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Items: 42

1.

Phase 2 studies of oral hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 for treatment of anemia in China.

Chen N, Qian J, Chen J, Yu X, Mei C, Hao C, Jiang G, Lin H, Zhang X, Zuo L, He Q, Fu P, Li X, Ni D, Hemmerich S, Liu C, Szczech L, Besarab A, Neff TB, Peony Yu KH, Valone FH.

Nephrol Dial Transplant. 2017 Aug 1;32(8):1373-1386. doi: 10.1093/ndt/gfx011.

2.

Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD.

Provenzano R, Besarab A, Sun CH, Diamond SA, Durham JH, Cangiano JL, Aiello JR, Novak JE, Lee T, Leong R, Roberts BK, Saikali KG, Hemmerich S, Szczech LA, Yu KH, Neff TB.

Clin J Am Soc Nephrol. 2016 Jun 6;11(6):982-91. doi: 10.2215/CJN.06890615. Epub 2016 Apr 19.

3.

Roxadustat (FG-4592) Versus Epoetin Alfa for Anemia in Patients Receiving Maintenance Hemodialysis: A Phase 2, Randomized, 6- to 19-Week, Open-Label, Active-Comparator, Dose-Ranging, Safety and Exploratory Efficacy Study.

Provenzano R, Besarab A, Wright S, Dua S, Zeig S, Nguyen P, Poole L, Saikali KG, Saha G, Hemmerich S, Szczech L, Yu KH, Neff TB.

Am J Kidney Dis. 2016 Jun;67(6):912-24. doi: 10.1053/j.ajkd.2015.12.020. Epub 2016 Feb 2.

4.

Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients.

Besarab A, Chernyavskaya E, Motylev I, Shutov E, Kumbar LM, Gurevich K, Chan DT, Leong R, Poole L, Zhong M, Saikali KG, Franco M, Hemmerich S, Yu KH, Neff TB.

J Am Soc Nephrol. 2016 Apr;27(4):1225-33. doi: 10.1681/ASN.2015030241. Epub 2015 Oct 22.

5.

Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients.

Besarab A, Provenzano R, Hertel J, Zabaneh R, Klaus SJ, Lee T, Leong R, Hemmerich S, Yu KH, Neff TB.

Nephrol Dial Transplant. 2015 Oct;30(10):1665-73. doi: 10.1093/ndt/gfv302. Epub 2015 Aug 3.

6.

rPSGL-Ig for improvement of early liver allograft function: a double-blind, placebo-controlled, single-center phase II study.

Busuttil RW, Lipshutz GS, Kupiec-Weglinski JW, Ponthieux S, Gjertson DW, Cheadle C, Watkins T, Ehrlich E, Katz E, Squiers EC, Rabb H, Hemmerich S.

Am J Transplant. 2011 Apr;11(4):786-97. doi: 10.1111/j.1600-6143.2011.03441.x. Epub 2011 Mar 14.

7.

Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs.

Arata-Kawai H, Singer MS, Bistrup A, Zante Av, Wang YQ, Ito Y, Bao X, Hemmerich S, Fukuda M, Rosen SD.

Am J Pathol. 2011 Jan;178(1):423-33. doi: 10.1016/j.ajpath.2010.11.009. Epub 2010 Dec 23.

8.

Effects of anti-adhesive therapy on kidney biomarkers of ischemia reperfusion injury in human deceased donor kidney allografts.

Cheadle C, Watkins T, Ehrlich E, Barnes K, Gaber AO, Hemmerich S, Rabb H.

Clin Transplant. 2011 Sep-Oct;25(5):766-75. doi: 10.1111/j.1399-0012.2010.01365.x. Epub 2010 Nov 28.

PMID:
21114535
9.

YSPSL (rPSGL-Ig) for improvement of early renal allograft function: a double-blind, placebo-controlled, multi-center Phase IIa study.

Gaber AO, Mulgaonkar S, Kahan BD, Woodle ES, Alloway R, Bajjoka I, Jensik S, Klintmalm GB, Patton PR, Wiseman A, Lipshutz G, Kupiec-Weglinski J, Gaber LW, Katz E, Irish W, Squiers EC, Hemmerich S.

Clin Transplant. 2011 Jul-Aug;25(4):523-33. doi: 10.1111/j.1399-0012.2010.01295.x. Epub 2010 Jun 22.

PMID:
20573162
10.

The shear modulus of the human vocal fold, preliminary results from 20 larynxes.

Goodyer E, Hemmerich S, Müller F, Kobler JB, Hess M.

Eur Arch Otorhinolaryngol. 2007 Jan;264(1):45-50. Epub 2006 Aug 19.

PMID:
16924433
11.
12.

Glycomics: coming of age across the globe.

Hemmerich S.

Drug Discov Today. 2005 Mar 1;10(5):307-9. No abstract available.

PMID:
15749278
13.

Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma.

Rosen SD, Tsay D, Singer MS, Hemmerich S, Abraham WM.

Am J Pathol. 2005 Mar;166(3):935-44.

14.

Sulfotransferase structural biology and inhibitor discovery.

Rath VL, Verdugo D, Hemmerich S.

Drug Discov Today. 2004 Dec 1;9(23):1003-11. Review.

PMID:
15574316
15.

Strategies for drug discovery by targeting sulfation pathways.

Hemmerich S, Verdugo D, Rath VL.

Drug Discov Today. 2004 Nov 15;9(22):967-75. Review.

PMID:
15539140
16.

Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking.

Palmeri D, Zuo FR, Rosen SD, Hemmerich S.

J Leukoc Biol. 2004 May;75(5):910-27. Epub 2004 Feb 3.

PMID:
14761935
17.

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans.

Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD.

J Biol Chem. 2002 Dec 20;277(51):49175-85. Epub 2002 Oct 3.

18.

Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression.

Uchimura K, El-Fasakhany FM, Hori M, Hemmerich S, Blink SE, Kansas GS, Kanamori A, Kumamoto K, Kannagi R, Muramatsu T.

J Biol Chem. 2002 Feb 8;277(6):3979-84. Epub 2001 Nov 28.

19.

Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes.

Hemmerich S, Bistrup A, Singer MS, van Zante A, Lee JK, Tsay D, Peters M, Carminati JL, Brennan TJ, Carver-Moore K, Leviten M, Fuentes ME, Ruddle NH, Rosen SD.

Immunity. 2001 Aug;15(2):237-47.

20.

Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta).

Bartes A, Bhakta S, Hemmerich S.

Biochem Biophys Res Commun. 2001 Apr 13;282(4):928-33.

PMID:
11352640
21.

Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family.

Hemmerich S, Lee JK, Bhakta S, Bistrup A, Ruddle NR, Rosen SD.

Glycobiology. 2001 Jan;11(1):75-87.

PMID:
11181564
22.
23.

Carbohydrate sulfotransferases in lymphocyte homing.

Hemmerich S, Rosen SD.

Glycobiology. 2000 Sep;10(9):849-56. Review.

PMID:
10988246
24.

Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5).

Bhakta S, Bartes A, Bowman KG, Kao WM, Polsky I, Lee JK, Cook BN, Bruehl RE, Rosen SD, Bertozzi CR, Hemmerich S.

J Biol Chem. 2000 Dec 22;275(51):40226-34.

25.
26.

Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2.

Jarnagin K, Grunberger D, Mulkins M, Wong B, Hemmerich S, Paavola C, Bloom A, Bhakta S, Diehl F, Freedman R, McCarley D, Polsky I, Ping-Tsou A, Kosaka A, Handel TM.

Biochemistry. 1999 Dec 7;38(49):16167-77.

PMID:
10587439
27.

Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2.

Hemmerich S, Paavola C, Bloom A, Bhakta S, Freedman R, Grunberger D, Krstenansky J, Lee S, McCarley D, Mulkins M, Wong B, Pease J, Mizoue L, Mirzadegan T, Polsky I, Thompson K, Handel TM, Jarnagin K.

Biochemistry. 1999 Oct 5;38(40):13013-25.

PMID:
10529171
28.
29.

Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue.

Lee JK, Bhakta S, Rosen SD, Hemmerich S.

Biochem Biophys Res Commun. 1999 Sep 24;263(2):543-9.

PMID:
10491328
30.

Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin.

Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen SD, Hemmerich S.

J Cell Biol. 1999 May 17;145(4):899-910.

31.

Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B.

Paavola CD, Hemmerich S, Grunberger D, Polsky I, Bloom A, Freedman R, Mulkins M, Bhakta S, McCarley D, Wiesent L, Wong B, Jarnagin K, Handel TM.

J Biol Chem. 1998 Dec 11;273(50):33157-65.

32.

Identification of an N-acetylglucosamine-6-0-sulfotransferase activity specific to lymphoid tissue: an enzyme with a possible role in lymphocyte homing.

Bowman KG, Hemmerich S, Bhakta S, Singer MS, Bistrup A, Rosen SD, Bertozzi CR.

Chem Biol. 1998 Aug;5(8):447-60.

33.

Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin.

Hemmerich S, Leffler H, Rosen SD.

J Biol Chem. 1995 May 19;270(20):12035-47.

35.

6'-sulfated sialyl Lewis x is a major capping group of GlyCAM-1.

Hemmerich S, Rosen SD.

Biochemistry. 1994 Apr 26;33(16):4830-5.

PMID:
8161542
36.

Identification of the sulfated monosaccharides of GlyCAM-1, an endothelial-derived ligand for L-selectin.

Hemmerich S, Bertozzi CR, Leffler H, Rosen SD.

Biochemistry. 1994 Apr 26;33(16):4820-9.

PMID:
7512827
37.

Binding of L-selectin to the vascular sialomucin CD34.

Baumheter S, Singer MS, Henzel W, Hemmerich S, Renz M, Rosen SD, Lasky LA.

Science. 1993 Oct 15;262(5132):436-8.

PMID:
7692600
38.
39.

A cromoglycate binding protein from rat mast cells of a leukemia line is a nucleoside diphosphate kinase.

Hemmerich S, Yarden Y, Pecht I.

Biochemistry. 1992 May 19;31(19):4574-9.

PMID:
1316151
41.

Calcium specificity of the antigen-induced channels in rat basophilic leukemia cells.

Corcia A, Pecht I, Hemmerich S, Ran S, Rivnay B.

Biochemistry. 1988 Sep 20;27(19):7499-506.

PMID:
2849994
42.

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