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Items: 15

1.

First-in-class allosteric inhibitors of bacterial IMPDHs.

Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H.

Eur J Med Chem. 2019 Apr 1;167:124-132. doi: 10.1016/j.ejmech.2019.01.064. Epub 2019 Feb 2.

PMID:
30769241
2.

A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism.

Laskaris P, Vicentefranqueira R, Helynck O, Jouvion G, Calera JA, du Merle L, Suzenet F, Buron F, de Sousa RA, Mansuy D, Cavaillon JM, Latgé JP, Munier-Lehmann H, Ibrahim-Granet O.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02510-17. doi: 10.1128/AAC.02510-17. Print 2018 Jun.

3.

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT.

Dabo S, Maillard P, Collados Rodriguez M, Hansen MD, Mazouz S, Bigot DJ, Tible M, Janvier G, Helynck O, Cassonnet P, Jacob Y, Bellalou J, Gatignol A, Patel RC, Hugon J, Munier-Lehmann H, Meurs EF.

Sci Rep. 2017 Nov 23;7(1):16129. doi: 10.1038/s41598-017-16089-8.

4.

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis.

Buchieri MV, Cimino M, Rebollo-Ramirez S, Beauvineau C, Cascioferro A, Favre-Rochex S, Helynck O, Naud-Martin D, Larrouy-Maumus G, Munier-Lehmann H, Gicquel B.

J Med Chem. 2017 Sep 14;60(17):7425-7433. doi: 10.1021/acs.jmedchem.7b00726. Epub 2017 Aug 28.

PMID:
28846409
5.

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response.

Lucas-Hourani M, Dauzonne D, Munier-Lehmann H, Khiar S, Nisole S, Dairou J, Helynck O, Afonso PV, Tangy F, Vidalain PO.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00383-17. doi: 10.1128/AAC.00383-17. Print 2017 Oct.

6.

Identification of a small molecule that primes the type I interferon response to cytosolic DNA.

Khiar S, Lucas-Hourani M, Nisole S, Smith N, Helynck O, Bourgine M, Ruffié C, Herbeuval JP, Munier-Lehmann H, Tangy F, Vidalain PO.

Sci Rep. 2017 May 31;7(1):2561. doi: 10.1038/s41598-017-02776-z.

7.

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.

Raj S, Krishnan K, Askew DS, Helynck O, Suzanne P, Lesnard A, Rault S, Zeidler U, d'Enfert C, Latgé JP, Munier-Lehmann H, Saveanu C.

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1438-49. doi: 10.1128/AAC.02239-15.

8.

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).

Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL.

J Med Chem. 2015 Jul 23;58(14):5579-98. doi: 10.1021/acs.jmedchem.5b00606. Epub 2015 Jun 30.

9.

[Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening].

Vidalain PO, Lucas-Hourani M, Helynck O, Tangy F, Munier-Lehmann H.

Med Sci (Paris). 2015 Jan;31(1):98-104. doi: 10.1051/medsci/20153101019. Epub 2015 Feb 6. Review. French.

10.

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).

Munier-Lehmann H, Lucas-Hourani M, Guillou S, Helynck O, Zanghi G, Noel A, Tangy F, Vidalain PO, Janin YL.

J Med Chem. 2015 Jan 22;58(2):860-77. doi: 10.1021/jm501446r. Epub 2015 Jan 6.

PMID:
25558988
11.

High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses.

Lucas-Hourani M, Munier-Lehmann H, Helynck O, Komarova A, Desprès P, Tangy F, Vidalain PO.

J Vis Exp. 2014 May 5;(87). doi: 10.3791/51222.

12.

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity.

Lucas-Hourani M, Dauzonne D, Jorda P, Cousin G, Lupan A, Helynck O, Caignard G, Janvier G, André-Leroux G, Khiar S, Escriou N, Desprès P, Jacob Y, Munier-Lehmann H, Tangy F, Vidalain PO.

PLoS Pathog. 2013;9(10):e1003678. doi: 10.1371/journal.ppat.1003678. Epub 2013 Oct 3.

13.

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.

Aulner N, Danckaert A, Rouault-Hardoin E, Desrivot J, Helynck O, Commere PH, Munier-Lehmann H, Späth GF, Shorte SL, Milon G, Prina E.

PLoS Negl Trop Dis. 2013 Apr 4;7(4):e2154. doi: 10.1371/journal.pntd.0002154. Print 2013.

14.

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species.

Zeidler U, Bougnoux ME, Lupan A, Helynck O, Doyen A, Garcia Z, Sertour N, Clavaud C, Munier-Lehmann H, Saveanu C, d'Enfert C.

J Antimicrob Chemother. 2013 Jun;68(6):1285-96. doi: 10.1093/jac/dks538. Epub 2013 Feb 1.

15.

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase.

Van Poecke S, Munier-Lehmann H, Helynck O, Froeyen M, Van Calenbergh S.

Bioorg Med Chem. 2011 Dec 15;19(24):7603-11. doi: 10.1016/j.bmc.2011.10.021. Epub 2011 Oct 18.

PMID:
22061826

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