Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 90


Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance.

Dalin S, Sullivan MR, Lau AN, Grauman-Boss B, Mueller HS, Kreidl E, Fenoglio S, Luengo A, Lees JA, Heiden MGV, Lauffenburger DA, Hemann MT.

Cancer Res. 2019 Nov 15;79(22):5723-5733. doi: 10.1158/0008-5472.CAN-19-0960. Epub 2019 Sep 4.


A dynamic view of chemotherapy effectiveness.

Liu Y, Hemann MT.

Nature. 2019 Aug;572(7769):321-322. doi: 10.1038/d41586-019-02336-7. No abstract available.


A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.

Wojtaszek JL, Chatterjee N, Najeeb J, Ramos A, Lee M, Bian K, Xue JY, Fenton BA, Park H, Li D, Hemann MT, Hong J, Walker GC, Zhou P.

Cell. 2019 Jun 27;178(1):152-159.e11. doi: 10.1016/j.cell.2019.05.028. Epub 2019 Jun 6.


Functional screens identify coordinators of RNA molecule birth, life, and death as targetable cancer vulnerabilities.

Braun CJ, Hemann MT.

Curr Opin Genet Dev. 2019 Feb;54:105-109. doi: 10.1016/j.gde.2019.04.003. Epub 2019 May 20. Review.


Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents.

Lossos C, Liu Y, Kolb KE, Christie AL, Van Scoyk A, Prakadan SM, Shigemori K, Stevenson KE, Morrow S, Plana OD, Fraser C, Jones KL, Liu H, Pallasch CP, Modiste R, Nguyen QD, Craig JW, Morgan EA, Vega F, Aster JC, Sarosiek KA, Shalek AK, Hemann MT, Weinstock DM.

Cancer Discov. 2019 Jul;9(7):944-961. doi: 10.1158/2159-8290.CD-18-1393. Epub 2019 Apr 30.


Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML.

Benajiba L, Alexe G, Su A, Raffoux E, Soulier J, Hemann MT, Hermine O, Itzykson R, Stegmaier K, Puissant A.

Leukemia. 2019 Mar;33(3):800-804. doi: 10.1038/s41375-018-0291-x. Epub 2018 Nov 2. No abstract available.


Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex.

Rizzo AA, Vassel FM, Chatterjee N, D'Souza S, Li Y, Hao B, Hemann MT, Walker GC, Korzhnev DM.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8191-E8200. doi: 10.1073/pnas.1801149115. Epub 2018 Aug 15.


In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1+ BCP-ALL.

Fiedler ERC, Bhutkar A, Lawler E, Besada R, Hemann MT.

Blood Adv. 2018 Jun 12;2(11):1229-1242. doi: 10.1182/bloodadvances.2017015610.


A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling.

Kauke MJ, Tisdale AW, Kelly RL, Braun CJ, Hemann MT, Wittrup KD.

Mol Cancer Ther. 2018 Aug;17(8):1773-1780. doi: 10.1158/1535-7163.MCT-17-0645. Epub 2018 May 2.


Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.

Wagner FF, Benajiba L, Campbell AJ, Weïwer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ, Stone RM, Kaya T, Shi X, Robers MB, Machleidt T, Wilkinson J, Hermine O, Kung A, Stein AJ, Lakshminarasimhan D, Hemann MT, Scolnick E, Zhang YL, Pan JQ, Stegmaier K, Holson EB.

Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. doi: 10.1126/scitranslmed.aam8460.


Publisher Correction: Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer.

Qi R, Wang Y, Bruno PM, Xiao H, Yu Y, Li T, Lauffer S, Wei W, Chen Q, Kang X, Song H, Yang X, Huang X, Detappe A, Matulonis U, Pepin D, Hemann MT, Birrer MJ, Ghoroghchian PP.

Nat Commun. 2018 Feb 7;9(1):628. doi: 10.1038/s41467-018-02963-0.


Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer.

Qi R, Wang Y, Bruno PM, Xiao H, Yu Y, Li T, Lauffer S, Wei W, Chen Q, Kang X, Song H, Yang X, Huang X, Detappe A, Matulonis U, Pepin D, Hemann MT, Birrer MJ, Ghoroghchian PP.

Nat Commun. 2017 Dec 18;8(1):2166. doi: 10.1038/s41467-017-02390-7. Erratum in: Nat Commun. 2018 Feb 7;9(1):628.


Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA.

Cancer Cell. 2017 Oct 9;32(4):411-426.e11. doi: 10.1016/j.ccell.2017.08.018. Epub 2017 Sep 28.


Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

Yamanaka K, Chatterjee N, Hemann MT, Walker GC.

PLoS Genet. 2017 Aug 17;13(8):e1006842. doi: 10.1371/journal.pgen.1006842. eCollection 2017 Aug. Review. No abstract available.


Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.

Tang YC, Yuwen H, Wang K, Bruno PM, Bullock K, Deik A, Santaguida S, Trakala M, Pfau SJ, Zhong N, Huang T, Wang L, Clish CB, Hemann MT, Amon A.

Cancer Res. 2017 Oct 1;77(19):5272-5286. doi: 10.1158/0008-5472.CAN-17-0049. Epub 2017 Aug 3.


Drugs, Bugs, and Cancer: Fusobacterium nucleatum Promotes Chemoresistance in Colorectal Cancer.

Ramos A, Hemann MT.

Cell. 2017 Jul 27;170(3):411-413. doi: 10.1016/j.cell.2017.07.018.


Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.

Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, Thummalapalli R, Hemann MT, Paddison PJ, Horbinski CM, Zuber J, Scacheri PC, Bernstein BE, Tesar PJ, Rich JN.

Nature. 2017 Jul 20;547(7663):355-359. doi: 10.1038/nature23000. Epub 2017 Jul 5.


PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.

Soto-Feliciano YM, Bartlebaugh JME, Liu Y, Sánchez-Rivera FJ, Bhutkar A, Weintraub AS, Buenrostro JD, Cheng CS, Regev A, Jacks TE, Young RA, Hemann MT.

Genes Dev. 2017 May 15;31(10):973-989. doi: 10.1101/gad.295857.117. Epub 2017 Jun 12.


Induction of Necroptosis in Cancer Stem Cells using a Nickel(II)-Dithiocarbamate Phenanthroline Complex.

Flamme M, Cressey PB, Lu C, Bruno PM, Eskandari A, Hemann MT, Hogarth G, Suntharalingam K.

Chemistry. 2017 Jul 18;23(40):9674-9682. doi: 10.1002/chem.201701837. Epub 2017 Jun 27.


Modeling Tumor Clonal Evolution for Drug Combinations Design.

Zhao B, Hemann MT, Lauffenburger DA.

Trends Cancer. 2016 Mar;2(3):144-158. doi: 10.1016/j.trecan.2016.02.001. Review.


A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.

Bruno PM, Liu Y, Park GY, Murai J, Koch CE, Eisen TJ, Pritchard JR, Pommier Y, Lippard SJ, Hemann MT.

Nat Med. 2017 Apr;23(4):461-471. doi: 10.1038/nm.4291. Epub 2017 Feb 27.


The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.

Fenouille N, Bassil CF, Ben-Sahra I, Benajiba L, Alexe G, Ramos A, Pikman Y, Conway AS, Burgess MR, Li Q, Luciano F, Auberger P, Galinsky I, DeAngelo DJ, Stone RM, Zhang Y, Perkins AS, Shannon K, Hemann MT, Puissant A, Stegmaier K.

Nat Med. 2017 Mar;23(3):301-313. doi: 10.1038/nm.4283. Epub 2017 Feb 13.


Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations.

Sun D, Dalin S, Hemann MT, Lauffenburger DA, Zhao B.

Sci Rep. 2016 Nov 7;6:36198. doi: 10.1038/srep36198.


Mechanistic Studies of the Anticancer Activity of An Octahedral Hexanuclear Pt(II) Cage.

Zheng YR, Suntharalingam K, Bruno PM, Lin W, Wang W, Hemann MT, Lippard SJ.

Inorganica Chim Acta. 2016 Oct 1;452:125-129. Epub 2016 Mar 25.


The breast cancer stem cell potency of copper(ii) complexes bearing nonsteroidal anti-inflammatory drugs and their encapsulation using polymeric nanoparticles.

Eskandari A, Boodram JN, Cressey PB, Lu C, Bruno PM, Hemann MT, Suntharalingam K.

Dalton Trans. 2016 Nov 28;45(44):17867-17873. Epub 2016 Oct 24.


Using an RNAi Signature Assay To Guide the Design of Three-Drug-Conjugated Nanoparticles with Validated Mechanisms, In Vivo Efficacy, and Low Toxicity.

Barnes JC, Bruno PM, Nguyen HV, Liao L, Liu J, Hemann MT, Johnson JA.

J Am Chem Soc. 2016 Sep 28;138(38):12494-501. doi: 10.1021/jacs.6b06321. Epub 2016 Sep 14.


A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses.

Bent EH, Gilbert LA, Hemann MT.

Genes Dev. 2016 Aug 15;30(16):1811-21. doi: 10.1101/gad.284851.116. Epub 2016 Aug 26.


Rewiring the solid tumor epigenome for cancer therapy.

Braun CJ, Hemann MT.

Expert Rev Anticancer Ther. 2016 Sep;16(9):977-87. doi: 10.1080/14737140.2016.1212663. Epub 2016 Aug 5. Review.


The Potent Inhibitory Effect of a Naproxen-Appended Cobalt(III)-Cyclam Complex on Cancer Stem Cells.

Cressey PB, Eskandari A, Bruno PM, Lu C, Hemann MT, Suntharalingam K.

Chembiochem. 2016 Sep 15;17(18):1713-8. doi: 10.1002/cbic.201600368. Epub 2016 Aug 11.


Targeting MTHFD2 in acute myeloid leukemia.

Pikman Y, Puissant A, Alexe G, Furman A, Chen LM, Frumm SM, Ross L, Fenouille N, Bassil CF, Lewis CA, Ramos A, Gould J, Stone RM, DeAngelo DJ, Galinsky I, Clish CB, Kung AL, Hemann MT, Vander Heiden MG, Banerji V, Stegmaier K.

J Exp Med. 2016 Jun 27;213(7):1285-306. doi: 10.1084/jem.20151574. Epub 2016 Jun 20.


Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.

Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman JS, Hemann MT.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3892-900. doi: 10.1073/pnas.1600582113. Epub 2016 Jun 20.


Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML.

Lindblad O, Cordero E, Puissant A, Macaulay L, Ramos A, Kabir NN, Sun J, Vallon-Christersson J, Haraldsson K, Hemann MT, Borg Å, Levander F, Stegmaier K, Pietras K, Rönnstrand L, Kazi JU.

Oncogene. 2016 Sep 29;35(39):5119-31. doi: 10.1038/onc.2016.41. Epub 2016 Mar 21.


Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution.

Zhao B, Sedlak JC, Srinivas R, Creixell P, Pritchard JR, Tidor B, Lauffenburger DA, Hemann MT.

Cell. 2016 Mar 24;165(1):234-246. doi: 10.1016/j.cell.2016.01.045. Epub 2016 Feb 25.


Correction to "A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy".

Awuah SG, Zheng YR, Bruno PM, Hemann MT, Lippard SJ.

J Am Chem Soc. 2016 Mar 9;138(9):3250. doi: 10.1021/jacs.6b01316. Epub 2016 Feb 26. No abstract available.


Breast Cancer Stem Cell Potent Copper(II)-Non-Steroidal Anti-Inflammatory Drug Complexes.

Boodram JN, Mcgregor IJ, Bruno PM, Cressey PB, Hemann MT, Suntharalingam K.

Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2845-50. doi: 10.1002/anie.201510443. Epub 2016 Jan 25.


A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.

Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB.

Cancer Cell. 2015 Dec 14;28(6):831. doi: 10.1016/j.ccell.2015.11.003. Epub 2015 Dec 14. No abstract available.


A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.

Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB.

Cancer Cell. 2015 Nov 9;28(5):623-637. doi: 10.1016/j.ccell.2015.09.009. Erratum in: Cancer Cell. 2015 Dec 14;28(6):831.


The Chromatin Regulator CHD8 Is a Context-Dependent Mediator of Cell Survival in Murine Hematopoietic Malignancies.

Shingleton JR, Hemann MT.

PLoS One. 2015 Nov 20;10(11):e0143275. doi: 10.1371/journal.pone.0143275. eCollection 2015.


A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy.

Awuah SG, Zheng YR, Bruno PM, Hemann MT, Lippard SJ.

J Am Chem Soc. 2015 Dec 2;137(47):14854-7. doi: 10.1021/jacs.5b10182. Epub 2015 Nov 18. Erratum in: J Am Chem Soc. 2016 Mar 9;138(9):3250.


Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.

McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD.

Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29.


A DNA/HDAC dual-targeting drug CY190602 with significantly enhanced anticancer potency.

Liu C, Ding H, Li X, Pallasch CP, Hong L, Guo D, Chen Y, Wang D, Wang W, Wang Y, Hemann MT, Jiang H.

EMBO Mol Med. 2015 Apr;7(4):438-49. doi: 10.15252/emmm.201404580.


A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.

Meacham CE, Lawton LN, Soto-Feliciano YM, Pritchard JR, Joughin BA, Ehrenberger T, Fenouille N, Zuber J, Williams RT, Young RA, Hemann MT.

Genes Dev. 2015 Mar 1;29(5):483-8. doi: 10.1101/gad.254151.114.


Necroptosis-inducing rhenium(V) oxo complexes.

Suntharalingam K, Awuah SG, Bruno PM, Johnstone TC, Wang F, Lin W, Zheng YR, Page JE, Hemann MT, Lippard SJ.

J Am Chem Soc. 2015 Mar 4;137(8):2967-74. doi: 10.1021/ja511978y. Epub 2015 Feb 20.


Reply to Azuaje: Predicting effective combined therapies for heterogeneous tumors.

Zhao B, Hemann MT, Lauffenburger DA.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4288. doi: 10.1073/pnas.1415737111. Epub 2014 Sep 24. No abstract available.


A breast cancer stem cell-selective, mammospheres-potent osmium(VI) nitrido complex.

Suntharalingam K, Lin W, Johnstone TC, Bruno PM, Zheng YR, Hemann MT, Lippard SJ.

J Am Chem Soc. 2014 Oct 15;136(41):14413-6. doi: 10.1021/ja508808v. Epub 2014 Oct 6.


Intratumor heterogeneity alters most effective drugs in designed combinations.

Zhao B, Hemann MT, Lauffenburger DA.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10773-8. doi: 10.1073/pnas.1323934111. Epub 2014 Jul 7.


From breaking bad to worse: exploiting homologous DNA repair deficiency in cancer.

Hemann MT.

Cancer Discov. 2014 May;4(5):516-8. doi: 10.1158/2159-8290.CD-14-0316.


SYK is a critical regulator of FLT3 in acute myeloid leukemia.

Puissant A, Fenouille N, Alexe G, Pikman Y, Bassil CF, Mehta S, Du J, Kazi JU, Luciano F, Rönnstrand L, Kung AL, Aster JC, Galinsky I, Stone RM, DeAngelo DJ, Hemann MT, Stegmaier K.

Cancer Cell. 2014 Feb 10;25(2):226-42. doi: 10.1016/j.ccr.2014.01.022.


Sensitizing protective tumor microenvironments to antibody-mediated therapy.

Pallasch CP, Leskov I, Braun CJ, Vorholt D, Drake A, Soto-Feliciano YM, Bent EH, Schwamb J, Iliopoulou B, Kutsch N, van Rooijen N, Frenzel LP, Wendtner CM, Heukamp L, Kreuzer KA, Hallek M, Chen J, Hemann MT.

Cell. 2014 Jan 30;156(3):590-602. doi: 10.1016/j.cell.2013.12.041.


Addressing genetic tumor heterogeneity through computationally predictive combination therapy.

Zhao B, Pritchard JR, Lauffenburger DA, Hemann MT.

Cancer Discov. 2014 Feb;4(2):166-74. doi: 10.1158/2159-8290.CD-13-0465. Epub 2013 Dec 6.

Supplemental Content

Loading ...
Support Center