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Items: 1 to 50 of 331

1.

Contributions of adult neurogenesis to dentate gyrus network activity and computations.

Tuncdemir SN, Lacefield CO, Hen R.

Behav Brain Res. 2019 Nov 18;374:112112. doi: 10.1016/j.bbr.2019.112112. Epub 2019 Aug 1. Review.

PMID:
31377252
2.

Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus.

Luna VM, Anacker C, Burghardt NS, Khandaker H, Andreu V, Millette A, Leary P, Ravenelle R, Jimenez JC, Mastrodonato A, Denny CA, Fenton AA, Scharfman HE, Hen R.

Science. 2019 May 10;364(6440):578-583. doi: 10.1126/science.aat8789. Epub 2019 May 9.

PMID:
31073064
3.

Resilience Is Associated With Larger Dentate Gyrus, While Suicide Decedents With Major Depressive Disorder Have Fewer Granule Neurons.

Boldrini M, Galfalvy H, Dwork AJ, Rosoklija GB, Trencevska-Ivanovska I, Pavlovski G, Hen R, Arango V, Mann JJ.

Biol Psychiatry. 2019 May 15;85(10):850-862. doi: 10.1016/j.biopsych.2018.12.022. Epub 2019 Jan 17.

PMID:
30819514
4.

Functional Interrogation of a Depression-Related Serotonergic Single Nucleotide Polymorphism, rs6295, Using a Humanized Mouse Model.

Cunningham AM, Santos TL, Gutzeit VA, Hamilton H, Hen R, Donaldson ZR.

ACS Chem Neurosci. 2019 Jul 17;10(7):3197-3206. doi: 10.1021/acschemneuro.8b00638. Epub 2019 Feb 12.

PMID:
30694044
5.

Loss of Adult 5-HT1A Autoreceptors Results in a Paradoxical Anxiogenic Response to Antidepressant Treatment.

Turcotte-Cardin V, Vahid-Ansari F, Luckhart C, Daigle M, Geddes SD, Tanaka KF, Hen R, James J, Merali Z, Béïque JC, Albert PR.

J Neurosci. 2019 Feb 20;39(8):1334-1346. doi: 10.1523/JNEUROSCI.0352-18.2018. Epub 2018 Dec 14.

6.

Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain.

Tartt AN, Fulmore CA, Liu Y, Rosoklija GB, Dwork AJ, Arango V, Hen R, Mann JJ, Boldrini M.

Cell Stem Cell. 2018 Dec 6;23(6):782-783. doi: 10.1016/j.stem.2018.10.025. No abstract available.

PMID:
30526880
7.

Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus.

Anacker C, Luna VM, Stevens GS, Millette A, Shores R, Jimenez JC, Chen B, Hen R.

Nature. 2018 Jul;559(7712):98-102. doi: 10.1038/s41586-018-0262-4. Epub 2018 Jun 27.

8.

Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses.

Besnard A, Langberg T, Levinson S, Chu D, Vicidomini C, Scobie KN, Dwork AJ, Arango V, Rosoklija GB, Mann JJ, Hen R, Leonardo ED, Boldrini M, Sahay A.

Cell Rep. 2018 Jun 12;23(11):3183-3196. doi: 10.1016/j.celrep.2018.05.040.

9.

Human Adult Neurogenesis: Evidence and Remaining Questions.

Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J.

Cell Stem Cell. 2018 Jul 5;23(1):25-30. doi: 10.1016/j.stem.2018.04.004. Epub 2018 Apr 19. Review.

10.

Optimization of immunolabeling and clearing techniques for indelibly labeled memory traces.

Pavlova IP, Shipley SC, Lanio M, Hen R, Denny CA.

Hippocampus. 2018 Jul;28(7):523-535. doi: 10.1002/hipo.22951.

11.

Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes.

Philippe TJ, Vahid-Ansari F, Donaldson ZR, Le François B, Zahrai A, Turcotte-Cardin V, Daigle M, James J, Hen R, Merali Z, Albert PR.

Sci Rep. 2018 Apr 10;8(1):5788. doi: 10.1038/s41598-018-24167-8.

12.

Human Hippocampal Neurogenesis Persists throughout Aging.

Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, Rosoklija GB, Stankov A, Arango V, Dwork AJ, Hen R, Mann JJ.

Cell Stem Cell. 2018 Apr 5;22(4):589-599.e5. doi: 10.1016/j.stem.2018.03.015.

13.

Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data.

Zhou P, Resendez SL, Rodriguez-Romaguera J, Jimenez JC, Neufeld SQ, Giovannucci A, Friedrich J, Pnevmatikakis EA, Stuber GD, Hen R, Kheirbek MA, Sabatini BL, Kass RE, Paninski L.

Elife. 2018 Feb 22;7. pii: e28728. doi: 10.7554/eLife.28728.

14.

Anxiety Cells in a Hippocampal-Hypothalamic Circuit.

Jimenez JC, Su K, Goldberg AR, Luna VM, Biane JS, Ordek G, Zhou P, Ong SK, Wright MA, Zweifel L, Paninski L, Hen R, Kheirbek MA.

Neuron. 2018 Feb 7;97(3):670-683.e6. doi: 10.1016/j.neuron.2018.01.016. Epub 2018 Jan 31.

15.

Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens.

Tritschler L, Kheirbek MA, Dantec YL, Mendez-David I, Guilloux JP, Faye C, Doan J, Pham TH, Hen R, David DJ, Gardier AM.

Neurosci Res. 2018 Sep;134:56-60. doi: 10.1016/j.neures.2017.12.002. Epub 2017 Dec 12.

16.

Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior.

Vahid-Ansari F, Daigle M, Manzini MC, Tanaka KF, Hen R, Geddes SD, Béïque JC, James J, Merali Z, Albert PR.

J Neurosci. 2017 Dec 6;37(49):11967-11978. doi: 10.1523/JNEUROSCI.1668-17.2017. Epub 2017 Nov 3.

17.

A Novel Method for Chronic Social Defeat Stress in Female Mice.

Harris AZ, Atsak P, Bretton ZH, Holt ES, Alam R, Morton MP, Abbas AI, Leonardo ED, Bolkan SS, Hen R, Gordon JA.

Neuropsychopharmacology. 2018 May;43(6):1276-1283. doi: 10.1038/npp.2017.259. Epub 2017 Nov 1.

18.

Increasing adult hippocampal neurogenesis in mice after exposure to unpredictable chronic mild stress may counteract some of the effects of stress.

Culig L, Surget A, Bourdey M, Khemissi W, Le Guisquet AM, Vogel E, Sahay A, Hen R, Belzung C.

Neuropharmacology. 2017 Nov;126:179-189. doi: 10.1016/j.neuropharm.2017.09.009. Epub 2017 Sep 7.

PMID:
28890366
19.

Treatment resistant depression: A multi-scale, systems biology approach.

Akil H, Gordon J, Hen R, Javitch J, Mayberg H, McEwen B, Meaney MJ, Nestler EJ.

Neurosci Biobehav Rev. 2018 Jan;84:272-288. doi: 10.1016/j.neubiorev.2017.08.019. Epub 2017 Aug 30. Review.

20.

Gambling disorder: an integrative review of animal and human studies.

Nautiyal KM, Okuda M, Hen R, Blanco C.

Ann N Y Acad Sci. 2017 Apr;1394(1):106-127. doi: 10.1111/nyas.13356. Review.

21.

Adult hippocampal neurogenesis and cognitive flexibility - linking memory and mood.

Anacker C, Hen R.

Nat Rev Neurosci. 2017 Jun;18(6):335-346. doi: 10.1038/nrn.2017.45. Epub 2017 May 4. Review.

22.

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice.

Chen WV, Nwakeze CL, Denny CA, O'Keeffe S, Rieger MA, Mountoufaris G, Kirner A, Dougherty JD, Hen R, Wu Q, Maniatis T.

Science. 2017 Apr 28;356(6336):406-411. doi: 10.1126/science.aal3231.

23.

The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor.

Samuels BA, Nautiyal KM, Kruegel AC, Levinstein MR, Magalong VM, Gassaway MM, Grinnell SG, Han J, Ansonoff MA, Pintar JE, Javitch JA, Sames D, Hen R.

Neuropsychopharmacology. 2017 Sep;42(10):2052-2063. doi: 10.1038/npp.2017.60. Epub 2017 Mar 17.

24.

Serotonin receptors in depression: from A to B.

Nautiyal KM, Hen R.

F1000Res. 2017 Feb 9;6:123. doi: 10.12688/f1000research.9736.1. eCollection 2017. Review.

25.

S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice.

Guilloux JP, Samuels BA, Mendez-David I, Hu A, Levinstein M, Faye C, Mekiri M, Mocaer E, Gardier AM, Hen R, Sors A, David DJ.

Sci Rep. 2017 Feb 20;7:42946. doi: 10.1038/srep42946.

26.

Genetic and Modeling Approaches Reveal Distinct Components of Impulsive Behavior.

Nautiyal KM, Wall MM, Wang S, Magalong VM, Ahmari SE, Balsam PD, Blanco C, Hen R.

Neuropsychopharmacology. 2017 May;42(6):1182-1191. doi: 10.1038/npp.2016.277. Epub 2016 Dec 15.

27.

Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits.

McAvoy KM, Scobie KN, Berger S, Russo C, Guo N, Decharatanachart P, Vega-Ramirez H, Miake-Lye S, Whalen M, Nelson M, Bergami M, Bartsch D, Hen R, Berninger B, Sahay A.

Neuron. 2016 Sep 21;91(6):1356-1373. doi: 10.1016/j.neuron.2016.08.009. Epub 2016 Sep 1.

28.

Retinal Neuroprotective Effects of Flibanserin, an FDA-Approved Dual Serotonin Receptor Agonist-Antagonist.

Coyner AS, Ryals RC, Ku CA, Fischer CM, Patel RC, Datta S, Yang P, Wen Y, Hen R, Pennesi ME.

PLoS One. 2016 Jul 22;11(7):e0159776. doi: 10.1371/journal.pone.0159776. eCollection 2016.

29.

A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors.

Nautiyal KM, Tritschler L, Ahmari SE, David DJ, Gardier AM, Hen R.

Neuropsychopharmacology. 2016 Nov;41(12):2941-2950. doi: 10.1038/npp.2016.109. Epub 2016 Jun 29.

30.

GluN2B-Containg NMDA Receptors on Adult-Born Granule Cells Contribute to the Antidepressant Action of Fluoxetine.

Tannenholz L, Hen R, Kheirbek MA.

Front Neurosci. 2016 May 31;10:242. doi: 10.3389/fnins.2016.00242. eCollection 2016.

31.

Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding.

Danielson NB, Kaifosh P, Zaremba JD, Lovett-Barron M, Tsai J, Denny CA, Balough EM, Goldberg AR, Drew LJ, Hen R, Losonczy A, Kheirbek MA.

Neuron. 2016 Apr 6;90(1):101-12. doi: 10.1016/j.neuron.2016.02.019. Epub 2016 Mar 10.

32.

The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription.

Donaldson ZR, le Francois B, Santos TL, Almli LM, Boldrini M, Champagne FA, Arango V, Mann JJ, Stockmeier CA, Galfalvy H, Albert PR, Ressler KJ, Hen R.

Transl Psychiatry. 2016 Mar 1;6:e746. doi: 10.1038/tp.2015.226.

33.

Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice.

Mingote S, Masson J, Gellman C, Thomsen GM, Lin CS, Merker RJ, Gaisler-Salomon I, Wang Y, Ernst R, Hen R, Rayport S.

Front Syst Neurosci. 2016 Jan 8;9:165. doi: 10.3389/fnsys.2015.00165. eCollection 2015.

34.

Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons.

Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R.

Hippocampus. 2016 Jun;26(6):763-78. doi: 10.1002/hipo.22557. Epub 2016 Feb 8.

35.

Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies.

Satała G, Duszyńska B, Stachowicz K, Rafalo A, Pochwat B, Luckhart C, Albert PR, Daigle M, Tanaka KF, Hen R, Lenda T, Nowak G, Bojarski AJ, Szewczyk B.

Mol Neurobiol. 2016 Dec;53(10):6869-6881. Epub 2015 Dec 12.

36.

Neuroanatomic Differences Associated With Stress Susceptibility and Resilience.

Anacker C, Scholz J, O'Donnell KJ, Allemang-Grand R, Diorio J, Bagot RC, Nestler EJ, Hen R, Lerch JP, Meaney MJ.

Biol Psychiatry. 2016 May 15;79(10):840-849. doi: 10.1016/j.biopsych.2015.08.009. Epub 2015 Aug 18.

37.

5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response.

Samuels BA, Anacker C, Hu A, Levinstein MR, Pickenhagen A, Tsetsenis T, Madroñal N, Donaldson ZR, Drew LJ, Dranovsky A, Gross CT, Tanaka KF, Hen R.

Nat Neurosci. 2015 Nov;18(11):1606-16. doi: 10.1038/nn.4116. Epub 2015 Sep 21.

38.

Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice.

Borgkvist A, Avegno EM, Wong MY, Kheirbek MA, Sonders MS, Hen R, Sulzer D.

Neuron. 2015 Sep 2;87(5):976-88. doi: 10.1016/j.neuron.2015.08.022.

39.

Running rescues a fear-based contextual discrimination deficit in aged mice.

Wu MV, Luna VM, Hen R.

Front Syst Neurosci. 2015 Aug 11;9:114. doi: 10.3389/fnsys.2015.00114. eCollection 2015.

40.

Role of adult hippocampal neurogenesis in persistent pain.

Apkarian AV, Mutso AA, Centeno MV, Kan L, Wu M, Levinstein M, Banisadr G, Gobeske KT, Miller RJ, Radulovic J, Hen R, Kessler JA.

Pain. 2016 Feb;157(2):418-28. doi: 10.1097/j.pain.0000000000000332.

41.

Experience-Dependent Regulation of Dentate Gyrus Excitability by Adult-Born Granule Cells.

Park EH, Burghardt NS, Dvorak D, Hen R, Fenton AA.

J Neurosci. 2015 Aug 19;35(33):11656-66. doi: 10.1523/JNEUROSCI.0885-15.2015.

42.

Functional differentiation of adult-born neurons along the septotemporal axis of the dentate gyrus.

Wu MV, Sahay A, Duman RS, Hen R.

Cold Spring Harb Perspect Biol. 2015 Aug 3;7(8):a018978. doi: 10.1101/cshperspect.a018978. Review.

43.

Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior.

Brachman RA, McGowan JC, Perusini JN, Lim SC, Pham TH, Faye C, Gardier AM, Mendez-David I, David DJ, Hen R, Denny CA.

Biol Psychiatry. 2016 May 1;79(9):776-786. doi: 10.1016/j.biopsych.2015.04.022. Epub 2015 May 4.

44.

Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity.

Nautiyal KM, Tanaka KF, Barr MM, Tritschler L, Le Dantec Y, David DJ, Gardier AM, Blanco C, Hen R, Ahmari SE.

Neuron. 2015 May 6;86(3):813-26. doi: 10.1016/j.neuron.2015.03.041. Epub 2015 Apr 16.

45.

Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors.

Hill AS, Sahay A, Hen R.

Neuropsychopharmacology. 2015 Sep;40(10):2368-78. doi: 10.1038/npp.2015.85. Epub 2015 Apr 2.

46.

Regulation of hippocampal memory traces by neurogenesis.

Anacker C, Denny CA, Hen R.

Neurogenesis (Austin). 2015 Sep 17;2(1):e1025180. doi: 10.1080/23262133.2015.1025180. eCollection 2015.

47.

Hippocampal subfields and major depressive disorder.

Adam Samuels B, Leonardo ED, Hen R.

Biol Psychiatry. 2015 Feb 1;77(3):210-211. doi: 10.1016/j.biopsych.2014.11.007. No abstract available.

48.

Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout.

Hall FS, Sora I, Hen R, Uhl GR.

PLoS One. 2014 Dec 16;9(12):e115009. doi: 10.1371/journal.pone.0115009. eCollection 2014.

49.

Serotonin 1A and Serotonin 4 Receptors: Essential Mediators of the Neurogenic and Behavioral Actions of Antidepressants.

Samuels BA, Mendez-David I, Faye C, David SA, Pierz KA, Gardier AM, Hen R, David DJ.

Neuroscientist. 2016 Feb;22(1):26-45. doi: 10.1177/1073858414561303. Epub 2014 Dec 8. Review.

50.

Suppression of adult neurogenesis increases the acute effects of kainic acid.

Iyengar SS, LaFrancois JJ, Friedman D, Drew LJ, Denny CA, Burghardt NS, Wu MV, Hsieh J, Hen R, Scharfman HE.

Exp Neurol. 2015 Feb;264:135-49. doi: 10.1016/j.expneurol.2014.11.009. Epub 2014 Dec 2.

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