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Items: 1 to 50 of 57

1.

Novel Antibody Drug Conjugates Targeting Tumor-Associated Receptor Tyrosine Kinase ROR2 by Functional Screening of Fully Human Antibody Libraries Using Transpo-mAb Display on Progenitor B Cells.

Hellmann I, Waldmeier L, Bannwarth-Escher MC, Maslova K, Wolter FI, Grawunder U, Beerli RR.

Front Immunol. 2018 Nov 2;9:2490. doi: 10.3389/fimmu.2018.02490. eCollection 2018.

2.

Human immunodeficiency virus 1 dual-target nucleic acid technology improves blood safety: 5 years of experience of the German Red Cross blood donor service Baden-Württemberg-Hessen.

Hourfar K, Eberle J, Müller M, Micha Nübling C, Chudy M, Kress J, Gürtler L, Mayr-Wohlfart U, Schrezenmeier H, Hellmann I, Luhm J, Kraas S, Ringwald J, Gubbe K, Frank K, Karl A, Tonn T, Jaeger M, Sireis W, Seifried E, Schmidt M.

Transfusion. 2018 Dec;58(12):2886-2893. doi: 10.1111/trf.14919. Epub 2018 Oct 16.

PMID:
30325043
3.

THE GERMAN DOSE RATE MONITORING NETWORK AND IMPLEMENTED DATA HARMONIZATION TECHNIQUES.

Stöhlker U, Bleher M, Doll H, Dombrowski H, Harms W, Hellmann I, Luff R, Prommer B, Seifert S, Weiler F.

Radiat Prot Dosimetry. 2018 Oct 1. doi: 10.1093/rpd/ncy154. [Epub ahead of print]

PMID:
30272224
4.

Sensitive and powerful single-cell RNA sequencing using mcSCRB-seq.

Bagnoli JW, Ziegenhain C, Janjic A, Wange LE, Vieth B, Parekh S, Geuder J, Hellmann I, Enard W.

Nat Commun. 2018 Jul 26;9(1):2937. doi: 10.1038/s41467-018-05347-6.

5.

zUMIs - A fast and flexible pipeline to process RNA sequencing data with UMIs.

Parekh S, Ziegenhain C, Vieth B, Enard W, Hellmann I.

Gigascience. 2018 Jun 1;7(6). doi: 10.1093/gigascience/giy059.

6.

Quantitative single-cell transcriptomics.

Ziegenhain C, Vieth B, Parekh S, Hellmann I, Enard W.

Brief Funct Genomics. 2018 Jul 1;17(4):220-232. doi: 10.1093/bfgp/ely009.

7.

Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients.

Greif PA, Hartmann L, Vosberg S, Stief SM, Mattes R, Hellmann I, Metzeler KH, Herold T, Bamopoulos SA, Kerbs P, Jurinovic V, Schumacher D, Pastore F, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Graf A, Krebs S, Blum H, Neumann M, Baldus CD, Bohlander SK, Wolf S, Görlich D, Berdel WE, Wörmann BJ, Hiddemann W, Spiekermann K.

Clin Cancer Res. 2018 Apr 1;24(7):1716-1726. doi: 10.1158/1078-0432.CCR-17-2344. Epub 2018 Jan 12.

PMID:
29330206
8.

powsimR: power analysis for bulk and single cell RNA-seq experiments.

Vieth B, Ziegenhain C, Parekh S, Enard W, Hellmann I.

Bioinformatics. 2017 Nov 1;33(21):3486-3488. doi: 10.1093/bioinformatics/btx435.

PMID:
29036287
9.

Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters.

Cremer M, Schmid VJ, Kraus F, Markaki Y, Hellmann I, Maiser A, Leonhardt H, John S, Stamatoyannopoulos J, Cremer T.

Epigenetics Chromatin. 2017 Aug 7;10(1):39. doi: 10.1186/s13072-017-0146-0.

10.

L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins.

Zhang P, Ludwig AK, Hastert FD, Rausch C, Lehmkuhl A, Hellmann I, Smets M, Leonhardt H, Cardoso MC.

Nucleus. 2017 Sep 3;8(5):548-562. doi: 10.1080/19491034.2017.1330238. Epub 2017 May 19.

11.

Comparative Analysis of Single-Cell RNA Sequencing Methods.

Ziegenhain C, Vieth B, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I, Enard W.

Mol Cell. 2017 Feb 16;65(4):631-643.e4. doi: 10.1016/j.molcel.2017.01.023.

12.

Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise.

Ludwig AK, Zhang P, Hastert FD, Meyer S, Rausch C, Herce HD, Müller U, Lehmkuhl A, Hellmann I, Trummer C, Storm C, Leonhardt H, Cardoso MC.

Nucleic Acids Res. 2017 Mar 17;45(5):2438-2457. doi: 10.1093/nar/gkw1197.

13.

Cytosine arabinoside and daunorubicin induction therapy in a patient with acute myeloid leukemia on chronic hemodialysis.

Krashin E, Dolberg OJ, Hellmann I, Huitema AD, Rosing H, Ellis M.

Anticancer Drugs. 2016 Sep;27(8):800-3. doi: 10.1097/CAD.0000000000000382.

PMID:
27254285
14.

The impact of amplification on differential expression analyses by RNA-seq.

Parekh S, Ziegenhain C, Vieth B, Enard W, Hellmann I.

Sci Rep. 2016 May 9;6:25533. doi: 10.1038/srep25533.

15.

SweepFinder2: increased sensitivity, robustness and flexibility.

DeGiorgio M, Huber CD, Hubisz MJ, Hellmann I, Nielsen R.

Bioinformatics. 2016 Jun 15;32(12):1895-7. doi: 10.1093/bioinformatics/btw051. Epub 2016 Feb 15.

PMID:
27153702
16.

Transpo-mAb display: Transposition-mediated B cell display and functional screening of full-length IgG antibody libraries.

Waldmeier L, Hellmann I, Gutknecht CK, Wolter FI, Cook SC, Reddy ST, Grawunder U, Beerli RR.

MAbs. 2016 May-Jun;8(4):726-40. doi: 10.1080/19420862.2016.1160990. Epub 2016 Mar 17.

17.

Estimating the terrestrial gamma dose rate by decomposition of the ambient dose equivalent rate.

Bossew P, Cinelli G, Hernández-Ceballos M, Cernohlawek N, Gruber V, Dehandschutter B, Menneson F, Bleher M, Stöhlker U, Hellmann I, Weiler F, Tollefsen T, Tognoli PV, de Cort M.

J Environ Radioact. 2017 Jan;166(Pt 2):296-308. doi: 10.1016/j.jenvrad.2016.02.013. Epub 2016 Feb 28.

PMID:
26926960
18.

Prospective comparison of early bone marrow evaluation on day 5 versus day 14 of the "3 + 7" induction regimen for acute myeloid leukemia.

Ofran Y, Leiba R, Ganzel C, Saban R, Gatt M, Ram R, Arad A, Bulvik S, Hellmann I, Gino-Moor S, Zuckerman T, Hoffman R, Horowitz N, Lavi N, Ringelstein S, Henig I, Hayun M, Rowe JM.

Am J Hematol. 2015 Dec;90(12):1159-64. doi: 10.1002/ajh.24207. Epub 2015 Nov 17.

19.

Detecting recent selective sweeps while controlling for mutation rate and background selection.

Huber CD, DeGiorgio M, Hellmann I, Nielsen R.

Mol Ecol. 2016 Jan;25(1):142-56. doi: 10.1111/mec.13351. Epub 2015 Sep 7.

20.

Higher infection rate after 7- compared with 5-day cycle of azacitidine in patients with higher-risk myelodysplastic syndrome.

Ofran Y, Filanovsky K, Gafter-Gvili A, Vidal L, Aviv A, Gatt ME, Silbershatz I, Herishanu Y, Arad A, Tadmor T, Dally N, Nemets A, Rouvio O, Ronson A, Herzog-Tzarfati K, Akria L, Braester A, Hellmann I, Yeganeh S, Nagler A, Leiba R, Mittelman M, Merkel D.

Clin Lymphoma Myeloma Leuk. 2015 Jun;15(6):e95-9. doi: 10.1016/j.clml.2015.02.030. Epub 2015 Mar 5.

PMID:
25819366
21.

Quantitative assessment of the robustness of next-generation sequencing of antibody variable gene repertoires from immunized mice.

Greiff V, Menzel U, Haessler U, Cook SC, Friedensohn S, Khan TA, Pogson M, Hellmann I, Reddy ST.

BMC Immunol. 2014 Oct 16;15:40. doi: 10.1186/s12865-014-0040-5.

22.

Keeping it local: evidence for positive selection in Swedish Arabidopsis thaliana.

Huber CD, Nordborg M, Hermisson J, Hellmann I.

Mol Biol Evol. 2014 Nov;31(11):3026-39. doi: 10.1093/molbev/msu247. Epub 2014 Aug 25.

23.

Comprehensive evaluation and optimization of amplicon library preparation methods for high-throughput antibody sequencing.

Menzel U, Greiff V, Khan TA, Haessler U, Hellmann I, Friedensohn S, Cook SC, Pogson M, Reddy ST.

PLoS One. 2014 May 8;9(5):e96727. doi: 10.1371/journal.pone.0096727. eCollection 2014.

24.

The complete genome sequence of a Neanderthal from the Altai Mountains.

Prüfer K, Racimo F, Patterson N, Jay F, Sankararaman S, Sawyer S, Heinze A, Renaud G, Sudmant PH, de Filippo C, Li H, Mallick S, Dannemann M, Fu Q, Kircher M, Kuhlwilm M, Lachmann M, Meyer M, Ongyerth M, Siebauer M, Theunert C, Tandon A, Moorjani P, Pickrell J, Mullikin JC, Vohr SH, Green RE, Hellmann I, Johnson PL, Blanche H, Cann H, Kitzman JO, Shendure J, Eichler EE, Lein ES, Bakken TE, Golovanova LV, Doronichev VB, Shunkov MV, Derevianko AP, Viola B, Slatkin M, Reich D, Kelso J, Pääbo S.

Nature. 2014 Jan 2;505(7481):43-9. doi: 10.1038/nature12886. Epub 2013 Dec 18.

25.

Massive genomic variation and strong selection in Arabidopsis thaliana lines from Sweden.

Long Q, Rabanal FA, Meng D, Huber CD, Farlow A, Platzer A, Zhang Q, Vilhjálmsson BJ, Korte A, Nizhynska V, Voronin V, Korte P, Sedman L, Mandáková T, Lysak MA, Seren Ü, Hellmann I, Nordborg M.

Nat Genet. 2013 Aug;45(8):884-890. doi: 10.1038/ng.2678. Epub 2013 Jun 23.

26.
27.

Predicting infections in high-risk patients with myelodysplastic syndrome/acute myeloid leukemia treated with azacitidine: a retrospective multicenter study.

Merkel D, Filanovsky K, Gafter-Gvili A, Vidal L, Aviv A, Gatt ME, Silbershatz I, Herishanu Y, Arad A, Tadmor T, Dally N, Nemets A, Rouvio O, Ronson A, Herzog-Tzarfati K, Akria L, Braester A, Hellmann I, Yeganeh S, Nagler A, Leiba R, Mittelman M, Ofran Y.

Am J Hematol. 2013 Feb;88(2):130-4. doi: 10.1002/ajh.23368.

28.

Activating KIR copy number variation is associated with granzyme B release by NK cells during primary simian immunodeficiency virus infection in rhesus monkeys.

Hellmann I, Schmitz JE, Letvin NL.

J Virol. 2012 Dec;86(23):13103-7. doi: 10.1128/JVI.00325-12. Epub 2012 Sep 26.

29.

The bonobo genome compared with the chimpanzee and human genomes.

Prüfer K, Munch K, Hellmann I, Akagi K, Miller JR, Walenz B, Koren S, Sutton G, Kodira C, Winer R, Knight JR, Mullikin JC, Meader SJ, Ponting CP, Lunter G, Higashino S, Hobolth A, Dutheil J, Karakoç E, Alkan C, Sajjadian S, Catacchio CR, Ventura M, Marques-Bonet T, Eichler EE, André C, Atencia R, Mugisha L, Junhold J, Patterson N, Siebauer M, Good JM, Fischer A, Ptak SE, Lachmann M, Symer DE, Mailund T, Schierup MH, Andrés AM, Kelso J, Pääbo S.

Nature. 2012 Jun 28;486(7404):527-31. doi: 10.1038/nature11128.

30.

Association of activating KIR copy number variation of NK cells with containment of SIV replication in rhesus monkeys.

Hellmann I, Lim SY, Gelman RS, Letvin NL.

PLoS Pathog. 2011 Dec;7(12):e1002436. doi: 10.1371/journal.ppat.1002436. Epub 2011 Dec 15. Erratum in: PLoS Pathog. 2012 Sep;8(9). doi:10.1371/annotation/03a74287-7d68-483d-858b-ae8f3b3df54a.

31.

Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.

Lohmueller KE, Albrechtsen A, Li Y, Kim SY, Korneliussen T, Vinckenbosch N, Tian G, Huerta-Sanchez E, Feder AF, Grarup N, Jørgensen T, Jiang T, Witte DR, Sandbæk A, Hellmann I, Lauritzen T, Hansen T, Pedersen O, Wang J, Nielsen R.

PLoS Genet. 2011 Oct;7(10):e1002326. doi: 10.1371/journal.pgen.1002326. Epub 2011 Oct 13.

32.

A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity.

Asmal M, Hellmann I, Liu W, Keele BF, Perelson AS, Bhattacharya T, Gnanakaran S, Daniels M, Haynes BF, Korber BT, Hahn BH, Shaw GM, Letvin NL.

PLoS One. 2011;6(8):e23673. doi: 10.1371/journal.pone.0023673. Epub 2011 Aug 18.

33.

Mutation rate distribution inferred from coincident SNPs and coincident substitutions.

Johnson PL, Hellmann I.

Genome Biol Evol. 2011;3:842-50. doi: 10.1093/gbe/evr044. Epub 2011 May 13.

34.

Prevention of venous thromboembolism in medical patients: recent advances and future directions.

Hellmann I, Ellis MH.

Isr Med Assoc J. 2009 Dec;11(12):753-7. Review. No abstract available.

35.

Population genetic inference from genomic sequence variation.

Pool JE, Hellmann I, Jensen JD, Nielsen R.

Genome Res. 2010 Mar;20(3):291-300. doi: 10.1101/gr.079509.108. Epub 2010 Jan 12. Review.

36.

Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx).

Xia Q, Guo Y, Zhang Z, Li D, Xuan Z, Li Z, Dai F, Li Y, Cheng D, Li R, Cheng T, Jiang T, Becquet C, Xu X, Liu C, Zha X, Fan W, Lin Y, Shen Y, Jiang L, Jensen J, Hellmann I, Tang S, Zhao P, Xu H, Yu C, Zhang G, Li J, Cao J, Liu S, He N, Zhou Y, Liu H, Zhao J, Ye C, Du Z, Pan G, Zhao A, Shao H, Zeng W, Wu P, Li C, Pan M, Li J, Yin X, Li D, Wang J, Zheng H, Wang W, Zhang X, Li S, Yang H, Lu C, Nielsen R, Zhou Z, Wang J, Xiang Z, Wang J.

Science. 2009 Oct 16;326(5951):433-6. doi: 10.1126/science.1176620. Epub 2009 Aug 27.

37.

The effects of probe binding affinity differences on gene expression measurements and how to deal with them.

Dannemann M, Lorenc A, Hellmann I, Khaitovich P, Lachmann M.

Bioinformatics. 2009 Nov 1;25(21):2772-9. doi: 10.1093/bioinformatics/btp492. Epub 2009 Aug 18.

PMID:
19689957
38.

Linkage disequilibrium extends across putative selected sites in FOXP2.

Ptak SE, Enard W, Wiebe V, Hellmann I, Krause J, Lachmann M, Pääbo S.

Mol Biol Evol. 2009 Oct;26(10):2181-4. doi: 10.1093/molbev/msp143. Epub 2009 Jul 16.

PMID:
19608635
39.

Darwinian and demographic forces affecting human protein coding genes.

Nielsen R, Hubisz MJ, Hellmann I, Torgerson D, Andrés AM, Albrechtsen A, Gutenkunst R, Adams MD, Cargill M, Boyko A, Indap A, Bustamante CD, Clark AG.

Genome Res. 2009 May;19(5):838-49. doi: 10.1101/gr.088336.108. Epub 2009 Mar 11.

40.

The diploid genome sequence of an Asian individual.

Wang J, Wang W, Li R, Li Y, Tian G, Goodman L, Fan W, Zhang J, Li J, Zhang J, Guo Y, Feng B, Li H, Lu Y, Fang X, Liang H, Du Z, Li D, Zhao Y, Hu Y, Yang Z, Zheng H, Hellmann I, Inouye M, Pool J, Yi X, Zhao J, Duan J, Zhou Y, Qin J, Ma L, Li G, Yang Z, Zhang G, Yang B, Yu C, Liang F, Li W, Li S, Li D, Ni P, Ruan J, Li Q, Zhu H, Liu D, Lu Z, Li N, Guo G, Zhang J, Ye J, Fang L, Hao Q, Chen Q, Liang Y, Su Y, San A, Ping C, Yang S, Chen F, Li L, Zhou K, Zheng H, Ren Y, Yang L, Gao Y, Yang G, Li Z, Feng X, Kristiansen K, Wong GK, Nielsen R, Durbin R, Bolund L, Zhang X, Li S, Yang H, Wang J.

Nature. 2008 Nov 6;456(7218):60-5. doi: 10.1038/nature07484.

41.

Field and temperature dependence of the superfluid density in LaFeAsO1-xFx superconductors: a muon spin relaxation study.

Luetkens H, Klauss HH, Khasanov R, Amato A, Klingeler R, Hellmann I, Leps N, Kondrat A, Hess C, Köhler A, Behr G, Werner J, Büchner B.

Phys Rev Lett. 2008 Aug 29;101(9):097009. Epub 2008 Aug 29.

PMID:
18851647
42.

Structure and electronic properties of Li-doped vanadium oxide nanotubes.

Hellmann I, Täschner Ch, Klingeler R, Leonhardt A, Büchner B, Knupfer M.

J Chem Phys. 2008 Jun 14;128(22):224701. doi: 10.1063/1.2931542.

PMID:
18554037
43.

Population genetic analysis of shotgun assemblies of genomic sequences from multiple individuals.

Hellmann I, Mang Y, Gu Z, Li P, de la Vega FM, Clark AG, Nielsen R.

Genome Res. 2008 Jul;18(7):1020-9. doi: 10.1101/gr.074187.107. Epub 2008 Apr 14.

44.

Recent and ongoing selection in the human genome.

Nielsen R, Hellmann I, Hubisz M, Bustamante C, Clark AG.

Nat Rev Genet. 2007 Nov;8(11):857-68. Review.

45.

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome.

Weber M, Hellmann I, Stadler MB, Ramos L, Pääbo S, Rebhan M, Schübeler D.

Nat Genet. 2007 Apr;39(4):457-66. Epub 2007 Mar 4.

PMID:
17334365
46.

Positive selection on gene expression in the human brain.

Khaitovich P, Tang K, Franz H, Kelso J, Hellmann I, Enard W, Lachmann M, Pääbo S.

Curr Biol. 2006 May 23;16(10):R356-8. Epub 2006 Apr 20. No abstract available.

47.

Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees.

Khaitovich P, Hellmann I, Enard W, Nowick K, Leinweber M, Franz H, Weiss G, Lachmann M, Pääbo S.

Science. 2005 Sep 16;309(5742):1850-4. Epub 2005 Sep 1.

48.

Why do human diversity levels vary at a megabase scale?

Hellmann I, Prüfer K, Ji H, Zody MC, Pääbo S, Ptak SE.

Genome Res. 2005 Sep;15(9):1222-31.

49.

Time-dependent changes of hs-CRP serum concentration in patients with non-ST elevation acute coronary syndrome.

Jahn J, Hellmann I, Maass M, Giannitsis E, Dalhoff K, Katus HA.

Herz. 2004 Dec;29(8):795-801.

PMID:
15599677
50.

Human versus chimpanzee chromosome-wide sequence comparison and its evolutionary implication.

Sakaki Y, Watanabe H, Taylor T, Hattori M, Fujiyama A, Toyoda A, Kuroki Y, Itoh T, Saitou N, Oota S, Kim CG, Kitano T, Lehrach H, Yaspo ML, Sudbrak R, Kahla A, Reinhardt R, Kube M, Platzer M, Taenzer S, Galgoczy P, Kel A, Blöecker H, Scharfe M, Nordsiek G, Hellmann I, Khaitovich P, Pääbo S, Chen Z, Wang SY, Ren SX, Zhang XL, Zheng HJ, Zhu GF, Wang BF, Zhao GP, Tsai SF, Wu K, Liu TT, Hsiao KJ, Park HS, Lee YS, Cheong JE, Choi SH; Chimpanzee Chromosome 22 Sequencing Consortium.

Cold Spring Harb Symp Quant Biol. 2003;68:455-60. No abstract available.

PMID:
15338648

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