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Items: 1 to 50 of 107

1.

Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis.

Liu R, Moriggl R, Zhang D, Li H, Karns R, Ruan HB, Niu H, Mayhew C, Watson C, Bangar H, Cha SW, Haslam D, Zhang T, Gilbert S, Li N, Helmrath M, Wells J, Denson L, Han X.

Life Sci Alliance. 2019 Apr 4;2(2). pii: e201900296. doi: 10.26508/lsa.201900296. Print 2019 Apr.

2.

Current operative management of congenital lobar emphysema in children: A report from the Midwest Pediatric Surgery Consortium.

Kunisaki SM, Saito JM, Fallat ME, St Peter SD, Kim AG, Johnson KN, Mon RA, Adams C, Aladegbami B, Bence C, Burns RC, Corkum KS, Deans KJ, Downard CD, Fraser JD, Gadepalli SK, Helmrath MA, Kabre R, Lal DR, Landman MP, Leys CM, Linden AF, Lopez JJ, Mak GZ, Minneci PC, Rademacher BL, Shaaban A, Walker SK, Wright TN, Hirschl RB; Midwest Pediatric Surgery Consortium.

J Pediatr Surg. 2019 Mar 1. pii: S0022-3468(19)30184-8. doi: 10.1016/j.jpedsurg.2019.02.043. [Epub ahead of print]

PMID:
30898401
3.

Can fecal continence be predicted in patients born with anorectal malformations?

Minneci PC, Kabre RS, Mak GZ, Halleran DR, Cooper JN, Afrazi A, Calkins CM, Corkum K, Downard CD, Ehrlich P, Fraser JD, Gadepalli SK, Helmrath MA, Kohler JE, Landisch R, Landman MP, Lee C, Leys CM, Lodwick DL, McLeod J, Mon R, McClure B, Rymeski B, Saito JM, Sato TT, St Peter SD, Wood R, Levitt MA, Deans KJ; Midwest Pediatric Surgery Consortium.

J Pediatr Surg. 2019 Mar 1. pii: S0022-3468(19)30176-9. doi: 10.1016/j.jpedsurg.2019.02.035. [Epub ahead of print]

PMID:
30898398
4.

Development of a multi-institutional registry for children with operative congenital lung malformations.

Kunisaki SM, Saito JM, Fallat ME, St Peter SD, Lal DR, Johnson KN, Mon RA, Adams C, Aladegbami B, Bence C, Burns RC, Corkum KS, Deans KJ, Downard CD, Fraser JD, Gadepalli SK, Helmrath MA, Kabre R, Landman MP, Leys CM, Linden AF, Lopez JJ, Mak GZ, Minneci PC, Rademacher BL, Shaaban A, Walker SK, Wright TN, Hirschl RB; Midwest Pediatric Surgery Consortium.

J Pediatr Surg. 2019 Feb 28. pii: S0022-3468(19)30112-5. doi: 10.1016/j.jpedsurg.2019.01.058. [Epub ahead of print]

PMID:
30879756
5.

Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection.

Holokai L, Chakrabarti J, Broda T, Chang J, Hawkins JA, Sundaram N, Wroblewski LE, Peek RM Jr, Wang J, Helmrath M, Wells JM, Zavros Y.

PLoS Pathog. 2019 Jan 31;15(1):e1007468. doi: 10.1371/journal.ppat.1007468. eCollection 2019 Jan.

6.

Nonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids.

Capeling MM, Czerwinski M, Huang S, Tsai YH, Wu A, Nagy MS, Juliar B, Sundaram N, Song Y, Han WM, Takayama S, Alsberg E, Garcia AJ, Helmrath M, Putnam AJ, Spence JR.

Stem Cell Reports. 2019 Feb 12;12(2):381-394. doi: 10.1016/j.stemcr.2018.12.001. Epub 2019 Jan 3.

7.

An Organoid-Based Preclinical Model of Human Gastric Cancer.

Steele NG, Chakrabarti J, Wang J, Biesiada J, Holokai L, Chang J, Nowacki LM, Hawkins J, Mahe M, Sundaram N, Shroyer N, Medvedovic M, Helmrath M, Ahmad S, Zavros Y.

Cell Mol Gastroenterol Hepatol. 2019;7(1):161-184. doi: 10.1016/j.jcmgh.2018.09.008. Epub 2018 Sep 20.

8.

Five-Fold Variation Among Surgeons and Hospitals in the Use of Secondary Palate Surgery.

Sitzman TJ, Carle AC, Heaton PC, Helmrath MA, Britto MT.

Cleft Palate Craniofac J. 2019 May;56(5):586-594. doi: 10.1177/1055665618799906. Epub 2018 Sep 24.

PMID:
30244603
9.

Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease.

Kelly D, Kotliar M, Woo V, Jagannathan S, Whitt J, Moncivaiz J, Aronow BJ, Dubinsky MC, Hyams JS, Markowitz JF, Baldassano RN, Stephens MC, Walters TD, Kugathasan S, Haberman Y, Sundaram N, Rosen MJ, Helmrath M, Karns R, Barski A, Denson LA, Alenghat T.

JCI Insight. 2018 Sep 20;3(18). pii: 122104. doi: 10.1172/jci.insight.122104. eCollection 2018 Sep 20.

10.

Infants with esophageal atresia and right aortic arch: Characteristics and outcomes from the Midwest Pediatric Surgery Consortium.

Lal DR, Gadepalli SK, Downard CD, Minneci PC, Knezevich M, Chelius TH, Rapp CT, Billmire D, Bruch S, Carland Burns R, Deans KJ, Fallat ME, Fraser JD, Grabowski J, Hebel F, Helmrath MA, Hirschl RB, Kabre R, Kohler J, Landman MP, Leys CM, Mak GZ, Ostlie DJ, Raque J, Rymeski B, Saito JM, St Peter SD, von Allmen D, Warner BW, Sato TT; Midwest Pediatric Surgery Consortium.

J Pediatr Surg. 2019 Apr;54(4):688-692. doi: 10.1016/j.jpedsurg.2018.08.002. Epub 2018 Aug 21.

PMID:
30224238
11.

Mechanically induced development and maturation of human intestinal organoids in vivo.

Poling HM, Wu D, Brown N, Baker M, Hausfeld TA, Huynh N, Chaffron S, Dunn JCY, Hogan SP, Wells JM, Helmrath MA, Mahe MM.

Nat Biomed Eng. 2018 Jun;2(6):429-442. doi: 10.1038/s41551-018-0243-9. Epub 2018 Jun 4.

12.

Deriving functional human enteroendocrine cells from pluripotent stem cells.

Sinagoga KL, McCauley HA, Múnera JO, Reynolds NA, Enriquez JR, Watson C, Yang HC, Helmrath MA, Wells JM.

Development. 2018 Oct 1;145(19). pii: dev165795. doi: 10.1242/dev.165795.

13.

Transplantation of human intestinal organoids into the mouse mesentery: A more physiologic and anatomic engraftment site.

Cortez AR, Poling HM, Brown NE, Singh A, Mahe MM, Helmrath MA.

Surgery. 2018 Oct;164(4):643-650. doi: 10.1016/j.surg.2018.04.048. Epub 2018 Jul 30.

PMID:
30072255
14.

Host-Gut Microbiota Crosstalk in Intestinal Adaptation.

Marchix J, Goddard G, Helmrath MA.

Cell Mol Gastroenterol Hepatol. 2018 Feb 15;6(2):149-162. doi: 10.1016/j.jcmgh.2018.01.024. eCollection 2018. Review.

15.

Organoid Center Strategies for Accelerating Clinical Translation.

Takebe T, Wells JM, Helmrath MA, Zorn AM.

Cell Stem Cell. 2018 Jun 1;22(6):806-809. doi: 10.1016/j.stem.2018.05.008.

PMID:
29859171
16.

Predictors of Preoperative Program Non-Completion in Adolescents Referred for Bariatric Surgery.

Brode C, Ratcliff M, Reiter-Purtill J, Hunsaker S, Helmrath M, Zeller M.

Obes Surg. 2018 Sep;28(9):2853-2859. doi: 10.1007/s11695-018-3261-5.

PMID:
29687342
17.

Initial development and validation of a fecal incontinence-specific quality of life measure.

Cushing CC, Threlkeld MRS, Martinez-Leo B, Hall J, Hossain M, Dickie BH, Rymeski B, Helmrath M, Zeller MH, Frischer JS.

J Pediatr Surg. 2018 Jun;53(6):1148-1153. doi: 10.1016/j.jpedsurg.2018.02.076. Epub 2018 Mar 7.

PMID:
29685491
18.

Screening practices and associated anomalies in infants with anorectal malformations: Results from the Midwest Pediatric Surgery Consortium.

Minneci PC, Kabre RS, Mak GZ, Halleran DR, Cooper JN, Afrazi A, Calkins CM, Downard CD, Ehrlich P, Fraser J, Gadepalli SK, Helmrath MA, Kohler JE, Landisch R, Landman MP, Lee C, Leys CM, Lodwick DL, Mon R, McClure B, Rymeski B, Saito JM, Sato TT, St Peter SD, Wood R, Levitt MA, Deans KJ; Midwest Pediatric Surgery Consortium.

J Pediatr Surg. 2018 Jun;53(6):1163-1167. doi: 10.1016/j.jpedsurg.2018.02.079. Epub 2018 Mar 7.

PMID:
29602552
19.

Cardiovascular Risk Factors After Adolescent Bariatric Surgery.

Michalsky MP, Inge TH, Jenkins TM, Xie C, Courcoulas A, Helmrath M, Brandt ML, Harmon CM, Chen M, Dixon JB, Urbina EM; Teen-LABS Consortium.

Pediatrics. 2018 Feb;141(2). pii: e20172485. doi: 10.1542/peds.2017-2485. Epub 2018 Jan 8.

20.

Guanylate cyclase 2C agonism corrects CFTR mutants.

Arora K, Huang Y, Mun K, Yarlagadda S, Sundaram N, Kessler MM, Hannig G, Kurtz CB, Silos-Santiago I, Helmrath M, Palermo JJ, Clancy JP, Steinbrecher KA, Naren AP.

JCI Insight. 2017 Oct 5;2(19). pii: 93686. doi: 10.1172/jci.insight.93686.

21.

Management of Pediatric Intestinal Failure.

Wessel J, Kotagal M, Helmrath MA.

Adv Pediatr. 2017 Aug;64(1):253-267. doi: 10.1016/j.yapd.2017.03.010. Review. No abstract available.

PMID:
28688591
22.

Erratum to: In Vivo Model of Small Intestine.

Mahe MM, Brown NE, Poling HM, Helmrath MA.

Methods Mol Biol. 2017;1597:E1. doi: 10.1007/978-1-4939-6949-4_18. No abstract available.

PMID:
28667364
23.

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.

Múnera JO, Sundaram N, Rankin SA, Hill D, Watson C, Mahe M, Vallance JE, Shroyer NF, Sinagoga KL, Zarzoso-Lacoste A, Hudson JR, Howell JC, Chatuvedi P, Spence JR, Shannon JM, Zorn AM, Helmrath MA, Wells JM.

Cell Stem Cell. 2017 Jul 6;21(1):51-64.e6. doi: 10.1016/j.stem.2017.05.020. Epub 2017 Jun 22.

24.

Changes in Dietary Intake and Eating Behavior in Adolescents After Bariatric Surgery: an Ancillary Study to the Teen-LABS Consortium.

Sarwer DB, Dilks RJ, Spitzer JC, Berkowitz RI, Wadden TA, Moore RH, Chittams JL, Brandt ML, Chen MK, Courcoulas AP, Harmon CM, Helmrath MA, Michalsky MP, Xanthakos SA, Zeller MH, Jenkins TM, Inge TH.

Obes Surg. 2017 Dec;27(12):3082-3091. doi: 10.1007/s11695-017-2764-9.

25.

Challenging surgical dogma in the management of proximal esophageal atresia with distal tracheoesophageal fistula: Outcomes from the Midwest Pediatric Surgery Consortium.

Lal DR, Gadepalli SK, Downard CD, Ostlie DJ, Minneci PC, Swedler RM, Chelius TH, Cassidy L, Rapp CT, Billmire D, Bruch S, Burns RC, Deans KJ, Fallat ME, Fraser JD, Grabowski J, Hebel F, Helmrath MA, Hirschl RB, Kabre R, Kohler J, Landman MP, Leys CM, Mak GZ, Raque J, Rymeski B, Saito JM, St Peter SD, von Allmen D, Warner BW, Sato TT; Midwest Pediatric Surgery Consortium.

J Pediatr Surg. 2018 Jul;53(7):1267-1272. doi: 10.1016/j.jpedsurg.2017.05.024. Epub 2017 Jun 1.

PMID:
28599967
26.

CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium.

Bertaux-Skeirik N, Wunderlich M, Teal E, Chakrabarti J, Biesiada J, Mahe M, Sundaram N, Gabre J, Hawkins J, Jian G, Engevik AC, Yang L, Wang J, Goldenring JR, Qualls JE, Medvedovic M, Helmrath MA, Diwan T, Mulloy JC, Zavros Y.

J Pathol. 2017 Aug;242(4):463-475. doi: 10.1002/path.4918.

27.

From adolescence to young adulthood: trajectories of psychosocial health following Roux-en-Y gastric bypass.

Zeller MH, Pendery EC, Reiter-Purtill J, Hunsaker SL, Jenkins TM, Helmrath MA, Inge TH.

Surg Obes Relat Dis. 2017 Jul;13(7):1196-1203. doi: 10.1016/j.soard.2017.03.008. Epub 2017 Mar 22.

28.

In Vivo Model of Small Intestine.

Mahe MM, Brown NE, Poling HM, Helmrath MA.

Methods Mol Biol. 2017;1597:229-245. doi: 10.1007/978-1-4939-6949-4_17. Erratum in: Methods Mol Biol. 2017;1597:E1.

29.

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.

Nalapareddy K, Nattamai KJ, Kumar RS, Karns R, Wikenheiser-Brokamp KA, Sampson LL, Mahe MM, Sundaram N, Yacyshyn MB, Yacyshyn B, Helmrath MA, Zheng Y, Geiger H.

Cell Rep. 2017 Mar 14;18(11):2608-2621. doi: 10.1016/j.celrep.2017.02.056.

30.

Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.

Asai A, Aihara E, Watson C, Mourya R, Mizuochi T, Shivakumar P, Phelan K, Mayhew C, Helmrath M, Takebe T, Wells J, Bezerra JA.

Development. 2017 Mar 15;144(6):1056-1064. doi: 10.1242/dev.142794.

31.

Development of a multi-institutional clinical research consortium for pediatric surgery.

Hirschl RB, Minneci P, Gadepalli S, Saito JM, Askegard-Giesmann J, Deans K, Downard C, Fallat M, Finnell M, Helmrath M, Kabre R, Lal D, Leys C, Mak G, Ostlie D, Rescorla F, Sato T, St Peter S, von Allmen D, Warner B; MidWest Pediatric Surgery Consortium (MWPSC).

J Pediatr Surg. 2017 Jul;52(7):1084-1088. doi: 10.1016/j.jpedsurg.2016.11.042. Epub 2016 Dec 27.

PMID:
28081853
32.

Long-term outcomes of bariatric surgery in adolescents with severe obesity (FABS-5+): a prospective follow-up analysis.

Inge TH, Jenkins TM, Xanthakos SA, Dixon JB, Daniels SR, Zeller MH, Helmrath MA.

Lancet Diabetes Endocrinol. 2017 Mar;5(3):165-173. doi: 10.1016/S2213-8587(16)30315-1. Epub 2017 Jan 6.

PMID:
28065736
33.

Perioperative management and outcomes of esophageal atresia and tracheoesophageal fistula.

Lal DR, Gadepalli SK, Downard CD, Ostlie DJ, Minneci PC, Swedler RM, Chelius T, Cassidy L, Rapp CT, Deans KJ, Fallat ME, Finnell SME, Helmrath MA, Hirschl RB, Kabre RS, Leys CM, Mak G, Raque J, Rescorla FJ, Saito JM, St Peter SD, von Allmen D, Warner BW, Sato TT; Midwest Pediatric Surgery Consortium.

J Pediatr Surg. 2017 Aug;52(8):1245-1251. doi: 10.1016/j.jpedsurg.2016.11.046. Epub 2016 Dec 5.

PMID:
27993359
34.

The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach.

Engevik AC, Feng R, Choi E, White S, Bertaux-Skeirik N, Li J, Mahe MM, Aihara E, Yang L, DiPasquale B, Oh S, Engevik KA, Giraud AS, Montrose MH, Medvedovic M, Helmrath MA, Goldenring JR, Zavros Y.

Cell Mol Gastroenterol Hepatol. 2016 May 17;2(5):605-624. eCollection 2016 Sep.

35.

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.

Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM.

Nat Med. 2017 Jan;23(1):49-59. doi: 10.1038/nm.4233. Epub 2016 Nov 21.

36.

Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection.

Cohran V, Managlia E, Bradford EM, Goretsky T, Li T, Katzman RB, Cheresh P, Brown JB, Hawkins J, Liu SXL, De Plaen IG, Weitkamp JH, Helmrath M, Zhang Z, Barrett TA.

Am J Pathol. 2016 Jul;186(7):1837-1846. doi: 10.1016/j.ajpath.2016.03.008. Epub 2016 May 6.

37.

Health-Related Quality of Life and Parental Stress in Children With Fecal Incontinence: A Normative Comparison.

Cushing CC, Martinez-Leo B, Bischoff A, Hall J, Helmrath M, Dickie BH, Levitt MA, Peña A, Zeller MH, Frischer JS.

J Pediatr Gastroenterol Nutr. 2016 Dec;63(6):633-636.

PMID:
27027905
38.

The human milk oligosaccharide 2'-fucosyllactose augments the adaptive response to extensive intestinal.

Mezoff EA, Hawkins JA, Ollberding NJ, Karns R, Morrow AL, Helmrath MA.

Am J Physiol Gastrointest Liver Physiol. 2016 Mar 15;310(6):G427-38. doi: 10.1152/ajpgi.00305.2015. Epub 2015 Dec 23.

39.

Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid.

Aihara E, Mahe MM, Schumacher MA, Matthis AL, Feng R, Ren W, Noah TK, Matsu-ura T, Moore SR, Hong CI, Zavros Y, Herness S, Shroyer NF, Iwatsuki K, Jiang P, Helmrath MA, Montrose MH.

Sci Rep. 2015 Nov 24;5:17185. doi: 10.1038/srep17185.

40.

Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents.

Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, Helmrath MA, Brandt ML, Harmon CM, Zeller MH, Chen MK, Xanthakos SA, Horlick M, Buncher CR; Teen-LABS Consortium.

N Engl J Med. 2016 Jan 14;374(2):113-23. doi: 10.1056/NEJMoa1506699. Epub 2015 Nov 6.

41.

Drug-induced secretory diarrhea: A role for CFTR.

Moon C, Zhang W, Sundaram N, Yarlagadda S, Reddy VS, Arora K, Helmrath MA, Naren AP.

Pharmacol Res. 2015 Dec;102:107-112. doi: 10.1016/j.phrs.2015.08.024. Epub 2015 Sep 30. Review.

42.

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo.

Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR.

Stem Cell Reports. 2015 Jun 3. pii: S2213-6711(15)00122-8. doi: 10.1016/j.stemcr.2015.04.010. [Epub ahead of print]

43.

High Prevalence of Nonalcoholic Fatty Liver Disease in Adolescents Undergoing Bariatric Surgery.

Xanthakos SA, Jenkins TM, Kleiner DE, Boyce TW, Mourya R, Karns R, Brandt ML, Harmon CM, Helmrath MA, Michalsky MP, Courcoulas AP, Zeller MH, Inge TH; Teen-LABS Consortium.

Gastroenterology. 2015 Sep;149(3):623-34.e8. doi: 10.1053/j.gastro.2015.05.039. Epub 2015 May 28.

44.

Musculoskeletal Pain, Self-reported Physical Function, and Quality of Life in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Cohort.

Bout-Tabaku S, Michalsky MP, Jenkins TM, Baughcum A, Zeller MH, Brandt ML, Courcoulas A, Buncher R, Helmrath M, Harmon CM, Chen MK, Inge TH.

JAMA Pediatr. 2015 Jun;169(6):552-9. doi: 10.1001/jamapediatrics.2015.0378.

45.

Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy.

Mahe MM, Sundaram N, Watson CL, Shroyer NF, Helmrath MA.

J Vis Exp. 2015 Mar 6;(97). doi: 10.3791/52483.

46.

IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations.

Van Landeghem L, Santoro MA, Mah AT, Krebs AE, Dehmer JJ, McNaughton KK, Helmrath MA, Magness ST, Lund PK.

FASEB J. 2015 Jul;29(7):2828-42. doi: 10.1096/fj.14-264010. Epub 2015 Apr 2.

47.

Cardiovascular Risk Factors in Severely Obese Adolescents: The Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study.

Michalsky MP, Inge TH, Simmons M, Jenkins TM, Buncher R, Helmrath M, Brandt ML, Harmon CM, Courcoulas A, Chen M, Horlick M, Daniels SR, Urbina EM; Teen-LABS Consortium.

JAMA Pediatr. 2015 May;169(5):438-44. doi: 10.1001/jamapediatrics.2014.3690.

48.

CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation.

Bertaux-Skeirik N, Feng R, Schumacher MA, Li J, Mahe MM, Engevik AC, Javier JE, Peek RM Jr, Ottemann K, Orian-Rousseau V, Boivin GP, Helmrath MA, Zavros Y.

PLoS Pathog. 2015 Feb 6;11(2):e1004663. doi: 10.1371/journal.ppat.1004663. eCollection 2015 Feb.

49.

The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas.

McGrath PS, Watson CL, Ingram C, Helmrath MA, Wells JM.

Diabetes. 2015 Jul;64(7):2497-505. doi: 10.2337/db14-1412. Epub 2015 Feb 3.

50.

Activated STAT5 confers resistance to intestinal injury by increasing intestinal stem cell proliferation and regeneration.

Gilbert S, Nivarthi H, Mayhew CN, Lo YH, Noah TK, Vallance J, Rülicke T, Müller M, Jegga AG, Tang W, Zhang D, Helmrath M, Shroyer N, Moriggl R, Han X.

Stem Cell Reports. 2015 Feb 10;4(2):209-25. doi: 10.1016/j.stemcr.2014.12.004. Epub 2015 Jan 8.

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