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Items: 1 to 50 of 527

1.

Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3.

Fu Z, Akula S, Thorpe M, Hellman L.

Int J Mol Sci. 2020 Jan 19;21(2). pii: E651. doi: 10.3390/ijms21020651.

2.

Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity.

Akula S, Paivandy A, Fu Z, Thorpe M, Pejler G, Hellman L.

Cells. 2020 Jan 14;9(1). pii: E211. doi: 10.3390/cells9010211.

3.

Extended cleavage specificities of two mast cell chymase-related proteases and one granzyme B-like protease from the platypus, a monotreme.

Fu Z, Akula S, Thorpe M, Hellman L.

Int J Mol Sci. 2020 Jan 2;21(1). pii: E319. doi: 10.3390/ijms21010319.

4.

Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Grujic M, Hellman L, Gustafson AM, Akula S, Melo FR, Pejler G.

Pigment Cell Melanoma Res. 2020 Jan 1. doi: 10.1111/pcmr.12859. [Epub ahead of print]

PMID:
31894627
5.

Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases.

Zhongwei Y, Akula S, Fu Z, de Garavilla L, Kervinen J, Thorpe M, Hellman L.

Int J Mol Sci. 2019 Dec 16;20(24). pii: E6340. doi: 10.3390/ijms20246340.

6.
7.

Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium.

Hallgren J, Hellman L, Maurer M, Nilsson GP, Wernersson S, Åbrink M, Pejler G.

Allergy. 2019 Sep 26. doi: 10.1111/all.14065. [Epub ahead of print] No abstract available.

PMID:
31557323
8.

Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility.

Ayres CM, Abualrous ET, Bailey A, Abraham C, Hellman LM, Corcelli SA, Noé F, Elliott T, Baker BM.

Front Immunol. 2019 May 3;10:966. doi: 10.3389/fimmu.2019.00966. eCollection 2019.

9.

Improving T Cell Receptor On-Target Specificity via Structure-Guided Design.

Hellman LM, Foley KC, Singh NK, Alonso JA, Riley TP, Devlin JR, Ayres CM, Keller GLJ, Zhang Y, Vander Kooi CW, Nishimura MI, Baker BM.

Mol Ther. 2019 Feb 6;27(2):300-313. doi: 10.1016/j.ymthe.2018.12.010. Epub 2018 Dec 14.

10.

Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5.

Thorpe M, Fu Z, Albat E, Akula S, de Garavilla L, Kervinen J, Hellman L.

PLoS One. 2018 Dec 6;13(12):e0207826. doi: 10.1371/journal.pone.0207826. eCollection 2018.

11.

Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues.

Fu Z, Akula S, Thorpe M, Chahal G, de Garavilla L, Kervinen J, Hellman L.

Dev Comp Immunol. 2019 Mar;92:160-169. doi: 10.1016/j.dci.2018.11.019. Epub 2018 Nov 24.

PMID:
30481523
12.
13.

Cleavage specificity of recombinant Giardia intestinalis cysteine proteases: Degradation of immunoglobulins and defensins.

Liu J, Fu Z, Hellman L, Svärd SG.

Mol Biochem Parasitol. 2019 Jan;227:29-38. doi: 10.1016/j.molbiopara.2018.10.004. Epub 2018 Nov 17.

PMID:
30458129
14.

Time to include burden of surgical injuries after disasters in the Global Surgery agenda? An assessment of DALYs and averted burden by surgery after the 2008 Wenchuan earthquake.

Rodriguez-Llanes JM, Hellman L, Wu Q, van den Oever B, Pan L, Albela Miranda M, Chen G, Zhang DS, Guha-Sapir D, Von Schreeb J.

BMJ Glob Health. 2018 Oct 1;3(5):e000909. doi: 10.1136/bmjgh-2018-000909. eCollection 2018.

15.

T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability.

Riley TP, Hellman LM, Gee MH, Mendoza JL, Alonso JA, Foley KC, Nishimura MI, Vander Kooi CW, Garcia KC, Baker BM.

Nat Chem Biol. 2018 Oct;14(10):934-942. doi: 10.1038/s41589-018-0130-4. Epub 2018 Sep 17.

16.

Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.

Liu J, Ma'ayeh S, Peirasmaki D, Lundström-Stadelmann B, Hellman L, Svärd SG.

Virulence. 2018 Dec 31;9(1):879-894. doi: 10.1080/21505594.2018.1451284.

17.

Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities.

Thorpe M, Fu Z, Chahal G, Akula S, Kervinen J, de Garavilla L, Hellman L.

PLoS One. 2018 Apr 13;13(4):e0195077. doi: 10.1371/journal.pone.0195077. eCollection 2018.

18.

Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells.

Spear TT, Wang Y, Smith TW Jr, Simms PE, Garrett-Mayer E, Hellman LM, Baker BM, Nishimura MI.

Mol Ther. 2018 Apr 4;26(4):996-1007. doi: 10.1016/j.ymthe.2018.01.015. Epub 2018 Feb 2.

19.

Tracing the Origins of IgE, Mast Cells, and Allergies by Studies of Wild Animals.

Hellman LT, Akula S, Thorpe M, Fu Z.

Front Immunol. 2017 Dec 19;8:1749. doi: 10.3389/fimmu.2017.01749. eCollection 2017. Review.

20.

Correction to: Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.

Moore T, Wagner CR, Scurti GM, Hutchens KA, Godellas C, Clark AL, Kolawole EM, Hellman LM, Singh NK, Huyke FA, Wang SY, Calabrese KM, Embree HD, Orentas R, Shirai K, Dellacecca E, Garrett-Mayer E, Li M, Eby JM, Stiff PJ, Evavold BD, Baker BM, Le Poole IC, Dropulic B, Clark JI, Nishimura MI.

Cancer Immunol Immunother. 2018 Feb;67(2):327. doi: 10.1007/s00262-017-2102-z.

PMID:
29264697
21.

Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.

Moore T, Wagner CR, Scurti GM, Hutchens KA, Godellas C, Clark AL, Kolawole EM, Hellman LM, Singh NK, Huyke FA, Wang SY, Calabrese KM, Embree HD, Orentas R, Shirai K, Dellacecca E, Garrett-Mayer E, Li M, Eby JM, Stiff PJ, Evavold BD, Baker BM, Le Poole IC, Dropulic B, Clark JI, Nishimura MI.

Cancer Immunol Immunother. 2018 Feb;67(2):311-325. doi: 10.1007/s00262-017-2073-0. Epub 2017 Oct 20. Erratum in: Cancer Immunol Immunother. 2017 Dec 20;:.

22.

The Appearance and Diversification of Receptors for IgM During Vertebrate Evolution.

Akula S, Hellman L.

Curr Top Microbiol Immunol. 2017;408:1-23. doi: 10.1007/82_2017_22. Review.

PMID:
28884191
23.

Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells.

Spear TT, Wang Y, Foley KC, Murray DC, Scurti GM, Simms PE, Garrett-Mayer E, Hellman LM, Baker BM, Nishimura MI.

Cancer Immunol Immunother. 2017 Nov;66(11):1411-1424. doi: 10.1007/s00262-017-2032-9. Epub 2017 Jun 20.

24.

How an alloreactive T-cell receptor achieves peptide and MHC specificity.

Wang Y, Singh NK, Spear TT, Hellman LM, Piepenbrink KH, McMahan RH, Rosen HR, Vander Kooi CW, Nishimura MI, Baker BM.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4792-E4801. doi: 10.1073/pnas.1700459114. Epub 2017 Jun 1.

25.

Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa.

Dik DA, Domínguez-Gil T, Lee M, Hesek D, Byun B, Fishovitz J, Boggess B, Hellman LM, Fisher JF, Hermoso JA, Mobashery S.

J Am Chem Soc. 2017 Feb 1;139(4):1448-1451. doi: 10.1021/jacs.6b12819. Epub 2017 Jan 17.

26.

Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G.

Fu Z, Thorpe M, Alemayehu R, Roy A, Kervinen J, de Garavilla L, Åbrink M, Hellman L.

J Immunol. 2017 Feb 15;198(4):1474-1483. doi: 10.4049/jimmunol.1601223. Epub 2017 Jan 4.

27.

Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously.

Saupe F, Reichel M, Huijbers EJ, Femel J, Markgren PO, Andersson CE, Deindl S, Danielson UH, Hellman LT, Olsson AK.

FASEB J. 2017 Mar;31(3):1204-1214. doi: 10.1096/fj.201600820R. Epub 2016 Dec 19.

PMID:
27993994
28.

A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.

Riley TP, Ayres CM, Hellman LM, Singh NK, Cosiano M, Cimons JM, Anderson MJ, Piepenbrink KH, Pierce BG, Weng Z, Baker BM.

Protein Eng Des Sel. 2016 Dec;29(12):595-606. Epub 2016 Sep 13.

29.

Channel catfish granzyme-like I is a highly specific serine protease with metase activity that is expressed by fish NK-like cells.

Thorpe M, Akula S, Hellman L.

Dev Comp Immunol. 2016 Oct;63:84-95. doi: 10.1016/j.dci.2016.05.013. Epub 2016 May 20.

PMID:
27216028
30.

Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution.

Fu Z, Thorpe M, Akula S, Hellman L.

PLoS One. 2016 May 6;11(5):e0154886. doi: 10.1371/journal.pone.0154886. eCollection 2016.

31.

Identification of Biological and Pharmaceutical Mast Cell- and Basophil-Related Targets.

Klein O, Ngo-Nyekel F, Stefanache T, Torres R, Salomonsson M, Hallgren J, Rådinger M, Bambouskova M, Campbell M, Cohen-Mor S, Dema B, Rose CG, Abrink M, Charles N, Ainooson G, Paivandy A, Pavlova VG, Serrano-Candelas E, Yu Y, Hellman L, Jensen BM, Van Anrooij B, Grootens J, Gura HK, Stylianou M, Tobio A, Blank U, Öhrvik H, Maurer M.

Scand J Immunol. 2016 Jun;83(6):465-72. doi: 10.1111/sji.12436. No abstract available.

32.

Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability.

Spear TT, Riley TP, Lyons GE, Callender GG, Roszkowski JJ, Wang Y, Simms PE, Scurti GM, Foley KC, Murray DC, Hellman LM, McMahan RH, Iwashima M, Garrett-Mayer E, Rosen HR, Baker BM, Nishimura MI.

J Leukoc Biol. 2016 Sep;100(3):545-57. doi: 10.1189/jlb.2A1215-561R. Epub 2016 Feb 26.

33.

Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes.

Hellman LM, Yin L, Wang Y, Blevins SJ, Riley TP, Belden OS, Spear TT, Nishimura MI, Stern LJ, Baker BM.

J Immunol Methods. 2016 May;432:95-101. doi: 10.1016/j.jim.2016.02.016. Epub 2016 Feb 18.

34.

Correction: Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution.

Akula S, Thorpe M, Boinapally V, Hellman L.

PLoS One. 2015 Dec 22;10(12):e0145592. doi: 10.1371/journal.pone.0145592. eCollection 2015. No abstract available.

35.

Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion.

Chicka MC, Ren Q, Richards D, Hellman LM, Zhang J, Fried MG, Whiteheart SW.

Biochem J. 2016 Mar 1;473(5):627-39. doi: 10.1042/BJ20151150. Epub 2015 Dec 4.

36.

Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution.

Akula S, Thorpe M, Boinapally V, Hellman L.

PLoS One. 2015 Nov 16;10(11):e0143091. doi: 10.1371/journal.pone.0143091. eCollection 2015. Erratum in: PLoS One. 2015;10(12):e0145592.

37.

FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function.

Thompson MG, Larson M, Vidrine A, Barrios K, Navarro F, Meyers K, Simms P, Prajapati K, Chitsike L, Hellman LM, Baker BM, Watkins SK.

J Immunol. 2015 Dec 15;195(12):5637-47. doi: 10.4049/jimmunol.1501758. Epub 2015 Nov 11.

38.

Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma.

Lei Y, Boinapally V, Zoltowska A, Adner M, Hellman L, Nilsson G.

PLoS One. 2015 Jul 27;10(7):e0133774. doi: 10.1371/journal.pone.0133774. eCollection 2015.

40.

The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin.

Chahal G, Thorpe M, Hellman L.

PLoS One. 2015 Jun 25;10(6):e0129511. doi: 10.1371/journal.pone.0129511. eCollection 2015.

41.

Vaccines targeting self-antigens: mechanisms and efficacy-determining parameters.

Saupe F, Huijbers EJ, Hein T, Femel J, Cedervall J, Olsson AK, Hellman L.

FASEB J. 2015 Aug;29(8):3253-62. doi: 10.1096/fj.15-271502. Epub 2015 Apr 13.

42.

Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease.

Raththagala M, Brewer MK, Parker MW, Sherwood AR, Wong BK, Hsu S, Bridges TM, Paasch BC, Hellman LM, Husodo S, Meekins DA, Taylor AO, Turner BD, Auger KD, Dukhande VV, Chakravarthy S, Sanz P, Woods VL Jr, Li S, Vander Kooi CW, Gentry MS.

Mol Cell. 2015 Jan 22;57(2):261-72. doi: 10.1016/j.molcel.2014.11.020. Epub 2014 Dec 24.

43.

IgA deficiency in wolves from Canada and Scandinavia.

Frankowiack M, Olsson M, Cluff HD, Evans AL, Hellman L, Månsson J, Arnemo JM, Hammarström L.

Dev Comp Immunol. 2015 May;50(1):26-8. doi: 10.1016/j.dci.2014.12.009. Epub 2014 Dec 18.

PMID:
25530092
44.

Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer.

Femel J, Huijbers EJ, Saupe F, Cedervall J, Zhang L, Roswall P, Larsson E, Olofsson H, Pietras K, Dimberg A, Hellman L, Olsson AK.

Oncotarget. 2014 Dec 15;5(23):12418-27.

45.

Repair of O6-methylguanine adducts in human telomeric G-quadruplex DNA by O6-alkylguanine-DNA alkyltransferase.

Hellman LM, Spear TJ, Koontz CJ, Melikishvili M, Fried MG.

Nucleic Acids Res. 2014 Sep;42(15):9781-91. doi: 10.1093/nar/gku659. Epub 2014 Jul 30.

46.

Characterization of an experimental vaccine for bovine respiratory syncytial virus.

Hägglund S, Hu K, Blodörn K, Makabi-Panzu B, Gaillard AL, Ellencrona K, Chevret D, Hellman L, Bengtsson KL, Riffault S, Taylor G, Valarcher JF, Eléouët JF.

Clin Vaccine Immunol. 2014 Jul;21(7):997-1004. doi: 10.1128/CVI.00162-14. Epub 2014 May 14.

47.

Fc receptors for immunoglobulins and their appearance during vertebrate evolution.

Akula S, Mohammadamin S, Hellman L.

PLoS One. 2014 May 9;9(5):e96903. doi: 10.1371/journal.pone.0096903. eCollection 2014. Erratum in: PLoS One. 2015;10(4):e0124530.

48.

Computational design of the affinity and specificity of a therapeutic T cell receptor.

Pierce BG, Hellman LM, Hossain M, Singh NK, Vander Kooi CW, Weng Z, Baker BM.

PLoS Comput Biol. 2014 Feb 13;10(2):e1003478. doi: 10.1371/journal.pcbi.1003478. eCollection 2014 Feb.

49.

Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation.

Roy A, Ganesh G, Sippola H, Bolin S, Sawesi O, Dagälv A, Schlenner SM, Feyerabend T, Rodewald HR, Kjellén L, Hellman L, Åbrink M.

J Biol Chem. 2014 Jan 3;289(1):237-50. doi: 10.1074/jbc.M112.435156. Epub 2013 Nov 20.

50.

Trimeric transmembrane domain interactions in paramyxovirus fusion proteins: roles in protein folding, stability, and function.

Smith EC, Smith SE, Carter JR, Webb SR, Gibson KM, Hellman LM, Fried MG, Dutch RE.

J Biol Chem. 2013 Dec 13;288(50):35726-35. doi: 10.1074/jbc.M113.514554. Epub 2013 Oct 31.

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