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Items: 1 to 50 of 167


Women in anaesthesia, a special issue of the British Journal of Anaesthesia.

Wong CA, Moonesinghe SR, Boer C, Hemmings HC Jr, Hunter JM.

Br J Anaesth. 2020 Mar;124(3):e40-e43. doi: 10.1016/j.bja.2019.12.038. Epub 2020 Jan 20. No abstract available.


Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice.

Zhao W, Zhang M, Liu J, Liang P, Wang R, Hemmings HC, Zhou C.

Anesthesiology. 2019 Jul;131(1):94-104. doi: 10.1097/ALN.0000000000002753.


Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.

Hemmings HC Jr, Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA.

Trends Pharmacol Sci. 2019 Jul;40(7):464-481. doi: 10.1016/ Epub 2019 May 27. Review.


Role of specific presynaptic calcium channel subtypes in isoflurane inhibition of synaptic vesicle exocytosis in rat hippocampal neurones.

Koyanagi Y, Torturo CL, Cook DC, Zhou Z, Hemmings HC Jr.

Br J Anaesth. 2019 Aug;123(2):219-227. doi: 10.1016/j.bja.2019.03.029. Epub 2019 May 2.


The good, the bad, and the ugly: the many faces of opioids.

Hemmings HC Jr, Lambert DG.

Br J Anaesth. 2019 Jun;122(6):705-707. doi: 10.1016/j.bja.2019.04.003. Epub 2019 Apr 18. No abstract available.


Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane.

Zhou C, Johnson KW, Herold KF, Hemmings HC Jr.

J Pharmacol Exp Ther. 2019 May;369(2):200-211. doi: 10.1124/jpet.118.254938. Epub 2019 Feb 21.


The many contributions of WW Mapleson to the British Journal of Anaesthesia.

Hunter JM, Hemmings HC Jr.

Br J Anaesth. 2019 Feb;122(2):159-162. doi: 10.1016/j.bja.2018.12.001. Epub 2018 Dec 19. No abstract available.


Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to CaV2.1 and CaV2.2 in Rat Midbrain Neurons.

Torturo CL, Zhou ZY, Ryan TA, Hemmings HC.

eNeuro. 2019 Jan 24;6(1). pii: ENEURO.0278-18.2018. doi: 10.1523/ENEURO.0278-18.2018. eCollection 2019 Jan-Feb.


Change management: the British Journal of Anaesthesia in 2018.

Hemmings HC Jr.

Br J Anaesth. 2019 Jan;122(1):1-3. doi: 10.1016/j.bja.2018.12.002. No abstract available.


Bioblasts, anaesthesia, and power failure: rein in the excitement.

Perouansky M, Hemmings HC.

Br J Anaesth. 2018 May;120(5):891-895. doi: 10.1016/j.bja.2018.02.018. Epub 2018 Mar 27. No abstract available.


Landmarks in UK anaesthesia.

Hemmings HC Jr, Hunter JM.

Br J Anaesth. 2017 Dec 1;119(6):1073-1074. doi: 10.1093/bja/aex370. No abstract available.


Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity.

Soriano SG, Vutskits L, Jevtovic-Todorovic V, Hemmings HC; 2016 BJA Neurotoxicology and Neuroplasticity Study Group.

Br J Anaesth. 2017 Sep 1;119(3):443-447. doi: 10.1093/bja/aex238. No abstract available.


Sodium channel subtypes are differentially localized to pre- and post-synaptic sites in rat hippocampus.

Johnson KW, Herold KF, Milner TA, Hemmings HC Jr, Platholi J.

J Comp Neurol. 2017 Nov 1;525(16):3563-3578. doi: 10.1002/cne.24291. Epub 2017 Aug 11.


Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.

Herold KF, Andersen OS, Hemmings HC Jr.

Eur Biophys J. 2017 Oct;46(7):617-626. doi: 10.1007/s00249-017-1239-1. Epub 2017 Jul 10. Review.


Isoflurane modulates activation and inactivation gating of the prokaryotic Na+ channel NaChBac.

Sand RM, Gingrich KJ, Macharadze T, Herold KF, Hemmings HC Jr.

J Gen Physiol. 2017 Jun 5;149(6):623-638. doi: 10.1085/jgp.201611600. Epub 2017 Apr 17.


Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties.

Herold KF, Sanford RL, Lee W, Andersen OS, Hemmings HC Jr.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3109-3114. doi: 10.1073/pnas.1611717114. Epub 2017 Mar 6.


A global vision for the British Journal of Anaesthesia.

Hemmings HC Jr.

Br J Anaesth. 2017 Jan;118(1):1-2. doi: 10.1093/bja/aew415. No abstract available.


The 2016 BJA/PGA special issue: a selection of six educational reviews.

Hemmings HC Jr, Mahajan R, Webster NR.

Br J Anaesth. 2016 Dec;117(suppl 3):i1-i2. No abstract available.


Relevance of Clinical Relevance.

Riegelhaupt PM, Hemmings HC Jr, Goldstein PA.

Anesthesiology. 2016 Oct;125(4):821-2. doi: 10.1097/ALN.0000000000001257. No abstract available.


α2-Adrenergic Receptor and Isoflurane Modulation of Presynaptic Ca2+ Influx and Exocytosis in Hippocampal Neurons.

Hara M, Zhou ZY, Hemmings HC Jr.

Anesthesiology. 2016 Sep;125(3):535-46. doi: 10.1097/ALN.0000000000001213.


2015 BJA/PGA Special Issue: a selection of nine educational reviews.

Hemmings HC Jr, Wlody D, Mahajan R, Webster NR.

Br J Anaesth. 2015 Dec;115 Suppl 2:ii1-2. doi: 10.1093/bja/aev405. No abstract available.


Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling.

Baumgart JP, Zhou ZY, Hara M, Cook DC, Hoppa MB, Ryan TA, Hemmings HC Jr.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11959-64. doi: 10.1073/pnas.1500525112. Epub 2015 Sep 8.


Memory and awareness in anaesthesia.

Kurata J, Hemmings HC Jr.

Br J Anaesth. 2015 Jul;115 Suppl 1:i1-i3. doi: 10.1093/bja/aev224. No abstract available.


Activity-dependent depression of neuronal sodium channels by the general anaesthetic isoflurane.

Purtell K, Gingrich KJ, Ouyang W, Herold KF, Hemmings HC Jr.

Br J Anaesth. 2015 Jul;115(1):112-21. doi: 10.1093/bja/aev203.


Information technology innovation: the power and perils of big data.

Giambrone GP, Hemmings HC, Sturm M, Fleischut PM.

Br J Anaesth. 2015 Sep;115(3):339-42. doi: 10.1093/bja/aev154. Epub 2015 Jun 1. No abstract available.


The 2014 BJA/PGA special issue: a selection of six educational reviews.

Hemmings HC Jr, Wlody D, Mahajan R, Webster NR.

Br J Anaesth. 2014 Dec;113 Suppl 2:ii1-2. doi: 10.1093/bja/aeu396. No abstract available.


Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties.

Herold KF, Sanford RL, Lee W, Schultz MF, Ingólfsson HI, Andersen OS, Hemmings HC Jr.

J Gen Physiol. 2014 Dec;144(6):545-60. doi: 10.1085/jgp.201411172. Epub 2014 Nov 10.


Sociosexual investigation in sexually experienced, hormonally manipulated male leopard geckos: relation with phosphorylated DARPP-32 in dopaminergic pathways.

Huang V, Hemmings HC Jr, Crews D.

J Exp Zool A Ecol Genet Physiol. 2014 Dec;321(10):595-602. doi: 10.1002/jez.1891. Epub 2014 Oct 28.


NAP5: intraoperative awareness detected, and undetected.

Pryor KO, Hemmings HC Jr.

Br J Anaesth. 2014 Oct;113(4):530-3. doi: 10.1093/bja/aeu350. No abstract available.


Consensus statement from the BJA Workshop on Cancer and Anaesthesia.

Buggy DJ, Borgeat A, Cata J, Doherty DG, Doornebal CW, Forget P, Gottumukkala V, Gottschalk A, Gupta A, Gupta K, Hales TG, Hemmings HC, Hollmann MW, Kurz A, Ma D, Parat MO, Sessler DI, Shorten G, Singleton P.

Br J Anaesth. 2015 Jan;114(1):2-3. doi: 10.1093/bja/aeu262. Epub 2014 Aug 7. No abstract available.


Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism.

Platholi J, Herold KF, Hemmings HC Jr, Halpain S.

PLoS One. 2014 Jul 28;9(7):e102978. doi: 10.1371/journal.pone.0102978. eCollection 2014.


Special issue on anaesthesia and cancer.

Buggy DJ, Hemmings HC.

Br J Anaesth. 2014 Jul;113 Suppl 1:i1-3. doi: 10.1093/bja/aeu261. No abstract available.


Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase.

Platholi J, Federman A, Detert JA, Heerdt P, Hemmings HC Jr.

J Biol Chem. 2014 Aug 22;289(34):23893-900. doi: 10.1074/jbc.M114.557744. Epub 2014 Jul 15.


Phytochemicals perturb membranes and promiscuously alter protein function.

Ingólfsson HI, Thakur P, Herold KF, Hobart EA, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K, Maretzky T, Hemmings HC Jr, Blobel C, Marrink SJ, Koçer A, Sack JT, Andersen OS.

ACS Chem Biol. 2014 Aug 15;9(8):1788-98. doi: 10.1021/cb500086e. Epub 2014 Jun 17.


2013 BJA/PGA Special Issue: a selection of nine educational reviews.

Hemmings HC Jr, Wlody D, Mahajan R, Webster NR.

Br J Anaesth. 2013 Dec;111 Suppl 1:i1-2. doi: 10.1093/bja/aet403. No abstract available.


Increased risk of awareness under anesthesia: an issue of consciousness or of memory?

Pryor KO, Hemmings HC Jr.

Anesthesiology. 2013 Dec;119(6):1236-8. doi: 10.1097/ALN.0000000000000024. No abstract available.


Special issue on anaesthetic neurotoxicity and neuroplasticity.

Hemmings HC Jr, Jevtovic-Todorovic V.

Br J Anaesth. 2013 Jun;110 Suppl 1:i1-2. doi: 10.1093/bja/aet195. No abstract available.


Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.

Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr.

Br J Anaesth. 2013 Aug;111(2):143-51. doi: 10.1093/bja/aet177. Epub 2013 May 30.


HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.

Tibbs GR, Rowley TJ, Sanford RL, Herold KF, Proekt A, Hemmings HC Jr, Andersen OS, Goldstein PA, Flood PD.

J Pharmacol Exp Ther. 2013 Jun;345(3):363-73. doi: 10.1124/jpet.113.203620. Epub 2013 Apr 2.


The 2012 BJA/PGA supplement: a selection of seven educational reviews.

Hemmings HC Jr, Rosenberg AD, Mahajan RP, Webster NR.

Br J Anaesth. 2012 Dec;109 Suppl 1:i1-i2. doi: 10.1093/bja/aes428. No abstract available.


Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane.

Westphalen RI, Desai KM, Hemmings HC Jr.

Br J Anaesth. 2013 Apr;110(4):592-9. doi: 10.1093/bja/aes448. Epub 2012 Dec 4.


Sodium channels as targets for volatile anesthetics.

Herold KF, Hemmings HC Jr.

Front Pharmacol. 2012 Mar 30;3:50. doi: 10.3389/fphar.2012.00050. eCollection 2012.


Anaesthesia awareness: 3 years of progress.

Hudetz AG, Hemmings HC Jr.

Br J Anaesth. 2012 Feb;108(2):180-2. doi: 10.1093/bja/aer454. No abstract available.


The 2011 BJA/PGA supplement: a selection of nine educational reviews.

Rosenberg AD, Hemmings HC Jr, Reilly CS, Webster NR.

Br J Anaesth. 2011 Dec;107 Suppl 1:i1-2. doi: 10.1093/bja/aer396. No abstract available.


Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases.

Walaas SI, Hemmings HC Jr, Greengard P, Nairn AC.

Front Neuroanat. 2011 Aug 26;5:50. doi: 10.3389/fnana.2011.00050. eCollection 2011.


Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery.

Rusinova R, Herold KF, Sanford RL, Greathouse DV, Hemmings HC Jr, Andersen OS.

J Gen Physiol. 2011 Aug;138(2):249-70. doi: 10.1085/jgp.201010529.


Regional differences in the effects of isoflurane on neurotransmitter release.

Westphalen RI, Kwak NB, Daniels K, Hemmings HC Jr.

Neuropharmacology. 2011 Sep;61(4):699-706. doi: 10.1016/j.neuropharm.2011.05.013. Epub 2011 May 30.


Are anaesthetics toxic to the brain?

Hudson AE, Hemmings HC Jr.

Br J Anaesth. 2011 Jul;107(1):30-7. doi: 10.1093/bja/aer122. Epub 2011 May 26. Review.


Sleep and anesthesia: the histamine connection.

Mantz J, Hemmings HC Jr.

Anesthesiology. 2011 Jul;115(1):8-9. doi: 10.1097/ALN.0b013e3182207581. No abstract available.


The rivers of Lethe and Mnemosyne converge: propofol and memory consolidation.

Hemmings HC Jr, Mackie K.

Anesthesiology. 2011 Jun;114(6):1277-9. doi: 10.1097/ALN.0b013e31821c647d. No abstract available.


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