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AGC kinases in cancer metastasis, immune checkpoint regulation and drug resistance.

Xue G, Hemmings BA.

Semin Cancer Biol. 2018 Feb;48:iii-iv. doi: 10.1016/j.semcancer.2018.01.013. No abstract available.


SYK inhibition blocks proliferation and migration of glioma cells and modifies the tumor microenvironment.

Moncayo G, Grzmil M, Smirnova T, Zmarz P, Huber RM, Hynx D, Kohler H, Wang Y, Hotz HR, Hynes NE, Keller G, Frank S, Merlo A, Hemmings BA.

Neuro Oncol. 2018 Apr 9;20(5):621-631. doi: 10.1093/neuonc/noy008.


mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition.

Xue G, Kohler R, Tang F, Hynx D, Wang Y, Orso F, Prêtre V, Ritschard R, Hirschmann P, Cron P, Roloff T, Dummer R, Mandalà M, Bichet S, Genoud C, Meyer AG, Muraro MG, Spagnoli GC, Taverna D, Rüegg C, Merghoub T, Massi D, Tang H, Levesque MP, Dirnhofer S, Zippelius A, Hemmings BA, Wicki A.

Oncotarget. 2017 May 25;8(41):69204-69218. doi: 10.18632/oncotarget.18213. eCollection 2017 Sep 19.


Modulation of PI3K/PTEN Pathway Does Not Affect Catalytic Activity of PDK1 in Jurkat Cells.

Yang KJ, Piao L, Shin S, Shin SY, Li Y, Lee H, Tran Q, Park J, Hong S, Brazil DP, Hemmings BA, Kim SH, Park J.

Anticancer Res. 2017 Oct;37(10):5415-5423. Retraction in: Anticancer Res. 2017 Nov;37(11):6496.


PKB/Akt-dependent regulation of inflammation in cancer.

Tang F, Wang Y, Hemmings BA, Rüegg C, Xue G.

Semin Cancer Biol. 2018 Feb;48:62-69. doi: 10.1016/j.semcancer.2017.04.018. Epub 2017 May 2. Review.


AKT-ions with a TWIST between EMT and MET.

Tang H, Massi D, Hemmings BA, Mandalà M, Hu Z, Wicki A, Xue G.

Oncotarget. 2016 Sep 20;7(38):62767-62777. doi: 10.18632/oncotarget.11232. Review.


Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy.

Grzmil M, Seebacher J, Hess D, Behe M, Schibli R, Moncayo G, Frank S, Hemmings BA.

Cell Signal. 2016 Sep;28(9):1412-21. doi: 10.1016/j.cellsig.2016.06.005. Epub 2016 Jun 8.


Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling.

Wicki A, Mandalà M, Massi D, Taverna D, Tang H, Hemmings BA, Xue G.

Physiol Rev. 2016 Jul;96(3):805-29. doi: 10.1152/physrev.00024.2015. Review.


The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.

Tang F, Gill J, Ficht X, Barthlott T, Cornils H, Schmitz-Rohmer D, Hynx D, Zhou D, Zhang L, Xue G, Grzmil M, Yang Z, Hergovich A, Hollaender GA, Stein JV, Hemmings BA, Matthias P.

Sci Signal. 2015 Oct 6;8(397):ra100. doi: 10.1126/scisignal.aab2425.


NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development.

Schmitz-Rohmer D, Probst S, Yang ZZ, Laurent F, Stadler MB, Zuniga A, Zeller R, Hynx D, Hemmings BA, Hergovich A.

PLoS One. 2015 Aug 25;10(8):e0136566. doi: 10.1371/journal.pone.0136566. eCollection 2015.


Integrated Akt/PKB signaling in immunomodulation and its potential role in cancer immunotherapy.

Xue G, Zippelius A, Wicki A, Mandalà M, Tang F, Massi D, Hemmings BA.

J Natl Cancer Inst. 2015 Jun 11;107(7). pii: djv171. doi: 10.1093/jnci/djv171. Print 2015 Jul. Review.


The PI3K-PKB/Akt pathway.

Hemmings BA, Restuccia DF.

Cold Spring Harb Perspect Biol. 2015 Apr 1;7(4). pii: a026609. doi: 10.1101/cshperspect.a026609. No abstract available.


All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.

Brand Y, Levano S, Radojevic V, Naldi AM, Setz C, Ryan AF, Pak K, Hemmings BA, Bodmer D.

PLoS One. 2015 Mar 26;10(3):e0121599. doi: 10.1371/journal.pone.0121599. eCollection 2015.


Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development.

Luo W, Zhao X, Jin H, Tao L, Zhu J, Wang H, Hemmings BA, Yang Z.

Development. 2015 Feb 15;142(4):732-42. doi: 10.1242/dev.119016.


NDR functions as a physiological YAP1 kinase in the intestinal epithelium.

Zhang L, Tang F, Terracciano L, Hynx D, Kohler R, Bichet S, Hess D, Cron P, Hemmings BA, Hergovich A, Schmitz-Rohmer D.

Curr Biol. 2015 Feb 2;25(3):296-305. doi: 10.1016/j.cub.2014.11.054. Epub 2015 Jan 15.


PKB/Akt phosphorylation of ERRγ contributes to insulin-mediated inhibition of hepatic gluconeogenesis.

Kim DK, Kim YH, Hynx D, Wang Y, Yang KJ, Ryu D, Kim KS, Yoo EK, Kim JS, Koo SH, Lee IK, Chae HZ, Park J, Lee CH, Biddinger SB, Hemmings BA, Choi HS.

Diabetologia. 2014 Dec;57(12):2576-85. doi: 10.1007/s00125-014-3366-x. Epub 2014 Sep 10.


hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.

Tang F, Zhang L, Xue G, Hynx D, Wang Y, Cron PD, Hundsrucker C, Hergovich A, Frank S, Hemmings BA, Schmitz-Rohmer D.

Cancer Res. 2014 Jul 15;74(14):3779-89. doi: 10.1158/0008-5472.CAN-13-3430. Epub 2014 May 28.


Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle.

Schultze SM, Dietrich M, Hynx D, Geier A, Niessen M, Spinas GA, Hemmings BA, Tschopp O.

Liver Int. 2015 Apr;35(4):1354-66. doi: 10.1111/liv.12600. Epub 2014 Jun 24.


Novel individual metabolic profile characterizes the protein kinase B-alpha (pkbα-/-) in vivo model.

Eberle C, Niessen M, Hemmings BA, Tschopp O, Ament C.

Arch Physiol Biochem. 2014 Jul;120(3):91-8. doi: 10.3109/13813455.2014.911330. Epub 2014 Apr 28.


MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.

Grzmil M, Huber RM, Hess D, Frank S, Hynx D, Moncayo G, Klein D, Merlo A, Hemmings BA.

J Clin Invest. 2014 Feb;124(2):742-54. doi: 10.1172/JCI70198. Epub 2014 Jan 9.


Multimodal imaging reveals a role for Akt1 in fetal cardiac development.

Vandoorne K, Vandsburger MH, Weisinger K, Brumfeld V, Hemmings BA, Harmelin A, Neeman M.

Physiol Rep. 2013 Nov;1(6):e00143. doi: 10.1002/phy2.143. Epub 2013 Nov 7.


Chronic Akt1 deficiency attenuates adverse remodeling and enhances angiogenesis after myocardial infarction.

Vandoorne K, Vandsburger MH, Raz T, Shalev M, Weisinger K, Biton I, Brumfeld V, Raanan C, Nevo N, Eilam R, Hemmings BA, Tzahor E, Harmelin A, Gepstein L, Neeman M.

Circ Cardiovasc Imaging. 2013 Nov;6(6):992-1000. doi: 10.1161/CIRCIMAGING.113.000828. Epub 2013 Oct 17.


Characterization of fragmented 3-phosphoinsitide-dependent protein kinase-1 (PDK1) by phosphosite-specific antibodies.

Park J, Li Y, Kim SH, Kong G, Shrestha R, Tran Q, Hong J, Hur GM, Hemmings BA, Koo BS, Park J.

Life Sci. 2013 Nov 4;93(18-19):700-6. doi: 10.1016/j.lfs.2013.09.007. Epub 2013 Sep 15.


Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations.

Green BD, Jabbour AM, Sandow JJ, Riffkin CD, Masouras D, Daunt CP, Salmanidis M, Brumatti G, Hemmings BA, Guthridge MA, Pearson RB, Ekert PG.

Cell Death Differ. 2013 Oct;20(10):1341-9. doi: 10.1038/cdd.2013.63. Epub 2013 Jun 21.


Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival.

Huber RM, Rajski M, Sivasankaran B, Moncayo G, Hemmings BA, Merlo A.

PLoS One. 2013;8(2):e57793. doi: 10.1371/journal.pone.0057793. Epub 2013 Feb 25.


Overcoming resistance to rapalogs in gliomas by combinatory therapies.

Grzmil M, Hemmings BA.

Biochim Biophys Acta. 2013 Jul;1834(7):1371-80. doi: 10.1016/j.bbapap.2013.01.041. Epub 2013 Feb 8. Review.


PKB/Akt-dependent regulation of cell motility.

Xue G, Hemmings BA.

J Natl Cancer Inst. 2013 Mar 20;105(6):393-404. doi: 10.1093/jnci/djs648. Epub 2013 Jan 25.


PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.

Li Y, Park J, Piao L, Kong G, Kim Y, Park KA, Zhang T, Hong J, Hur GM, Seok JH, Choi SW, Yoo BC, Hemmings BA, Brazil DP, Kim SH, Park J.

Cell Signal. 2013 Jan;25(1):74-84. doi: 10.1016/j.cellsig.2012.09.009. Epub 2012 Sep 11.


PI3K-PKB/Akt pathway.

Hemmings BA, Restuccia DF.

Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a011189. doi: 10.1101/cshperspect.a011189. Review. No abstract available. Erratum in: Cold Spring Harb Perspect Biol. 2015 Apr;7(4). pii: a026609. doi: 10.1101/cshperspect.a026609.


Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET.

Kleylein-Sohn J, Pöllinger B, Ohmer M, Hofmann F, Nigg EA, Hemmings BA, Wartmann M.

J Cell Sci. 2012 Nov 15;125(Pt 22):5391-402. doi: 10.1242/jcs.107474. Epub 2012 Sep 3.


Translation regulation as a therapeutic target in cancer.

Grzmil M, Hemmings BA.

Cancer Res. 2012 Aug 15;72(16):3891-900. doi: 10.1158/0008-5472.CAN-12-0026. Epub 2012 Jul 31. Review.


Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry.

Tchorz JS, Tome M, Cloëtta D, Sivasankaran B, Grzmil M, Huber RM, Rutz-Schatzmann F, Kirchhoff F, Schaeren-Wiemers N, Gassmann M, Hemmings BA, Merlo A, Bettler B.

Cell Death Dis. 2012 Jun 21;3:e325. doi: 10.1038/cddis.2012.65.


Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development.

Zhuravleva E, Gut H, Hynx D, Marcellin D, Bleck CK, Genoud C, Cron P, Keusch JJ, Dummler B, Esposti MD, Hemmings BA.

Mol Cell Biol. 2012 Jul;32(14):2685-97. doi: 10.1128/MCB.00312-12. Epub 2012 May 14.


Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.

Xue G, Restuccia DF, Lan Q, Hynx D, Dirnhofer S, Hess D, Rüegg C, Hemmings BA.

Cancer Discov. 2012 Mar;2(3):248-59. doi: 10.1158/2159-8290.CD-11-0270. Epub 2012 Jan 25.


Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.

Hergovich A, Hemmings BA.

Semin Cell Dev Biol. 2012 Sep;23(7):794-802. doi: 10.1016/j.semcdb.2012.04.001. Epub 2012 Apr 15. Review.


Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme.

Wang Y, Moncayo G, Morin P Jr, Xue G, Grzmil M, Lino MM, Clément-Schatlo V, Frank S, Merlo A, Hemmings BA.

Oncogene. 2013 Feb 14;32(7):872-82. doi: 10.1038/onc.2012.104. Epub 2012 Apr 2.


Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo.

Restuccia DF, Hynx D, Hemmings BA.

Dis Model Mech. 2012 May;5(3):403-11. doi: 10.1242/dmm.008136. Epub 2012 Jan 24.


Phosphorylation of basic helix-loop-helix transcription factor Twist in development and disease.

Xue G, Hemmings BA.

Biochem Soc Trans. 2012 Feb;40(1):90-3. doi: 10.1042/BST20110678. Review.


PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.

Schultze SM, Hemmings BA, Niessen M, Tschopp O.

Expert Rev Mol Med. 2012 Jan 11;14:e1. doi: 10.1017/S1462399411002109. Review.


The Akt1 isoform is an essential mediator of ischaemic preconditioning.

Kunuthur SP, Mocanu MM, Hemmings BA, Hausenloy DJ, Yellon DM.

J Cell Mol Med. 2012 Aug;16(8):1739-49. doi: 10.1111/j.1582-4934.2011.01491.x.


S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt.

Di R, Wu X, Chang Z, Zhao X, Feng Q, Lu S, Luan Q, Hemmings BA, Li X, Yang Z.

Biochem J. 2012 Jan 1;441(1):199-207. doi: 10.1042/BJ20110033.


AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer.

Chan JC, Hannan KM, Riddell K, Ng PY, Peck A, Lee RS, Hung S, Astle MV, Bywater M, Wall M, Poortinga G, Jastrzebski K, Sheppard KE, Hemmings BA, Hall MN, Johnstone RW, McArthur GA, Hannan RD, Pearson RB.

Sci Signal. 2011 Aug 30;4(188):ra56. doi: 10.1126/scisignal.2001754.


Downstream of human NDR kinases: impacting on c-myc and p21 protein stability to control cell cycle progression.

Cornils H, Kohler RS, Hergovich A, Hemmings BA.

Cell Cycle. 2011 Jun 15;10(12):1897-904. Epub 2011 Jun 15. Review.


Phosphorylation of the Twist1-family basic helix-loop-helix transcription factors is involved in pathological cardiac remodeling.

Lu S, Nie J, Luan Q, Feng Q, Xiao Q, Chang Z, Shan C, Hess D, Hemmings BA, Yang Z.

PLoS One. 2011 Apr 29;6(4):e19251. doi: 10.1371/journal.pone.0019251.


MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma.

Grzmil M, Morin P Jr, Lino MM, Merlo A, Frank S, Wang Y, Moncayo G, Hemmings BA.

Cancer Res. 2011 Mar 15;71(6):2392-402. doi: 10.1158/0008-5472.CAN-10-3112. Epub 2011 Mar 14.


Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.

Cornils H, Kohler RS, Hergovich A, Hemmings BA.

Mol Cell Biol. 2011 Apr;31(7):1382-95. doi: 10.1128/MCB.01216-10. Epub 2011 Jan 24.


Promiscuous affairs of PKB/AKT isoforms in metabolism.

Schultze SM, Jensen J, Hemmings BA, Tschopp O, Niessen M.

Arch Physiol Biochem. 2011 May;117(2):70-7. doi: 10.3109/13813455.2010.539236. Epub 2011 Jan 10. Review.


Survival and size are differentially regulated by placental and fetal PKBalpha/AKT1 in mice.

Plaks V, Berkovitz E, Vandoorne K, Berkutzki T, Damari GM, Haffner R, Dekel N, Hemmings BA, Neeman M, Harmelin A.

Biol Reprod. 2011 Mar;84(3):537-45. doi: 10.1095/biolreprod.110.085951. Epub 2010 Oct 27.


From man to mouse and back again: advances in defining tumor AKTivities in vivo.

Restuccia DF, Hemmings BA.

Dis Model Mech. 2010 Nov-Dec;3(11-12):705-20. doi: 10.1242/dmm.004671. Epub 2010 Oct 12. Review.


Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation.

Chang Z, Zhang Q, Feng Q, Xu J, Teng T, Luan Q, Shan C, Hu Y, Hemmings BA, Gao X, Yang Z.

Dev Biol. 2010 Nov 15;347(2):384-91. doi: 10.1016/j.ydbio.2010.08.033. Epub 2010 Sep 15.

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