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Items: 27

1.

Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers.

Talwelkar SS, Nagaraj AS, Devlin JR, Hemmes A, Potdar S, Kiss EA, Saharinen P, Salmenkivi K, Mäyränpää MI, Wennerberg K, Verschuren EW.

Mol Cancer Ther. 2019 Oct;18(10):1863-1874. doi: 10.1158/1535-7163.MCT-18-0573. Epub 2019 Jul 18.

PMID:
31320402
2.

Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing.

Nagaraj AS, Bao J, Hemmes A, Machado M, Närhi K, Verschuren EW.

J Vis Exp. 2018 Nov 29;(141). doi: 10.3791/58569.

PMID:
30582602
3.

Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours.

Närhi K, Nagaraj AS, Parri E, Turkki R, van Duijn PW, Hemmes A, Lahtela J, Uotinen V, Mäyränpää MI, Salmenkivi K, Räsänen J, Linder N, Trapman J, Rannikko A, Kallioniemi O, Af Hällström TM, Lundin J, Sommergruber W, Anders S, Verschuren EW.

J Pathol. 2018 May;245(1):101-113. doi: 10.1002/path.5059. Epub 2018 Apr 2. Erratum in: J Pathol. 2019 Jan;247(1):147.

4.

Systems pathology by multiplexed immunohistochemistry and whole-slide digital image analysis.

Blom S, Paavolainen L, Bychkov D, Turkki R, Mäki-Teeri P, Hemmes A, Välimäki K, Lundin J, Kallioniemi O, Pellinen T.

Sci Rep. 2017 Nov 14;7(1):15580. doi: 10.1038/s41598-017-15798-4.

5.

Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1.

Nagaraj AS, Lahtela J, Hemmes A, Pellinen T, Blom S, Devlin JR, Salmenkivi K, Kallioniemi O, Mäyränpää MI, Närhi K, Verschuren EW.

Cell Rep. 2017 Jan 17;18(3):673-684. doi: 10.1016/j.celrep.2016.12.059.

6.

Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers.

Tumiati M, Munne PM, Edgren H, Eldfors S, Hemmes A, Kuznetsov SG.

Oncogene. 2016 Sep 1;35(35):4601-10. doi: 10.1038/onc.2015.528. Epub 2016 Jan 25.

PMID:
26820992
7.

The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis.

Lahtela J, Pradhan B, Närhi K, Hemmes A, Särkioja M, Kovanen PE, Brown A, Verschuren EW.

Dis Model Mech. 2015 Apr;8(4):393-401. doi: 10.1242/dmm.019257. Epub 2015 Feb 20.

8.

Loss of Rad51c accelerates tumourigenesis in sebaceous glands of Trp53-mutant mice.

Tumiati M, Hemmes A, Uusivirta S, Koopal S, Kankainen M, Lehtonen E, Kuznetsov SG.

J Pathol. 2015 Jan;235(1):136-46. doi: 10.1002/path.4455.

PMID:
25270124
9.

A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3.

Lahtela J, Corson LB, Hemmes A, Brauer MJ, Koopal S, Lee J, Hunsaker TL, Jackson PK, Verschuren EW.

Cell Cycle. 2013 Feb 15;12(4):625-34. doi: 10.4161/cc.23515. Epub 2013 Jan 16.

10.

Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice.

Thiel A, Narko K, Heinonen M, Hemmes A, Tomasetto C, Rio MC, Haglund C, Mäkelä TP, Ristimäki A.

Int J Cancer. 2012 Sep 1;131(5):1032-41. doi: 10.1002/ijc.27331. Epub 2011 Dec 14.

11.

Prognostic role of CIP2A expression in serous ovarian cancer.

Böckelman C, Lassus H, Hemmes A, Leminen A, Westermarck J, Haglund C, Bützow R, Ristimäki A.

Br J Cancer. 2011 Sep 27;105(7):989-95. doi: 10.1038/bjc.2011.346. Epub 2011 Sep 6.

12.

Role of RNA binding protein HuR in ductal carcinoma in situ of the breast.

Heinonen M, Hemmes A, Salmenkivi K, Abdelmohsen K, Vilén ST, Laakso M, Leidenius M, Salo T, Hautaniemi S, Gorospe M, Heikkilä P, Haglund C, Ristimäki A.

J Pathol. 2011 Aug;224(4):529-39. doi: 10.1002/path.2889. Epub 2011 Apr 11.

13.

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice.

Ghosh M, Aguila HL, Michaud J, Ai Y, Wu MT, Hemmes A, Ristimaki A, Guo C, Furneaux H, Hla T.

J Clin Invest. 2009 Dec;119(12):3530-43. doi: 10.1172/JCI38263. Epub 2009 Nov 2.

14.

15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer.

Thiel A, Ganesan A, Mrena J, Junnila S, Nykänen A, Hemmes A, Tai HH, Monni O, Kokkola A, Haglund C, Petrova TV, Ristimäki A.

Clin Cancer Res. 2009 Jul 15;15(14):4572-80. doi: 10.1158/1078-0432.CCR-08-2518. Epub 2009 Jul 7.

15.

MYC-dependent regulation and prognostic role of CIP2A in gastric cancer.

Khanna A, Böckelman C, Hemmes A, Junttila MR, Wiksten JP, Lundin M, Junnila S, Murphy DJ, Evan GI, Haglund C, Westermarck J, Ristimäki A.

J Natl Cancer Inst. 2009 Jun 3;101(11):793-805. doi: 10.1093/jnci/djp103. Epub 2009 May 26.

PMID:
19470954
16.

HIF1a expression in bronchial biopsies correlates with tumor microvascular saturation determined using optical spectroscopy.

Aerts JG, Amelink A, van der Leest C, Hegmans JP, Hemmes A, den Hamer B, Sterenborg HC, Hoogsteden HC, Lambrecht BN.

Lung Cancer. 2007 Sep;57(3):317-21. Epub 2007 May 7.

PMID:
17485134
17.

Mesothelioma environment comprises cytokines and T-regulatory cells that suppress immune responses.

Hegmans JP, Hemmes A, Hammad H, Boon L, Hoogsteden HC, Lambrecht BN.

Eur Respir J. 2006 Jun;27(6):1086-95. Epub 2006 Mar 15.

18.

Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells.

Thiel A, Heinonen M, Rintahaka J, Hallikainen T, Hemmes A, Dixon DA, Haglund C, Ristimäki A.

J Biol Chem. 2006 Feb 24;281(8):4564-9. Epub 2005 Dec 21.

19.

Immunotherapy of murine malignant mesothelioma using tumor lysate-pulsed dendritic cells.

Hegmans JP, Hemmes A, Aerts JG, Hoogsteden HC, Lambrecht BN.

Am J Respir Crit Care Med. 2005 May 15;171(10):1168-77. Epub 2005 Mar 11.

PMID:
15764728
20.

Proteomic analysis of exosomes secreted by human mesothelioma cells.

Hegmans JP, Bard MP, Hemmes A, Luider TM, Kleijmeer MJ, Prins JB, Zitvogel L, Burgers SA, Hoogsteden HC, Lambrecht BN.

Am J Pathol. 2004 May;164(5):1807-15.

21.

Proteomic analysis of exosomes isolated from human malignant pleural effusions.

Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN.

Am J Respir Cell Mol Biol. 2004 Jul;31(1):114-21. Epub 2004 Feb 19.

PMID:
14975938
22.

Colony lift assay using cell-coated filters: a fast and efficient method to screen phage libraries for cell-binding clones.

Radosević K, Voerman JS, Hemmes A, Muskens F, Speleman L, de Weers M, Rosmalen JG, Knegt P, van Ewijk W.

J Immunol Methods. 2003 Jan 15;272(1-2):219-33.

PMID:
12505726
23.

Submandibular salivary gland hypertrophy induced by phenytoin.

Brandenburg AH, Smits MG, Voorbrood BS, Hemmes AM, Ros JJ.

Epilepsia. 1993 Jan-Feb;34(1):151-2.

PMID:
8422848
24.

Rapid diagnosis of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency via enzyme activity measurements in leukocytes or platelets using a simple spectrophotometric method.

Wanders RJ, Zoeters PH, Schutgens RB, de Klerk JB, Duran M, Wadman SK, van Sprang FJ, Hemmes AM, Voorbrood BS.

Clin Chim Acta. 1990 Aug 31;189(3):327-34.

PMID:
2225463
25.

A new short rib syndrome: report of two cases.

Beemer FA, Langer LO Jr, Klep-de Pater JM, Hemmes AM, Bylsma JB, Pauli RM, Myers TL, Haws CC 3rd.

Am J Med Genet. 1983 Jan;14(1):115-23.

PMID:
6829599
26.

A possible new short rib syndrome in two sibs.

Beemer FA, Bijlsma JB, Wladimiroff J, Klep-de Pater J, Hemmes AM.

Birth Defects Orig Artic Ser. 1982;18(3B):247-8. No abstract available.

PMID:
7139109
27.

Early diagnosis of skeletal dysplasia by real-time ultrasound.

Wladimiroff JW, Beemer FA, Hemmes AM.

Lancet. 1981 Mar 21;1(8221):661-2. No abstract available.

PMID:
6110881

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