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Items: 1 to 50 of 56

1.

Cerebral differences between dopamine-resistant and dopamine-responsive Parkinson's tremor.

Dirkx MF, Zach H, van Nuland A, Bloem BR, Toni I, Helmich RC.

Brain. 2019 Sep 11. pii: awz261. doi: 10.1093/brain/awz261. [Epub ahead of print]

PMID:
31509182
2.

Tremor habituation to deep brain stimulation: Underlying mechanisms and solutions.

Fasano A, Helmich RC.

Mov Disord. 2019 Aug 21. doi: 10.1002/mds.27821. [Epub ahead of print] Review.

PMID:
31433906
4.

The Personalized Parkinson Project: examining disease progression through broad biomarkers in early Parkinson's disease.

Bloem BR, Marks WJ Jr, Silva de Lima AL, Kuijf ML, van Laar T, Jacobs BPF, Verbeek MM, Helmich RC, van de Warrenburg BP, Evers LJW, intHout J, van de Zande T, Snyder TM, Kapur R, Meinders MJ.

BMC Neurol. 2019 Jul 17;19(1):160. doi: 10.1186/s12883-019-1394-3.

5.

Network abnormalities among non-manifesting Parkinson disease related LRRK2 mutation carriers.

Jacob Y, Rosenberg-Katz K, Gurevich T, Helmich RC, Bloem BR, Orr-Urtreger A, Giladi N, Mirelman A, Hendler T, Thaler A.

Hum Brain Mapp. 2019 Jun 1;40(8):2546-2555. doi: 10.1002/hbm.24543. Epub 2019 Feb 21.

PMID:
30793410
6.

The Shaking Shoelace.

Bloem BR, Helmich RC, Tilanus T, van de Warrenburg BP.

J Parkinsons Dis. 2019;9(1):249-250. doi: 10.3233/JPD-181541. No abstract available.

7.

The Future of Brain Imaging in Parkinson's Disease.

Helmich RC, Vaillancourt DE, Brooks DJ.

J Parkinsons Dis. 2018;8(s1):S47-S51. doi: 10.3233/JPD-181482.

8.

Author response: The nature of postural tremor in Parkinson disease.

Helmich RC, Hallett M, Dirkx MF.

Neurology. 2018 Oct 9;91(15):724. doi: 10.1212/WNL.0000000000006314. No abstract available.

PMID:
30297510
9.

Altered reward-related neural responses in non-manifesting carriers of the Parkinson disease related LRRK2 mutation.

Thaler A, Gonen T, Mirelman A, Helmich RC, Gurevich T, Orr-Urtreger A, Bloem BR, Giladi N, Hendler T; LRRK2 Ashkenazi Jewish consortium.

Brain Imaging Behav. 2019 Aug;13(4):1009-1020. doi: 10.1007/s11682-018-9920-2.

PMID:
29971685
10.

The patchy tremor landscape: recent advances in pathophysiology.

Nieuwhof F, Panyakaew P, van de Warrenburg BP, Gallea C, Helmich RC.

Curr Opin Neurol. 2018 Aug;31(4):455-461. doi: 10.1097/WCO.0000000000000582. Review.

PMID:
29750732
11.

The nature of postural tremor in Parkinson disease.

Dirkx MF, Zach H, Bloem BR, Hallett M, Helmich RC.

Neurology. 2018 Mar 27;90(13):e1095-e1103. doi: 10.1212/WNL.0000000000005215. Epub 2018 Feb 23.

12.

The cerebral basis of Parkinsonian tremor: A network perspective.

Helmich RC.

Mov Disord. 2018 Feb;33(2):219-231. doi: 10.1002/mds.27224. Epub 2017 Nov 9. Review.

PMID:
29119634
13.

Entangled cerebral networks in Parkinson's disease.

Nieuwhof F, Helmich RC.

Brain. 2017 Nov 1;140(11):2767-2769. doi: 10.1093/brain/awx267. No abstract available.

PMID:
29088350
14.

The etiology of essential tremor: Genes versus environment.

Hopfner F, Helmich RC.

Parkinsonism Relat Disord. 2018 Jan;46 Suppl 1:S92-S96. doi: 10.1016/j.parkreldis.2017.07.014. Epub 2017 Jul 17. Review.

PMID:
28735798
15.

Parkinson's disease as a system-level disorder.

Caligiore D, Helmich RC, Hallett M, Moustafa AA, Timmermann L, Toni I, Baldassarre G.

NPJ Parkinsons Dis. 2016 Dec 1;2:16025. doi: 10.1038/npjparkd.2016.25. eCollection 2016. Review.

16.

Pathophysiology and Management of Parkinsonian Tremor.

Helmich RC, Dirkx MF.

Semin Neurol. 2017 Apr;37(2):127-134. doi: 10.1055/s-0037-1601558. Epub 2017 May 16. Review.

PMID:
28511253
17.

Impaired dual tasking in Parkinson's disease is associated with reduced focusing of cortico-striatal activity.

Nieuwhof F, Bloem BR, Reelick MF, Aarts E, Maidan I, Mirelman A, Hausdorff JM, Toni I, Helmich RC.

Brain. 2017 May 1;140(5):1384-1398. doi: 10.1093/brain/awx042.

PMID:
28335024
18.

Dopamine controls Parkinson's tremor by inhibiting the cerebellar thalamus.

Dirkx MF, den Ouden HE, Aarts E, Timmer MH, Bloem BR, Toni I, Helmich RC.

Brain. 2017 Mar 1;140(3):721-734. doi: 10.1093/brain/aww331.

PMID:
28073788
19.

Cognitive Stress Reduces the Effect of Levodopa on Parkinson's Resting Tremor.

Zach H, Dirkx MF, Pasman JW, Bloem BR, Helmich RC.

CNS Neurosci Ther. 2017 Mar;23(3):209-215. doi: 10.1111/cns.12670. Epub 2017 Jan 10.

20.

The patient's perspective: The effect of levodopa on Parkinson symptoms.

Zach H, Dirkx M, Pasman JW, Bloem BR, Helmich RC.

Parkinsonism Relat Disord. 2017 Feb;35:48-54. doi: 10.1016/j.parkreldis.2016.11.015. Epub 2016 Nov 27.

PMID:
27919585
21.

Knowledge gaps and research recommendations for essential tremor.

Hopfner F, Haubenberger D, Galpern WR, Gwinn K, Van't Veer A, White S, Bhatia K, Adler CH, Eidelberg D, Ondo W, Stebbins GT, Tanner CM, Helmich RC, Lenz FA, Sillitoe RV, Vaillancourt D, Vitek JL, Louis ED, Shill HA, Frosch MP, Foroud T, Kuhlenbäumer G, Singleton A, Testa CM, Hallett M, Elble R, Deuschl G.

Parkinsonism Relat Disord. 2016 Dec;33:27-35. doi: 10.1016/j.parkreldis.2016.10.002. Epub 2016 Oct 4. Review.

22.

Unmasking levodopa resistance in Parkinson's disease.

Nonnekes J, Timmer MH, de Vries NM, Rascol O, Helmich RC, Bloem BR.

Mov Disord. 2016 Nov;31(11):1602-1609. doi: 10.1002/mds.26712. Epub 2016 Jul 19. Review.

PMID:
27430479
23.

A cognitive fMRI study in non-manifesting LRRK2 and GBA carriers.

Bregman N, Thaler A, Mirelman A, Helmich RC, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N; LRRK2 Ashkenazi Jewish consortium.

Brain Struct Funct. 2017 Apr;222(3):1207-1218. doi: 10.1007/s00429-016-1271-4. Epub 2016 Jul 11.

PMID:
27401793
24.

The Cerebral Network of Parkinson's Tremor: An Effective Connectivity fMRI Study.

Dirkx MF, den Ouden H, Aarts E, Timmer M, Bloem BR, Toni I, Helmich RC.

J Neurosci. 2016 May 11;36(19):5362-72. doi: 10.1523/JNEUROSCI.3634-15.2016.

25.

Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex.

Caligiore D, Pezzulo G, Baldassarre G, Bostan AC, Strick PL, Doya K, Helmich RC, Dirkx M, Houk J, Jörntell H, Lago-Rodriguez A, Galea JM, Miall RC, Popa T, Kishore A, Verschure PF, Zucca R, Herreros I.

Cerebellum. 2017 Feb;16(1):203-229. doi: 10.1007/s12311-016-0763-3.

26.

Intact working memory in non-manifesting LRRK2 carriers--an fMRI study.

Thaler A, Helmich RC, Or-Borichev A, van Nuenen BF, Shapira-Lichter I, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T, Mirelman A; LRRK2 Ashkenazi Jewish consortium.

Eur J Neurosci. 2016 Jan;43(1):106-12. doi: 10.1111/ejn.13120. Epub 2015 Dec 18.

PMID:
26536050
27.

The Clinical Evaluation of Parkinson's Tremor.

Zach H, Dirkx M, Bloem BR, Helmich RC.

J Parkinsons Dis. 2015;5(3):471-4. doi: 10.3233/JPD-150650.

28.

Normalization of sensorimotor integration by repetitive transcranial magnetic stimulation in cervical dystonia.

Zittel S, Helmich RC, Demiralay C, Münchau A, Bäumer T.

J Neurol. 2015 Aug;262(8):1883-9. doi: 10.1007/s00415-015-7789-1. Epub 2015 May 28.

PMID:
26016685
29.

Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers.

Helmich RC, Thaler A, van Nuenen BF, Gurevich T, Mirelman A, Marder KS, Bressman S, Orr-Urtreger A, Giladi N, Bloem BR, Toni I; LRRK2 Ashkenazi Jewish Consortium.

Neurology. 2015 Jan 27;84(4):399-406. doi: 10.1212/WNL.0000000000001189. Epub 2014 Dec 24.

30.

Greater striatal responses to medication in Parkinson׳s disease are associated with better task-switching but worse reward performance.

Aarts E, Nusselein AA, Smittenaar P, Helmich RC, Bloem BR, Cools R.

Neuropsychologia. 2014 Sep;62:390-7. doi: 10.1016/j.neuropsychologia.2014.05.023. Epub 2014 Jun 6.

PMID:
24912070
31.

A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers.

Thaler A, Artzi M, Mirelman A, Jacob Y, Helmich RC, van Nuenen BF, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Hendler T, Giladi N, Ben Bashat D; LRRK2 Ashkenazi Jewish Consortium.

Mov Disord. 2014 May;29(6):823-7. doi: 10.1002/mds.25827. Epub 2014 Jan 30.

PMID:
24482120
32.

The pathophysiology of essential tremor and Parkinson's tremor.

Helmich RC, Toni I, Deuschl G, Bloem BR.

Curr Neurol Neurosci Rep. 2013 Sep;13(9):378. doi: 10.1007/s11910-013-0378-8. Review.

PMID:
23893097
33.

Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers.

Thaler A, Mirelman A, Helmich RC, van Nuenen BF, Rosenberg-Katz K, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T; LRRK2 Ashkenazi Jewish consortium.

Cortex. 2013 Oct;49(9):2501-11. doi: 10.1016/j.cortex.2012.12.017. Epub 2013 Jan 7.

PMID:
23357204
34.

The distributed somatotopy of tremor: a window into the motor system.

Helmich RC.

Exp Neurol. 2013 Mar;241:156-8. doi: 10.1016/j.expneurol.2012.12.015. Epub 2013 Jan 5.

PMID:
23298522
35.

Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism.

van Nuenen BF, Helmich RC, Ferraye M, Thaler A, Hendler T, Orr-Urtreger A, Mirelman A, Bressman S, Marder KS, Giladi N, van de Warrenburg BP, Bloem BR, Toni I; LRRK2 Ashkenazi Jewish Consortium.

Brain. 2012 Dec;135(Pt 12):3687-98. doi: 10.1093/brain/aws288.

PMID:
23250886
36.

Reduced parietal connectivity with a premotor writing area in writer's cramp.

Delnooz CC, Helmich RC, Toni I, van de Warrenburg BP.

Mov Disord. 2012 Sep 15;27(11):1425-31. doi: 10.1002/mds.25029. Epub 2012 Aug 7.

PMID:
22886735
37.

Compensatory activity in the extrastriate body area of Parkinson's disease patients.

van Nuenen BF, Helmich RC, Buenen N, van de Warrenburg BP, Bloem BR, Toni I.

J Neurosci. 2012 Jul 11;32(28):9546-53. doi: 10.1523/JNEUROSCI.0335-12.2012.

38.

Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?

Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR.

Brain. 2012 Nov;135(Pt 11):3206-26. doi: 10.1093/brain/aws023. Epub 2012 Mar 1. Review.

39.

Aberrant reward processing in Parkinson's disease is associated with dopamine cell loss.

Aarts E, Helmich RC, Janssen MJ, Oyen WJ, Bloem BR, Cools R.

Neuroimage. 2012 Feb 15;59(4):3339-46. doi: 10.1016/j.neuroimage.2011.11.073. Epub 2011 Dec 6.

PMID:
22166793
40.

Writer's cramp: increased dorsal premotor activity during intended writing.

Delnooz CC, Helmich RC, Medendorp WP, Van de Warrenburg BP, Toni I.

Hum Brain Mapp. 2013 Mar;34(3):613-25. doi: 10.1002/hbm.21464. Epub 2011 Nov 24.

PMID:
22113948
41.

Motor imagery evokes increased somatosensory activity in Parkinson's disease patients with tremor.

Helmich RC, Bloem BR, Toni I.

Hum Brain Mapp. 2012 Aug;33(8):1763-79. doi: 10.1002/hbm.21318. Epub 2011 Jun 14.

PMID:
21674693
42.

Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor.

Helmich RC, Janssen MJ, Oyen WJ, Bloem BR, Toni I.

Ann Neurol. 2011 Feb;69(2):269-81. doi: 10.1002/ana.22361.

PMID:
21387372
43.

The dynamic regulation of cortical excitability is altered in episodic ataxia type 2.

Helmich RC, Siebner HR, Giffin N, Bestmann S, Rothwell JC, Bloem BR.

Brain. 2010 Dec;133(Pt 12):3519-29. doi: 10.1093/brain/awq315.

PMID:
21126994
44.

Gait-related cerebral alterations in patients with Parkinson's disease with freezing of gait.

Snijders AH, Leunissen I, Bakker M, Overeem S, Helmich RC, Bloem BR, Toni I.

Brain. 2011 Jan;134(Pt 1):59-72. doi: 10.1093/brain/awq324. Epub 2010 Dec 1.

PMID:
21126990
45.

Side of symptom onset affects motor dysfunction in Parkinson's disease.

Haaxma CA, Helmich RC, Borm GF, Kappelle AC, Horstink MW, Bloem BR.

Neuroscience. 2010 Nov 10;170(4):1282-5. doi: 10.1016/j.neuroscience.2010.07.030. Epub 2010 Aug 17.

PMID:
20723583
46.

Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging.

Aarts E, Roelofs A, Franke B, Rijpkema M, Fernández G, Helmich RC, Cools R.

Neuropsychopharmacology. 2010 Aug;35(9):1943-51. doi: 10.1038/npp.2010.68. Epub 2010 May 12.

47.

Spatial remapping of cortico-striatal connectivity in Parkinson's disease.

Helmich RC, Derikx LC, Bakker M, Scheeringa R, Bloem BR, Toni I.

Cereb Cortex. 2010 May;20(5):1175-86. doi: 10.1093/cercor/bhp178. Epub 2009 Aug 26.

PMID:
19710357
48.

Increased dependence of action selection on recent motor history in Parkinson's disease.

Helmich RC, Aarts E, de Lange FP, Bloem BR, Toni I.

J Neurosci. 2009 May 13;29(19):6105-13. doi: 10.1523/JNEUROSCI.0704-09.2009.

49.

Ischemic neuropathy and rhabdomyolysis as presenting symptoms of postpartum cardiomyopathy.

Helmich RC, van Laarhoven HW, Schoonderwaldt HC, Janssen MC.

J Thromb Thrombolysis. 2009 May;27(4):458-60. doi: 10.1007/s11239-008-0237-7. Epub 2008 Jun 26.

PMID:
18581059
50.

Cerebral correlates of motor imagery of normal and precision gait.

Bakker M, De Lange FP, Helmich RC, Scheeringa R, Bloem BR, Toni I.

Neuroimage. 2008 Jul 1;41(3):998-1010. doi: 10.1016/j.neuroimage.2008.03.020. Epub 2008 Mar 25.

PMID:
18455930

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