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Spatial distribution of clinical computer systems in primary care in England in 2016 and implications for primary care electronic medical record databases: a cross-sectional population study.

Kontopantelis E, Stevens RJ, Helms PJ, Edwards D, Doran T, Ashcroft DM.

BMJ Open. 2018 Feb 28;8(2):e020738. doi: 10.1136/bmjopen-2017-020738.


Core requirements for successful data linkage: an example of a triangulation method.

Hopf YM, Francis J, Helms PJ, Haughney J, Bond C.

BMJ Open. 2016 Oct 21;6(10):e011879. doi: 10.1136/bmjopen-2016-011879.


Linking NHS data for pediatric pharmacovigilance: Results of a Delphi survey.

Hopf YM, Francis J, Helms PJ, Haughney J, Bond C.

Res Social Adm Pharm. 2016 Mar-Apr;12(2):267-80. doi: 10.1016/j.sapharm.2015.06.006. Epub 2015 Jul 2.


Airway epithelial cytokine responses in childhood wheeze are independent of atopic status.

McDougall CM, Helms PJ, Walsh GM.

Respir Med. 2015 Jun;109(6):689-700. doi: 10.1016/j.rmed.2015.04.001. Epub 2015 Apr 14.


Maternal vitamin D and E intakes during pregnancy are associated with asthma in children.

Allan KM, Prabhu N, Craig LC, McNeill G, Kirby B, McLay J, Helms PJ, Ayres JG, Seaton A, Turner SW, Devereux G.

Eur Respir J. 2015 Apr;45(4):1027-36. doi: 10.1183/09031936.00102214. Epub 2014 Oct 30.


'The more you link, the more you risk …' - a focus group study exploring views about data linkage for pharmacovigilance.

Hopf YM, Bond C, Francis J, Haughney J, Helms PJ.

Br J Clin Pharmacol. 2014 Nov;78(5):1143-50. doi: 10.1111/bcp.12445.


Unplanned medication discontinuation as a potential pharmacovigilance signal: a nested young person cohort study.

Sun AP, Kirby B, Black C, Helms PJ, Bennie M, McLay JS.

BMC Pharmacol Toxicol. 2014 Mar 4;15:11. doi: 10.1186/2050-6511-15-11.


Linked health data for pharmacovigilance in children: perceived legal and ethical issues for stakeholders and data guardians.

Hopf YM, Bond CB, Francis JJ, Haughney J, Helms PJ.

BMJ Open. 2014 Feb 12;4(2):e003875. doi: 10.1136/bmjopen-2013-003875.


Development of an enantiomer selective microsampling assay for the quantification of ketorolac suitable for paediatric pharmacokinetic studies.

Mohammed BS, Engelhardt T, Cameron GA, Hawwa AF, Helms PJ, McLay JS.

Biopharm Drug Dispos. 2013 Oct;34(7):377-86.


Views of healthcare professionals to linkage of routinely collected healthcare data: a systematic literature review.

Hopf YM, Bond C, Francis J, Haughney J, Helms PJ.

J Am Med Inform Assoc. 2014 Feb;21(e1):e6-10. doi: 10.1136/amiajnl-2012-001575. Epub 2013 May 28. Review.


Adequate levels of adherence with controller medication is associated with increased use of rescue medication in asthmatic children.

Elkout H, Helms PJ, Simpson CR, McLay JS.

PLoS One. 2012;7(6):e39130. doi: 10.1371/journal.pone.0039130. Epub 2012 Jun 27.


Using primary care prescribing databases to determine drug switching and continuation of care.

Mohamed IN, Helms PJ, McLay JS.

Basic Clin Pharmacol Toxicol. 2012 Dec;111(6):396-401. doi: 10.1111/j.1742-7843.2012.00917.x. Epub 2012 Jul 14.


Population pharmacokinetics of single-dose intravenous paracetamol in children.

Mohammed BS, Engelhardt T, Cameron GA, Cameron L, Hawksworth GM, Hawwa AF, McElnay J, Helms PJ, McLay JS.

Br J Anaesth. 2012 May;108(5):823-9. doi: 10.1093/bja/aes025. Epub 2012 Mar 1.


A European Network of Paediatric Research at the European Medicines Agency (Enpr-EMA).

Ruperto N, Eichler I, Herold R, Vassal G, Giaquinto C, Hjorth L, Valls-i-Soler A, Peters C, Helms PJ, Saint Raymond A.

Arch Dis Child. 2012 Mar;97(3):185-8. doi: 10.1136/archdischild-2011-300286. Epub 2011 Nov 27. No abstract available.


Alpha-nicotinic acetylcholine receptor and tobacco smoke exposure: effects on bronchial hyperresponsiveness in children.

Torjussen TM, Lødrup Carlsen KC, Munthe-Kaas MC, Mowinckel P, Carlsen KH, Helms PJ, Gerritsen J, Whyte MK, Lenney W, Undlien DE, Shianna KV, Zhu G, Pillai SG.

Pediatr Allergy Immunol. 2012 Feb;23(1):40-9. doi: 10.1111/j.1399-3038.2011.01222.x. Epub 2011 Oct 21.


Changes in primary care prescribing patterns for paediatric asthma: a prescribing database analysis.

Elkout H, Helms PJ, Simpson CR, McLay JS.

Arch Dis Child. 2012 Jun;97(6):521-5. doi: 10.1136/adc.2010.206268. Epub 2011 May 19.


Paracetamol prescribing in primary care: too little and too much?

Kazouini A, Mohammed BS, Simpson CR, Helms PJ, McLay JS.

Br J Clin Pharmacol. 2011 Sep;72(3):500-4. doi: 10.1111/j.1365-2125.2011.03993.x.


Parental reporting of adverse drug reactions associated with attention-deficit hyperactivity disorder (ADHD) medications in children attending specialist paediatric clinics in the UK.

Tobaiqy M, Stewart D, Helms PJ, Williams J, Crum J, Steer C, McLay J.

Drug Saf. 2011 Mar 1;34(3):211-9. doi: 10.2165/11586050-000000000-00000.


Using primary care prescribing databases for pharmacovigilance.

Mohamed IN, Helms PJ, Simpson CR, Milne RM, McLay JS.

Br J Clin Pharmacol. 2011 Feb;71(2):244-9. doi: 10.1111/j.1365-2125.2010.03816.x.


A retrospective observational study comparing rescue medication use in children on combined versus separate long-acting beta-agonists and corticosteroids.

Elkout H, McLay JS, Simpson CR, Helms PJ.

Arch Dis Child. 2010 Oct;95(10):817-21. doi: 10.1136/adc.2009.179069. Epub 2010 Jul 23.


Can finger-prick sampling replace venous sampling to determine the pharmacokinetic profile of oral paracetamol?

Mohammed BS, Cameron GA, Cameron L, Hawksworth GH, Helms PJ, McLay JS.

Br J Clin Pharmacol. 2010 Jul;70(1):52-6. doi: 10.1111/j.1365-2125.2010.03668.x.


Recent advances in pediatric asthma treatment.

Helms PJ.

Expert Rev Respir Med. 2009 Apr;3(2):165-75. doi: 10.1586/ers.09.2.


Associations between fetal size, maternal {alpha}-tocopherol and childhood asthma.

Turner SW, Campbell D, Smith N, Craig LC, McNeill G, Forbes SH, Harbour PJ, Seaton A, Helms PJ, Devereux GS.

Thorax. 2010 May;65(5):391-7. doi: 10.1136/thx.2008.111385.


Using routinely collected prescribing data to determine drug persistence for the purpose of pharmacovigilance.

Mohamed IN, Helms PJ, Simpson CR, McLay JS.

J Clin Pharmacol. 2011 Feb;51(2):279-84. doi: 10.1177/0091270010366444. Epub 2010 Apr 16. No abstract available.


First trimester maternal tobacco smoking habits and fetal growth.

Prabhu N, Smith N, Campbell D, Craig LC, Seaton A, Helms PJ, Devereux G, Turner SW.

Thorax. 2010 Mar;65(3):235-40. doi: 10.1136/thx.2009.123232.


A pilot study to evaluate a community pharmacy-based monitoring system to identify adverse drug reactions associated with paediatric medicines use.

Tobaiqy M, Stewart D, Helms PJ, Bond C, Lee AJ, Bateman N, McCaig D, McLay J.

Eur J Clin Pharmacol. 2010 Jun;66(6):627-32. doi: 10.1007/s00228-010-0790-9. Epub 2010 Mar 2.


Views of parents and pharmacists following participation in a paediatric pharmacovigilance study.

Tobaiqy M, Stewart D, Helms PJ, Bond CM, Lee AJ, McLay J.

Pharm World Sci. 2010 Jun;32(3):334-8. doi: 10.1007/s11096-010-9374-0. Epub 2010 Feb 25.


Changes in the prevalence of asthma, eczema and hay fever in pre-pubertal children: a 40-year perspective.

McNeill G, Tagiyeva N, Aucott L, Russell G, Helms PJ.

Paediatr Perinat Epidemiol. 2009 Nov;23(6):506-12. doi: 10.1111/j.1365-3016.2009.01057.x.


CMIP and ATP2C2 modulate phonological short-term memory in language impairment.

Newbury DF, Winchester L, Addis L, Paracchini S, Buckingham LL, Clark A, Cohen W, Cowie H, Dworzynski K, Everitt A, Goodyer IM, Hennessy E, Kindley AD, Miller LL, Nasir J, O'Hare A, Shaw D, Simkin Z, Simonoff E, Slonims V, Watson J, Ragoussis J, Fisher SE, Seckl JR, Helms PJ, Bolton PF, Pickles A, Conti-Ramsden G, Baird G, Bishop DV, Monaco AP.

Am J Hum Genet. 2009 Aug;85(2):264-72. doi: 10.1016/j.ajhg.2009.07.004. Epub 2009 Jul 30.


How well are general practice trainees prepared for paediatric prescribing?

Isa NM, Taylor MW, Helms PJ, McLay JS.

Br J Clin Pharmacol. 2009 Mar;67(3):370-3. doi: 10.1111/j.1365-2125.2008.03341.x. Epub 2008 Nov 24.


Climate change and respiratory disease: European Respiratory Society position statement.

Ayres JG, Forsberg B, Annesi-Maesano I, Dey R, Ebi KL, Helms PJ, Medina-Ramón M, Windt M, Forastiere F; Environment and Health Committee of the European Respiratory Society.

Eur Respir J. 2009 Aug;34(2):295-302. doi: 10.1183/09031936.00003409. Epub 2009 Feb 27.


Early identification of atopy in the prediction of persistent asthma in children.

Sly PD, Boner AL, Björksten B, Bush A, Custovic A, Eigenmann PA, Gern JE, Gerritsen J, Hamelmann E, Helms PJ, Lemanske RF, Martinez F, Pedersen S, Renz H, Sampson H, von Mutius E, Wahn U, Holt PG.

Lancet. 2008 Sep 20;372(9643):1100-6. doi: 10.1016/S0140-6736(08)61451-8. Review.


Nasal epithelial cells as surrogates for bronchial epithelial cells in airway inflammation studies.

McDougall CM, Blaylock MG, Douglas JG, Brooker RJ, Helms PJ, Walsh GM.

Am J Respir Cell Mol Biol. 2008 Nov;39(5):560-8. doi: 10.1165/rcmb.2007-0325OC. Epub 2008 May 15.


Early rattles, purrs and whistles as predictors of later wheeze.

Turner SW, Craig LC, Harbour PJ, Forbes SH, McNeill G, Seaton A, Devereux G, Russell G, Helms PJ.

Arch Dis Child. 2008 Aug;93(8):701-4. doi: 10.1136/adc.2007.134569. Epub 2008 Mar 12.


Factor analysis in the Genetics of Asthma International Network family study identifies five major quantitative asthma phenotypes.

Pillai SG, Tang Y, van den Oord E, Klotsman M, Barnes K, Carlsen K, Gerritsen J, Lenney W, Silverman M, Sly P, Sundy J, Tsanakas J, von Berg A, Whyte M, Ortega HG, Anderson WH, Helms PJ.

Clin Exp Allergy. 2008 Mar;38(3):421-9. doi: 10.1111/j.1365-2222.2007.02918.x. Epub 2008 Jan 2.


A prospective study of phrenic nerve damage after cardiac surgery in children.

Ross Russell RI, Helms PJ, Elliott MJ.

Intensive Care Med. 2008 Apr;34(4):728-34. doi: 10.1007/s00134-007-0977-4. Epub 2008 Jan 5.


Adolescent females and hormonal contraception: a retrospective study in primary care.

Krishnamoorthy N, Simpson CD, Townend J, Helms PJ, McLay JS.

J Adolesc Health. 2008 Jan;42(1):97-101. Epub 2007 Oct 4.


Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report.

Bacharier LB, Boner A, Carlsen KH, Eigenmann PA, Frischer T, Götz M, Helms PJ, Hunt J, Liu A, Papadopoulos N, Platts-Mills T, Pohunek P, Simons FE, Valovirta E, Wahn U, Wildhaber J; European Pediatric Asthma Group.

Allergy. 2008 Jan;63(1):5-34. Review. Erratum in: Allergy. 2008 May;63(5):630.


Effects of treating postnatal depression on mother-infant interaction and child development: systematic review.

Poobalan AS, Aucott LS, Ross L, Smith WC, Helms PJ, Williams JH.

Br J Psychiatry. 2007 Nov;191:378-86. Review.


Spirometry in 5-year-olds--validation of current guidelines and the relation with asthma.

Turner SW, Craig LC, Harbour PJ, Forbes SH, McNeill G, Seaton A, Devereux G, Helms PJ.

Pediatr Pulmonol. 2007 Dec;42(12):1144-51.


A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects.

Lakind JS, Holgate ST, Ownby DR, Mansur AH, Helms PJ, Pyatt D, Hays SM.

Biomarkers. 2007 Sep-Oct;12(5):445-67. Review.


Carbonated drink consumption and increased exhaled nitric oxide in atopic children.

Turner SW, Craig LC, Harbour PJ, Forbes SH, Martindale S, McNeill G, Seaton A, Ayres JG, Devereux G, Helms PJ.

Eur Respir J. 2007 Jul;30(1):177-8. No abstract available.


Maternal food consumption during pregnancy and asthma, respiratory and atopic symptoms in 5-year-old children.

Willers SM, Devereux G, Craig LC, McNeill G, Wijga AH, Abou El-Magd W, Turner SW, Helms PJ, Seaton A.

Thorax. 2007 Sep;62(9):773-9. Epub 2007 Mar 27.


Maternal vitamin D intake during pregnancy and early childhood wheezing.

Devereux G, Litonjua AA, Turner SW, Craig LC, McNeill G, Martindale S, Helms PJ, Seaton A, Weiss ST.

Am J Clin Nutr. 2007 Mar;85(3):853-9.


Attitudes and experiences of community pharmacists towards paediatric off-label prescribing: a prospective survey.

Stewart D, Rouf A, Snaith A, Elliott K, Helms PJ, McLay JS.

Br J Clin Pharmacol. 2007 Jul;64(1):90-5. Epub 2007 Feb 23.


Gender-specific presentations for asthma, allergic rhinitis and eczema in primary care.

Osman M, Hansell AL, Simpson CR, Hollowell J, Helms PJ.

Prim Care Respir J. 2007 Feb;16(1):28-35. Erratum in: Prim Care Respir J. 2007 Apr;16(2):126. Prim Care Respir J. 2007 Apr;16(2):126.


Changing trends in sex specific prevalence rates for childhood asthma, eczema, and hay fever.

Osman M, Tagiyeva N, Wassall HJ, Ninan TK, Devenny AM, McNeill G, Helms PJ, Russell G.

Pediatr Pulmonol. 2007 Jan;42(1):60-5.


Quantitative linkage genome scan for atopy in a large collection of Caucasian families.

Webb BT, van den Oord E, Akkari A, Wilton S, Ly T, Duff R, Barnes KC, Carlsen K, Gerritsen J, Lenney W, Silverman M, Sly P, Sundy J, Tsanakas J, von Berg A, Whyte M, Blumenthal M, Vestbo J, Middleton L, Helms PJ, Anderson WH, Pillai SG.

Hum Genet. 2007 Mar;121(1):83-92. Epub 2006 Nov 14.


Neutrophil airway inflammation in childhood asthma.

McDougall CM, Helms PJ.

Thorax. 2006 Sep;61(9):739-41. No abstract available.


Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children.

Devereux G, Turner SW, Craig LC, McNeill G, Martindale S, Harbour PJ, Helms PJ, Seaton A.

Am J Respir Crit Care Med. 2006 Sep 1;174(5):499-507. Epub 2006 Jun 8.


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