epub 2017 Sep 14. Review.


Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.

Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML.

Nature. 2017 May 18;545(7654):305-310. doi: 10.1038/nature22075. Epub 2017 May 10.


miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling.

Hori D, Dunkerly-Eyring B, Nomura Y, Biswas D, Steppan J, Henao-Mejia J, Adachi H, Santhanam L, Berkowitz DE, Steenbergen C, Flavell RA, Das S.

PLoS One. 2017 Mar 21;12(3):e0174108. doi: 10.1371/journal.pone.0174108. eCollection 2017.


Divergent Effects of miR-181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets.

Das S, Kohr M, Dunkerly-Eyring B, Lee DI, Bedja D, Kent OA, Leung AK, Henao-Mejia J, Flavell RA, Steenbergen C.

J Am Heart Assoc. 2017 Feb 27;6(3). pii: e004694. doi: 10.1161/JAHA.116.004694.


The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.

Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA.

Science. 2016 Nov 11;354(6313):765-768.


Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.

Philip NH, DeLaney A, Peterson LW, Santos-Marrero M, Grier JT, Sun Y, Wynosky-Dolfi MA, Zwack EE, Hu B, Olsen TM, Rongvaux A, Pope SD, López CB, Oberst A, Beiting DP, Henao-Mejia J, Brodsky IE.

PLoS Pathog. 2016 Oct 13;12(10):e1005910. doi: 10.1371/journal.ppat.1005910. eCollection 2016 Oct.


The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan.

Kotzin JJ, Spencer SP, McCright SJ, Kumar DBU, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CCD, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J.

Nature. 2016 Sep 8;537(7619):239-243. doi: 10.1038/nature19346. Epub 2016 Aug 15.


Editing the Mouse Genome Using the CRISPR-Cas9 System.

Williams A, Henao-Mejia J, Flavell RA.

Cold Spring Harb Protoc. 2016 Feb 1;2016(2):pdb.top087536. doi: 10.1101/pdb.top087536.


Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System.

Henao-Mejia J, Williams A, Rongvaux A, Stein J, Hughes C, Flavell RA.

Cold Spring Harb Protoc. 2016 Feb 1;2016(2):pdb.prot090704. doi: 10.1101/pdb.prot090704.


Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.

Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA.

Nature. 2016 Feb 25;530(7591):504. doi: 10.1038/nature16074. Epub 2015 Nov 25. No abstract available.


Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.

Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Müller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3056-61. doi: 10.1073/pnas.1501554112. Epub 2015 Feb 23.


NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.

Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, Elinav E, Finlay BB, Flavell RA.

Cell. 2014 Feb 27;156(5):1045-59. doi: 10.1016/j.cell.2014.01.026.


Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre.

Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL.

Nat Struct Mol Biol. 2014 Feb;21(2):198-206. doi: 10.1038/nsmb.2764. Epub 2014 Jan 26.


Inflammasomes and metabolic disease.

Henao-Mejia J, Elinav E, Thaiss CA, Flavell RA.

Annu Rev Physiol. 2014;76:57-78. doi: 10.1146/annurev-physiol-021113-170324. Epub 2013 Nov 21. Review.


miR-181 and metabolic regulation in the immune system.

Williams A, Henao-Mejia J, Harman CC, Flavell RA.

Cold Spring Harb Symp Quant Biol. 2013;78:223-30. doi: 10.1101/sqb.2013.78.020024. Epub 2013 Oct 25.


Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection.

Licona-Limón P, Henao-Mejia J, Temann AU, Gagliani N, Licona-Limón I, Ishigame H, Hao L, Herbert DR, Flavell RA.

Immunity. 2013 Oct 17;39(4):744-57. doi: 10.1016/j.immuni.2013.07.020.


Role of the intestinal microbiome in liver disease.

Henao-Mejia J, Elinav E, Thaiss CA, Licona-Limon P, Flavell RA.

J Autoimmun. 2013 Oct;46:66-73. doi: 10.1016/j.jaut.2013.07.001. Epub 2013 Sep 24. Review.


Innate immune receptors: key regulators of metabolic disease progression.

Jin C, Henao-Mejia J, Flavell RA.

Cell Metab. 2013 Jun 4;17(6):873-82. doi: 10.1016/j.cmet.2013.05.011. Review.


Microbiota keep the intestinal clock ticking.

Henao-Mejia J, Strowig T, Flavell RA.

Cell. 2013 May 9;153(4):741-3. doi: 10.1016/j.cell.2013.04.043. Erratum in: Cell. 2013 Jun 20;153(7):1612.


The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.

Henao-Mejia J, Williams A, Goff LA, Staron M, Licona-Limón P, Kaech SM, Nakayama M, Rinn JL, Flavell RA.

Immunity. 2013 May 23;38(5):984-97. doi: 10.1016/j.immuni.2013.02.021. Epub 2013 Apr 25.


The intestinal microbiota in chronic liver disease.

Henao-Mejia J, Elinav E, Thaiss CA, Flavell RA.

Adv Immunol. 2013;117:73-97. doi: 10.1016/B978-0-12-410524-9.00003-7. Review.


Integrative inflammasome activity in the regulation of intestinal mucosal immune responses.

Elinav E, Henao-Mejia J, Flavell RA.

Mucosal Immunol. 2013 Jan;6(1):4-13. doi: 10.1038/mi.2012.115. Epub 2012 Dec 5. Review.


NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.

Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA.

Nature. 2012 Apr 25;484(7395):510-3. doi: 10.1038/nature11012. Erratum in: Nature. 2016 Feb 25;530(7591):504.


Inflammasomes: far beyond inflammation.

Henao-Mejia J, Elinav E, Strowig T, Flavell RA.

Nat Immunol. 2012 Mar 19;13(4):321-4. doi: 10.1038/ni.2257. Review.


Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.

Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA.

Nature. 2012 Feb 1;482(7384):179-85. doi: 10.1038/nature10809.


Inflammasomes in health and disease.

Strowig T, Henao-Mejia J, Elinav E, Flavell R.

Nature. 2012 Jan 18;481(7381):278-86. doi: 10.1038/nature10759. Review.


Association between maternal prenatal vitamin use and congenital abnormalities of the genitourinary tract in a developing country.

Fernández N, Henao-Mejía J, Monterrey P, Pérez J, Zarante I.

J Pediatr Urol. 2012 Apr;8(2):121-6. doi: 10.1016/j.jpurol.2011.07.005. Epub 2011 Sep 17.


Regulation of the antimicrobial response by NLR proteins.

Elinav E, Strowig T, Henao-Mejia J, Flavell RA.

Immunity. 2011 May 27;34(5):665-79. doi: 10.1016/j.immuni.2011.05.007. Review.


NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.

Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA.

Cell. 2011 May 27;145(5):745-57. doi: 10.1016/j.cell.2011.04.022. Epub 2011 May 12.


Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3.

Liu J, Henao-Mejia J, Liu H, Zhao Y, He JJ.

J Neuroimmune Pharmacol. 2011 Jun;6(2):308-21. doi: 10.1007/s11481-011-9265-8. Epub 2011 Mar 1.


Hepatitis C virus is restricted at both entry and replication in mouse hepatocytes.

Park IW, Ndjomou J, Fan Y, Henao-Mejia J, He JJ.

Biochem Biophys Res Commun. 2009 Sep 25;387(3):489-93. doi: 10.1016/j.bbrc.2009.07.076. Epub 2009 Jul 18.


Sam68 relocalization into stress granules in response to oxidative stress through complexing with TIA-1.

Henao-Mejia J, He JJ.

Exp Cell Res. 2009 Nov 15;315(19):3381-95. doi: 10.1016/j.yexcr.2009.07.011. Epub 2009 Jul 14.


Sam68 functions in nuclear export and translation of HIV-1 RNA.

He JJ, Henao-Mejia J, Liu Y.

RNA Biol. 2009 Sep-Oct;6(4):384-6. Epub 2009 Sep 1.


Suppression of HIV-1 Nef translation by Sam68 mutant-induced stress granules and nef mRNA sequestration.

Henao-Mejia J, Liu Y, Park IW, Zhang J, Sanford J, He JJ.

Mol Cell. 2009 Jan 16;33(1):87-96. doi: 10.1016/j.molcel.2008.11.024.

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