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Items: 24

1.

Emergence of a Ph-negative Clone in a Child With Ph+ ALL.

Mehrhoff CJ, Hemenway CS, Suh E.

J Pediatr Hematol Oncol. 2019 May 29. doi: 10.1097/MPH.0000000000001521. [Epub ahead of print]

PMID:
31149920
2.

Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.

Kuntimaddi A, Achille NJ, Thorpe J, Lokken AA, Singh R, Hemenway CS, Adli M, Zeleznik-Le NJ, Bushweller JH.

Cell Rep. 2015 May 5;11(5):808-20. doi: 10.1016/j.celrep.2015.04.004. Epub 2015 Apr 23.

3.

An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias.

Barretto NN, Karahalios DS, You D, Hemenway CS.

J Exp Ther Oncol. 2014;10(4):293-300.

4.

Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4.

Lokken AA, Achille NJ, Chang MJ, Lin JJ, Kuntimaddi A, Leach BI, Malik B, Nesbit JB, Zhang S, Bushweller JH, Zeleznik-Le NJ, Hemenway CS.

Leuk Res. 2014 Nov;38(11):1309-15. doi: 10.1016/j.leukres.2014.08.010. Epub 2014 Aug 24.

5.

CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3.

Malik B, Hemenway CS.

FEBS Lett. 2013 Sep 17;587(18):3038-44. doi: 10.1016/j.febslet.2013.07.034. Epub 2013 Jul 25.

6.

Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.

Chang MJ, Wu H, Achille NJ, Reisenauer MR, Chou CW, Zeleznik-Le NJ, Hemenway CS, Zhang W.

Cancer Res. 2010 Dec 15;70(24):10234-42. doi: 10.1158/0008-5472.CAN-10-3294.

7.

Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression.

Lin JJ, Hemenway CS.

J Biol Chem. 2010 Apr 16;285(16):11966-73. doi: 10.1074/jbc.M110.101642. Epub 2010 Feb 16.

8.

Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents.

Bennett CA, Winters AC, Barretto NN, Hemenway CS.

Leuk Res. 2009 Jul;33(7):937-47. doi: 10.1016/j.leukres.2009.01.018. Epub 2009 Feb 20.

9.

The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells.

Palermo CM, Bennett CA, Winters AC, Hemenway CS.

Leuk Res. 2008 Apr;32(4):633-42. Epub 2007 Sep 17.

10.

Hurricane Katrina's impact on pediatric and adult patients with sickle cell disease.

Karras NA, Hemenway CS.

J Health Care Poor Underserved. 2007 May;18(2):382-93.

PMID:
17483566
11.

Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner.

Zhang W, Xia X, Reisenauer MR, Hemenway CS, Kone BC.

J Biol Chem. 2006 Jun 30;281(26):18059-68. Epub 2006 Apr 24.

12.

Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseases.

Reiser J, Zhang XY, Hemenway CS, Mondal D, Pradhan L, La Russa VF.

Expert Opin Biol Ther. 2005 Dec;5(12):1571-84. Review.

13.

The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells.

Srinivasan RS, Nesbit JB, Marrero L, Erfurth F, LaRussa VF, Hemenway CS.

Leukemia. 2004 Aug;18(8):1364-72.

PMID:
15269783
14.

MLL fusion partners AF4 and AF9 interact at subnuclear foci.

Erfurth F, Hemenway CS, de Erkenez AC, Domer PH.

Leukemia. 2004 Jan;18(1):92-102.

PMID:
14603337
15.

The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor.

Srinivasan RS, de Erkenez AC, Hemenway CS.

Oncogene. 2003 May 29;22(22):3395-406.

PMID:
12776190
16.

The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias.

Hemenway CS, de Erkenez AC, Gould GC.

Oncogene. 2001 Jun 28;20(29):3798-805.

17.

Identification and analysis of a third mouse Polycomb gene, MPc3.

Hemenway CS, Halligan BW, Gould GC, Levy LS.

Gene. 2000 Jan 25;242(1-2):31-40.

PMID:
10721694
18.
19.

Calcineurin. Structure, function, and inhibition.

Hemenway CS, Heitman J.

Cell Biochem Biophys. 1999;30(1):115-51. Review.

PMID:
10099825
20.

A method to generate full-length cDNA molecules from yeast two-hybrid clones and RACE products.

Hemenway CS, Halligan BW, Gould GC.

Anal Biochem. 1999 Mar 1;268(1):161-2. No abstract available.

PMID:
10036178
21.

The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains.

Hemenway CS, Halligan BW, Levy LS.

Oncogene. 1998 May 14;16(19):2541-7.

22.

Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.

Hemenway CS, Heitman J.

J Biol Chem. 1996 Aug 2;271(31):18527-34.

23.

vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.

Hemenway CS, Dolinski K, Cardenas ME, Hiller MA, Jones EW, Heitman J.

Genetics. 1995 Nov;141(3):833-44.

24.

Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.

Breuder T, Hemenway CS, Movva NR, Cardenas ME, Heitman J.

Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5372-6.

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