Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 93


Retinoids in health and disease: A role for hepatic stellate cells in affecting retinoid levels.

Haaker MW, Vaandrager AB, Helms JB.

Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jun;1865(6):158674. doi: 10.1016/j.bbalip.2020.158674. Epub 2020 Feb 24. Review.


Identification of potential drugs for treatment of hepatic lipidosis in cats using an in vitro feline liver organoid system.

Haaker MW, Kruitwagen HS, Vaandrager AB, Houweling M, Penning LC, Molenaar MR, van Wolferen ME, Oosterhoff LA, Spee B, Helms JB.

J Vet Intern Med. 2020 Jan;34(1):132-138. doi: 10.1111/jvim.15670. Epub 2019 Dec 12.


Metal ions and redox balance regulate distinct amyloid-like aggregation pathways of GAPR-1.

Sheng J, Olrichs NK, Geerts WJ, Kaloyanova DV, Helms JB.

Sci Rep. 2019 Oct 21;9(1):15048. doi: 10.1038/s41598-019-51232-7.


LION/web: a web-based ontology enrichment tool for lipidomic data analysis.

Molenaar MR, Jeucken A, Wassenaar TA, van de Lest CHA, Brouwers JF, Helms JB.

Gigascience. 2019 Jun 1;8(6). pii: giz061. doi: 10.1093/gigascience/giz061.


A Comprehensive Functional Characterization of Escherichia coli Lipid Genes.

Jeucken A, Molenaar MR, van de Lest CHA, Jansen JWA, Helms JB, Brouwers JF.

Cell Rep. 2019 Apr 30;27(5):1597-1606.e2. doi: 10.1016/j.celrep.2019.04.018.


Zinc binding regulates amyloid-like aggregation of GAPR-1.

Sheng J, Olrichs NK, Geerts WJ, Li X, Rehman AU, Gadella BM, Kaloyanova DV, Helms JB.

Biosci Rep. 2019 Feb 12;39(2). pii: BSR20182345. doi: 10.1042/BSR20182345. Print 2019 Feb 28.


Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.

van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB.

Cell Stem Cell. 2019 Mar 7;24(3):363-375.e9. doi: 10.1016/j.stem.2018.12.013. Epub 2019 Jan 24.


Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice.

van Elst K, Brouwers JF, Merkens JE, Broekhoven MH, Birtoli B, Helms JB, Kas MJH.

Eur Neuropsychopharmacol. 2019 Jan;29(1):16-31. doi: 10.1016/j.euroneuro.2018.11.1106. Epub 2018 Dec 15.


Cardiolipin synthases of Escherichia coli have phospholipid class specific phospholipase D activity dependent on endogenous and foreign phospholipids.

Jeucken A, Helms JB, Brouwers JF.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1345-1353. doi: 10.1016/j.bbalip.2018.06.017. Epub 2018 Jun 19.


Lipid analysis of Eimeria sporozoites reveals exclusive phospholipids, a phylogenetic mosaic of endogenous synthesis, and a host-independent lifestyle.

Kong P, Lehmann MJ, Helms JB, Brouwers JF, Gupta N.

Cell Discov. 2018 May 22;4:24. doi: 10.1038/s41421-018-0023-4. eCollection 2018.


Some Lipid Droplets Are More Equal Than Others: Different Metabolic Lipid Droplet Pools in Hepatic Stellate Cells.

Molenaar MR, Vaandrager AB, Helms JB.

Lipid Insights. 2017 Dec 15;10:1178635317747281. doi: 10.1177/1178635317747281. eCollection 2017.


Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation.

Tuohetahuntila M, Molenaar MR, Spee B, Brouwers JF, Wubbolts R, Houweling M, Yan C, Du H, VanderVen BC, Vaandrager AB, Helms JB.

J Biol Chem. 2017 Jul 28;292(30):12436-12448. doi: 10.1074/jbc.M117.778472. Epub 2017 Jun 14.


Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis.

Kruitwagen HS, Oosterhoff LA, Vernooij IGWH, Schrall IM, van Wolferen ME, Bannink F, Roesch C, van Uden L, Molenaar MR, Helms JB, Grinwis GCM, Verstegen MMA, van der Laan LJW, Huch M, Geijsen N, Vries RG, Clevers H, Rothuizen J, Schotanus BA, Penning LC, Spee B.

Stem Cell Reports. 2017 Apr 11;8(4):822-830. doi: 10.1016/j.stemcr.2017.02.015. Epub 2017 Mar 23.


Two phylogenetically and compartmentally distinct CDP-diacylglycerol synthases cooperate for lipid biogenesis in Toxoplasma gondii.

Kong P, Ufermann CM, Zimmermann DLM, Yin Q, Suo X, Helms JB, Brouwers JF, Gupta N.

J Biol Chem. 2017 Apr 28;292(17):7145-7159. doi: 10.1074/jbc.M116.765487. Epub 2017 Mar 17.


Hepatic stellate cells retain the capacity to synthesize retinyl esters and to store neutral lipids in small lipid droplets in the absence of LRAT.

Ajat M, Molenaar M, Brouwers JFHM, Vaandrager AB, Houweling M, Helms JB.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Feb;1862(2):176-187. doi: 10.1016/j.bbalip.2016.10.013. Epub 2016 Nov 1.


ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells.

Tuohetahuntila M, Molenaar MR, Spee B, Brouwers JF, Houweling M, Vaandrager AB, Helms JB.

J Lipid Res. 2016 Jul;57(7):1162-74. doi: 10.1194/jlr.M066415. Epub 2016 May 14.


Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence.

Arroyo-Olarte RD, Brouwers JF, Kuchipudi A, Helms JB, Biswas A, Dunay IR, Lucius R, Gupta N.

PLoS Biol. 2015 Nov 13;13(11):e1002288. doi: 10.1371/journal.pbio.1002288. eCollection 2015.


Ultrastructure and lipid composition of detergent-resistant membranes derived from mammalian sperm and two types of epithelial cells.

van Gestel RA, Brouwers JF, Ultee A, Helms JB, Gadella BM.

Cell Tissue Res. 2016 Jan;363(1):129-145. doi: 10.1007/s00441-015-2272-y. Epub 2015 Sep 16.


Targeting of the hydrophobic metabolome by pathogens.

Helms JB, Kaloyanova DV, Strating JR, van Hellemond JJ, van der Schaar HM, Tielens AG, van Kuppeveld FJ, Brouwers JF.

Traffic. 2015 May;16(5):439-60. doi: 10.1111/tra.12280. Review.


LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery.

Brachet A, Norwood S, Brouwers JF, Palomer E, Helms JB, Dotti CG, Esteban JA.

J Cell Biol. 2015 Mar 16;208(6):791-806. doi: 10.1083/jcb.201407122. Epub 2015 Mar 9.


Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells.

Tuohetahuntila M, Spee B, Kruitwagen HS, Wubbolts R, Brouwers JF, van de Lest CH, Molenaar MR, Houweling M, Helms JB, Vaandrager AB.

Biochim Biophys Acta. 2015 Feb;1851(2):220-30. doi: 10.1016/j.bbalip.2014.12.003. Epub 2014 Dec 9.


The cumulus cell layer protects the bovine maturing oocyte against fatty acid-induced lipotoxicity.

Lolicato F, Brouwers JF, de Lest CH, Wubbolts R, Aardema H, Priore P, Roelen BA, Helms JB, Gadella BM.

Biol Reprod. 2015 Jan;92(1):16. doi: 10.1095/biolreprod.114.120634. Epub 2014 Oct 8.


Quantitative proteomic identification of host factors involved in the Salmonella typhimurium infection cycle.

Kaloyanova D, Vogels M, van Balkom BW, Helms JB.

Methods Mol Biol. 2015;1225:29-45. doi: 10.1007/978-1-4939-1625-2_2.


Removal of GPI-anchored membrane proteins causes clustering of lipid microdomains in the apical head area of porcine sperm.

Boerke A, van der Lit J, Lolicato F, Stout TA, Helms JB, Gadella BM.

Theriogenology. 2014 Mar 1;81(4):613-24. doi: 10.1016/j.theriogenology.2013.11.014. Epub 2013 Dec 8.


ATP protects against FITC labeling of Solanum lycopersicon and Arabidopsis thaliana Ca2+-ATPase ATP binding domains.

Galva C, Virgin GK, Helms JB, Gatto C.

Plant Physiol Biochem. 2013 Oct;71:261-7. doi: 10.1016/j.plaphy.2013.07.010. Epub 2013 Aug 6.


Bovine cumulus cells protect maturing oocytes from increased fatty acid levels by massive intracellular lipid storage.

Aardema H, Lolicato F, van de Lest CH, Brouwers JF, Vaandrager AB, van Tol HT, Roelen BA, Vos PL, Helms JB, Gadella BM.

Biol Reprod. 2013 Jun 27;88(6):164. doi: 10.1095/biolreprod.112.106062. Print 2013 Jun.


Distinct lipid compositions of two types of human prostasomes.

Brouwers JF, Aalberts M, Jansen JW, van Niel G, Wauben MH, Stout TA, Helms JB, Stoorvogel W.

Proteomics. 2013 May;13(10-11):1660-6. doi: 10.1002/pmic.201200348. Epub 2013 Apr 2.


Identification of a candidate therapeutic autophagy-inducing peptide.

Shoji-Kawata S, Sumpter R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D, Huerta C, Virgin HW, Helms JB, Eerland R, Tooze SA, Xavier R, Lenschow DJ, Yamamoto A, King D, Lichtarge O, Grishin NV, Spector SA, Kaloyanova DV, Levine B.

Nature. 2013 Feb 14;494(7436):201-6. doi: 10.1038/nature11866. Epub 2013 Jan 30.


Involvement of bicarbonate-induced radical signaling in oxysterol formation and sterol depletion of capacitating mammalian sperm during in vitro fertilization.

Boerke A, Brouwers JF, Olkkonen VM, van de Lest CH, Sostaric E, Schoevers EJ, Helms JB, Gadella BM.

Biol Reprod. 2013 Jan 25;88(1):21. doi: 10.1095/biolreprod.112.101253. Print 2013 Jan.


Phosphatidylinositol-3-phosphate clearance plays a key role in autophagosome completion.

Cebollero E, van der Vaart A, Zhao M, Rieter E, Klionsky DJ, Helms JB, Reggiori F.

Curr Biol. 2012 Sep 11;22(17):1545-53. doi: 10.1016/j.cub.2012.06.029. Epub 2012 Jul 5.


Interaction of GAPR-1 with lipid bilayers is regulated by alternative homodimerization.

van Galen J, Olrichs NK, Schouten A, Serrano RL, Nolte-'t Hoen EN, Eerland R, Kaloyanova D, Gros P, Helms JB.

Biochim Biophys Acta. 2012 Sep;1818(9):2175-83. doi: 10.1016/j.bbamem.2012.04.016. Epub 2012 Apr 26.


Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation.

Testerink N, Ajat M, Houweling M, Brouwers JF, Pully VV, van Manen HJ, Otto C, Helms JB, Vaandrager AB.

PLoS One. 2012;7(4):e34945. doi: 10.1371/journal.pone.0034945. Epub 2012 Apr 20.


Cholesterol loss during glutamate-mediated excitotoxicity.

Sodero AO, Vriens J, Ghosh D, Stegner D, Brachet A, Pallotto M, Sassoè-Pognetto M, Brouwers JF, Helms JB, Nieswandt B, Voets T, Dotti CG.

EMBO J. 2012 Apr 4;31(7):1764-73. doi: 10.1038/emboj.2012.31. Epub 2012 Feb 17.


Quantitative proteomic identification of host factors involved in the Salmonella typhimurium infection cycle.

Vogels MW, van Balkom BW, Heck AJ, de Haan CA, Rottier PJ, Batenburg JJ, Kaloyanova DV, Helms JB.

Proteomics. 2011 Dec;11(23):4477-91. doi: 10.1002/pmic.201100224. Epub 2011 Oct 28.


Mass spectrometric detection of cholesterol oxidation in bovine sperm.

Brouwers JF, Boerke A, Silva PF, Garcia-Gil N, van Gestel RA, Helms JB, van de Lest CH, Gadella BM.

Biol Reprod. 2011 Jul;85(1):128-36. doi: 10.1095/biolreprod.111.091207. Epub 2011 Mar 17.


Oleic acid prevents detrimental effects of saturated fatty acids on bovine oocyte developmental competence.

Aardema H, Vos PL, Lolicato F, Roelen BA, Knijn HM, Vaandrager AB, Helms JB, Gadella BM.

Biol Reprod. 2011 Jul;85(1):62-9. doi: 10.1095/biolreprod.110.088815. Epub 2011 Feb 10.


Identification of host factors involved in coronavirus replication by quantitative proteomics analysis.

Vogels MW, van Balkom BW, Kaloyanova DV, Batenburg JJ, Heck AJ, Helms JB, Rottier PJ, de Haan CA.

Proteomics. 2011 Jan;11(1):64-80. doi: 10.1002/pmic.201000309. Epub 2010 Dec 6.


Atherosclerotic lesion progression changes lysophosphatidic acid homeostasis to favor its accumulation.

Bot M, Bot I, Lopez-Vales R, van de Lest CH, Saulnier-Blache JS, Helms JB, David S, van Berkel TJ, Biessen EA.

Am J Pathol. 2010 Jun;176(6):3073-84. doi: 10.2353/ajpath.2010.090009. Epub 2010 Apr 29.


Binding of GAPR-1 to negatively charged phospholipid membranes: unusual binding characteristics to phosphatidylinositol.

Van Galen J, Van Balkom BW, Serrano RL, Kaloyanova D, Eerland R, Stüven E, Helms JB.

Mol Membr Biol. 2010 Apr;27(2-3):81-91. doi: 10.3109/09687680903507080.


SCAP is required for timely and proper myelin membrane synthesis.

Verheijen MH, Camargo N, Verdier V, Nadra K, de Preux Charles AS, Médard JJ, Luoma A, Crowther M, Inouye H, Shimano H, Chen S, Brouwers JF, Helms JB, Feltri ML, Wrabetz L, Kirschner D, Chrast R, Smit AB.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21383-8. doi: 10.1073/pnas.0905633106. Epub 2009 Nov 30.


Lipids in host-pathogen interactions: pathogens exploit the complexity of the host cell lipidome.

van der Meer-Janssen YP, van Galen J, Batenburg JJ, Helms JB.

Prog Lipid Res. 2010 Jan;49(1):1-26. doi: 10.1016/j.plipres.2009.07.003. Epub 2009 Jul 26. Review.


Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo.

van de Wetering K, Feddema W, Helms JB, Brouwers JF, Borst P.

Gastroenterology. 2009 Nov;137(5):1725-35. doi: 10.1053/j.gastro.2009.06.052. Epub 2009 Jul 3.


Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex.

Testerink N, van der Sanden MH, Houweling M, Helms JB, Vaandrager AB.

J Lipid Res. 2009 Nov;50(11):2182-92. doi: 10.1194/jlr.M800660-JLR200. Epub 2009 May 20.


The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species.

Bleijerveld OB, Brouwers JF, Vaandrager AB, Helms JB, Houweling M.

J Biol Chem. 2007 Sep 28;282(39):28362-72. Epub 2007 Aug 2.


Soluble factors released by ATDC5 cells affect the formation of calcium phosphate crystals.

Huitema LF, van Weeren PR, van Balkom BW, Visser T, van de Lest CH, Barneveld A, Helms JB, Vaandrager AB.

Biochim Biophys Acta. 2007 Sep;1774(9):1108-17. Epub 2007 Jun 30.


Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure.

Li X, Kaloyanova D, van Eijk M, Eerland R, van der Goot G, Oorschot V, Klumperman J, Lottspeich F, Starkuviene V, Wieland FT, Helms JB.

Mol Biol Cell. 2007 Apr;18(4):1261-71. Epub 2007 Jan 24.


Similarities and differences between organic cation inhibition of the Na,K-ATPase and PMCA.

Gatto C, Helms JB, Prasse MC, Huang SY, Zou X, Arnett KL, Milanick MA.

Biochemistry. 2006 Nov 7;45(44):13331-45.


Iron ions derived from the nitric oxide donor sodium nitroprusside inhibit mineralization.

Huitema LF, van Weeren PR, Barneveld A, van de Lest CH, Helms JB, Vaandrager AB.

Eur J Pharmacol. 2006 Aug 7;542(1-3):48-53. Epub 2006 Jun 9.


The nitric oxide donor sodium nitroprusside inhibits mineralization in ATDC5 cells.

Huitema LF, Vaandrager AB, van Weeren PR, Barneveld A, Helms JB, van de Lest CH.

Calcif Tissue Int. 2006 Mar;78(3):171-7. Epub 2006 Mar 8.


Supplemental Content

Loading ...
Support Center