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Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence.

Do H, Makthal N, Chandrangsu P, Olsen RJ, Helmann JD, Musser JM, Kumaraswami M.

Nucleic Acids Res. 2019 Jun 12. pii: gkz524. doi: 10.1093/nar/gkz524. [Epub ahead of print]


Bacillus subtilis FolE is sustained by the ZagA zinc metallochaperone and the alarmone ZTP under conditions of zinc deficiency.

Chandrangsu P, Huang X, Gaballa A, Helmann JD.

Mol Microbiol. 2019 May 27. doi: 10.1111/mmi.14314. [Epub ahead of print]


Where to begin? Sigma factors and the selectivity of transcription initiation in bacteria.

Helmann JD.

Mol Microbiol. 2019 May 22. doi: 10.1111/mmi.14309. [Epub ahead of print] Review.


Identification of Novel Spx Regulatory Pathways in Bacillus subtilis Uncovers a Close Relationship between the CtsR and Spx Regulons.

Rojas-Tapias DF, Helmann JD.

J Bacteriol. 2019 Jun 10;201(13). pii: e00151-19. doi: 10.1128/JB.00151-19. Print 2019 Jul 1.


A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme.

Sachla AJ, Helmann JD.

Nat Commun. 2019 Apr 4;10(1):1526. doi: 10.1038/s41467-019-09508-z.


Deciphering the essentiality and function of the anti-σM factors in Bacillus subtilis.

Zhao H, Roistacher DM, Helmann JD.

Mol Microbiol. 2019 Feb 4. doi: 10.1111/mmi.14216. [Epub ahead of print]


A metabolic checkpoint protein GlmR is important for diverting carbon into peptidoglycan biosynthesis in Bacillus subtilis.

Patel V, Wu Q, Chandrangsu P, Helmann JD.

PLoS Genet. 2018 Sep 24;14(9):e1007689. doi: 10.1371/journal.pgen.1007689. eCollection 2018 Sep.


Stabilization of Bacillus subtilis Spx under cell wall stress requires the anti-adaptor protein YirB.

Rojas-Tapias DF, Helmann JD.

PLoS Genet. 2018 Jul 12;14(7):e1007531. doi: 10.1371/journal.pgen.1007531. eCollection 2018 Jul.


Aspartate deficiency limits peptidoglycan synthesis and sensitizes cells to antibiotics targeting cell wall synthesis in Bacillus subtilis.

Zhao H, Roistacher DM, Helmann JD.

Mol Microbiol. 2018 Sep;109(6):826-844. doi: 10.1111/mmi.14078. Epub 2018 Aug 20.


Antagonism of Two Plant-Growth Promoting Bacillus velezensis Isolates Against Ralstonia solanacearum and Fusarium oxysporum.

Cao Y, Pi H, Chandrangsu P, Li Y, Wang Y, Zhou H, Xiong H, Helmann JD, Cai Y.

Sci Rep. 2018 Mar 12;8(1):4360. doi: 10.1038/s41598-018-22782-z.


Induction of the Spx regulon by cell wall stress reveals novel regulatory mechanisms in Bacillus subtilis.

Rojas-Tapias DF, Helmann JD.

Mol Microbiol. 2018 Mar;107(5):659-674. doi: 10.1111/mmi.13906. Epub 2018 Jan 18.


Sequential induction of Fur-regulated genes in response to iron limitation in Bacillus subtilis.

Pi H, Helmann JD.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12785-12790. doi: 10.1073/pnas.1713008114. Epub 2017 Nov 13.


Modulation of extracytoplasmic function (ECF) sigma factor promoter selectivity by spacer region sequence.

Gaballa A, Guariglia-Oropeza V, Dürr F, Butcher BG, Chen AY, Chandrangsu P, Helmann JD.

Nucleic Acids Res. 2018 Jan 9;46(1):134-145. doi: 10.1093/nar/gkx953.


Don't let sleeping dogmas lie: new views of peptidoglycan synthesis and its regulation.

Zhao H, Patel V, Helmann JD, Dörr T.

Mol Microbiol. 2017 Dec;106(6):847-860. doi: 10.1111/mmi.13853. Epub 2017 Oct 26. Review.


Redox Sensing by Fe2+ in Bacterial Fur Family Metalloregulators.

Pinochet-Barros A, Helmann JD.

Antioxid Redox Signal. 2018 Dec 20;29(18):1858-1871. doi: 10.1089/ars.2017.7359. Epub 2017 Oct 31.


Ferrous iron efflux systems in bacteria.

Pi H, Helmann JD.

Metallomics. 2017 Jul 19;9(7):840-851. doi: 10.1039/c7mt00112f. Review.


A Critical Role of Zinc Importer AdcABC in Group A Streptococcus-Host Interactions During Infection and Its Implications for Vaccine Development.

Makthal N, Nguyen K, Do H, Gavagan M, Chandrangsu P, Helmann JD, Olsen RJ, Kumaraswami M.

EBioMedicine. 2017 Jul;21:131-141. doi: 10.1016/j.ebiom.2017.05.030. Epub 2017 Jun 2.


Corrigendum: Metal homeostasis and resistance in bacteria.

Chandrangsu P, Rensing C, Helmann JD.

Nat Rev Microbiol. 2017 May 12;15(6):379. doi: 10.1038/nrmicro.2017.53. No abstract available.


Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus Virulence.

VanderWal AR, Makthal N, Pinochet-Barros A, Helmann JD, Olsen RJ, Kumaraswami M.

Infect Immun. 2017 May 23;85(6). pii: e00091-17. doi: 10.1128/IAI.00091-17. Print 2017 Jun.


Metal homeostasis and resistance in bacteria.

Chandrangsu P, Rensing C, Helmann JD.

Nat Rev Microbiol. 2017 Jun;15(6):338-350. doi: 10.1038/nrmicro.2017.15. Epub 2017 Mar 27. Review. Erratum in: Nat Rev Microbiol. 2017 May 12;15(6):379.


The Role of Bacillithiol in Gram-Positive Firmicutes.

Chandrangsu P, Loi VV, Antelmann H, Helmann JD.

Antioxid Redox Signal. 2018 Feb 20;28(6):445-462. doi: 10.1089/ars.2017.7057. Epub 2017 Apr 24. Review.


Editorial: An Inaugural Series of Thematic MicroReviews from the BLAST Meeting.

Bourret R, Ottemann K, Helmann JD.

Mol Microbiol. 2017 Jan;103(2):195-196. doi: 10.1111/mmi.13600. No abstract available.


Lack of formylated methionyl-tRNA has pleiotropic effects on Bacillus subtilis.

Cai Y, Chandrangsu P, Gaballa A, Helmann JD.

Microbiology. 2017 Feb;163(2):185-196. doi: 10.1099/mic.0.000413. Epub 2017 Mar 9.


Intracellular Zn(II) Intoxication Leads to Dysregulation of the PerR Regulon Resulting in Heme Toxicity in Bacillus subtilis.

Chandrangsu P, Helmann JD.

PLoS Genet. 2016 Dec 9;12(12):e1006515. doi: 10.1371/journal.pgen.1006515. eCollection 2016 Dec.


Bacillus subtilis MntR coordinates the transcriptional regulation of manganese uptake and efflux systems.

Huang X, Shin JH, Pinochet-Barros A, Su TT, Helmann JD.

Mol Microbiol. 2017 Jan;103(2):253-268. doi: 10.1111/mmi.13554. Epub 2016 Nov 2.


Molecular logic of the Zur-regulated zinc deprivation response in Bacillus subtilis.

Shin JH, Helmann JD.

Nat Commun. 2016 Aug 26;7:12612. doi: 10.1038/ncomms12612.


Depletion of Undecaprenyl Pyrophosphate Phosphatases Disrupts Cell Envelope Biogenesis in Bacillus subtilis.

Zhao H, Sun Y, Peters JM, Gross CA, Garner EC, Helmann JD.

J Bacteriol. 2016 Oct 7;198(21):2925-2935. Print 2016 Nov 1.


The Listeria monocytogenes Fur-regulated virulence protein FrvA is an Fe(II) efflux P1B4 -type ATPase.

Pi H, Patel SJ, Argüello JM, Helmann JD.

Mol Microbiol. 2016 Jun;100(6):1066-79. doi: 10.1111/mmi.13368. Epub 2016 Apr 14.


Bacillus subtilis extracytoplasmic function (ECF) sigma factors and defense of the cell envelope.

Helmann JD.

Curr Opin Microbiol. 2016 Apr;30:122-132. doi: 10.1016/j.mib.2016.02.002. Epub 2016 Feb 20. Review.


Metalloregulator CueR biases RNA polymerase's kinetic sampling of dead-end or open complex to repress or activate transcription.

Martell DJ, Joshi CP, Gaballa A, Santiago AG, Chen TY, Jung W, Helmann JD, Chen P.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13467-72. doi: 10.1073/pnas.1515231112. Epub 2015 Oct 19.


PfeT, a P1B4 -type ATPase, effluxes ferrous iron and protects Bacillus subtilis against iron intoxication.

Guan G, Pinochet-Barros A, Gaballa A, Patel SJ, Argüello JM, Helmann JD.

Mol Microbiol. 2015 Nov;98(4):787-803. doi: 10.1111/mmi.13158. Epub 2015 Sep 10.


Molecular scribes in the spotlight: Methods for illuminating Bacterial and Archaeal transcription.

Helmann JD.

Methods. 2015 Sep 15;86:1-3. doi: 10.1016/j.ymeth.2015.07.007. Epub 2015 Jul 17. No abstract available.


Concentration- and chromosome-organization-dependent regulator unbinding from DNA for transcription regulation in living cells.

Chen TY, Santiago AG, Jung W, Krzemiński Ł, Yang F, Martell DJ, Helmann JD, Chen P.

Nat Commun. 2015 Jul 6;6:7445. doi: 10.1038/ncomms8445.


Staphylococcus aureus PerR Is a Hypersensitive Hydrogen Peroxide Sensor using Iron-mediated Histidine Oxidation.

Ji CJ, Kim JH, Won YB, Lee YE, Choi TW, Ju SY, Youn H, Helmann JD, Lee JW.

J Biol Chem. 2015 Aug 14;290(33):20374-86. doi: 10.1074/jbc.M115.664961. Epub 2015 Jul 1.


Mn(2+)-sensing mechanisms of yybP-ykoY orphan riboswitches.

Price IR, Gaballa A, Ding F, Helmann JD, Ke A.

Mol Cell. 2015 Mar 19;57(6):1110-1123. doi: 10.1016/j.molcel.2015.02.016.


Chemical proteomics reveals a second family of cyclic-di-AMP hydrolases.

Helmann JD.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):1921-2. doi: 10.1073/pnas.1500077112. Epub 2015 Jan 30. No abstract available.


Lipid-linked cell wall precursors regulate membrane association of bacterial actin MreB.

Schirner K, Eun YJ, Dion M, Luo Y, Helmann JD, Garner EC, Walker S.

Nat Chem Biol. 2015 Jan;11(1):38-45. doi: 10.1038/nchembio.1689. Epub 2014 Nov 17.


Bacillithiol is a major buffer of the labile zinc pool in Bacillus subtilis.

Ma Z, Chandrangsu P, Helmann TC, Romsang A, Gaballa A, Helmann JD.

Mol Microbiol. 2014 Nov;94(4):756-70. doi: 10.1111/mmi.12794. Epub 2014 Oct 7.


Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis.

Helmann JD.

J Biol Chem. 2014 Oct 10;289(41):28112-20. doi: 10.1074/jbc.R114.587071. Epub 2014 Aug 26. Review.


Mutations in the primary sigma factor σA and termination factor rho that reduce susceptibility to cell wall antibiotics.

Lee YH, Helmann JD.

J Bacteriol. 2014 Nov;196(21):3700-11. doi: 10.1128/JB.02022-14. Epub 2014 Aug 11.


Peptidoglycan recognition proteins kill bacteria by inducing oxidative, thiol, and metal stress.

Kashyap DR, Rompca A, Gaballa A, Helmann JD, Chan J, Chang CJ, Hozo I, Gupta D, Dziarski R.

PLoS Pathog. 2014 Jul 17;10(7):e1004280. doi: 10.1371/journal.ppat.1004280. eCollection 2014 Jul.


Cu(I)-mediated allosteric switching in a copper-sensing operon repressor (CsoR).

Chang FM, Coyne HJ, Cubillas C, Vinuesa P, Fang X, Ma Z, Ma D, Helmann JD, García-de los Santos A, Wang YX, Dann CE 3rd, Giedroc DP.

J Biol Chem. 2014 Jul 4;289(27):19204-17. doi: 10.1074/jbc.M114.556704. Epub 2014 May 15.


Accumulation of heptaprenyl diphosphate sensitizes Bacillus subtilis to bacitracin: implications for the mechanism of resistance mediated by the BceAB transporter.

Kingston AW, Zhao H, Cook GM, Helmann JD.

Mol Microbiol. 2014 Jul;93(1):37-49. doi: 10.1111/mmi.12637. Epub 2014 May 23.


Methylglyoxal resistance in Bacillus subtilis: contributions of bacillithiol-dependent and independent pathways.

Chandrangsu P, Dusi R, Hamilton CJ, Helmann JD.

Mol Microbiol. 2014 Feb;91(4):706-15. doi: 10.1111/mmi.12489. Epub 2014 Jan 7.


Redox regulation in Bacillus subtilis: The bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-bacillithiolated OhrR and MetE.

Gaballa A, Chi BK, Roberts AA, Becher D, Hamilton CJ, Antelmann H, Helmann JD.

Antioxid Redox Signal. 2014 Jul 20;21(3):357-67. doi: 10.1089/ars.2013.5327. Epub 2014 Mar 13.


Contributions of the σ(W) , σ(M) and σ(X) regulons to the lantibiotic resistome of Bacillus subtilis.

Kingston AW, Liao X, Helmann JD.

Mol Microbiol. 2013 Nov;90(3):502-18. doi: 10.1111/mmi.12380. Epub 2013 Sep 16.


Regulation of Bacillus subtilis bacillithiol biosynthesis operons by Spx.

Gaballa A, Antelmann H, Hamilton CJ, Helmann JD.

Microbiology. 2013 Oct;159(Pt 10):2025-35. doi: 10.1099/mic.0.070482-0. Epub 2013 Jul 26.


Reducing the Level of Undecaprenyl Pyrophosphate Synthase Has Complex Effects on Susceptibility to Cell Wall Antibiotics.

Lee YH, Helmann JD.

Antimicrob Agents Chemother. 2013 Sep;57(9):4267-4275. doi: 10.1128/AAC.00794-13. Epub 2013 Jun 24.


RaoN, a small RNA encoded within Salmonella pathogenicity island-11, confers resistance to macrophage-induced stress.

Lee YH, Kim S, Helmann JD, Kim BH, Park YK.

Microbiology. 2013 Jul;159(Pt 7):1366-78. doi: 10.1099/mic.0.066688-0. Epub 2013 May 8.

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