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Items: 1 to 50 of 181

1.

Extended Dosing Regimens for Fungal Prophylaxis.

Lehrnbecher T, Bochennek K, Klingebiel T, Gastine S, Hempel G, Groll AH.

Clin Microbiol Rev. 2019 May 15;32(3). pii: e00010-19. doi: 10.1128/CMR.00010-19. Print 2019 Jun 19. Review.

PMID:
31092507
2.

Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure.

Freundt JK, Frommeyer G, Spieker T, Wötzel F, Grotthoff JS, Stypmann J, Hempel G, Schäfers M, Jacobs AH, Eckardt L, Lange PS.

BMC Pharmacol Toxicol. 2019 Mar 6;20(1):16. doi: 10.1186/s40360-019-0294-x.

3.

Medical Education for "Generation Z": Everything online?! - An analysis of Internet-based media use by teachers in medicine.

Vogelsang M, Rockenbauch K, Wrigge H, Heinke W, Hempel G.

GMS J Med Educ. 2018 May 15;35(2):Doc21. doi: 10.3205/zma001168. eCollection 2018. Review.

4.

Treating Anemia in the Preanesthesia Assessment Clinic: Results of a Retrospective Evaluation.

Ellermann I, Bueckmann A, Eveslage M, Buddendick H, Latal T, Niehoff D, Geissler RG, Hempel G, Kerkhoff A, Berdel WE, Roeder N, Van Aken HK, Zarbock A, Steinbicker AU.

Anesth Analg. 2018 Nov;127(5):1202-1210. doi: 10.1213/ANE.0000000000003583.

PMID:
29944518
5.

Clinical consequences of chest tube malposition in trauma resuscitation: single-center experience.

Struck MF, Ewens S, Fakler JKM, Hempel G, Beilicke A, Bernhard M, Stumpp P, Josten C, Stehr SN, Wrigge H, Krämer S.

Eur J Trauma Emerg Surg. 2018 May 31. doi: 10.1007/s00068-018-0966-z. [Epub ahead of print]

PMID:
29855668
6.

Electrical Impedance Tomography for Confirmation of Lung Isolation during One-lung Ventilation.

Hempel G, Schulze G, Wirtz H, Wrigge H.

Anesthesiology. 2018 Sep;129(3):580. doi: 10.1097/ALN.0000000000002189. No abstract available. Erratum in: Anesthesiology. 2018 Aug;129(2):388.

PMID:
29578863
7.

Mechanical complications and outcomes following invasive emergency procedures in severely injured trauma patients.

Struck MF, Fakler JKM, Bernhard M, Busch T, Stumpp P, Hempel G, Beilicke A, Stehr SN, Josten C, Wrigge H.

Sci Rep. 2018 Mar 5;8(1):3976. doi: 10.1038/s41598-018-22457-9.

8.

[Respiratory Failure: Innovations in Diagnostics and Therapy].

Hempel G, Simon P, Salz P, Wrigge H.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2018 Feb;53(2):126-140. doi: 10.1055/s-0043-108216. Epub 2018 Feb 9. Review. German.

PMID:
29426051
9.

Investigation of the age dependency of vancomycin clearance by population pharmacokinetic modeling.

Usman M, Fobker M, Hempel G.

Int J Clin Pharmacol Ther. 2018 Feb;56(2):56-63. doi: 10.5414/CP203033.

PMID:
29319495
10.

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group.

Perego P, Hempel G, Linder S, Bradshaw TD, Larsen AK, Peters GJ, Phillips RM; EORTC PAMM Group.

Cancer Chemother Pharmacol. 2018 Mar;81(3):427-441. doi: 10.1007/s00280-017-3502-7. Epub 2017 Dec 28. Review.

PMID:
29285635
11.

Pharmacokinetics of recombinant asparaginase in children with acute lymphoblastic leukemia.

Völler S, Pichlmeier U, Zens A, Hempel G.

Cancer Chemother Pharmacol. 2018 Feb;81(2):305-314. doi: 10.1007/s00280-017-3492-5. Epub 2017 Dec 5.

PMID:
29204688
12.

An ethnopharmacological survey of medicinal plants traditionally used for cancer treatment in the Ashanti region, Ghana.

Agyare C, Spiegler V, Asase A, Scholz M, Hempel G, Hensel A.

J Ethnopharmacol. 2018 Feb 15;212:137-152. doi: 10.1016/j.jep.2017.10.019. Epub 2017 Oct 21.

PMID:
29066406
13.

Pharmacokinetic Modeling of Voriconazole To Develop an Alternative Dosing Regimen in Children.

Gastine S, Lehrnbecher T, Müller C, Farowski F, Bader P, Ullmann-Moskovits J, Cornely OA, Groll AH, Hempel G.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01194-17. doi: 10.1128/AAC.01194-17. Print 2018 Jan.

14.

Noninvasive ventilation during acute respiratory distress syndrome in patients with cancer-what really matters.

Hempel G, Petroff D, Wrigge H.

J Thorac Dis. 2017 Aug;9(8):2224-2227. doi: 10.21037/jtd.2017.06.131. No abstract available.

15.

A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.

Dallmann A, Ince I, Coboeken K, Eissing T, Hempel G.

Clin Pharmacokinet. 2018 Jun;57(6):749-768. doi: 10.1007/s40262-017-0594-5.

PMID:
28924743
16.

Gestation-Specific Changes in the Anatomy and Physiology of Healthy Pregnant Women: An Extended Repository of Model Parameters for Physiologically Based Pharmacokinetic Modeling in Pregnancy.

Dallmann A, Ince I, Meyer M, Willmann S, Eissing T, Hempel G.

Clin Pharmacokinet. 2017 Nov;56(11):1303-1330. doi: 10.1007/s40262-017-0539-z. Review.

PMID:
28401479
17.

Validation of a dried blood spot method for therapeutic drug monitoring of citalopram, mirtazapine and risperidone and its active metabolite 9-hydroxyrisperidone using HPLC-MS.

Weber J, Oberfeld S, Bonse A, Telger K, Lingg R, Hempel G.

J Pharm Biomed Anal. 2017 Jun 5;140:347-354. doi: 10.1016/j.jpba.2017.02.061. Epub 2017 Mar 27.

PMID:
28395245
18.

Physiologically Based Pharmacokinetic Modeling of Renally Cleared Drugs in Pregnant Women.

Dallmann A, Ince I, Solodenko J, Meyer M, Willmann S, Eissing T, Hempel G.

Clin Pharmacokinet. 2017 Dec;56(12):1525-1541. doi: 10.1007/s40262-017-0538-0.

PMID:
28391404
19.

Addressing Adherence Using Genotype-Specific PBPK Modeling-Impact of Drug Holidays on Tamoxifen and Endoxifen Plasma Levels.

Dickschen KJ, Willmann S, Hempel G, Block M.

Front Pharmacol. 2017 Mar 14;8:67. doi: 10.3389/fphar.2017.00067. eCollection 2017.

20.

Population Pharmacokinetics to Model the Time-Varying Clearance of the PEGylated Asparaginase Oncaspar® in Children with Acute Lymphoblastic Leukemia.

Würthwein G, Lanvers-Kaminsky C, Hempel G, Gastine S, Möricke A, Schrappe M, Karlsson MO, Boos J.

Eur J Drug Metab Pharmacokinet. 2017 Dec;42(6):955-963. doi: 10.1007/s13318-017-0410-5.

PMID:
28349335
21.

Elimination of digital and analog artefacts from time-domain signals.

Hempel G.

Solid State Nucl Magn Reson. 2017 Apr - May;82-83:29-34. doi: 10.1016/j.ssnmr.2017.01.009. Epub 2017 Feb 3.

PMID:
28187332
22.

Detection of patient-ventilator asynchrony should be improved: and then what?

Wrigge H, Girrbach F, Hempel G.

J Thorac Dis. 2016 Dec;8(12):E1661-E1664. doi: 10.21037/jtd.2016.12.101. No abstract available.

23.

Effect of training and structured medication review on medication appropriateness in nursing home residents and on cooperation between health care professionals: the InTherAKT study protocol.

Mahlknecht A, Nestler N, Bauer U, Schüßler N, Schuler J, Scharer S, Becker R, Waltering I, Hempel G, Schwalbe O, Flamm M, Osterbrink J.

BMC Geriatr. 2017 Jan 18;17(1):24. doi: 10.1186/s12877-017-0418-3.

24.

[Traumatology in the elderly : Multimodal prevention of delirium and use of augmentation techniques].

Wähnert D, Roos A, Glasbrenner J, Ilting-Reuke K, Ohrmann P, Hempel G, Duning T, Roeder N, Raschke MJ.

Chirurg. 2017 Feb;88(2):95-104. doi: 10.1007/s00104-016-0339-2. Review. German.

PMID:
28058496
25.

Development of a Physiologically Based Pharmacokinetic Modelling Approach to Predict the Pharmacokinetics of Vancomycin in Critically Ill Septic Patients.

Radke C, Horn D, Lanckohr C, Ellger B, Meyer M, Eissing T, Hempel G.

Clin Pharmacokinet. 2017 Jul;56(7):759-779. doi: 10.1007/s40262-016-0475-3.

PMID:
28039606
26.

Population pharmacokinetics of meropenem in elderly patients: dosing simulations based on renal function.

Usman M, Frey OR, Hempel G.

Eur J Clin Pharmacol. 2017 Mar;73(3):333-342. doi: 10.1007/s00228-016-2172-4. Epub 2016 Dec 13.

PMID:
27966034
27.

[Information content of medication schedules prior to the implementation of the federal standard medication plan].

Waltering I, Schwalbe O, Hempel G.

Z Evid Fortbild Qual Gesundhwes. 2016 Oct;115-116:24-32. doi: 10.1016/j.zefq.2016.06.004. German.

PMID:
27837957
28.

Pharmacokinetic and pharmacodynamic study of doxorubicin in children with cancer: results of a "European Pediatric Oncology Off-patents Medicines Consortium" trial.

Krischke M, Hempel G, Völler S, André N, D'Incalci M, Bisogno G, Köpcke W, Borowski M, Herold R, Boddy AV, Boos J.

Cancer Chemother Pharmacol. 2016 Dec;78(6):1175-1184. doi: 10.1007/s00280-016-3174-8. Epub 2016 Oct 21.

29.

Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis.

Bartelink IH, Lalmohamed A, van Reij EM, Dvorak CC, Savic RM, Zwaveling J, Bredius RG, Egberts AC, Bierings M, Kletzel M, Shaw PJ, Nath CE, Hempel G, Ansari M, Krajinovic M, Théorêt Y, Duval M, Keizer RJ, Bittencourt H, Hassan M, Güngör T, Wynn RF, Veys P, Cuvelier GD, Marktel S, Chiesa R, Cowan MJ, Slatter MA, Stricherz MK, Jennissen C, Long-Boyle JR, Boelens JJ.

Lancet Haematol. 2016 Nov;3(11):e526-e536. doi: 10.1016/S2352-3026(16)30114-4. Epub 2016 Oct 13.

30.

[Perioperative adverse respiratory events in overweight and obese children].

Ulrici J, Hempel G, Sasse M, Vollrath J, Höhne C.

Anaesthesist. 2016 Dec;65(12):911-916. Epub 2016 Oct 10. German.

PMID:
27726001
31.

The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy.

Ahlmann M, Hempel G.

Cancer Chemother Pharmacol. 2016 Oct;78(4):661-71. doi: 10.1007/s00280-016-3152-1. Epub 2016 Sep 19. Review.

PMID:
27646791
32.

Towards a Model-Based Dose Recommendation for Doxorubicin in Children.

Völler S, Hempel G, Würthwein G, Boddy AV, Krischke M, André N, D'Incalci M, Bisogno G, Boos J.

Clin Pharmacokinet. 2017 Mar;56(3):215-223. doi: 10.1007/s40262-016-0451-y.

33.

Pharmacokinetic characteristics and microbiologic appropriateness of cefazolin for perioperative antibiotic prophylaxis in elective cardiac surgery.

Lanckohr C, Horn D, Voeller S, Hempel G, Fobker M, Welp H, Koeck R, Ellger B.

J Thorac Cardiovasc Surg. 2016 Aug;152(2):603-10. doi: 10.1016/j.jtcvs.2016.04.024. Epub 2016 Apr 11.

34.
35.

Asymmetrical flow field-flow fractionation for the analysis of PEG-asparaginase.

John C, Herz T, Boos J, Langer K, Hempel G.

Talanta. 2016;146:335-9. doi: 10.1016/j.talanta.2015.08.028. Epub 2015 Aug 29.

PMID:
26695272
36.

Impact of medication therapy management in patients with Parkinson's disease.

Henrichsmann M, Hempel G.

Int J Clin Pharm. 2016 Feb;38(1):54-60. doi: 10.1007/s11096-015-0206-0. Epub 2015 Nov 21.

PMID:
26590989
37.

Basic principles of static proton low-resolution spin diffusion NMR in nanophase-separated materials with mobility contrast.

Schäler K, Roos M, Micke P, Golitsyn Y, Seidlitz A, Thurn-Albrecht T, Schneider H, Hempel G, Saalwächter K.

Solid State Nucl Magn Reson. 2015 Nov;72:50-63. doi: 10.1016/j.ssnmr.2015.09.001. Epub 2015 Sep 3.

PMID:
26404771
38.

Moderate MAS enhances local (1)H spin exchange and spin diffusion.

Roos M, Micke P, Saalwächter K, Hempel G.

J Magn Reson. 2015 Nov;260:28-37. doi: 10.1016/j.jmr.2015.08.016. Epub 2015 Sep 5.

PMID:
26397218
39.

Quantitative analysis of DNA methylation in the promoter region of the methylguanine-O(6) -DNA-methyltransferase gene by COBRA and subsequent native capillary gel electrophoresis.

Goedecke S, Mühlisch J, Hempel G, Frühwald MC, Wünsch B.

Electrophoresis. 2015 Dec;36(23):2939-50. doi: 10.1002/elps.201500242. Epub 2015 Oct 8.

PMID:
26331436
40.

The effect of intraoperative administration of dexamethasone for PONV prophylaxis on perioperative blood glucose level in obese and normal weight children.

Gnatzy R, Hempel G, Kaisers UX, Höhne C.

J Pediatr Endocrinol Metab. 2015 Nov 1;28(11-12):1287-92. doi: 10.1515/jpem-2014-0529.

PMID:
26197463
41.

Discrepancies on Medication Plans detected in German Community Pharmacies.

Waltering I, Schwalbe O, Hempel G.

J Eval Clin Pract. 2015 Oct;21(5):886-92. doi: 10.1111/jep.12395. Epub 2015 Jul 2.

PMID:
26139566
42.

Age-Dependent Pharmacokinetics of Doxorubicin in Children with Cancer.

Völler S, Boos J, Krischke M, Würthwein G, Kontny NE, Boddy AV, Hempel G.

Clin Pharmacokinet. 2015 Nov;54(11):1139-49. doi: 10.1007/s40262-015-0272-4.

PMID:
25925711
43.

Physiology-based pharmacokinetics of caspofungin for adults and paediatrics.

Stader F, Wuerthwein G, Groll AH, Vehreschild JJ, Cornely OA, Hempel G.

Pharm Res. 2015 Jun;32(6):2029-37. doi: 10.1007/s11095-014-1595-9. Epub 2014 Dec 19.

PMID:
25522788
44.

Patterns and determinants of new first-line antihyperglycaemic drug use in patients with type 2 diabetes mellitus.

Geier AS, Wellmann I, Wellmann J, Kajüter H, Heidinger O, Hempel G, Hense HW.

Diabetes Res Clin Pract. 2014 Oct;106(1):73-80. doi: 10.1016/j.diabres.2014.07.014. Epub 2014 Jul 29.

PMID:
25139631
45.

Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling.

Bernemann C, Hülsewig C, Ruckert C, Schäfer S, Blümel L, Hempel G, Götte M, Greve B, Barth PJ, Kiesel L, Liedtke C.

Mol Cancer. 2014 Jul 17;13:174. doi: 10.1186/1476-4598-13-174.

46.

Predictive performance of a physiologically based pharmacokinetic model of busulfan in children.

Diestelhorst C, Boos J, McCune JS, Russell J, Kangarloo SB, Hempel G.

Pediatr Hematol Oncol. 2014 Nov;31(8):731-42. doi: 10.3109/08880018.2014.927945. Epub 2014 Jul 9.

PMID:
25007236
47.

Concomitant use of tamoxifen and endoxifen in postmenopausal early breast cancer: prediction of plasma levels by physiologically-based pharmacokinetic modeling.

Dickschen K, Eissing T, Mürdter T, Schwab M, Willmann S, Hempel G.

Springerplus. 2014 Jun 5;3:285. doi: 10.1186/2193-1801-3-285. eCollection 2014.

48.

Comparative pharmacokinetic/pharmacodynamic characterisation of a new pegylated recombinant E. coli L-asparaginase preparation (MC0609) in Beagle dog.

Borghorst S, Hempel G, Poppenborg S, Franke D, König T, Baumgart J.

Cancer Chemother Pharmacol. 2014 Aug;74(2):367-78. doi: 10.1007/s00280-014-2506-9. Epub 2014 Jun 17.

PMID:
24934864
49.

Population pharmacokinetics of intravenous busulfan in children: revised body weight-dependent NONMEM® model to optimize dosing.

Diestelhorst C, Boos J, McCune JS, Hempel G.

Eur J Clin Pharmacol. 2014 Jul;70(7):839-47. doi: 10.1007/s00228-014-1692-z. Epub 2014 May 9.

PMID:
24810613
50.

Evaluation of effects of busulfan and DMA on SOS in pediatric stem cell recipients.

Kerl K, Diestelhorst C, Bartelink I, Boelens J, Trame MN, Boos J, Hempel G.

Pediatr Blood Cancer. 2014 Feb;61(2):306-11. doi: 10.1002/pbc.24827. Epub 2013 Oct 30.

PMID:
24174393

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