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Items: 1 to 50 of 146


Thermodynamics of clay-drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography.

Totea AM, Sabin J, Dorin I, Hemming K, Laity PR, Conway BR, Waters L, Asare-Addo K.

J Pharm Anal. 2020 Feb;10(1):78-85. doi: 10.1016/j.jpha.2019.12.001. Epub 2019 Dec 5.


A tutorial on sample size calculation for multiple-period cluster randomized parallel, cross-over and stepped-wedge trials using the Shiny CRT Calculator.

Hemming K, Kasza J, Hooper R, Forbes A, Taljaard M.

Int J Epidemiol. 2020 Feb 22. pii: dyz237. doi: 10.1093/ije/dyz237. [Epub ahead of print]


Polypill for prevention of cardiovascular diseases - Authors' reply.

Roshandel G, Kamangar F, Marshall T, Cheng KK, Hemming K, Malekzadeh R.

Lancet. 2020 Feb 8;395(10222):414-415. doi: 10.1016/S0140-6736(19)32966-6. No abstract available.


Effectiveness and cost-effectiveness of The Daily Mile on childhood weight outcomes and wellbeing: a cluster randomised controlled trial.

Breheny K, Passmore S, Adab P, Martin J, Hemming K, Lancashire ER, Frew E.

Int J Obes (Lond). 2020 Apr;44(4):812-822. doi: 10.1038/s41366-019-0511-0. Epub 2020 Jan 28.


Ethical issues in the design and conduct of stepped-wedge cluster randomized trials in low-resource settings.

Joag K, Ambrosio G, Kestler E, Weijer C, Hemming K, Van der Graaf R.

Trials. 2019 Dec 19;20(Suppl 2):703. doi: 10.1186/s13063-019-3842-1.


Stepped-wedge trials should be classified as research for the purpose of ethical review.

Hemming K, Taljaard M, Marshall T, Goldstein CE, Weijer C.

Clin Trials. 2019 Dec;16(6):580-588. doi: 10.1177/1740774519873322.


Effects of emergency obstetric care training on maternal and perinatal outcomes: a stepped wedge cluster randomised trial in South Africa.

van den Broek N, Ameh C, Madaj B, Makin J, White S, Hemming K, Moodley J, Pattinson R.

BMJ Glob Health. 2019 Nov 10;4(6):e001670. doi: 10.1136/bmjgh-2019-001670. eCollection 2019.


The CHIRPY DRAGON intervention in preventing obesity in Chinese primary-school--aged children: A cluster-randomised controlled trial.

Li B, Pallan M, Liu WJ, Hemming K, Frew E, Lin R, Liu W, Martin J, Zanganeh M, Hurley K, Cheng KK, Adab P.

PLoS Med. 2019 Nov 26;16(11):e1002971. doi: 10.1371/journal.pmed.1002971. eCollection 2019 Nov.


Sedation AND Weaning In Children (SANDWICH): protocol for a cluster randomised stepped wedge trial.

Blackwood B, Agus A, Boyle R, Clarke M, Hemming K, Jordan J, Macrae D, McAuley DF, McDowell C, McIlmurray L, Morris KP, Murray M, Parslow R, Peters MJ, Tume LN, Walsh T; Paediatric Intensive Care Society Study Group (PICS-SG).

BMJ Open. 2019 Nov 10;9(11):e031630. doi: 10.1136/bmjopen-2019-031630.


The tiliroside derivative, 3-O-[(E)-(2-oxo-4-(p-tolyl) but-3-en-1-yl] kaempferol produced inhibition of neuroinflammation and activation of AMPK and Nrf2/HO-1 pathways in BV-2 microglia.

Velagapudi R, Jamshaid F, Lepiarz I, Katola FO, Hemming K, Olajide OA.

Int Immunopharmacol. 2019 Dec;77:105951. doi: 10.1016/j.intimp.2019.105951. Epub 2019 Oct 18.


How many times should a cluster randomized crossover trial cross over?

Grantham KL, Kasza J, Heritier S, Hemming K, Litton E, Forbes AB.

Stat Med. 2019 Nov 10;38(25):5021-5033. doi: 10.1002/sim.8349. Epub 2019 Sep 1.


Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.

Roshandel G, Khoshnia M, Poustchi H, Hemming K, Kamangar F, Gharavi A, Ostovaneh MR, Nateghi A, Majed M, Navabakhsh B, Merat S, Pourshams A, Nalini M, Malekzadeh F, Sadeghi M, Mohammadifard N, Sarrafzadegan N, Naemi-Tabiei M, Fazel A, Brennan P, Etemadi A, Boffetta P, Thomas N, Marshall T, Cheng KK, Malekzadeh R.

Lancet. 2019 Aug 24;394(10199):672-683. doi: 10.1016/S0140-6736(19)31791-X.


Cultural adaptation of an existing children's weight management programme: the CHANGE intervention and feasibility RCT.

Pallan M, Griffin T, Hurley KL, Lancashire E, Blissett J, Frew E, Griffith L, Hemming K, Jolly K, McGee E, Thompson JL, Jackson L, Gill P, Parry J, Adab P.

Health Technol Assess. 2019 Jul;23(33):1-166. doi: 10.3310/hta23330.


Economic evaluation of a childhood obesity prevention programme for children: Results from the WAVES cluster randomised controlled trial conducted in schools.

Canaway A, Frew E, Lancashire E, Pallan M, Hemming K, Adab P; WAVES trial investigators.

PLoS One. 2019 Jul 10;14(7):e0219500. doi: 10.1371/journal.pone.0219500. eCollection 2019.


Pregabalin add-on for drug-resistant focal epilepsy.

Panebianco M, Bresnahan R, Hemming K, Marson AG.

Cochrane Database Syst Rev. 2019 Jul 9;7:CD005612. doi: 10.1002/14651858.CD005612.pub4.


The impact of varying cluster size in cross-sectional stepped-wedge cluster randomised trials.

Martin JT, Hemming K, Girling A.

BMC Med Res Methodol. 2019 Jun 14;19(1):123. doi: 10.1186/s12874-019-0760-6.


Development and external validation of predictive models for prevalent and recurrent atrial fibrillation: a protocol for the analysis of the CATCH ME combined dataset.

Chua W, Easter CL, Guasch E, Sitch A, Casadei B, Crijns HJGM, Haase D, Hatem S, Kääb S, Mont L, Schotten U, Sinner MF, Hemming K, Deeks JJ, Kirchhof P, Fabritz L.

BMC Cardiovasc Disord. 2019 May 21;19(1):120. doi: 10.1186/s12872-019-1105-4.


PARROT Ireland: Placental growth factor in Assessment of women with suspected pre-eclampsia to reduce maternal morbidity: a Stepped Wedge Cluster Randomised Control Trial Research Study Protocol.

Hayes-Ryan D, Hemming K, Breathnach F, Cotter A, Devane D, Hunter A, McAuliffe FM, Morrison JJ, Murphy DJ, Khashan A, McElroy B, Murphy A, Dempsey E, O'Donoghue K, Kenny LC.

BMJ Open. 2019 Mar 1;9(2):e023562. doi: 10.1136/bmjopen-2018-023562.


The stepped wedge cluster randomised trial: what it is and when it should be used.

Campbell MJ, Hemming K, Taljaard M.

Med J Aust. 2019 Apr;210(6):253-254.e1. doi: 10.5694/mja2.50018. Epub 2019 Feb 13. No abstract available.


Accounting for a decaying correlation structure in cluster randomized trials with continuous recruitment.

Grantham KL, Kasza J, Heritier S, Hemming K, Forbes AB.

Stat Med. 2019 May 20;38(11):1918-1934. doi: 10.1002/sim.8089. Epub 2019 Jan 21.


PreImplantation Trial of Histopathology In renal Allografts (PITHIA): a stepped-wedge cluster randomised controlled trial protocol.

Ayorinde JO, Summers DM, Pankhurst L, Laing E, Deary AJ, Hemming K, Wilson EC, Bardsley V, Neil DA, Pettigrew GJ.

BMJ Open. 2019 Jan 17;9(1):e026166. doi: 10.1136/bmjopen-2018-026166.


Introducing the new CONSORT extension for stepped-wedge cluster randomised trials.

Hemming K, Taljaard M, Grimshaw J.

Trials. 2019 Jan 18;20(1):68. doi: 10.1186/s13063-018-3116-3.


The current use of feasibility studies in the assessment of feasibility for stepped-wedge cluster randomised trials: a systematic review.

Kristunas CA, Hemming K, Eborall H, Eldridge S, Gray LJ.

BMC Med Res Methodol. 2019 Jan 10;19(1):12. doi: 10.1186/s12874-019-0658-3.


Effectiveness of cognitive-behavioural therapy: a protocol for an overview of systematic reviews and meta-analyses.

Fordham B, Sugavanam T, Hopewell S, Hemming K, Howick J, Kirtley S, das Nair R, Hamer-Hunt J, Lamb SE.

BMJ Open. 2018 Dec 14;8(12):e025761. doi: 10.1136/bmjopen-2018-025761.


A cluster-randomised feasibility trial of a children's weight management programme: the Child weigHt mANaGement for Ethnically diverse communities (CHANGE) study.

Pallan M, Hurley KL, Griffin T, Lancashire E, Blissett J, Frew E, Gill P, Hemming K, Jackson L, Jolly K, McGee E, Parry J, Thompson JL, Adab P.

Pilot Feasibility Stud. 2018 Nov 26;4:175. doi: 10.1186/s40814-018-0373-6. eCollection 2018.


Quality of stepped-wedge trial reporting can be reliably assessed using an updated CONSORT: crowd-sourcing systematic review.

Hemming K, Carroll K, Thompson J, Forbes A, Taljaard M; SW-CRT Review Group.

J Clin Epidemiol. 2019 Mar;107:77-88. doi: 10.1016/j.jclinepi.2018.11.017. Epub 2018 Nov 28. Review.


Reporting of stepped wedge cluster randomised trials: extension of the CONSORT 2010 statement with explanation and elaboration.

Hemming K, Taljaard M, McKenzie JE, Hooper R, Copas A, Thompson JA, Dixon-Woods M, Aldcroft A, Doussau A, Grayling M, Kristunas C, Goldstein CE, Campbell MK, Girling A, Eldridge S, Campbell MJ, Lilford RJ, Weijer C, Forbes AB, Grimshaw JM.

BMJ. 2018 Nov 9;363:k1614. doi: 10.1136/bmj.k1614. No abstract available.


Discriminatory performance of adiponectin and leptin in the identification of impaired glucose tolerance: The Guangzhou Biobank Cohort Study - Cardiovascular Disease Subcohort.

Toulis KA, Jiang CQ, Hemming K, Nirantharakumar K, Cheng KK, Lam TH, Thomas GN.

PLoS One. 2018 Nov 6;13(11):e0206964. doi: 10.1371/journal.pone.0206964. eCollection 2018.


External validity is also an ethical consideration in cluster-randomised trials of policy changes: the author's reply.

Hemming K; all authors.

BMJ Qual Saf. 2019 Feb;28(2):168. doi: 10.1136/bmjqs-2018-008805. Epub 2018 Oct 12. No abstract available.


Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol.

Taljaard M, Weijer C, Grimshaw JM, Ali A, Brehaut JC, Campbell MK, Carroll K, Edwards S, Eldridge S, Forrest CB, Giraudeau B, Goldstein CE, Graham ID, Hemming K, Hey SP, Horn AR, Jairath V, Klassen TP, London AJ, Marlin S, Marshall JC, McIntyre L, McKenzie JE, Nicholls SG, Alison Paprica P, Zwarenstein M, Fergusson DA.

Trials. 2018 Sep 27;19(1):525. doi: 10.1186/s13063-018-2895-x.


Promoting hygienic weaning food handling practices through a community-based programme: intervention implementation and baseline characteristics for a cluster randomised controlled trial in rural Gambia.

Manjang B, Hemming K, Bradley C, Ensink J, Martin JT, Sowe J, Jarju A, Cairncross S, Manaseki-Holland S.

BMJ Open. 2018 Aug 5;8(8):e017573. doi: 10.1136/bmjopen-2017-017573.


Accommodating quality and service improvement research within existing ethical principles.

Goldstein CE, Weijer C, Brehaut JC, Campbell M, Fergusson DA, Grimshaw JM, Hemming K, Horn AR, Taljaard M.

Trials. 2018 Jun 25;19(1):334. doi: 10.1186/s13063-018-2724-2.


Cluster randomised trials: useful for interventions delivered to groups: Study design: cluster randomised trials.

Hemming K, Girling A.

BJOG. 2019 Feb;126(3):340. doi: 10.1111/1471-0528.15195. Epub 2018 Jun 19. No abstract available.


Simulation-based power calculations for planning a two-stage individual participant data meta-analysis.

Ensor J, Burke DL, Snell KIE, Hemming K, Riley RD.

BMC Med Res Methodol. 2018 May 18;18(1):41. doi: 10.1186/s12874-018-0492-z.


Analysis of cluster randomised trials with an assessment of outcome at baseline.

Hooper R, Forbes A, Hemming K, Takeda A, Beresford L.

BMJ. 2018 Mar 20;360:k1121. doi: 10.1136/bmj.k1121. No abstract available.


Ethical implications of excessive cluster sizes in cluster randomised trials.

Hemming K, Taljaard M, Forbes G, Eldridge SM, Weijer C.

BMJ Qual Saf. 2018 Aug;27(8):664-670. doi: 10.1136/bmjqs-2017-007164. Epub 2018 Feb 20.


Effectiveness of a childhood obesity prevention programme delivered through schools, targeting 6 and 7 year olds: cluster randomised controlled trial (WAVES study).

Adab P, Pallan MJ, Lancashire ER, Hemming K, Frew E, Barrett T, Bhopal R, Cade JE, Canaway A, Clarke JL, Daley A, Deeks JJ, Duda JL, Ekelund U, Gill P, Griffin T, McGee E, Hurley K, Martin J, Parry J, Passmore S, Cheng KK.

BMJ. 2018 Feb 7;360:k211. doi: 10.1136/bmj.k211. Erratum in: BMJ. 2018 May 2;361:k1954.


The West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES) study: a cluster randomised controlled trial testing the clinical effectiveness and cost-effectiveness of a multifaceted obesity prevention intervention programme targeted at children aged 6-7 years.

Adab P, Barrett T, Bhopal R, Cade JE, Canaway A, Cheng KK, Clarke J, Daley A, Deeks J, Duda J, Ekelund U, Frew E, Gill P, Griffin T, Hemming K, Hurley K, Lancashire ER, Martin J, McGee E, Pallan MJ, Parry J, Passmore S.

Health Technol Assess. 2018 Feb;22(8):1-608. doi: 10.3310/hta22080.


Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds.

Waters LJ, Finch CV, Bhuiyan AKMMH, Hemming K, Mitchell JC.

J Pharm Anal. 2017 Oct;7(5):338-342. doi: 10.1016/j.jpha.2017.05.003. Epub 2017 May 19.


A cluster randomised controlled trial evaluating the effectiveness and cost-effectiveness of the daily mile on childhood obesity and wellbeing; the Birmingham daily mile protocol.

Breheny K, Adab P, Passmore S, Martin J, Lancashire E, Hemming K, Frew E.

BMC Public Health. 2018 Jan 11;18(1):126. doi: 10.1186/s12889-017-5019-8.


Modeling clustering and treatment effect heterogeneity in parallel and stepped-wedge cluster randomized trials.

Hemming K, Taljaard M, Forbes A.

Stat Med. 2018 Mar 15;37(6):883-898. doi: 10.1002/sim.7553. Epub 2018 Jan 8.


Stepped-wedge cluster-randomised trials: level of evidence, feasibility and reporting.

Haines TP, Hemming K.

J Physiother. 2018 Jan;64(1):63-66. doi: 10.1016/j.jphys.2017.11.008. Epub 2017 Dec 27. No abstract available.


Facilitating dual careers by improving resistance to chronic stress: effects of an intervention programme for elite student athletes.

Sallen J, Hemming K, Richartz A.

Eur J Sport Sci. 2018 Feb;18(1):112-122. doi: 10.1080/17461391.2017.1407363. Epub 2017 Dec 3.


Cluster-randomised controlled trial to assess the effectiveness and cost-effectiveness of an obesity prevention programme for Chinese primary school-aged children: the CHIRPY DRAGON study protocol.

Li B, Liu WJ, Adab P, Pallan M, Hemming K, Frew E, Lin R, Martin J, Liu W, Cheng KK.

BMJ Open. 2017 Dec 1;7(11):e018415. doi: 10.1136/bmjopen-2017-018415.


Impact of non-uniform correlation structure on sample size and power in multiple-period cluster randomised trials.

Kasza J, Hemming K, Hooper R, Matthews J, Forbes AB.

Stat Methods Med Res. 2019 Mar;28(3):703-716. doi: 10.1177/0962280217734981. Epub 2017 Oct 13.


Perioperative supplementation with a fruit and vegetable juice powder concentrate and postsurgical morbidity: A double-blind, randomised, placebo-controlled clinical trial.

Gorecki P, Burke DL, Chapple ILC, Hemming K, Saund D, Pearson D, Stahl W, Lello R, Dietrich T.

Clin Nutr. 2018 Oct;37(5):1448-1455. doi: 10.1016/j.clnu.2017.08.004. Epub 2017 Aug 10.


Understanding the cluster randomised crossover design: a graphical illustraton of the components of variation and a sample size tutorial.

Arnup SJ, McKenzie JE, Hemming K, Pilcher D, Forbes AB.

Trials. 2017 Aug 15;18(1):381. doi: 10.1186/s13063-017-2113-2.


The use of feasibility studies for stepped-wedge cluster randomised trials: protocol for a review of impact and scope.

Kristunas CA, Hemming K, Eborall HC, Gray LJ.

BMJ Open. 2017 Aug 1;7(7):e017290. doi: 10.1136/bmjopen-2017-017290. Review.


Evaluation of a bespoke training to increase uptake by midwifery teams of NICE Guidance for membrane sweeping to reduce induction of labour: a stepped wedge cluster randomised design.

Kenyon S, Dann S, Hope L, Clarke P, Hogan A, Jenkinson D, Hemming K.

Trials. 2017 Jul 27;18(1):357. doi: 10.1186/s13063-017-2106-1.


How to design efficient cluster randomised trials.

Hemming K, Eldridge S, Forbes G, Weijer C, Taljaard M.

BMJ. 2017 Jul 14;358:j3064. doi: 10.1136/bmj.j3064. No abstract available.

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