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Items: 15

1.

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.

Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger LJ, Arastu-Kapur S, Kaba S, Lee A, Ryder MI, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker GD, Reynolds EC, Faull RLM, Curtis MA, Dragunow M, Potempa J.

Sci Adv. 2019 Jan 23;5(1):eaau3333. doi: 10.1126/sciadv.aau3333. eCollection 2019 Jan.

2.

Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targeting Porphyromonas gingivalis.

Kamińska M, Aliko A, Hellvard A, Bielecka E, Binder V, Marczyk A, Potempa J, Delaleu N, Kantyka T, Mydel P.

J Periodontol. 2018 Dec 2. doi: 10.1002/JPER.18-0179. [Epub ahead of print]

PMID:
30506795
3.

Impact of fibrinogen carbamylation on fibrin clot formation and stability.

Binder V, Bergum B, Jaisson S, Gillery P, Scavenius C, Spriet E, Nyhaug AK, Roberts HM, Chapple ILC, Hellvard A, Delaleu N, Mydel P.

Thromb Haemost. 2017 May 3;117(5):899-910. doi: 10.1160/TH16-09-0704. Epub 2017 Apr 6.

4.

Effects by periodontitis on pristane-induced arthritis in rats.

Eriksson K, Lönnblom E, Tour G, Kats A, Mydel P, Georgsson P, Hultgren C, Kharlamova N, Norin U, Jönsson J, Lundmark A, Hellvard A, Lundberg K, Jansson L, Holmdahl R, Yucel-Lindberg T.

J Transl Med. 2016 Nov 3;14(1):311.

5.

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis.

Hellvard A, Zeitlmann L, Heiser U, Kehlen A, Niestroj A, Demuth HU, Koziel J, Delaleu N, Jan Potempa, Mydel P.

Sci Rep. 2016 Aug 11;6:31441. doi: 10.1038/srep31441.

6.

Carbamylated LL-37 as a modulator of the immune response.

Koro C, Hellvard A, Delaleu N, Binder V, Scavenius C, Bergum B, Główczyk I, Roberts HM, Chapple IL, Grant MM, Rapala-Kozik M, Klaga K, Enghild JJ, Potempa J, Mydel P.

Innate Immun. 2016 Apr;22(3):218-29. doi: 10.1177/1753425916631404. Epub 2016 Feb 15.

7.

Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.

Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.

Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442.

8.

Antibodies against carbamylated proteins are present in primary Sjögren's syndrome and are associated with disease severity.

Bergum B, Koro C, Delaleu N, Solheim M, Hellvard A, Binder V, Jonsson R, Valim V, Hammenfors DS, Jonsson MV, Mydel P.

Ann Rheum Dis. 2016 Aug;75(8):1494-500. doi: 10.1136/annrheumdis-2015-207751. Epub 2015 Sep 8.

9.

Carbamylation of immunoglobulin abrogates activation of the classical complement pathway.

Koro C, Bielecka E, Dahl-Knudsen A, Enghild JJ, Scavenius C, Brun JG, Binder V, Hellvard A, Bergum B, Jonsson R, Potempa J, Blom AM, Mydel P.

Eur J Immunol. 2014 Nov;44(11):3403-12. doi: 10.1002/eji.201444869. Epub 2014 Oct 20.

10.

The 2013 Nobel Prize in Physiology or Medicine.

Hellvard A, Mydel P.

Scand J Immunol. 2013 Dec;78(6):485. doi: 10.1111/sji.12124. No abstract available.

11.

Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD).

Maresz KJ, Hellvard A, Sroka A, Adamowicz K, Bielecka E, Koziel J, Gawron K, Mizgalska D, Marcinska KA, Benedyk M, Pyrc K, Quirke AM, Jonsson R, Alzabin S, Venables PJ, Nguyen KA, Mydel P, Potempa J.

PLoS Pathog. 2013 Sep;9(9):e1003627. doi: 10.1371/journal.ppat.1003627. Epub 2013 Sep 12.

12.

Glutaminyl cyclases as novel targets for the treatment of septic arthritis.

Hellvard A, Maresz K, Schilling S, Graubner S, Heiser U, Jonsson R, Cynis H, Demuth HU, Potempa J, Mydel P.

J Infect Dis. 2013 Mar 1;207(5):768-77. doi: 10.1093/infdis/jis729. Epub 2012 Nov 29.

13.

The N-methyl-d-aspartic acid receptor antagonist memantine ameliorates and delays the development of arthritis by enhancing regulatory T cells.

Lindblad SS, Mydel P, Hellvard A, Jonsson IM, Bokarewa MI.

Neurosignals. 2012;20(2):61-71. doi: 10.1159/000329551. Epub 2011 Dec 1.

14.

S100A4 deficiency is associated with efficient bacterial clearance and protects against joint destruction during Staphylococcal infection.

Bian L, Strzyz P, Jonsson IM, Erlandsson M, Hellvard A, Brisslert M, Ohlsson C, Ambartsumian N, Grigorian M, Bokarewa M.

J Infect Dis. 2011 Sep 1;204(5):722-30. doi: 10.1093/infdis/jir369.

PMID:
21844298
15.

Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis.

Mydel P, Wang Z, Brisslert M, Hellvard A, Dahlberg LE, Hazen SL, Bokarewa M.

J Immunol. 2010 Jun 15;184(12):6882-90. doi: 10.4049/jimmunol.1000075. Epub 2010 May 19.

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