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Items: 22

1.

NHS-modified ethynylphosphonamidates enable the synthesis of configurationally defined protein conjugates.

Kasper MA, Gerlach M, Schneider AFL, Groneberg C, Ochtrop P, Boldt S, Schumacher D, Helma J, Leonhardt H, Christmann M, Hackenberger C.

Chembiochem. 2019 Oct 29. doi: 10.1002/cbic.201900587. [Epub ahead of print]

PMID:
31661184
2.

One-Step Fluorescent Protein Labeling by Tubulin Tyrosine Ligase.

Schumacher D, Leonhardt H, Hackenberger CPR, Helma J.

Methods Mol Biol. 2019;2033:167-189. doi: 10.1007/978-1-4939-9654-4_12.

PMID:
31332754
3.

Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates.

Kasper MA, Stengl A, Ochtrop P, Gerlach M, Stoschek T, Schumacher D, Helma J, Penkert M, Krause E, Leonhardt H, Hackenberger CPR.

Angew Chem Int Ed Engl. 2019 Aug 19;58(34):11631-11636. doi: 10.1002/anie.201904193. Epub 2019 Jul 18.

4.

Tubulin Tyrosine Ligase-Mediated Modification of Proteins.

Gerlach M, Stoschek T, Leonhardt H, Hackenberger CPR, Schumacher D, Helma J.

Methods Mol Biol. 2019;2012:327-355. doi: 10.1007/978-1-4939-9546-2_17.

PMID:
31161516
5.

TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles.

Stengl A, Gerlach M, Kasper MA, Hackenberger CPR, Leonhardt H, Schumacher D, Helma J.

Org Biomol Chem. 2019 May 28;17(20):4964-4969. doi: 10.1039/c9ob00508k. Epub 2019 Apr 1.

PMID:
30932115
6.

Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations.

Kasper MA, Glanz M, Stengl A, Penkert M, Klenk S, Sauer T, Schumacher D, Helma J, Krause E, Cardoso MC, Leonhardt H, Hackenberger CPR.

Angew Chem Int Ed Engl. 2019 Aug 19;58(34):11625-11630. doi: 10.1002/anie.201814715. Epub 2019 Apr 29.

PMID:
30828930
7.

FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers.

Effenberger M, Stengl A, Schober K, Gerget M, Kampick M, Müller TR, Schumacher D, Helma J, Leonhardt H, Busch DH.

J Immunol. 2019 Apr 1;202(7):2164-2171. doi: 10.4049/jimmunol.1801435. Epub 2019 Feb 13.

PMID:
30760621
8.

Nanoparticle mediated delivery and small molecule triggered activation of proteins in the nucleus.

Chiu HY, Bates JA, Helma J, Engelke H, Harz H, Bein T, Leonhardt H.

Nucleus. 2018;9(1):530-542. doi: 10.1080/19491034.2018.1523665.

9.

Tub-Tag Labeling; Chemoenzymatic Incorporation of Unnatural Amino Acids.

Helma J, Leonhardt H, Hackenberger CPR, Schumacher D.

Methods Mol Biol. 2018;1728:67-93. doi: 10.1007/978-1-4939-7574-7_4.

PMID:
29404991
10.

Nanobodies: Chemical Functionalization Strategies and Intracellular Applications.

Schumacher D, Helma J, Schneider AFL, Leonhardt H, Hackenberger CPR.

Angew Chem Int Ed Engl. 2018 Feb 23;57(9):2314-2333. doi: 10.1002/anie.201708459. Epub 2018 Jan 26. Review.

11.

Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling.

Schumacher D, Lemke O, Helma J, Gerszonowicz L, Waller V, Stoschek T, Durkin PM, Budisa N, Leonhardt H, Keller BG, Hackenberger CPR.

Chem Sci. 2017 May 1;8(5):3471-3478. doi: 10.1039/c7sc00574a. Epub 2017 Mar 20.

12.

A Simple and Sensitive High-Content Assay for the Characterization of Antiproliferative Therapeutic Antibodies.

Stengl A, Hörl D, Leonhardt H, Helma J.

SLAS Discov. 2017 Mar;22(3):309-315. doi: 10.1177/1087057116677821. Epub 2016 Dec 13.

13.

Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells.

Röder R, Helma J, Preiß T, Rädler JO, Leonhardt H, Wagner E.

Pharm Res. 2017 Jan;34(1):161-174. doi: 10.1007/s11095-016-2052-8. Epub 2016 Oct 31.

PMID:
27800572
14.

Intracellular chromobody delivery by mesoporous silica nanoparticles for antigen targeting and visualization in real time.

Chiu HY, Deng W, Engelke H, Helma J, Leonhardt H, Bein T.

Sci Rep. 2016 May 13;6:25019. doi: 10.1038/srep25019.

15.

Current Status: Site-Specific Antibody Drug Conjugates.

Schumacher D, Hackenberger CP, Leonhardt H, Helma J.

J Clin Immunol. 2016 May;36 Suppl 1:100-7. doi: 10.1007/s10875-016-0265-6. Epub 2016 Mar 22. Review.

16.

Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase.

Schumacher D, Helma J, Mann FA, Pichler G, Natale F, Krause E, Cardoso MC, Hackenberger CP, Leonhardt H.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13787-91. doi: 10.1002/anie.201505456. Epub 2015 Sep 25.

PMID:
26404067
17.

Nanobodies and recombinant binders in cell biology.

Helma J, Cardoso MC, Muyldermans S, Leonhardt H.

J Cell Biol. 2015 Jun 8;209(5):633-44. doi: 10.1083/jcb.201409074. Review.

18.

Visualization and targeted disruption of protein interactions in living cells.

Herce HD, Deng W, Helma J, Leonhardt H, Cardoso MC.

Nat Commun. 2013;4:2660. doi: 10.1038/ncomms3660.

19.

Direct and dynamic detection of HIV-1 in living cells.

Helma J, Schmidthals K, Lux V, Nüske S, Scholz AM, Kräusslich HG, Rothbauer U, Leonhardt H.

PLoS One. 2012;7(11):e50026. doi: 10.1371/journal.pone.0050026. Epub 2012 Nov 28.

20.

Magnetosome expression of functional camelid antibody fragments (nanobodies) in Magnetospirillum gryphiswaldense.

Pollithy A, Romer T, Lang C, Müller FD, Helma J, Leonhardt H, Rothbauer U, Schüler D.

Appl Environ Microbiol. 2011 Sep;77(17):6165-71. doi: 10.1128/AEM.05282-11. Epub 2011 Jul 15.

21.

Novel antibody derivatives for proteome and high-content analysis.

Schmidthals K, Helma J, Zolghadr K, Rothbauer U, Leonhardt H.

Anal Bioanal Chem. 2010 Aug;397(8):3203-8. doi: 10.1007/s00216-010-3657-0. Epub 2010 Apr 7.

22.

Modulation of protein properties in living cells using nanobodies.

Kirchhofer A, Helma J, Schmidthals K, Frauer C, Cui S, Karcher A, Pellis M, Muyldermans S, Casas-Delucchi CS, Cardoso MC, Leonhardt H, Hopfner KP, Rothbauer U.

Nat Struct Mol Biol. 2010 Jan;17(1):133-8. doi: 10.1038/nsmb.1727. Epub 2009 Dec 13.

PMID:
20010839

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