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Multidisciplinary data infrastructures in multiple sclerosis: Why they are needed and can be done!

Peeters LM, van Munster CE, Van Wijmeersch B, Bruyndonckx R, Lamers I, Hellings N, Popescu V, Thalheim C, Feys P.

Mult Scler. 2018 Nov 1:1352458518807076. doi: 10.1177/1352458518807076. [Epub ahead of print]


Size-dependent properties of functional PPV-based conjugated polymer nanoparticles for bioimaging.

Peters M, Seneca S, Hellings N, Junkers T, Ethirajan A.

Colloids Surf B Biointerfaces. 2018 May 24;169:494-501. doi: 10.1016/j.colsurfb.2018.05.055. [Epub ahead of print]


Corrigendum: Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes.

Bogie JFJ, Mailleux J, Wouters E, Jorissen W, Grajchen E, Vanmol J, Wouters K, Hellings N, Horssen JV, Vanmierlo T, Hendriks JJA.

Sci Rep. 2017 Dec 22;7:46925. doi: 10.1038/srep46925.


Human Wharton's Jelly-Derived Stem Cells Display a Distinct Immunomodulatory and Proregenerative Transcriptional Signature Compared to Bone Marrow-Derived Stem Cells.

Donders R, Bogie JFJ, Ravanidis S, Gervois P, Vanheusden M, Marée R, Schrynemackers M, Smeets HJM, Pinxteren J, Gijbels K, Walbers S, Mays RW, Deans R, Van Den Bosch L, Stinissen P, Lambrichts I, Gyselaers W, Hellings N.

Stem Cells Dev. 2018 Jan 15;27(2):65-84. doi: 10.1089/scd.2017.0029. Epub 2017 Dec 21.


Planarians Customize Their Stem Cell Responses Following Genotoxic Stress as a Function of Exposure Time and Regenerative State.

Stevens AS, Wouters A, Ploem JP, Pirotte N, Van Roten A, Willems M, Hellings N, Franken C, Koppen G, Artois T, Plusquin M, Smeets K.

Toxicol Sci. 2018 Mar 1;162(1):251-263. doi: 10.1093/toxsci/kfx247.


Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression.

Peeters LM, Vanheusden M, Somers V, Van Wijmeersch B, Stinissen P, Broux B, Hellings N.

Front Immunol. 2017 Sep 20;8:1160. doi: 10.3389/fimmu.2017.01160. eCollection 2017.


Crosstalk with Inflammatory Macrophages Shapes the Regulatory Properties of Multipotent Adult Progenitor Cells.

Ravanidis S, Bogie JFJ, Donders R, Deans R, Hendriks JJA, Stinissen P, Pinxteren J, Mays RW, Hellings N.

Stem Cells Int. 2017;2017:2353240. doi: 10.1155/2017/2353240. Epub 2017 Jul 12.


Cytomegalovirus infection exacerbates autoimmune mediated neuroinflammation.

Vanheusden M, Broux B, Welten SPM, Peeters LM, Panagioti E, Van Wijmeersch B, Somers V, Stinissen P, Arens R, Hellings N.

Sci Rep. 2017 Apr 6;7(1):663. doi: 10.1038/s41598-017-00645-3.


Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes.

Bogie JF, Mailleux J, Wouters E, Jorissen W, Grajchen E, Vanmol J, Wouters K, Hellings N, Van Horsen J, Vanmierlo T, Hendriks JJ.

Sci Rep. 2017 Mar 20;7:44794. doi: 10.1038/srep44794. Erratum in: Sci Rep. 2017 Dec 22;7:46925.


CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis.

Bogie JF, Boelen E, Louagie E, Delputte P, Elewaut D, van Horssen J, Hendriks JJ, Hellings N.

Mult Scler. 2018 Mar;24(3):290-300. doi: 10.1177/1352458517698759. Epub 2017 Mar 9.


Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL.

Jorissen W, Wouters E, Bogie JF, Vanmierlo T, Noben JP, Sviridov D, Hellings N, Somers V, Valcke R, Vanwijmeersch B, Stinissen P, Mulder MT, Remaley AT, Hendriks JJ.

Sci Rep. 2017 Feb 23;7:43410. doi: 10.1038/srep43410.


Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients.

Claes N, Fraussen J, Vanheusden M, Hellings N, Stinissen P, Van Wijmeersch B, Hupperts R, Somers V.

J Immunol. 2016 Dec 15;197(12):4576-4583. Epub 2016 Nov 11.


Label-Free Imaging of Umbilical Cord Tissue Morphology and Explant-Derived Cells.

Donders R, Sanen K, Paesen R, Slenders E, Gyselaers W, Stinissen P, Ameloot M, Hellings N.

Stem Cells Int. 2016;2016:5457132. Epub 2016 Sep 26.


Systematic Analysis of the Cytokine and Anhedonia Response to Peripheral Lipopolysaccharide Administration in Rats.

Biesmans S, Matthews LJ, Bouwknecht JA, De Haes P, Hellings N, Meert TF, Nuydens R, Ver Donck L.

Biomed Res Int. 2016;2016:9085273. doi: 10.1155/2016/9085273. Epub 2016 Jul 18.


PPV-Based Conjugated Polymer Nanoparticles as a Versatile Bioimaging Probe: A Closer Look at the Inherent Optical Properties and Nanoparticle-Cell Interactions.

Peters M, Zaquen N, D'Olieslaeger L, Bové H, Vanderzande D, Hellings N, Junkers T, Ethirajan A.

Biomacromolecules. 2016 Aug 8;17(8):2562-71. doi: 10.1021/acs.biomac.6b00574. Epub 2016 Jul 5.


Circulating Follicular Regulatory T Cells in Autoimmune Diseases and Their Waning in Multiple Sclerosis.

Dhaeze T, Hellings N.

Crit Rev Immunol. 2016;36(6):511-522. doi: 10.1615/CritRevImmunol.2017019850.


Tolerogenic Dendritic Cells Generated by In Vitro Treatment With SAHA Are Not Stable In Vivo.

Thewissen K, Broux B, Hendriks JJ, Vanhees M, Stinissen P, Slaets H, Hellings N.

Cell Transplant. 2016;25(6):1207-18. doi: 10.3727/096368915X690305. Epub 2015 Dec 18.


Neuroinflammatory signals enhance the immunomodulatory and neuroprotective properties of multipotent adult progenitor cells.

Ravanidis S, Bogie JF, Donders R, Craeye D, Mays RW, Deans R, Gijbels K, Bronckaers A, Stinissen P, Pinxteren J, Hellings N.

Stem Cell Res Ther. 2015 Sep 16;6:176. doi: 10.1186/s13287-015-0169-z.


Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice.

Biesmans S, Bouwknecht JA, Ver Donck L, Langlois X, Acton PD, De Haes P, Davoodi N, Meert TF, Hellings N, Nuydens R.

Biomed Res Int. 2015;2015:716920. doi: 10.1155/2015/716920. Epub 2015 Jul 28.


Immunomodulatory properties of the IL-6 cytokine family in multiple sclerosis.

Janssens K, Slaets H, Hellings N.

Ann N Y Acad Sci. 2015 Sep;1351:52-60. doi: 10.1111/nyas.12821. Epub 2015 Jun 22. Review.


Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis.

Dhaeze T, Peelen E, Hombrouck A, Peeters L, Van Wijmeersch B, Lemkens N, Lemkens P, Somers V, Lucas S, Broux B, Stinissen P, Hellings N.

J Immunol. 2015 Aug 1;195(3):832-40. doi: 10.4049/jimmunol.1500759. Epub 2015 Jun 12.


Oncostatin M protects against demyelination by inducing a protective microglial phenotype.

Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N.

Glia. 2015 Oct;63(10):1729-37. doi: 10.1002/glia.22840. Epub 2015 Apr 29.


Humoral autoimmunity: a failure of regulatory T cells?

Dhaeze T, Stinissen P, Liston A, Hellings N.

Autoimmun Rev. 2015 Aug;14(8):735-41. doi: 10.1016/j.autrev.2015.04.006. Epub 2015 Apr 23. Review.


Comment on "Dysregulated production of leukemia inhibitory factor in immune cells of relapsing remitting multiple sclerosis patients" by Levy et al. J. Neuroimmunol. 2015 Jan 15; 278C:85-89.

Vanderlocht J, Hellings N.

J Neuroimmunol. 2015 Mar 15;280:56-7. doi: 10.1016/j.jneuroim.2015.02.003. Epub 2015 Feb 23. No abstract available.


Urodynamic changes in mice with experimental autoimmune encephalomyelitis correlate with neurological impairment.

Franken J, Gevaert T, Uvin P, Wauterickx K, Boeve AC, Rietjens R, Boudes M, Hendriks JJ, Hellings N, Voets T, De Ridder D.

Neurourol Urodyn. 2016 Apr;35(4):450-6. doi: 10.1002/nau.22742. Epub 2015 Mar 1.


Effect of stress and peripheral immune activation on astrocyte activation in transgenic bioluminescent Gfap-luc mice.

Biesmans S, Acton PD, Cotto C, Langlois X, Ver Donck L, Bouwknecht JA, Aelvoet SA, Hellings N, Meert TF, Nuydens R.

Glia. 2015 Jul;63(7):1126-37. doi: 10.1002/glia.22804. Epub 2015 Feb 17.


IL-15 amplifies the pathogenic properties of CD4+CD28- T cells in multiple sclerosis.

Broux B, Mizee MR, Vanheusden M, van der Pol S, van Horssen J, Van Wijmeersch B, Somers V, de Vries HE, Stinissen P, Hellings N.

J Immunol. 2015 Mar 1;194(5):2099-109. doi: 10.4049/jimmunol.1401547. Epub 2015 Jan 23.


Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis.

Janssens K, Van den Haute C, Baekelandt V, Lucas S, van Horssen J, Somers V, Van Wijmeersch B, Stinissen P, Hendriks JJ, Slaets H, Hellings N.

Brain Behav Immun. 2015 Mar;45:180-8. doi: 10.1016/j.bbi.2014.11.010. Epub 2014 Dec 13.


Cytomegalovirus: a culprit or protector in multiple sclerosis?

Vanheusden M, Stinissen P, 't Hart BA, Hellings N.

Trends Mol Med. 2015 Jan;21(1):16-23. doi: 10.1016/j.molmed.2014.11.002. Epub 2014 Nov 20.


Compositional changes of B and T cell subtypes during fingolimod treatment in multiple sclerosis patients: a 12-month follow-up study.

Claes N, Dhaeze T, Fraussen J, Broux B, Van Wijmeersch B, Stinissen P, Hupperts R, Hellings N, Somers V.

PLoS One. 2014 Oct 31;9(10):e111115. doi: 10.1371/journal.pone.0111115. eCollection 2014.


The influence of interleukin-7 receptor α-chain haplotypes on outcome after allogeneic hematopoietic cell transplantation.

Broux B, Shamim Z, Wang T, Spellman S, Haagenson M, Stinissen P, Ryder LP, Müller K, Hellings N.

Int J Immunogenet. 2014 Dec;41(6):521-7. doi: 10.1111/iji.12158. Epub 2014 Oct 29.


Human Wharton's Jelly-Derived Stem Cells Display Immunomodulatory Properties and Transiently Improve Rat Experimental Autoimmune Encephalomyelitis.

Donders R, Vanheusden M, Bogie JF, Ravanidis S, Thewissen K, Stinissen P, Gyselaers W, Hendriks JJ, Hellings N.

Cell Transplant. 2015;24(10):2077-98. doi: 10.3727/096368914X685104. Epub 2014 Oct 10.


Sperm-associated antigen 16 is a novel target of the humoral autoimmune response in multiple sclerosis.

de Bock L, Somers K, Fraussen J, Hendriks JJ, van Horssen J, Rouwette M, Hellings N, Villar LM, Alvarez-Cermeño JC, Espiño M, Hupperts R, Jongen P, Damoiseaux J, Verbeek MM, De Deyn PP, D'hooghe M, Van Wijmeersch B, Stinissen P, Somers V.

J Immunol. 2014 Sep 1;193(5):2147-56. doi: 10.4049/jimmunol.1401166. Epub 2014 Aug 1.


Oncostatin M reduces lesion size and promotes functional recovery and neurite outgrowth after spinal cord injury.

Slaets H, Nelissen S, Janssens K, Vidal PM, Lemmens E, Stinissen P, Hendrix S, Hellings N.

Mol Neurobiol. 2014 Dec;50(3):1142-51. doi: 10.1007/s12035-014-8795-5. Epub 2014 Jul 5.


Prognostic value of circulating cytokines on overall survival and disease-free survival in cancer patients.

Visconti L, Nelissen K, Deckx L, van den Akker M, Adriaensen W, Daniels L, Matheï C, Linsen L, Hellings N, Stinissen P, Buntinx F.

Biomark Med. 2014;8(2):297-306. doi: 10.2217/bmm.13.122. Review.


Myelin alters the inflammatory phenotype of macrophages by activating PPARs.

Bogie JF, Jorissen W, Mailleux J, Nijland PG, Zelcer N, Vanmierlo T, Van Horssen J, Stinissen P, Hellings N, Hendriks JJ.

Acta Neuropathol Commun. 2013 Aug 2;1:43. doi: 10.1186/2051-5960-1-43.


HLA-E restricted CD8+ T cell subsets are phenotypically altered in multiple sclerosis patients.

Pannemans K, Broux B, Goris A, Dubois B, Broekmans T, Van Wijmeersch B, Geraghty D, Stinissen P, Hellings N.

Mult Scler. 2014 Jun;20(7):790-801. doi: 10.1177/1352458513509703. Epub 2013 Oct 21.


High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system.

Timmermans S, Bogie JF, Vanmierlo T, Lütjohann D, Stinissen P, Hellings N, Hendriks JJ.

J Neuroimmune Pharmacol. 2014 Mar;9(2):209-17. doi: 10.1007/s11481-013-9502-4. Epub 2013 Sep 26.


Circulating dendritic cells of multiple sclerosis patients are proinflammatory and their frequency is correlated with MS-associated genetic risk factors.

Thewissen K, Nuyts AH, Deckx N, Van Wijmeersch B, Nagels G, D'hooghe M, Willekens B, Cras P, Eijnde BO, Goossens H, Van Tendeloo VF, Stinissen P, Berneman ZN, Hellings N, Cools N.

Mult Scler. 2014 Apr;20(5):548-57. doi: 10.1177/1352458513505352. Epub 2013 Sep 20.


Which immune cells matter? The immunopathogenesis of multiple sclerosis.

Broux B, Stinissen P, Hellings N.

Crit Rev Immunol. 2013;33(4):283-306. Review.


Systemic immune activation leads to neuroinflammation and sickness behavior in mice.

Biesmans S, Meert TF, Bouwknecht JA, Acton PD, Davoodi N, De Haes P, Kuijlaars J, Langlois X, Matthews LJ, Ver Donck L, Hellings N, Nuydens R.

Mediators Inflamm. 2013;2013:271359. doi: 10.1155/2013/271359. Epub 2013 Jul 10.


Local overexpression of interleukin-11 in the central nervous system limits demyelination and enhances remyelination.

Maheshwari A, Janssens K, Bogie J, Van Den Haute C, Struys T, Lambrichts I, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N.

Mediators Inflamm. 2013;2013:685317. doi: 10.1155/2013/685317. Epub 2013 May 30.


Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis.

Gomez AM, Vanheel A, Losen M, Molenaar PC, De Baets MH, Noben JP, Hellings N, Martinez-Martinez P.

J Neuroimmunol. 2013 Aug 15;261(1-2):141-5. doi: 10.1016/j.jneuroim.2013.05.008. Epub 2013 Jun 18.


Systemic treatment with the inhibitory neurotransmitter γ-aminobutyric acid aggravates experimental autoimmune encephalomyelitis by affecting proinflammatory immune responses.

Carmans S, Hendriks JJ, Slaets H, Thewissen K, Stinissen P, Rigo JM, Hellings N.

J Neuroimmunol. 2013 Feb 15;255(1-2):45-53. doi: 10.1016/j.jneuroim.2012.11.001. Epub 2012 Nov 26.


Myelin-derived lipids modulate macrophage activity by liver X receptor activation.

Bogie JF, Timmermans S, Huynh-Thu VA, Irrthum A, Smeets HJ, Gustafsson JÅ, Steffensen KR, Mulder M, Stinissen P, Hellings N, Hendriks JJ.

PLoS One. 2012;7(9):e44998. doi: 10.1371/journal.pone.0044998. Epub 2012 Sep 12.


B-cell depletion abrogates T cell-mediated demyelination in an antibody-nondependent common marmoset experimental autoimmune encephalomyelitis model.

Jagessar SA, Heijmans N, Bauer J, Blezer EL, Laman JD, Hellings N, 't Hart BA.

J Neuropathol Exp Neurol. 2012 Aug;71(8):716-28.


Pathogenic features of CD4+CD28- T cells in immune disorders.

Broux B, Markovic-Plese S, Stinissen P, Hellings N.

Trends Mol Med. 2012 Aug;18(8):446-53. doi: 10.1016/j.molmed.2012.06.003. Epub 2012 Jul 10. Review.


Identification of protein networks involved in the disease course of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.

Vanheel A, Daniels R, Plaisance S, Baeten K, Hendriks JJ, Leprince P, Dumont D, Robben J, Brône B, Stinissen P, Noben JP, Hellings N.

PLoS One. 2012;7(4):e35544. doi: 10.1371/journal.pone.0035544. Epub 2012 Apr 17.


CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients.

Broux B, Pannemans K, Zhang X, Markovic-Plese S, Broekmans T, Eijnde BO, Van Wijmeersch B, Somers V, Geusens P, van der Pol S, van Horssen J, Stinissen P, Hellings N.

J Autoimmun. 2012 Feb;38(1):10-9. doi: 10.1016/j.jaut.2011.11.006. Epub 2011 Nov 26.


Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation.

Bogie JF, Stinissen P, Hellings N, Hendriks JJ.

J Neuroinflammation. 2011 Jul 25;8:85. doi: 10.1186/1742-2094-8-85.

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