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Items: 1 to 50 of 68

1.

Consideration of confounding was suboptimal in the reporting of observational studies in psychiatry: a meta-epidemiological study.

Munkholm K, Faurholt-Jepsen M, Ioannidis JPA, Hemkens LG.

J Clin Epidemiol. 2019 Dec 3. pii: S0895-4356(19)30765-6. doi: 10.1016/j.jclinepi.2019.12.002. [Epub ahead of print]

PMID:
31809848
2.

Contrasting evidence to reimbursement reality for off-label use (OLU) of drug treatments in cancer care: rationale and design of the CEIT-OLU project.

Herbrand AK, Schmitt AM, Briel M, Diem S, Ewald H, Hoogkamer A, Joerger M, Mc Cord KA, Novak U, Sricharoenchai S, Hemkens LG, Kasenda B.

ESMO Open. 2019 Dec 1;4(6):e000596. doi: 10.1136/esmoopen-2019-000596. eCollection 2019.

3.

Nonrandomized studies using causal-modeling may give different answers than RCTs: a meta-epidemiological study.

Ewald H, Ioannidis JPA, Ladanie A, Mc Cord K, Bucher HC, Hemkens LG.

J Clin Epidemiol. 2019 Nov 5;118:29-41. doi: 10.1016/j.jclinepi.2019.10.012. [Epub ahead of print]

PMID:
31704350
4.

Effect of Combination l-Citrulline and Metformin Treatment on Motor Function in Patients With Duchenne Muscular Dystrophy: A Randomized Clinical Trial.

Hafner P, Bonati U, Klein A, Rubino D, Gocheva V, Schmidt S, Schroeder J, Bernert G, Laugel V, Steinlin M, Capone A, Gloor M, Bieri O, Hemkens LG, Speich B, Zumbrunn T, Gueven N, Fischer D.

JAMA Netw Open. 2019 Oct 2;2(10):e1914171. doi: 10.1001/jamanetworkopen.2019.14171.

5.

A scoping review shows that several nonvalidated budget planning tools for randomized trials are available.

Speich B, Gloy V, Schur N, Ewald H, Hemkens LG, Schwenkglenks M, Briel M; MAking Randomized Trials Affordable (MARTA) Group.

J Clin Epidemiol. 2019 Sep 15;117:9-19. doi: 10.1016/j.jclinepi.2019.09.009. [Epub ahead of print]

PMID:
31533072
6.

Rituximab in primary central nervous system lymphoma-A systematic review and meta-analysis.

Schmitt AM, Herbrand AK, Fox CP, Bakunina K, Bromberg JEC, Cwynarski K, Doorduijn JK, Ferreri AJM, Illerhaus G, Issa S, Schorb E, Zucca E, Hemkens LG, Schandelmaier S, Kasenda B.

Hematol Oncol. 2019 Aug 16. doi: 10.1002/hon.2666. [Epub ahead of print] Review.

PMID:
31418878
7.

La déclaration RECORD-PE (Reporting of Studies Conducted Using Observational Routinely Collected Health Data Statement for Pharmacoepdemiology) : directives pour la communication des études realisées à partir de données de santé observationelles collectées en routine en pharmacoépidémiologie.

Langan SM, Schmidt SAJ, Wing K, Ehrenstein V, Nicholls SG, Filion KB, Klungel O, Petersen I, Sørensen HT, Dixon WG, Guttmann A, Harron K, Hemkens LG, Moher D, Schneeweiss S, Smeeth L, Sturkenboom M, von Elm E, Wang SV, Benchimol EI.

CMAJ. 2019 Jun 24;191(25):E689-E708. doi: 10.1503/cmaj.190347. French. No abstract available.

PMID:
31235490
8.

Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies.

Ladanie A, Speich B, Briel M, Sclafani F, Bucher HC, Agarwal A, Ioannidis JPA, Pereira TV, Kasenda B, Hemkens LG.

J Clin Epidemiol. 2019 Oct;114:49-59. doi: 10.1016/j.jclinepi.2019.05.033. Epub 2019 May 31.

PMID:
31158450
9.

Single-dose versus 3-day cotrimoxazole prophylaxis in transurethral resection or greenlight laser vaporisation of the prostate: study protocol for a multicentre randomised placebo controlled non-inferiority trial (CITrUS trial).

Speich B, Bausch K, Roth JA, Hemkens LG, Ewald H, Vogt DR, Bruni N, Deuster S, Seifert HH, Widmer AF.

Trials. 2019 Feb 19;20(1):142. doi: 10.1186/s13063-019-3237-3.

10.

Current use and costs of electronic health records for clinical trial research: a descriptive study.

Mc Cord KA, Ewald H, Ladanie A, Briel M, Speich B, Bucher HC, Hemkens LG; RCD for RCTs initiative and the Making Randomized Trials More Affordable Group.

CMAJ Open. 2019 Feb 3;7(1):E23-E32. doi: 10.9778/cmajo.20180096. Print 2019 Jan-Mar.

11.

Using electronic health records for clinical trials: Where do we stand and where can we go?

Mc Cord KA, Hemkens LG.

CMAJ. 2019 Feb 4;191(5):E128-E133. doi: 10.1503/cmaj.180841. No abstract available.

PMID:
30718337
12.

How Routinely Collected Data for Randomized Trials Provide Long-term Randomized Real-World Evidence.

Hemkens LG.

JAMA Netw Open. 2018 Dec 7;1(8):e186014. doi: 10.1001/jamanetworkopen.2018.6014. No abstract available.

PMID:
30646306
13.

Resource use, costs, and approval times for planning and preparing a randomized clinical trial before and after the implementation of the new Swiss human research legislation.

Speich B, Schur N, Gryaznov D, von Niederhäusern B, Hemkens LG, Schandelmaier S, Amstutz A, Kasenda B, Pauli-Magnus C, Ojeda-Ruiz E, Tomonaga Y, McCord K, Nordmann A, von Elm E, Briel M, Schwenkglenks M; a collaboration of the MARTA (MAking Randomized Trials Affordable) and ASPIRE (Adherence to Standard Protocol Items: REcommendations for interventional trials) Study Groups.

PLoS One. 2019 Jan 11;14(1):e0210669. doi: 10.1371/journal.pone.0210669. eCollection 2019.

14.

The reporting of studies conducted using observational routinely collected health data statement for pharmacoepidemiology (RECORD-PE).

Langan SM, Schmidt SA, Wing K, Ehrenstein V, Nicholls SG, Filion KB, Klungel O, Petersen I, Sorensen HT, Dixon WG, Guttmann A, Harron K, Hemkens LG, Moher D, Schneeweiss S, Smeeth L, Sturkenboom M, von Elm E, Wang SV, Benchimol EI.

BMJ. 2018 Nov 14;363:k3532. doi: 10.1136/bmj.k3532. No abstract available.

15.

Marginal structural models and other analyses allow multiple estimates of treatment effects in randomized clinical trials: Meta-epidemiological analysis.

Ewald H, Speich B, Ladanie A, Bucher HC, Ioannidis JPA, Hemkens LG.

J Clin Epidemiol. 2019 Mar;107:12-26. doi: 10.1016/j.jclinepi.2018.11.001. Epub 2018 Nov 10.

PMID:
30423375
16.

Protocol for the development of a CONSORT extension for RCTs using cohorts and routinely collected health data.

Kwakkenbos L, Juszczak E, Hemkens LG, Sampson M, Fröbert O, Relton C, Gale C, Zwarenstein M, Langan SM, Moher D, Boutron I, Ravaud P, Campbell MK, Mc Cord KA, van Staa TP, Thabane L, Uher R, Verkooijen HM, Benchimol EI, Erlinge D, Sauvé M, Torgerson D, Thombs BD.

Res Integr Peer Rev. 2018 Oct 29;3:9. doi: 10.1186/s41073-018-0053-3. eCollection 2018.

17.

The Comparative Effectiveness of Innovative Treatments for Cancer (CEIT-Cancer) project: Rationale and design of the database and the collection of evidence available at approval of novel drugs.

Ladanie A, Speich B, Naudet F, Agarwal A, Pereira TV, Sclafani F, Martin-Liberal J, Schmid T, Ewald H, Ioannidis JPA, Bucher HC, Kasenda B, Hemkens LG.

Trials. 2018 Sep 19;19(1):505. doi: 10.1186/s13063-018-2877-z.

18.

Treatments for subacute cough in primary care: systematic review and meta-analyses of randomised clinical trials.

Speich B, Thomer A, Aghlmandi S, Ewald H, Zeller A, Hemkens LG.

Br J Gen Pract. 2018 Oct;68(675):e694-e702. doi: 10.3399/bjgp18X698885. Epub 2018 Sep 10.

19.

Protocol for a scoping review to support development of a CONSORT extension for randomised controlled trials using cohorts and routinely collected health data.

Kwakkenbos L, Imran M, McCord KA, Sampson M, Fröbert O, Gale C, Hemkens LG, Langan SM, Moher D, Relton C, Zwarenstein M, Benchimol EI, Boutron I, Campbell MK, Erlinge D, Jawad S, Ravaud P, Rice DB, Sauve M, van Staa TP, Thabane L, Uher R, Verkooijen HM, Juszczak E, Thombs BD.

BMJ Open. 2018 Aug 5;8(8):e025266. doi: 10.1136/bmjopen-2018-025266.

20.

How to use FDA drug approval documents for evidence syntheses.

Ladanie A, Ewald H, Kasenda B, Hemkens LG.

BMJ. 2018 Jul 10;362:k2815. doi: 10.1136/bmj.k2815. No abstract available.

PMID:
29991565
21.

Off-label prescription: experience is a gloomy lantern that does not even illuminate its bearer. Author response.

Ladanie A, Ioannidis JPA, Stafford RS, Ewald H, Bucher HC, Hemkens LG, Hemkens LG.

J Clin Epidemiol. 2018 Sep;101:127-128. doi: 10.1016/j.jclinepi.2018.05.012. Epub 2018 May 22. No abstract available.

PMID:
29800688
22.

Systematic review and simulation study of ignoring clustered data in surgical trials.

Dell-Kuster S, Droeser RA, Schäfer J, Gloy V, Ewald H, Schandelmaier S, Hemkens LG, Bucher HC, Young J, Rosenthal R.

Br J Surg. 2018 Feb;105(3):182-191. doi: 10.1002/bjs.10763. Review.

PMID:
29405280
23.

Routinely collected data for randomized trials: promises, barriers, and implications.

Mc Cord KA, Al-Shahi Salman R, Treweek S, Gardner H, Strech D, Whiteley W, Ioannidis JPA, Hemkens LG.

Trials. 2018 Jan 11;19(1):29. doi: 10.1186/s13063-017-2394-5. Review.

24.

Retrospective assessment of resource use and costs in two investigator-initiated randomized trials exemplified a comprehensive cost item list.

Speich B, von Niederhäusern B, Blum CA, Keiser J, Schur N, Fürst T, Kasenda B, Christ-Crain M, Hemkens LG, Pauli-Magnus C, Schwenkglenks M, Briel M; MAking Randomized Trials Affordable (MARTA) Group.

J Clin Epidemiol. 2018 Apr;96:73-83. doi: 10.1016/j.jclinepi.2017.12.022. Epub 2017 Dec 30.

PMID:
29292203
25.

Systematic review on costs and resource use of randomized clinical trials shows a lack of transparent and comprehensive data.

Speich B, von Niederhäusern B, Schur N, Hemkens LG, Fürst T, Bhatnagar N, Alturki R, Agarwal A, Kasenda B, Pauli-Magnus C, Schwenkglenks M, Briel M; MAking Randomized Trials Affordable (MARTA) Group.

J Clin Epidemiol. 2018 Apr;96:1-11. doi: 10.1016/j.jclinepi.2017.12.018. Epub 2017 Dec 27. Review.

PMID:
29288136
26.

Off-label treatments were not consistently better or worse than approved drug treatments in randomized trials.

Ladanie A, Ioannidis JPA, Stafford RS, Ewald H, Bucher HC, Hemkens LG.

J Clin Epidemiol. 2018 Feb;94:35-45. doi: 10.1016/j.jclinepi.2017.11.006. Epub 2017 Nov 13. Review.

PMID:
29146289
27.

Quality of antibiotic prescribing of Swiss primary care physicians with high prescription rates: a nationwide survey.

Glinz D, Leon Reyes S, Saccilotto R, Widmer AF, Zeller A, Bucher HC, Hemkens LG.

J Antimicrob Chemother. 2017 Nov 1;72(11):3205-3212. doi: 10.1093/jac/dkx278.

PMID:
28961815
28.

Interpretation of epidemiologic studies very often lacked adequate consideration of confounding.

Hemkens LG, Ewald H, Naudet F, Ladanie A, Shaw JG, Sajeev G, Ioannidis JPA.

J Clin Epidemiol. 2018 Jan;93:94-102. doi: 10.1016/j.jclinepi.2017.09.013. Epub 2017 Sep 21.

PMID:
28943377
29.

Towards the development of a comprehensive framework: Qualitative systematic survey of definitions of clinical research quality.

von Niederhäusern B, Schandelmaier S, Mi Bonde M, Brunner N, Hemkens LG, Rutquist M, Bhatnagar N, Guyatt GH, Pauli-Magnus C, Briel M.

PLoS One. 2017 Jul 17;12(7):e0180635. doi: 10.1371/journal.pone.0180635. eCollection 2017.

30.

Niacin for primary and secondary prevention of cardiovascular events.

Schandelmaier S, Briel M, Saccilotto R, Olu KK, Arpagaus A, Hemkens LG, Nordmann AJ.

Cochrane Database Syst Rev. 2017 Jun 14;6:CD009744. doi: 10.1002/14651858.CD009744.pub2. Review.

31.

Premature Discontinuation of Pediatric Randomized Controlled Trials: A Retrospective Cohort Study.

Schandelmaier S, Tomonaga Y, Bassler D, Meerpohl JJ, von Elm E, You JJ, Bluemle A, Lamontagne F, Saccilotto R, Amstutz A, Bengough T, Stegert M, Olu KK, Tikkinen KAO, Neumann I, Carrasco-Labra A, Faulhaber M, Mulla SM, Mertz D, Akl EA, Sun X, Busse JW, Ferreira-González I, Nordmann A, Gloy V, Raatz H, Moja L, Rosenthal R, Ebrahim S, Vandvik PO, Johnston BC, Walter MA, Burnand B, Schwenkglenks M, Hemkens LG, Guyatt G, Bucher HC, Kasenda B, Briel M.

J Pediatr. 2017 May;184:209-214.e1. doi: 10.1016/j.jpeds.2017.01.071. Epub 2017 Mar 3.

PMID:
28410086
32.

Personalized Prescription Feedback Using Routinely Collected Data to Reduce Antibiotic Use in Primary Care: A Randomized Clinical Trial.

Hemkens LG, Saccilotto R, Reyes SL, Glinz D, Zumbrunn T, Grolimund O, Gloy V, Raatz H, Widmer A, Zeller A, Bucher HC.

JAMA Intern Med. 2017 Feb 1;177(2):176-183. doi: 10.1001/jamainternmed.2016.8040.

PMID:
28027333
33.

Authors' reply to Pérol and colleagues.

Hemkens LG, Contopoulos-Ioannidis DG, Ioannidis JP.

BMJ. 2016 Dec 16;355:i6747. doi: 10.1136/bmj.i6747. No abstract available.

PMID:
27986652
34.

Comparative effectiveness of tenofovir in HIV-infected treatment-experienced patients: systematic review and meta-analysis.

Ewald H, Santini-Oliveira M, Bühler JE, Vuichard D, Schandelmaier S, Stöckle M, Briel M, Bucher HC, Hemkens LG.

HIV Clin Trials. 2017 Jan;18(1):17-27. doi: 10.1080/15284336.2016.1261073. Epub 2016 Dec 13. Review.

PMID:
27951755
35.

[The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement].

Benchimol EI, Smeeth L, Guttmann A, Harron K, Hemkens LG, Moher D, Petersen I, Sørensen HT, von Elm E, Langan SM; RECORD Working Committee.

Z Evid Fortbild Qual Gesundhwes. 2016 Oct;115-116:33-48. doi: 10.1016/j.zefq.2016.07.010. Epub 2016 Sep 28. German.

36.

Colchicine and Prevention of Cardiovascular Events.

Hemkens LG, Ewald H, Briel M.

JAMA. 2016 Sep 13;316(10):1106-7. doi: 10.1001/jama.2016.11044.

PMID:
27623465
37.

Personalized prescription feedback to reduce antibiotic overuse in primary care: rationale and design of a nationwide pragmatic randomized trial.

Hemkens LG, Saccilotto R, Reyes SL, Glinz D, Zumbrunn T, Grolimund O, Gloy V, Raatz H, Widmer A, Zeller A, Bucher HC.

BMC Infect Dis. 2016 Aug 17;16:421. doi: 10.1186/s12879-016-1739-0.

38.

Current use of routinely collected health data to complement randomized controlled trials: a meta-epidemiological survey.

Hemkens LG, Contopoulos-Ioannidis DG, Ioannidis JP.

CMAJ Open. 2016 Apr 6;4(2):E132-40. doi: 10.9778/cmajo.20150036. eCollection 2016 Apr-Jun.

39.

Agreements between Industry and Academia on Publication Rights: A Retrospective Study of Protocols and Publications of Randomized Clinical Trials.

Kasenda B, von Elm E, You JJ, Blümle A, Tomonaga Y, Saccilotto R, Amstutz A, Bengough T, Meerpohl JJ, Stegert M, Olu KK, Tikkinen KA, Neumann I, Carrasco-Labra A, Faulhaber M, Mulla SM, Mertz D, Akl EA, Bassler D, Busse JW, Ferreira-González I, Lamontagne F, Nordmann A, Gloy V, Raatz H, Moja L, Ebrahim S, Schandelmaier S, Sun X, Vandvik PO, Johnston BC, Walter MA, Burnand B, Schwenkglenks M, Hemkens LG, Bucher HC, Guyatt GH, Briel M.

PLoS Med. 2016 Jun 28;13(6):e1002046. doi: 10.1371/journal.pmed.1002046. eCollection 2016 Jun.

40.

The reporting of studies using routinely collected health data was often insufficient.

Hemkens LG, Benchimol EI, Langan SM, Briel M, Kasenda B, Januel JM, Herrett E, von Elm E.

J Clin Epidemiol. 2016 Nov;79:104-111. doi: 10.1016/j.jclinepi.2016.06.005. Epub 2016 Jun 23.

41.

Better research reporting to improve the utility of routine data for making better treatment decisions.

Hemkens LG, Langan SM, Benchimol EI.

J Comp Eff Res. 2016 Mar;5(2):117-22. doi: 10.2217/cer.15.66. Epub 2016 Mar 1. Review.

42.

Routinely collected data and comparative effectiveness evidence: promises and limitations.

Hemkens LG, Contopoulos-Ioannidis DG, Ioannidis JPA.

CMAJ. 2016 May 17;188(8):E158-E164. doi: 10.1503/cmaj.150653. Epub 2016 Feb 16. No abstract available.

43.

Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey.

Hemkens LG, Contopoulos-Ioannidis DG, Ioannidis JP.

BMJ. 2016 Feb 8;352:i493. doi: 10.1136/bmj.i493. Erratum in: BMJ. 2018 Aug 17;362:k3210.

44.

Cardiovascular effects and safety of long-term colchicine treatment: Cochrane review and meta-analysis.

Hemkens LG, Ewald H, Gloy VL, Arpagaus A, Olu KK, Nidorf M, Glinz D, Nordmann AJ, Briel M.

Heart. 2016 Apr;102(8):590-6. doi: 10.1136/heartjnl-2015-308542. Epub 2016 Feb 1. Review.

PMID:
26830663
45.

Colchicine for prevention of cardiovascular events.

Hemkens LG, Ewald H, Gloy VL, Arpagaus A, Olu KK, Nidorf M, Glinz D, Nordmann AJ, Briel M.

Cochrane Database Syst Rev. 2016 Jan 27;(1):CD011047. doi: 10.1002/14651858.CD011047.pub2. Review.

PMID:
26816301
46.

Planning and reporting of quality-of-life outcomes in cancer trials.

Schandelmaier S, Conen K, von Elm E, You JJ, Blümle A, Tomonaga Y, Saccilotto R, Amstutz A, Bengough T, Meerpohl JJ, Stegert M, Olu KK, Tikkinen KA, Neumann I, Carrasco-Labra A, Faulhaber M, Mulla SM, Mertz D, Akl EA, Sun X, Bassler D, Busse JW, Ferreira-González I, Lamontagne F, Nordmann A, Gloy V, Raatz H, Moja L, Rosenthal R, Ebrahim S, Vandvik PO, Johnston BC, Walter MA, Burnand B, Schwenkglenks M, Hemkens LG, Bucher HC, Guyatt GH, Briel M, Kasenda B; DISCO study group.

Ann Oncol. 2016 Jan;27(1):209. doi: 10.1093/annonc/mdv559. Epub 2015 Nov 25. No abstract available.

47.

Premature Discontinuation of Randomized Trials in Critical and Emergency Care: A Retrospective Cohort Study.

Schandelmaier S, von Elm E, You JJ, Blümle A, Tomonaga Y, Lamontagne F, Saccilotto R, Amstutz A, Bengough T, Meerpohl JJ, Stegert M, Olu KK, Tikkinen KA, Neumann I, Carrasco-Labra A, Faulhaber M, Mulla SM, Mertz D, Akl EA, Sun X, Bassler D, Busse JW, Ferreira-González I, Nordmann A, Gloy V, Raatz H, Moja L, Rosenthal R, Ebrahim S, Vandvik PO, Johnston BC, Walter MA, Burnand B, Schwenkglenks M, Hemkens LG, Cook DJ, Meade MO, Bucher HC, Kasenda B, Briel M.

Crit Care Med. 2016 Jan;44(1):130-7. doi: 10.1097/CCM.0000000000001369.

48.

Comparative effectiveness of tenofovir in treatment-naïve HIV-infected patients: systematic review and meta-analysis.

Hemkens LG, Ewald H, Santini-Oliveira M, Bühler JE, Vuichard D, Schandelmaier S, Stöckle M, Briel M, Bucher HC.

HIV Clin Trials. 2015 Oct;16(5):178-89. doi: 10.1179/1945577115Y.0000000004. Review.

PMID:
26395328
49.

Planning and reporting of quality-of-life outcomes in cancer trials.

Schandelmaier S, Conen K, von Elm E, You JJ, Blümle A, Tomonaga Y, Saccilotto, Amstutz A, Bengough T, Meerpohl JJ, Stegert M, Olu KK, Tikkinen KA, Neumann I, Carrasco-Labra A, Faulhaber M, Mulla SM, Mertz D, Akl EA, Sun X, Bassler D, Busse JW, Ferreira-González I, Lamontagne F, Nordmann A, Gloy V, Raatz H, Moja L, Rosenthal R, Ebrahim S, Vandvik PO, Johnston BC, Walter MA, Burnand B, Schwenkglenks M, Hemkens LG, Bucher HC, Guyatt GH, Briel M, Kasenda B; DISCO study group.

Ann Oncol. 2015 Sep;26(9):1966-73. doi: 10.1093/annonc/mdv283. Epub 2015 Jun 30. Erratum in: Ann Oncol. 2016 Jan;27(1):209.

50.

Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and meta-analysis.

Eze IC, Hemkens LG, Bucher HC, Hoffmann B, Schindler C, Künzli N, Schikowski T, Probst-Hensch NM.

Environ Health Perspect. 2015 May;123(5):381-9. doi: 10.1289/ehp.1307823. Epub 2015 Jan 27. Review.

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