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Items: 27

1.

Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide.

Snyder NA, Kim A, Kester L, Gale AN, Studer C, Hoepfner D, Roggo S, Helliwell SB, Cunningham KW.

G3 (Bethesda). 2019 Mar 7;9(3):829-840. doi: 10.1534/g3.118.200748.

2.

Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.

Bourgoint C, Rispal D, Berti M, Filipuzzi I, Helliwell SB, Prouteau M, Loewith R.

J Biol Chem. 2018 Aug 3;293(31):12043-12053. doi: 10.1074/jbc.RA117.001615. Epub 2018 Jun 12.

3.

Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo.

Russell OM, Fruh I, Rai PK, Marcellin D, Doll T, Reeve A, Germain M, Bastien J, Rygiel KA, Cerino R, Sailer AW, Lako M, Taylor RW, Mueller M, Lightowlers RN, Turnbull DM, Helliwell SB.

Sci Rep. 2018 Jan 29;8(1):1799. doi: 10.1038/s41598-018-20064-2.

4.

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy.

Potting C, Crochemore C, Moretti F, Nigsch F, Schmidt I, Manneville C, Carbone W, Knehr J, DeJesus R, Lindeman A, Maher R, Russ C, McAllister G, Reece-Hoyes JS, Hoffman GR, Roma G, Müller M, Sailer AW, Helliwell SB.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E180-E189. doi: 10.1073/pnas.1711023115. Epub 2017 Dec 21. Erratum in: Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8579.

5.

Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import.

Filipuzzi I, Steffen J, Germain M, Goepfert L, Conti MA, Potting C, Cerino R, Pfeifer M, Krastel P, Hoepfner D, Bastien J, Koehler CM, Helliwell SB.

Nat Chem Biol. 2017 Dec;13(12):1239-1244. doi: 10.1038/nchembio.2493. Epub 2017 Oct 9.

6.

Two low complexity ultra-high throughput methods to identify diverse chemically bioactive molecules using Saccharomyces cerevisiae.

Petrovic K, Pfeifer M, Parker CN, Schuierer S, Tallarico J, Hoepfner D, Movva NR, Scheel G, Helliwell SB.

Microbiol Res. 2017 Jun;199:10-18. doi: 10.1016/j.micres.2017.02.004. Epub 2017 Feb 21.

7.

High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines.

Filipuzzi I, Cotesta S, Perruccio F, Knapp B, Fu Y, Studer C, Pries V, Riedl R, Helliwell SB, Petrovic KT, Movva NR, Sanglard D, Tao J, Hoepfner D.

PLoS Genet. 2016 Nov 17;12(11):e1006374. doi: 10.1371/journal.pgen.1006374. eCollection 2016 Nov.

8.

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.

Helliwell SB, Karkare S, Bergdoll M, Rahier A, Leighton-Davis JR, Fioretto C, Aust T, Filipuzzi I, Frederiksen M, Gounarides J, Hoepfner D, Hofmann A, Imbert PE, Jeker R, Knochenmuss R, Krastel P, Margerit A, Memmert K, Miault CV, Movva NR, Muller A, Naegeli HU, Oberer L, Prindle V, Riedl R, Schuierer S, Sexton JA, Tao J, Wagner T, Yin H, Zhang J, Roggo S, Reinker S, Parker CN.

Nat Commun. 2015 Oct 12;6:8613. doi: 10.1038/ncomms9613.

9.

Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.

Rispal D, Eltschinger S, Stahl M, Vaga S, Bodenmiller B, Abraham Y, Filipuzzi I, Movva NR, Aebersold R, Helliwell SB, Loewith R.

J Biol Chem. 2015 Jun 12;290(24):14963-78. doi: 10.1074/jbc.M114.627794. Epub 2015 Apr 16.

10.

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO.

Nat Cell Biol. 2014 Nov;16(11):1069-79. doi: 10.1038/ncb3053. Epub 2014 Oct 19.

PMID:
25327288
11.

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.

Hoepfner D, Helliwell SB, Sadlish H, Schuierer S, Filipuzzi I, Brachat S, Bhullar B, Plikat U, Abraham Y, Altorfer M, Aust T, Baeriswyl L, Cerino R, Chang L, Estoppey D, Eichenberger J, Frederiksen M, Hartmann N, Hohendahl A, Knapp B, Krastel P, Melin N, Nigsch F, Oakeley EJ, Petitjean V, Petersen F, Riedl R, Schmitt EK, Staedtler F, Studer C, Tallarico JA, Wetzel S, Fishman MC, Porter JA, Movva NR.

Microbiol Res. 2014 Feb-Mar;169(2-3):107-20. doi: 10.1016/j.micres.2013.11.004. Epub 2013 Dec 1.

12.

TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.

Shimada K, Filipuzzi I, Stahl M, Helliwell SB, Studer C, Hoepfner D, Seeber A, Loewith R, Movva NR, Gasser SM.

Mol Cell. 2013 Sep 26;51(6):829-39. doi: 10.1016/j.molcel.2013.08.019. Epub 2013 Sep 12.

13.

Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex.

Sadlish H, Galicia-Vazquez G, Paris CG, Aust T, Bhullar B, Chang L, Helliwell SB, Hoepfner D, Knapp B, Riedl R, Roggo S, Schuierer S, Studer C, Porco JA Jr, Pelletier J, Movva NR.

ACS Chem Biol. 2013 Jul 19;8(7):1519-27. doi: 10.1021/cb400158t. Epub 2013 May 7.

14.

An integrated approach for identification and target validation of antifungal compounds active against Erg11p.

Hoepfner D, Karkare S, Helliwell SB, Pfeifer M, Trunzer M, De Bonnechose S, Zimmerlin A, Tao J, Richie D, Hofmann A, Reinker S, Frederiksen M, Movva NR, Porter JA, Ryder NS, Parker CN.

Antimicrob Agents Chemother. 2012 Aug;56(8):4233-40. doi: 10.1128/AAC.06332-11. Epub 2012 May 21.

15.

Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of rapamycin (TOR) signaling pathway in yeast.

Devasahayam G, Ritz D, Helliwell SB, Burke DJ, Sturgill TW.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17840-5. Epub 2006 Nov 9.

16.

NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae.

Crespo JL, Helliwell SB, Wiederkehr C, Demougin P, Fowler B, Primig M, Hall MN.

J Biol Chem. 2004 Sep 3;279(36):37512-7. Epub 2004 Jul 9.

17.

Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.

Bowers K, Lottridge J, Helliwell SB, Goldthwaite LM, Luzio JP, Stevens TH.

Traffic. 2004 Mar;5(3):194-210.

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20.

Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae.

Cosentino GP, Schmelzle T, Haghighat A, Helliwell SB, Hall MN, Sonenberg N.

Mol Cell Biol. 2000 Jul;20(13):4604-13.

21.
22.

The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton.

Helliwell SB, Schmidt A, Ohya Y, Hall MN.

Curr Biol. 1998 Nov 5;8(22):1211-4.

23.

TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae.

Helliwell SB, Howald I, Barbet N, Hall MN.

Genetics. 1998 Jan;148(1):99-112.

24.

TOR controls translation initiation and early G1 progression in yeast.

Barbet NC, Schneider U, Helliwell SB, Stansfield I, Tuite MF, Hall MN.

Mol Biol Cell. 1996 Jan;7(1):25-42.

25.

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

Helliwell SB, Wagner P, Kunz J, Deuter-Reinhard M, Henriquez R, Hall MN.

Mol Biol Cell. 1994 Jan;5(1):105-18.

26.

A novel Kex2 enzyme can process the proregion of the yeast alpha-factor leader in the endoplasmic reticulum instead of in the Golgi.

Chaudhuri B, Latham SE, Helliwell SB, Seeboth P.

Biochem Biophys Res Commun. 1992 Feb 28;183(1):212-9.

PMID:
1543492

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