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Items: 1 to 50 of 169

1.

Multiple pro-tumor roles for protein acyltransferase DHHC3.

Sharma C, Hemler ME.

Oncoscience. 2017 Dec 20;4(11-12):152-153. doi: 10.18632/oncoscience.385. eCollection 2017 Nov. No abstract available.

2.

Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence.

Sharma C, Wang HX, Li Q, Knoblich K, Reisenbichler ES, Richardson AL, Hemler ME.

Cancer Res. 2017 Dec 15;77(24):6880-6890. doi: 10.1158/0008-5472.CAN-17-1536. Epub 2017 Oct 20.

3.

Novel impact of EWI-2, CD9, and CD81 on TGF-β signaling in melanoma.

Wang HX, Hemler ME.

Mol Cell Oncol. 2015 Oct 2;2(1). pii: e1030536. Epub 2015 Apr 15.

4.

EWI-2 negatively regulates TGF-β signaling leading to altered melanoma growth and metastasis.

Wang HX, Sharma C, Knoblich K, Granter SR, Hemler ME.

Cell Res. 2015 Mar;25(3):370-85. doi: 10.1038/cr.2015.17. Epub 2015 Feb 6.

5.

Tetraspanin proteins promote multiple cancer stages.

Hemler ME.

Nat Rev Cancer. 2014 Jan;14(1):49-60. Review.

PMID:
24505619
6.

Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation.

Knoblich K, Wang HX, Sharma C, Fletcher AL, Turley SJ, Hemler ME.

Cell Mol Life Sci. 2014 Apr;71(7):1305-14. doi: 10.1007/s00018-013-1444-8. Epub 2013 Aug 18.

PMID:
23955570
7.

Renal disease appears not to affect carcinogenesis in CD151-null mice.

Hemler ME, Hoff J, Li Q, Yang XH.

Oncogene. 2013 Sep 12;32(37):4458. doi: 10.1038/onc.2013.79. Epub 2013 Mar 18. No abstract available.

PMID:
23503459
8.

Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis.

Deng X, Li Q, Hoff J, Novak M, Yang H, Jin H, Erfani SF, Sharma C, Zhou P, Rabinovitz I, Sonnenberg A, Yi Y, Zhou P, Stipp CS, Kaetzel DM, Hemler ME, Yang XH.

Neoplasia. 2012 Aug;14(8):678-89.

9.

Tetraspanin CD151 plays a key role in skin squamous cell carcinoma.

Li Q, Yang XH, Xu F, Sharma C, Wang HX, Knoblich K, Rabinovitz I, Granter SR, Hemler ME.

Oncogene. 2013 Apr 4;32(14):1772-83. doi: 10.1038/onc.2012.205. Epub 2012 Jul 23.

10.

Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity.

Tsujino K, Takeda Y, Arai T, Shintani Y, Inagaki R, Saiga H, Iwasaki T, Tetsumoto S, Jin Y, Ihara S, Minami T, Suzuki M, Nagatomo I, Inoue K, Kida H, Kijima T, Ito M, Kitaichi M, Inoue Y, Tachibana I, Takeda K, Okumura M, Hemler ME, Kumanogoh A.

Am J Respir Crit Care Med. 2012 Jul 15;186(2):170-80. doi: 10.1164/rccm.201201-0117OC. Epub 2012 May 16.

11.

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks.

Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ; Immunological Genome Project Consortium.

Nat Immunol. 2012 Apr 1;13(5):499-510. doi: 10.1038/ni.2262.

12.

CD151 restricts the α6 integrin diffusion mode.

Yang XH, Mirchev R, Deng X, Yacono P, Yang HL, Golan DE, Hemler ME.

J Cell Sci. 2012 Mar 15;125(Pt 6):1478-87. doi: 10.1242/jcs.093963. Epub 2012 Feb 10.

13.

Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin α6β4.

Sharma C, Rabinovitz I, Hemler ME.

Cell Mol Life Sci. 2012 Jul;69(13):2233-44. doi: 10.1007/s00018-012-0924-6.

14.

The C-terminal tail of tetraspanin protein CD9 contributes to its function and molecular organization.

Wang HX, Kolesnikova TV, Denison C, Gygi SP, Hemler ME.

J Cell Sci. 2011 Aug 15;124(Pt 16):2702-10. doi: 10.1242/jcs.085449. Epub 2011 Jul 19.

15.

Diminished metastasis in tetraspanin CD151-knockout mice.

Takeda Y, Li Q, Kazarov AR, Epardaud M, Elpek K, Turley SJ, Hemler ME.

Blood. 2011 Jul 14;118(2):464-72. doi: 10.1182/blood-2010-08-302240. Epub 2011 May 2.

16.

Tetraspanin protein contributions to cancer.

Wang HX, Li Q, Sharma C, Knoblich K, Hemler ME.

Biochem Soc Trans. 2011 Apr;39(2):547-52. doi: 10.1042/BST0390547. Review.

PMID:
21428937
17.

Disruption of laminin-integrin-CD151-focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists.

Yang XH, Flores LM, Li Q, Zhou P, Xu F, Krop IE, Hemler ME.

Cancer Res. 2010 Mar 15;70(6):2256-63. doi: 10.1158/0008-5472.CAN-09-4032. Epub 2010 Mar 2.

18.

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein.

Xu D, Sharma C, Hemler ME.

FASEB J. 2009 Nov;23(11):3674-81. doi: 10.1096/fj.09-133462. Epub 2009 Jul 8.

19.

Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis.

Lafleur MA, Xu D, Hemler ME.

Mol Biol Cell. 2009 Apr;20(7):2030-40. doi: 10.1091/mbc.E08-11-1149. Epub 2009 Feb 11.

20.

Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo.

Kolesnikova TV, Kazarov AR, Lemieux ME, Lafleur MA, Kesari S, Kung AL, Hemler ME.

Neoplasia. 2009 Jan;11(1):77-86, 4p following 86.

21.

Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer.

Fiorentino M, Zadra G, Palescandolo E, Fedele G, Bailey D, Fiore C, Nguyen PL, Migita T, Zamponi R, Di Vizio D, Priolo C, Sharma C, Xie W, Hemler ME, Mucci L, Giovannucci E, Finn S, Loda M.

Lab Invest. 2008 Dec;88(12):1340-8. doi: 10.1038/labinvest.2008.97. Epub 2008 Oct 6.

22.

Targeting of tetraspanin proteins--potential benefits and strategies.

Hemler ME.

Nat Rev Drug Discov. 2008 Sep;7(9):747-58. doi: 10.1038/nrd2659. Review.

23.

DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151.

Sharma C, Yang XH, Hemler ME.

Mol Biol Cell. 2008 Aug;19(8):3415-25. doi: 10.1091/mbc.E07-11-1164. Epub 2008 May 28.

24.

CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization.

Yang XH, Richardson AL, Torres-Arzayus MI, Zhou P, Sharma C, Kazarov AR, Andzelm MM, Strominger JL, Brown M, Hemler ME.

Cancer Res. 2008 May 1;68(9):3204-13. doi: 10.1158/0008-5472.CAN-07-2949.

25.

A novel cysteine cross-linking method reveals a direct association between claudin-1 and tetraspanin CD9.

Kovalenko OV, Yang XH, Hemler ME.

Mol Cell Proteomics. 2007 Nov;6(11):1855-67. Epub 2007 Jul 20.

26.

Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro.

Takeda Y, Kazarov AR, Butterfield CE, Hopkins BD, Benjamin LE, Kaipainen A, Hemler ME.

Blood. 2007 Feb 15;109(4):1524-32. Epub 2006 Oct 5.

27.

In vitro interaction between hepatitis C virus (HCV) envelope glycoprotein E2 and serum lipoproteins (LPs) results in enhanced cellular binding of both HCV E2 and LPs.

Wunschmann S, Muller HM, Stipp CS, Hemler ME, Stapleton JT.

J Infect Dis. 2006 Oct 15;194(8):1058-67. Epub 2006 Sep 8.

PMID:
16991080
28.

EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins.

Sala-Valdés M, Ursa A, Charrin S, Rubinstein E, Hemler ME, Sánchez-Madrid F, Yáñez-Mó M.

J Biol Chem. 2006 Jul 14;281(28):19665-75. Epub 2006 May 10.

29.

Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization.

Yang XH, Kovalenko OV, Kolesnikova TV, Andzelm MM, Rubinstein E, Strominger JL, Hemler ME.

J Biol Chem. 2006 May 5;281(18):12976-85. Epub 2006 Mar 13.

30.

Tetraspanin functions and associated microdomains.

Hemler ME.

Nat Rev Mol Cell Biol. 2005 Oct;6(10):801-11. Review.

PMID:
16314869
31.

Structural organization and interactions of transmembrane domains in tetraspanin proteins.

Kovalenko OV, Metcalf DG, DeGrado WF, Hemler ME.

BMC Struct Biol. 2005 Jun 28;5:11.

32.

Metabolic activation-related CD147-CD98 complex.

Xu D, Hemler ME.

Mol Cell Proteomics. 2005 Aug;4(8):1061-71. Epub 2005 May 18.

33.

Palmitoylation supports assembly and function of integrin-tetraspanin complexes.

Yang X, Kovalenko OV, Tang W, Claas C, Stipp CS, Hemler ME.

J Cell Biol. 2004 Dec 20;167(6):1231-40.

34.

Links between CD147 function, glycosylation, and caveolin-1.

Tang W, Chang SB, Hemler ME.

Mol Biol Cell. 2004 Sep;15(9):4043-50. Epub 2004 Jun 16.

35.

EWI-2 modulates lymphocyte integrin alpha4beta1 functions.

Kolesnikova TV, Stipp CS, Rao RM, Lane WS, Luscinskas FW, Hemler ME.

Blood. 2004 Apr 15;103(8):3013-9. Epub 2003 Dec 18.

36.
37.

Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering.

Tang W, Hemler ME.

J Biol Chem. 2004 Mar 19;279(12):11112-8. Epub 2004 Jan 5.

38.

EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5.

Stipp CS, Kolesnikova TV, Hemler ME.

J Cell Biol. 2003 Dec 8;163(5):1167-77.

39.
40.
41.

Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening.

Lammerding J, Kazarov AR, Huang H, Lee RT, Hemler ME.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7616-21. Epub 2003 Jun 12.

42.

Functional domains in tetraspanin proteins.

Stipp CS, Kolesnikova TV, Hemler ME.

Trends Biochem Sci. 2003 Feb;28(2):106-12. Review. Erratum in: Trends Biochem Sci. 2003 Mar;28(3):124.

PMID:
12575999
43.

An extracellular site on tetraspanin CD151 determines alpha 3 and alpha 6 integrin-dependent cellular morphology.

Kazarov AR, Yang X, Stipp CS, Sehgal B, Hemler ME.

J Cell Biol. 2002 Sep 30;158(7):1299-309.

44.

Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology.

Yang X, Claas C, Kraeft SK, Chen LB, Wang Z, Kreidberg JA, Hemler ME.

Mol Biol Cell. 2002 Mar;13(3):767-81.

45.

Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis.

Zhang XA, Kazarov AR, Yang X, Bontrager AL, Stipp CS, Hemler ME.

Mol Biol Cell. 2002 Jan;13(1):1-11.

46.

Specific tetraspanin functions.

Hemler ME.

J Cell Biol. 2001 Dec 24;155(7):1103-7. Epub 2001 Dec 24. Review.

47.
48.

Beta1 integrins show specific association with CD98 protein in low density membranes.

Kolesnikova TV, Mannion BA, Berditchevski F, Hemler ME.

BMC Biochem. 2001;2:10. Epub 2001 Oct 15.

49.

EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.

Stipp CS, Kolesnikova TV, Hemler ME.

J Biol Chem. 2001 Nov 2;276(44):40545-54. Epub 2001 Aug 14.

50.

Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins.

Zhang XA, Bontrager AL, Hemler ME.

J Biol Chem. 2001 Jul 6;276(27):25005-13. Epub 2001 Apr 26.

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