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On the Horizon of Aging and Physical Activity Research.

Jakobi JM, Dempsey JA, Hellsten Y, Monette R, Kalmar JM.

Appl Physiol Nutr Metab. 2019 Jul 17. doi: 10.1139/apnm-2018-0738. [Epub ahead of print]


Muscle-strain injury exudate favors acute tissue healing and prolonged connective tissue formation in humans.

Bayer ML, Bang L, Hoegberget-Kalisz M, Svensson RB, Olesen JL, Karlsson MM, Schjerling P, Hellsten Y, Hoier B, Magnusson SP, Kjaer M.

FASEB J. 2019 Jun 18:fj201900542R. doi: 10.1096/fj.201900542R. [Epub ahead of print]


Regulatory Mechanisms of Estrogen on Vascular Ageing.

Novella S, Dantas AP, Hermenegildo C, Hellsten Y.

Oxid Med Cell Longev. 2019 Apr 28;2019:4859082. doi: 10.1155/2019/4859082. eCollection 2019. No abstract available.


The exercise timing hypothesis: can exercise training compensate for the reduction in blood vessel function after menopause if timed right?

Gliemann L, Hellsten Y.

J Physiol. 2019 May 11. doi: 10.1113/JP277056. [Epub ahead of print]


Cardiac perfusion and function after high-intensity exercise training in late premenopausal and recent postmenopausal women: an MRI study.

Egelund J, Nyberg M, Mandrup CM, Abdulla J, Stallknecht B, Bangsbo J, Hellsten Y, Larsson HBW.

J Appl Physiol (1985). 2019 May 1;126(5):1272-1280. doi: 10.1152/japplphysiol.01089.2017. Epub 2019 Mar 14.


Copenhagen Consensus statement 2019: physical activity and ageing.

Bangsbo J, Blackwell J, Boraxbekk CJ, Caserotti P, Dela F, Evans AB, Jespersen AP, Gliemann L, Kramer AF, Lundbye-Jensen J, Mortensen EL, Lassen AJ, Gow AJ, Harridge SDR, Hellsten Y, Kjaer M, Kujala UM, Rhodes RE, Pike ECJ, Skinner T, Skovgaard T, Troelsen J, Tulle E, Tully MA, van Uffelen JGZ, Viña J.

Br J Sports Med. 2019 Jul;53(14):856-858. doi: 10.1136/bjsports-2018-100451. Epub 2019 Feb 21.


The Endothelial Mechanotransduction Protein Platelet Endothelial Cell Adhesion Molecule-1 Is Influenced by Aging and Exercise Training in Human Skeletal Muscle.

Gliemann L, Rytter N, Piil P, Nilton J, Lind T, Nyberg M, Cocks M, Hellsten Y.

Front Physiol. 2018 Dec 18;9:1807. doi: 10.3389/fphys.2018.01807. eCollection 2018.


Reduced skeletal-muscle perfusion and impaired ATP release during hypoxia and exercise in individuals with type 2 diabetes.

Groen MB, Knudsen TA, Finsen SH, Pedersen BK, Hellsten Y, Mortensen SP.

Diabetologia. 2019 Mar;62(3):485-493. doi: 10.1007/s00125-018-4790-0. Epub 2019 Jan 3.


The effect of two exercise modalities on skeletal muscle capillary ultrastructure in individuals with type 2 diabetes.

Mortensen SP, Winding KM, Iepsen UW, Munch GW, Marcussen N, Hellsten Y, Pedersen BK, Baum O.

Scand J Med Sci Sports. 2019 Mar;29(3):360-368. doi: 10.1111/sms.13348. Epub 2019 Jan 4.


Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate.

Yafasova A, Mandrup CM, Egelund J, Nyberg M, Stallknecht B, Hellsten Y, Nielsen LB, Christoffersen C.

J Appl Physiol (1985). 2019 Jan 1;126(1):214-220. doi: 10.1152/japplphysiol.00527.2018. Epub 2018 Nov 15.


The effect of tyramine infusion and exercise on blood flow, coagulation and clot microstructure in healthy individuals.

Lawrence MJ, Davies G, Nyberg M, Whitley J, Evans V, Williams R, Hellsten Y, Evans PA.

Thromb Res. 2018 Oct;170:32-37. doi: 10.1016/j.thromres.2018.07.025. Epub 2018 Jul 27.


Leg blood flow and skeletal muscle microvascular perfusion responses to submaximal exercise in peripheral arterial disease.

Meneses AL, Nam MCY, Bailey TG, Magee R, Golledge J, Hellsten Y, Keske MA, Greaves K, Askew CD.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1425-H1433. doi: 10.1152/ajpheart.00232.2018. Epub 2018 Aug 10. Erratum in: Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H433.


High-intensity interval, but not endurance, training induces muscle fiber type-specific subsarcolemmal lipid droplet size reduction in type 2 diabetic patients.

Koh HE, Ørtenblad N, Winding KM, Hellsten Y, Mortensen SP, Nielsen J.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E872-E884. doi: 10.1152/ajpendo.00161.2018. Epub 2018 Jul 17.


Effect of endurance versus resistance training on local muscle and systemic inflammation and oxidative stress in COPD.

Ryrsø CK, Thaning P, Siebenmann C, Lundby C, Lange P, Pedersen BK, Hellsten Y, Iepsen UW.

Scand J Med Sci Sports. 2018 Nov;28(11):2339-2348. doi: 10.1111/sms.13227. Epub 2018 Jun 19.


Methods for the determination of skeletal muscle blood flow: development, strengths and limitations.

Gliemann L, Mortensen SP, Hellsten Y.

Eur J Appl Physiol. 2018 Jun;118(6):1081-1094. doi: 10.1007/s00421-018-3880-5. Epub 2018 May 14. Review.


Effects of aging and exercise training on leg hemodynamics and oxidative metabolism in the transition from rest to steady-state exercise: role of cGMP signaling.

Piil P, Jørgensen TS, Egelund J, Rytter N, Gliemann L, Bangsbo J, Hellsten Y, Nyberg M.

Am J Physiol Regul Integr Comp Physiol. 2018 Aug 1;315(2):R274-R283. doi: 10.1152/ajpregu.00446.2017. Epub 2018 Apr 18.


Regulation of bone blood flow in humans: The role of nitric oxide, prostaglandins, and adenosine.

Heinonen I, Boushel R, Hellsten Y, Kalliokoski K.

Scand J Med Sci Sports. 2018 May;28(5):1552-1558. doi: 10.1111/sms.13064. Epub 2018 Mar 7.


Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels.

Lundberg Slingsby MH, Gliemann L, Thrane M, Rytter N, Egelund J, Chan MV, Armstrong PC, Warner TD, Hellsten Y.

Acta Physiol (Oxf). 2018 May;223(1):e13028. doi: 10.1111/apha.13028. Epub 2018 Jan 19.


Probenecid Inhibits α-Adrenergic Receptor-Mediated Vasoconstriction in the Human Leg Vasculature.

Nyberg M, Piil P, Kiehn OT, Maagaard C, Jørgensen TS, Egelund J, Isakson BE, Nielsen MS, Gliemann L, Hellsten Y.

Hypertension. 2018 Jan;71(1):151-159. doi: 10.1161/HYPERTENSIONAHA.117.10251. Epub 2017 Oct 30.


Aerobic exercise training lowers platelet reactivity and improves platelet sensitivity to prostacyclin in pre- and postmenopausal women.

Lundberg Slingsby MH, Nyberg M, Egelund J, Mandrup CM, Frikke-Schmidt R, Kirkby NS, Hellsten Y.

J Thromb Haemost. 2017 Dec;15(12):2419-2431. doi: 10.1111/jth.13866. Epub 2017 Oct 27.


Exercise training improves blood flow to contracting skeletal muscle of older men via enhanced cGMP signaling.

Piil P, Smith Jørgensen T, Egelund J, Damsgaard R, Gliemann L, Hellsten Y, Nyberg M.

J Appl Physiol (1985). 2018 Jan 1;124(1):109-117. doi: 10.1152/japplphysiol.00634.2017. Epub 2017 Oct 5.


Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism.

Mandrup CM, Egelund J, Nyberg M, Enevoldsen LH, Kjær A, Clemmensen AE, Christensen AN, Suetta C, Frikke-Schmidt R, Steenberg DE, Wojtaszewski JFP, Hellsten Y, Stallknecht BM.

Menopause. 2018 Feb;25(2):165-175. doi: 10.1097/GME.0000000000000981.


Impact of β-adrenergic signaling in PGC-1α-mediated adaptations in mouse skeletal muscle.

Brandt N, Nielsen L, Thiellesen Buch B, Gudiksen A, Ringholm S, Hellsten Y, Bangsbo J, Pilegaard H.

Am J Physiol Endocrinol Metab. 2018 Jan 1;314(1):E1-E20. doi: 10.1152/ajpendo.00082.2017. Epub 2017 Sep 5.


Cardiac Adaptations to High-Intensity Aerobic Training in Premenopausal and Recent Postmenopausal Women: The Copenhagen Women Study.

Egelund J, Jørgensen PG, Mandrup CM, Fritz-Hansen T, Stallknecht B, Bangsbo J, Nyberg M, Hellsten Y.

J Am Heart Assoc. 2017 Aug 18;6(8). pii: e005469. doi: 10.1161/JAHA.117.005469.


Leg blood flow is impaired during small muscle mass exercise in patients with COPD.

Iepsen UW, Munch GW, Rugbjerg M, Ryrsø CK, Secher NH, Hellsten Y, Lange P, Pedersen BK, Thaning P, Mortensen SP.

J Appl Physiol (1985). 2017 Sep 1;123(3):624-631. doi: 10.1152/japplphysiol.00178.2017. Epub 2017 Jul 20.


Endothelial mechanotransduction proteins and vascular function are altered by dietary sucrose supplementation in healthy young male subjects.

Gliemann L, Rytter N, Lindskrog M, Slingsby MHL, Åkerström T, Sylow L, Richter EA, Hellsten Y.

J Physiol. 2017 Aug 15;595(16):5557-5571. doi: 10.1113/JP274623.


The effect of nitric oxide synthase inhibition with and without inhibition of prostaglandins on blood flow in different human skeletal muscles.

Heinonen I, Saltin B, Hellsten Y, Kalliokoski KK.

Eur J Appl Physiol. 2017 Jun;117(6):1175-1180. doi: 10.1007/s00421-017-3604-2. Epub 2017 Apr 21.


Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase.

Nyberg M, Egelund J, Mandrup CM, Andersen CB, Hansen KMBE, Hergel IF, Valbak-Andersen N, Frikke-Schmidt R, Stallknecht B, Bangsbo J, Hellsten Y.

J Physiol. 2017 May 1;595(9):2969-2983. doi: 10.1113/JP273871. Epub 2017 Mar 29.


Alpha adrenergic receptor blockade increases capillarization and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle.

Mortensen SP, Egginton S, Madsen M, Hansen JB, Munch GDW, Iepsen UW, Åkerström T, Pedersen BK, Hellsten Y.

Acta Physiol (Oxf). 2017 Sep;221(1):32-43. doi: 10.1111/apha.12857. Epub 2017 Apr 11.


Effects of high-intensity training on cardiovascular risk factors in premenopausal and postmenopausal women.

Mandrup CM, Egelund J, Nyberg M, Lundberg Slingsby MH, Andersen CB, Løgstrup S, Bangsbo J, Suetta C, Stallknecht B, Hellsten Y.

Am J Obstet Gynecol. 2017 Apr;216(4):384.e1-384.e11. doi: 10.1016/j.ajog.2016.12.017. Epub 2016 Dec 23.


Adaptations with Intermittent Exercise Training in Post- and Premenopausal Women.

Seidelin K, Nyberg M, Piil P, Jørgensen NR, Hellsten Y, Bangsbo J.

Med Sci Sports Exerc. 2017 Jan;49(1):96-105.


Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study.

Iepsen UW, Munch GD, Rugbjerg M, Rinnov AR, Zacho M, Mortensen SP, Secher NH, Ringbaek T, Pedersen BK, Hellsten Y, Lange P, Thaning P.

Int J Chron Obstruct Pulmon Dis. 2016 Oct 27;11:2659-2669. eCollection 2016.


Early Postmenopausal Phase Is Associated With Reduced Prostacyclin-Induced Vasodilation That Is Reversed by Exercise Training: The Copenhagen Women Study.

Nyberg M, Egelund J, Mandrup CM, Nielsen MB, Mogensen AS, Stallknecht B, Bangsbo J, Hellsten Y.

Hypertension. 2016 Oct;68(4):1011-20. doi: 10.1161/HYPERTENSIONAHA.116.07866. Epub 2016 Aug 22.


Effects of exercise training and resveratrol on vascular health in aging.

Gliemann L, Nyberg M, Hellsten Y.

Free Radic Biol Med. 2016 Sep;98:165-176. doi: 10.1016/j.freeradbiomed.2016.03.037. Epub 2016 Apr 13. Review.


Limitations of skeletal muscle oxygen supply in ageing.

Hellsten Y.

J Physiol. 2016 Apr 15;594(8):2259-60. doi: 10.1113/JP272062. No abstract available.


Capillary ultrastructure and mitochondrial volume density in skeletal muscle in relation to reduced exercise capacity of patients with intermittent claudication.

Baum O, Torchetti E, Malik C, Hoier B, Walker M, Walker PJ, Odriozola A, Graber F, Tschanz SA, Bangsbo J, Hoppeler H, Askew CD, Hellsten Y.

Am J Physiol Regul Integr Comp Physiol. 2016 May 15;310(10):R943-51. doi: 10.1152/ajpregu.00480.2015. Epub 2016 Mar 23.


Vasoactive enzymes and blood flow responses to passive and active exercise in peripheral arterial disease.

Walker MA, Hoier B, Walker PJ, Schulze K, Bangsbo J, Hellsten Y, Askew CD.

Atherosclerosis. 2016 Mar;246:98-105. doi: 10.1016/j.atherosclerosis.2015.12.029. Epub 2015 Dec 24.


Cardiovascular Adaptations to Exercise Training.

Hellsten Y, Nyberg M.

Compr Physiol. 2015 Dec 15;6(1):1-32. doi: 10.1002/cphy.c140080. Review.


Advances and challenges in skeletal muscle angiogenesis.

Olfert IM, Baum O, Hellsten Y, Egginton S.

Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H326-36. doi: 10.1152/ajpheart.00635.2015. Epub 2015 Nov 25. Review.


Vascular function in health, hypertension, and diabetes: effect of physical activity on skeletal muscle microcirculation.

Nyberg M, Gliemann L, Hellsten Y.

Scand J Med Sci Sports. 2015 Dec;25 Suppl 4:60-73. doi: 10.1111/sms.12591. Review.


Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle.

Akerstrom T, Vedel K, Needham J, Hojman P, Kontou E, Hellsten Y, Wojtaszewski JFP.

Biochem Biophys Rep. 2015 Oct 22;4:342-350. doi: 10.1016/j.bbrep.2015.10.007. eCollection 2015 Dec.


Effect of PDE5 inhibition on the modulation of sympathetic α-adrenergic vasoconstriction in contracting skeletal muscle of young and older recreationally active humans.

Nyberg M, Piil P, Egelund J, Sprague RS, Mortensen SP, Hellsten Y.

Am J Physiol Heart Circ Physiol. 2015 Dec 1;309(11):H1867-75. doi: 10.1152/ajpheart.00653.2015. Epub 2015 Oct 2.


Potentiation of cGMP signaling increases oxygen delivery and oxidative metabolism in contracting skeletal muscle of older but not young humans.

Nyberg M, Piil P, Egelund J, Sprague RS, Mortensen SP, Hellsten Y.

Physiol Rep. 2015 Aug;3(8). pii: e12508. doi: 10.14814/phy2.12508.


What turns off the angiogenic switch in skeletal muscle?

Hellsten Y, Hoier B, Gliemann L.

Exp Physiol. 2015 Jul 1;100(7):772-3. doi: 10.1113/EP085164. Review. No abstract available.


Reduced blood flow to contracting skeletal muscle in ageing humans: is it all an effect of sand through the hourglass?

Nyberg M, Hellsten Y.

J Physiol. 2016 Apr 15;594(8):2297-305. doi: 10.1113/JP270594. Epub 2015 Jul 5. Review.


Effects of Exercise Training on Regulation of Skeletal Muscle Glucose Metabolism in Elderly Men.

Biensø RS, Olesen J, Gliemann L, Schmidt JF, Matzen MS, Wojtaszewski JF, Hellsten Y, Pilegaard H.

J Gerontol A Biol Sci Med Sci. 2015 Jul;70(7):866-72. doi: 10.1093/gerona/glv012. Epub 2015 May 19.


Capillary growth, ultrastructure remodelling and exercise training in skeletal muscle of essential hypertensive patients.

Gliemann L, Buess R, Nyberg M, Hoppeler H, Odriozola A, Thaning P, Hellsten Y, Baum O, Mortensen SP.

Acta Physiol (Oxf). 2015 Jun;214(2):210-20. doi: 10.1111/apha.12501. Epub 2015 Apr 24.


Bengt Saltin (1935-2014).

Bangsbo J, Kjær M, Hellsten Y.

J Physiol. 2014 Dec 1;592(23):5149-51. doi: 10.1113/jphysiol.2014.285411. No abstract available.


10-20-30 training increases performance and lowers blood pressure and VEGF in runners.

Gliemann L, Gunnarsson TP, Hellsten Y, Bangsbo J.

Scand J Med Sci Sports. 2015 Oct;25(5):e479-89. doi: 10.1111/sms.12356. Epub 2014 Dec 1.


Capillary growth in human skeletal muscle: physiological factors and the balance between pro-angiogenic and angiostatic factors.

Hellsten Y, Hoier B.

Biochem Soc Trans. 2014 Dec;42(6):1616-22. doi: 10.1042/BST20140197. Review.


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