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Items: 1 to 50 of 201

1.

Advillin acts upstream of phospholipase C ϵ1 in steroid-resistant nephrotic syndrome.

Rao J, Ashraf S, Tan W, van der Ven AT, Gee HY, Braun DA, Fehér K, George SP, Esmaeilniakooshkghazi A, Choi WI, Jobst-Schwan T, Schneider R, Schmidt JM, Widmeier E, Warejko JK, Hermle T, Schapiro D, Lovric S, Shril S, Daga A, Nayir A, Shenoy M, Tse Y, Bald M, Helmchen U, Mir S, Berdeli A, Kari JA, El Desoky S, Soliman NA, Bagga A, Mane S, Jairajpuri MA, Lifton RP, Khurana S, Martins JC, Hildebrandt F.

J Clin Invest. 2017 Dec 1;127(12):4257-4269. doi: 10.1172/JCI94138. Epub 2017 Oct 23.

2.

A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy.

Tomas NM, Meyer-Schwesinger C, von Spiegel H, Kotb AM, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl RAK.

J Am Soc Nephrol. 2017 Nov;28(11):3262-3277. doi: 10.1681/ASN.2017010030. Epub 2017 Aug 16.

PMID:
28814510
3.

An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy.

Hoxha E, Beck LH Jr, Wiech T, Tomas NM, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl PR, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant DJ, Stahl RA.

J Am Soc Nephrol. 2017 Feb;28(2):520-531. doi: 10.1681/ASN.2016010050. Epub 2016 Jul 19.

4.

Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy.

Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.

J Clin Invest. 2016 Jul 1;126(7):2519-32. doi: 10.1172/JCI85265. Epub 2016 May 23.

5.

Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome.

Braun DA, Sadowski CE, Kohl S, Lovric S, Astrinidis SA, Pabst WL, Gee HY, Ashraf S, Lawson JA, Shril S, Airik M, Tan W, Schapiro D, Rao J, Choi WI, Hermle T, Kemper MJ, Pohl M, Ozaltin F, Konrad M, Bogdanovic R, Büscher R, Helmchen U, Serdaroglu E, Lifton RP, Antonin W, Hildebrandt F.

Nat Genet. 2016 Apr;48(4):457-65. doi: 10.1038/ng.3512. Epub 2016 Feb 15.

6.

Spontaneous remission of proteinuria is a frequent event in phospholipase A2 receptor antibody-negative patients with membranous nephropathy.

Hoxha E, Harendza S, Pinnschmidt HO, Tomas NM, Helmchen U, Panzer U, Stahl RA.

Nephrol Dial Transplant. 2015 Nov;30(11):1862-9. doi: 10.1093/ndt/gfv228. Epub 2015 Jul 3.

PMID:
26142398
7.

Response to cyclosporine in steroid-resistant nephrotic syndrome: discontinuation is possible.

Klaassen I, Özgören B, Sadowski CE, Möller K, van Husen M, Lehnhardt A, Timmermann K, Freudenberg F, Helmchen U, Oh J, Kemper MJ.

Pediatr Nephrol. 2015 Sep;30(9):1477-83. doi: 10.1007/s00467-015-3109-3. Epub 2015 Apr 24.

PMID:
25903641
8.

CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN.

Brix SR, Stege G, Disteldorf E, Hoxha E, Krebs C, Krohn S, Otto B, Klätschke K, Herden E, Heymann F, Lira SA, Tacke F, Wolf G, Busch M, Jabs WJ, Özcan F, Keller F, Beige J, Wagner K, Helmchen U, Noriega M, Wiech T, Panzer U, Stahl RA.

J Am Soc Nephrol. 2015 Sep;26(9):2105-17. doi: 10.1681/ASN.2014040407. Epub 2015 Mar 11.

9.

Smaller caliber renal arteries are a novel feature of uromodulin-associated kidney disease.

Prejbisz A, Sellin L, Szwench-Pietrasz E, Woznowski M, Michałowska I, Blondin D, Sajnaga D, Epplen JT, Litwin M, Dekomien G, Januszewicz M, Helmchen U, Matuszkiewicz-Rowińska J, Adamczak M, Więcek A, Januszewicz A, Rump LC.

Kidney Int. 2015 Jul;88(1):160-6. doi: 10.1038/ki.2015.2. Epub 2015 Feb 11.

PMID:
25671765
10.

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.

Tomas NM, Beck LH Jr, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay AS, Debayle D, Merchant M, Klein J, Salant DJ, Stahl RAK, Lambeau G.

N Engl J Med. 2014 Dec 11;371(24):2277-2287. doi: 10.1056/NEJMoa1409354. Epub 2014 Nov 13.

11.

[Membranous nephropathy--crucial developments for diagnostic and treatment].

Stahl RA, Harendza S, Helmchen U, Hoxha E.

Dtsch Med Wochenschr. 2014 Jul;139(27):1433-6. doi: 10.1055/s-0034-1370136. Epub 2014 Jun 17. German. No abstract available.

PMID:
24937082
12.

CXCL5 drives neutrophil recruitment in TH17-mediated GN.

Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RA, Kurts C, Kaufmann SH, Panzer U.

J Am Soc Nephrol. 2015 Jan;26(1):55-66. doi: 10.1681/ASN.2013101061. Epub 2014 Jun 5.

13.

Whole-exome resequencing distinguishes cystic kidney diseases from phenocopies in renal ciliopathies.

Gee HY, Otto EA, Hurd TW, Ashraf S, Chaki M, Cluckey A, Vega-Warner V, Saisawat P, Diaz KA, Fang H, Kohl S, Allen SJ, Airik R, Zhou W, Ramaswami G, Janssen S, Fu C, Innis JL, Weber S, Vester U, Davis EE, Katsanis N, Fathy HM, Jeck N, Klaus G, Nayir A, Rahim KA, Al Attrach I, Al Hassoun I, Ozturk S, Drozdz D, Helmchen U, O'Toole JF, Attanasio M, Lewis RA, Nürnberg G, Nürnberg P, Washburn J, MacDonald J, Innis JW, Levy S, Hildebrandt F.

Kidney Int. 2014 Apr;85(4):880-7. doi: 10.1038/ki.2013.450. Epub 2013 Nov 20.

14.

[Tubulointerstitial nephritis with uveitis (TINU) syndrome. A relatively rare rheumatological differential diagnosis with unexplained uveitis].

Häusler U, Guminski B, Helmchen U, Kisters K, Heinz C, Braun J.

Z Rheumatol. 2013 May;72(4):393-7. doi: 10.1007/s00393-012-1100-y. German.

PMID:
23340909
15.

Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy.

Hoxha E, Kneißler U, Stege G, Zahner G, Thiele I, Panzer U, Harendza S, Helmchen UM, Stahl RA.

Kidney Int. 2012 Oct;82(7):797-804. doi: 10.1038/ki.2012.209. Epub 2012 Jun 6.

16.

Renal IL-17 expression in human ANCA-associated glomerulonephritis.

Velden J, Paust HJ, Hoxha E, Turner JE, Steinmetz OM, Wolf G, Jabs WJ, Özcan F, Beige J, Heering PJ, Schröder S, Kneißler U, Disteldorf E, Mittrücker HW, Stahl RA, Helmchen U, Panzer U.

Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1663-73. doi: 10.1152/ajprenal.00683.2011. Epub 2012 Mar 21.

17.

[From mice to men - insights from the hantavirus epidemic in 2010].

Loyen M, Helmchen U, Hofmann J, Krüger DH, Clasen W.

Dtsch Med Wochenschr. 2012 Feb;137(7):309-13. doi: 10.1055/s-0031-1298904. Epub 2012 Feb 8. German.

PMID:
22318843
18.

[Membranous glomerulonephritis: better therapy with autoantibody monitoring?].

Stahl RA, Hoxha E, Helmchen U.

Dtsch Med Wochenschr. 2011 Aug;136(34-35):1733-7. doi: 10.1055/s-0031-1286067. Epub 2011 Aug 29. Review. German.

PMID:
21877306
19.

An immunofluorescence test for phospholipase-A₂-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis.

Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, Fechner K, Helmchen U, Stahl RA.

Nephrol Dial Transplant. 2011 Aug;26(8):2526-32. doi: 10.1093/ndt/gfr247. Epub 2011 Jun 1.

PMID:
21633097
20.

Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.

Meyer-Schwesinger C, Meyer TN, Sievert H, Hoxha E, Sachs M, Klupp EM, Münster S, Balabanov S, Carrier L, Helmchen U, Thaiss F, Stahl RA.

Am J Pathol. 2011 May;178(5):2044-57. doi: 10.1016/j.ajpath.2011.01.017.

21.

Progressive renal insufficiency, hypercalcaemia, bicytopaenia and a history of breast cancer.

Letterer S, Lindner U, Bernd HW, Vogt FM, Helmchen U, Lehnert H, Haas CS.

NDT Plus. 2011 Feb;4(1):28-31. doi: 10.1093/ndtplus/sfq184. Epub 2010 Oct 19.

22.

CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis.

Steinmetz OM, Turner JE, Paust HJ, Lindner M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer TN, Helmchen U, Mittrücker HW, Stahl RA, Panzer U.

J Immunol. 2009 Oct 1;183(7):4693-704. doi: 10.4049/jimmunol.0802626. Epub 2009 Sep 4.

23.

Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases.

Panzer U, Steinmetz OM, Turner JE, Meyer-Schwesinger C, von Ruffer C, Meyer TN, Zahner G, Gómez-Guerrero C, Schmid RM, Helmchen U, Moeckel GW, Wolf G, Stahl RA, Thaiss F.

Am J Physiol Renal Physiol. 2009 Aug;297(2):F429-39. doi: 10.1152/ajprenal.90435.2008. Epub 2009 May 20.

24.

Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice.

Benndorf RA, Krebs C, Hirsch-Hoffmann B, Schwedhelm E, Cieslar G, Schmidt-Haupt R, Steinmetz OM, Meyer-Schwesinger C, Thaiss F, Haddad M, Fehr S, Heilmann A, Helmchen U, Hein L, Ehmke H, Stahl RA, Böger RH, Wenzel UO.

Kidney Int. 2009 May;75(10):1039-49. doi: 10.1038/ki.2009.2. Epub 2009 Feb 11.

25.

A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies.

Meyer-Schwesinger C, Meyer TN, Münster S, Klug P, Saleem M, Helmchen U, Stahl RA.

J Pathol. 2009 Feb;217(3):452-64. doi: 10.1002/path.2446.

PMID:
18985619
26.

CCR5 deficiency aggravates crescentic glomerulonephritis in mice.

Turner JE, Paust HJ, Steinmetz OM, Peters A, Meyer-Schwesinger C, Heymann F, Helmchen U, Fehr S, Horuk R, Wenzel U, Kurts C, Mittrücker HW, Stahl RA, Panzer U.

J Immunol. 2008 Nov 1;181(9):6546-56.

27.

Characterization of the transcriptional regulation of the human MT1-MMP gene and association of risk reduction for focal-segmental glomerulosclerosis with two functional promoter SNPs.

Munkert A, Helmchen U, Kemper MJ, Bubenheim M, Stahl RA, Harendza S.

Nephrol Dial Transplant. 2009 Mar;24(3):735-42. doi: 10.1093/ndt/gfn576. Epub 2008 Oct 16.

PMID:
18927121
28.

Early conversion from cyclosporine to tacrolimus increases renal graft function in chronic allograft nephropathy at BANFF stages I and II.

Marcard T, Ivens K, Grabensee B, Willers R, Helmchen U, Rump LC, Blume C.

Transpl Int. 2008 Dec;21(12):1153-62. doi: 10.1111/j.1432-2277.2008.00731.x. Epub 2008 Aug 5. Erratum in: Transpl Int. 2008 Dec;21(12):1196.

29.

Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritis.

Steinmetz OM, Velden J, Kneissler U, Marx M, Klein A, Helmchen U, Stahl RA, Panzer U.

Kidney Int. 2008 Aug;74(4):448-57. doi: 10.1038/ki.2008.191. Epub 2008 Jun 4.

30.

[A 42 year old patient with bilateral loss of sight and hypertension. Gemcitabine-associated thrombotic microangiopathy (TMA)].

Schmidt A, Schwella N, Helmchen U, von Renteln D, Caca K.

Internist (Berl). 2008 Aug;49(8):989-90, 992-4. doi: 10.1007/s00108-008-2123-y. German.

PMID:
18427761
31.

Rapid development of severe end-organ damage in C57BL/6 mice by combining DOCA salt and angiotensin II.

Kirchhoff F, Krebs C, Abdulhag UN, Meyer-Schwesinger C, Maas R, Helmchen U, Hilgers KF, Wolf G, Stahl RA, Wenzel U.

Kidney Int. 2008 Mar;73(5):643-50. Epub 2007 Nov 21.

32.

Rituximab removes intrarenal B cell clusters in patients with renal vascular allograft rejection.

Steinmetz OM, Lange-Hüsken F, Turner JE, Vernauer A, Helmchen U, Stahl RA, Thaiss F, Panzer U.

Transplantation. 2007 Oct 15;84(7):842-50.

PMID:
17984836
33.

Acute cellular allograft rejection in homozygous CCR5 Delta32 patients after renal transplantation.

Steinmetz OM, Fischereder M, Weiss M, Helmchen U, Stahl RA, Panzer U.

Transplantation. 2007 Aug 27;84(4):559-61. No abstract available.

PMID:
17713445
34.

Acute hantavirus infection or renal transplant rejection.

Meier M, Helmchen U, Fricke L, Ulrich R, Schütt M.

Transpl Infect Dis. 2007 Sep;9(3):225-8.

PMID:
17692069
35.

Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.

Panzer U, Steinmetz OM, Paust HJ, Meyer-Schwesinger C, Peters A, Turner JE, Zahner G, Heymann F, Kurts C, Hopfer H, Helmchen U, Haag F, Schneider A, Stahl RA.

J Am Soc Nephrol. 2007 Jul;18(7):2071-84. Epub 2007 May 30.

36.

Five-year outcome in pediatric patients with mycophenolate mofetil-based renal transplantation.

Jungraithmayr TC, Wiesmayr S, Staskewitz A, Kirste G, Bulla M, Fehrenbach H, Dippell J, Greiner C, Griebel M, Helmchen U, Klaus G, Leichter HE, Mihatsch MJ, Michalk DV, Misselwitz J, Plank C, Tönshoff B, Weber LT, Zimmerhackl LB; German Pediatric Renal Transplantation Study Group.

Transplantation. 2007 Apr 15;83(7):900-5.

PMID:
17460560
37.

Multi-organ affecting CMV-associated cryoglobulinemic vasculitis.

Kramer J, Hennig H, Lensing C, Krüger S, Helmchen U, Steinhoff J, Dodt C.

Clin Nephrol. 2006 Oct;66(4):284-90.

PMID:
17063996
38.

Massive bleeding after biopsy of a renal allograft.

Wenzel U, Helmchen U, Stahl RA, Nolte-Ernsting C.

Kidney Int. 2006 Apr;69(7):1101. No abstract available.

39.

Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury.

Panzer U, Steinmetz OM, Reinking RR, Meyer TN, Fehr S, Schneider A, Zahner G, Wolf G, Helmchen U, Schaerli P, Stahl RA, Thaiss F.

J Am Soc Nephrol. 2006 Feb;17(2):454-64. Epub 2005 Dec 28.

40.

BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection.

Steinmetz OM, Panzer U, Kneissler U, Harendza S, Lipp M, Helmchen U, Stahl RA.

Kidney Int. 2005 Apr;67(4):1616-21.

41.

Crescentic glomerulonephritis associated with myeloperoxidase-antineutrophil-cytoplasmic antibodies: first report on the efficacy of primary anti-TNF-alpha treatment.

Zaenker M, Arbach O, Helmchen U, Glorius P, Ludewig S, Braasch E.

Int J Tissue React. 2004;26(3-4):85-92. Erratum in: Int J Tissue React. 2005;27(1):39.

PMID:
15648440
42.

The chemokine receptor 5 Delta32 mutation is associated with increased renal survival in patients with IgA nephropathy.

Panzer U, Schneider A, Steinmetz OM, Wenzel U, Barth P, Reinking R, Becker JU, Harendza S, Zahner G, Fischereder M, Krämer BK, Schlöndorff D, Ostendorf T, Floege J, Helmchen U, Stahl RA.

Kidney Int. 2005 Jan;67(1):75-81. Erratum in: Kidney Int. 2005 Mar;67(3):1213. Krämer, Bernhard H [corrected to Krämer, Bernhard K].

43.

CXCR3 and CCR5 positive T-cell recruitment in acute human renal allograft rejection.

Panzer U, Reinking RR, Steinmetz OM, Zahner G, Sudbeck U, Fehr S, Pfalzer B, Schneider A, Thaiss F, Mack M, Conrad S, Huland H, Helmchen U, Stahl RA.

Transplantation. 2004 Nov 15;78(9):1341-50.

PMID:
15548973
44.

Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion.

Baldus S, Heitzer T, Eiserich JP, Lau D, Mollnau H, Ortak M, Petri S, Goldmann B, Duchstein HJ, Berger J, Helmchen U, Freeman BA, Meinertz T, Münzel T.

Free Radic Biol Med. 2004 Sep 15;37(6):902-11.

PMID:
15304260
45.

[Dysfunction of a kidney allograft with life-threatening results].

Harendza S, Ahrens M, Schneider A, Pfalzer B, Erbersdobler A, Helmchen U, Feller AC, Stahl RA.

Internist (Berl). 2004 May;45(5):592-6. German.

PMID:
15014890
46.

A 63-year-old man with acute abdominal pain and laboratory signs of rapid progressive renal disease.

Wolf G, Schneider C, Petri S, Helmchen U, Stahl RA.

Nephrol Dial Transplant. 2004 Mar;19(3):742-4. No abstract available.

PMID:
14767038
47.

No association of the -2518 MCP-1 A/G promoter polymorphism with incidence and clinical course of IgA nephropathy.

Steinmetz OM, Panzer U, Harendza S, Mertens PR, Ostendorf T, Floege J, Helmchen U, Stahl RA.

Nephrol Dial Transplant. 2004 Mar;19(3):596-601.

PMID:
14767014
48.

[Minimal Change Glomerulonephritis].

Stracke S, Helmchen U, Aymanns C, Kadlec N, Lindemann B, Hüttner S, Keller F.

Internist (Berl). 2003 Sep;44(9):1090-7. German.

PMID:
14566462
49.

Polyoma virus-associated interstitial nephritis in a patient with acute myeloic leukaemia and peripheral blood stem cell transplantation.

Stracke S, Helmchen U, von Müller L, Bunjes D, Keller F.

Nephrol Dial Transplant. 2003 Nov;18(11):2431-3. No abstract available.

PMID:
14551380
50.

Beneficial and adverse renal and vascular effects of the vasopeptidase inhibitor omapatrilat in renovascular hypertensive rats.

Wenzel UO, Wolf G, Jacob I, Schwegler C, Qasqas A, Amann K, Helmchen U, Stahl RA.

Nephrol Dial Transplant. 2003 Oct;18(10):2005-13.

PMID:
13679474

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