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Pediatrics. 2020 Feb;145(2). pii: e20192373. doi: 10.1542/peds.2019-2373. Epub 2020 Jan 8.

Hearing in Schoolchildren After Neonatal Exposure to a High-Dose Gentamicin Regimen.

Author information

1
Departments of Otorhinolaryngology and Head and Neck Surgery and.
2
Paediatric Research Group, Faculty of Health Sciences, Univeristy of Tromsø-Arctic University of Norway, Tromsø, Norway; and.
3
Ear-Nose-Throat Unit, Ishavsklinikken, Tromsø, Norway.
4
Paediatrics and Adolescence Medicine, University Hospital of North Norway, Tromsø, Norway; claus.klingenberg@unn.no.

Abstract

OBJECTIVE:

To assess the association between gentamicin exposure in the neonatal period and hearing in school age.

METHODS:

This study included children exposed to a high-dose (6 mg/kg) gentamicin regimen as neonates (2004-2012), invited for follow-up at school age, and a healthy age-matched control group. We assessed hearing with pure tone audiometry including the extended high-frequency (EHF) range. Outcomes were average hearing thresholds in the midfrequencies (0.5-4 kHz) and the EHFs (9-16 kHz). The measures of gentamicin exposure were cumulative dose and highest trough plasma concentration. We used linear regression models to assess the impact of gentamicin exposure, and other peri- and postnatal morbidities, on hearing thresholds.

RESULTS:

A total of 219 gentamicin-exposed and 33 healthy-control children were included in the audiological analysis. In the gentamicin cohort, 39 (17%) had a birth weight <1500 g. Median cumulative doses and trough plasma concentrations were 30 (interquartile range 24-42) mg/kg and 1.0 (interquartile range 0.7-1.2) mg/L, respectively. Median hearing thresholds for the midfrequencies and the EHFs were 2.5 (0 to 6.3) dB hearing level and -1.7 (-5.0 to 5.0) dB hearing level, both of which were within the normal range. In an adjusted analysis, increasing hearing thresholds were associated with lower birth weight and postnatal middle-ear disease but not level of gentamicin exposure. After adjusting for birth weight, there was no difference in hearing threshold between the gentamicin-exposed cohort and healthy controls.

CONCLUSIONS:

Exposure to a high-dose gentamicin regimen in the neonatal period was not associated with an increase in hearing thresholds in schoolchildren being able to complete audiometry.

PMID:
31915192
DOI:
10.1542/peds.2019-2373

Conflict of interest statement

POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

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