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Items: 1 to 50 of 114

1.

Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium.

Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L, Long M, Parry S, Woods R, Hulston C, Benedikter B, Niespolo C, Bazaz R, Francis S, Kiss-Toth E, van Zandvoort M, Schober A, Hellewell P, Evans PC, Ridger V.

Nat Commun. 2020 Jan 10;11(1):214. doi: 10.1038/s41467-019-14043-y.

2.

Angiopoietin-1 enhances neutrophil chemotaxis in vitro and migration in vivo through interaction with CD18 and release of CCL4.

Burnett A, Gomez I, De Leon DD, Ariaans M, Progias P, Kammerer RA, Velasco G, Marron M, Hellewell P, Ridger V.

Sci Rep. 2017 May 24;7(1):2332. doi: 10.1038/s41598-017-02216-y.

3.

Atorvastatin reduces endotoxin-induced microvascular inflammation via NOSII.

McGown CC, Brookes ZL, Hellewell PG, Ross JJ, Brown NJ.

Naunyn Schmiedebergs Arch Pharmacol. 2015 May;388(5):557-64. doi: 10.1007/s00210-015-1100-y. Epub 2015 Feb 14.

PMID:
25678054
4.

A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia.

Marriott HM, Daigneault M, Thompson AA, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MK, Dockrell DH.

Thorax. 2012 Nov;67(11):985-92. doi: 10.1136/thoraxjnl-2012-201591. Epub 2012 Jun 26.

5.

ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase.

McGown CC, Brown NJ, Hellewell PG, Brookes ZL.

Microvasc Res. 2011 May;81(3):281-8. doi: 10.1016/j.mvr.2011.02.003. Epub 2011 Feb 23.

PMID:
21354186
6.

Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III.

McGown CC, Brown NJ, Hellewell PG, Reilly CS, Brookes ZL.

Br J Anaesth. 2010 Feb;104(2):183-90. doi: 10.1093/bja/aep361.

7.

Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos.

Packham IM, Gray C, Heath PR, Hellewell PG, Ingham PW, Crossman DC, Milo M, Chico TJ.

Physiol Genomics. 2009 Aug 7;38(3):319-27. doi: 10.1152/physiolgenomics.00049.2009. Epub 2009 Jun 9.

PMID:
19509081
8.
9.

Antibody ligation of murine Ly-6G induces neutropenia, blood flow cessation, and death via complement-dependent and independent mechanisms.

Abbitt KB, Cotter MJ, Ridger VC, Crossman DC, Hellewell PG, Norman KE.

J Leukoc Biol. 2009 Jan;85(1):55-63. doi: 10.1189/jlb.0507305. Epub 2008 Oct 16.

PMID:
18927400
10.

Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia.

Marriott HM, Jackson LE, Wilkinson TS, Simpson AJ, Mitchell TJ, Buttle DJ, Cross SS, Ince PG, Hellewell PG, Whyte MK, Dockrell DH.

Am J Respir Crit Care Med. 2008 Apr 15;177(8):887-95. doi: 10.1164/rccm.200707-990OC. Epub 2008 Jan 17.

11.

Nitric oxide regulates neutrophil migration through microparticle formation.

Nolan S, Dixon R, Norman K, Hellewell P, Ridger V.

Am J Pathol. 2008 Jan;172(1):265-73. Epub 2007 Dec 13.

12.

Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

Bianchi SM, Prince LR, McPhillips K, Allen L, Marriott HM, Taylor GW, Hellewell PG, Sabroe I, Dockrell DH, Henson PW, Whyte MK.

Am J Respir Crit Care Med. 2008 Jan 1;177(1):35-43. Epub 2007 Oct 4.

PMID:
17916805
13.

Ischemia is not required for arteriogenesis in zebrafish embryos.

Gray C, Packham IM, Wurmser F, Eastley NC, Hellewell PG, Ingham PW, Crossman DC, Chico TJ.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2135-41. Epub 2007 Jul 26.

14.

Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia.

Marriott HM, Hellewell PG, Cross SS, Ince PG, Whyte MK, Dockrell DH.

J Immunol. 2006 Nov 1;177(9):6480-8.

15.

Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae.

Marriott HM, Hellewell PG, Whyte MK, Dockrell DH.

Vaccine. 2007 Mar 22;25(13):2485-90. Epub 2006 Sep 20.

PMID:
17030496
16.

Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo.

Allen L, Dockrell DH, Pattery T, Lee DG, Cornelis P, Hellewell PG, Whyte MK.

J Immunol. 2005 Mar 15;174(6):3643-9.

18.

Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance.

Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MK, Dockrell DH.

J Clin Invest. 2005 Feb;115(2):359-68.

19.

The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival.

Prince LR, Allen L, Jones EC, Hellewell PG, Dower SK, Whyte MK, Sabroe I.

Am J Pathol. 2004 Nov;165(5):1819-26.

20.

The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo.

Hicks AE, Abbitt KB, Dodd P, Ridger VC, Hellewell PG, Norman KE.

J Leukoc Biol. 2005 Jan;77(1):59-66. Epub 2004 Oct 5.

PMID:
15466915
21.

Leptin indirectly activates human neutrophils via induction of TNF-alpha.

Zarkesh-Esfahani H, Pockley AG, Wu Z, Hellewell PG, Weetman AP, Ross RJ.

J Immunol. 2004 Feb 1;172(3):1809-14.

22.

Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection.

Dockrell DH, Marriott HM, Prince LR, Ridger VC, Ince PG, Hellewell PG, Whyte MK.

J Immunol. 2003 Nov 15;171(10):5380-8.

23.

Polymers bearing sLex-mimetics are superior inhibitors of E-selectin-dependent leukocyte rolling in vivo.

Ali M, Hicks AE, Hellewell PG, Thoma G, Norman KE.

FASEB J. 2004 Jan;18(1):152-4. Epub 2003 Nov 3.

PMID:
14597557
24.
25.
26.

Combined anticoagulant and antiselectin treatments prevent lethal intravascular coagulation.

Norman KE, Cotter MJ, Stewart JB, Abbitt KB, Ali M, Wagner BE, Wallace WA, Forlow SB, Hellewell PG.

Blood. 2003 Feb 1;101(3):921-8. Epub 2002 Sep 19.

PMID:
12393622
27.

Glycosulfopeptides modeled on P-selectin glycoprotein ligand 1 inhibit P-selectin-dependent leukocyte rolling in vivo.

Hicks AE, Leppänen A, Cummings RD, McEver RP, Hellewell PG, Norman KE.

FASEB J. 2002 Sep;16(11):1461-2. Epub 2002 Jul 1.

PMID:
12205048
28.
29.

A novel method for isolation of neutrophils from murine blood using negative immunomagnetic separation.

Cotter MJ, Norman KE, Hellewell PG, Ridger VC.

Am J Pathol. 2001 Aug;159(2):473-81.

30.

Dominant role of L- and P-selectin in mediating CXC chemokine-induced neutrophil migration in vivo.

Miotla JM, Ridger VC, Hellewell PG.

Br J Pharmacol. 2001 Jun;133(4):550-6.

31.

Eosinophil recruitment into sites of delayed-type hypersensitivity reactions in mice.

Teixeira MM, Talvani A, Tafuri WL, Lukacs NW, Hellewell PG.

J Leukoc Biol. 2001 Mar;69(3):353-60.

32.
33.

alpha(4) integrin-dependent eosinophil recruitment in allergic but not non-allergic inflammation.

Teixeira MM, Robinson MK, Shock A, Hellewell PG.

Br J Pharmacol. 2001 Jan;132(2):596-604.

34.

P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo.

Norman KE, Katopodis AG, Thoma G, Kolbinger F, Hicks AE, Cotter MJ, Pockley AG, Hellewell PG.

Blood. 2000 Nov 15;96(10):3585-91.

PMID:
11071658
35.

7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.

Buckley G, Cooper N, Dyke HJ, Galleway F, Gowers L, Gregory JC, Hannah DR, Haughan AF, Hellewell PG, Kendall HJ, Lowe C, Maxey R, Montana JG, Naylor R, Picken CL, Runcie KA, Sabin V, Tuladhar BR, Warneck JB.

Bioorg Med Chem Lett. 2000 Sep 18;10(18):2137-40.

PMID:
10999488
36.

Role of arachidonic acid in leukotriene B(4)-induced guinea-pig eosinophil homotypic aggregation.

Teixeira MM, Lindsay MA, Giembycz MA, Hellewell PG.

Eur J Pharmacol. 1999 Nov 19;384(2-3):183-90.

PMID:
10611440
37.

'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils.

Lynch OT, Giembycz MA, Barnes PJ, Hellewell PG, Lindsay MA.

Br J Pharmacol. 1999 Nov;128(6):1149-58.

38.
39.

Cytokine-induced airway epithelial ICAM-1 upregulation: quantification by high-resolution scanning and transmission electron microscopy.

Zhu J, Rogers AV, Burke-Gaffney A, Hellewell PG, Jeffery PK.

Eur Respir J. 1999 Jun;13(6):1318-28.

40.

Adhesion molecule strategies.

Hellewell PG.

Pulm Pharmacol Ther. 1999;12(2):137-41. Review. No abstract available.

PMID:
10373397
41.

A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo.

Cooper N, Teixeira MM, Warneck J, Miotla JM, Wills RE, Macari DM, Gristwood RW, Hellewell PG.

Br J Pharmacol. 1999 Apr;126(8):1863-71.

42.

alpha4 integrin-dependent eotaxin induction of bronchial hyperresponsiveness and eosinophil migration in interleukin-5 transgenic mice.

Hisada T, Hellewell PG, Teixeira MM, Malm MG, Salmon M, Huang TJ, Chung KF.

Am J Respir Cell Mol Biol. 1999 May;20(5):992-1000.

PMID:
10226069
43.

Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure.

Anker SD, Ponikowski PP, Clark AL, Leyva F, Rauchhaus M, Kemp M, Teixeira MM, Hellewell PG, Hooper J, Poole-Wilson PA, Coats AJ.

Eur Heart J. 1999 May;20(9):683-93.

PMID:
10208789
44.

Loss of bone mineral in patients with cachexia due to chronic heart failure.

Anker SD, Clark AL, Teixeira MM, Hellewell PG, Coats AJ.

Am J Cardiol. 1999 Feb 15;83(4):612-5, A10.

PMID:
10073875
45.

Uric acid in chronic heart failure: a marker of chronic inflammation.

Leyva F, Anker SD, Godsland IF, Teixeira M, Hellewell PG, Kox WJ, Poole-Wilson PA, Coats AJ.

Eur Heart J. 1998 Dec;19(12):1814-22.

PMID:
9886724
46.

PDE4 inhibitors: new xanthine analogues.

Montana JG, Cooper N, Dyke HJ, Gowers L, Gregory JP, Hellewell PG, Miotla J, Morris K, Naylor R, Tuladhar B, Warneck JB.

Bioorg Med Chem Lett. 1998 Oct 20;8(20):2925-30.

PMID:
9873649
47.

Aryl sulfonamides as selective PDE4 inhibitors.

Montana JG, Buckley GM, Cooper N, Dyke HJ, Gowers L, Gregory JP, Hellewell PG, Kendall HJ, Lowe C, Maxey R, Miotla J, Naylor RJ, Runcie KA, Tuladhar B, Warneck JB.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2635-40.

PMID:
9873594
48.

Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma.

Beasley SC, Cooper N, Gowers L, Gregory JP, Haughan AF, Hellewell PG, Macari D, Miotla J, Montana JG, Morgan T, Naylor R, Runcie KA, Tuladhar B, Warneck JB.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2629-34.

PMID:
9873593
49.

Priming and induction of eosinophil trafficking in guinea-pig cutaneous inflammation by tumour necrosis factor alpha.

Macari DM, Teixeira MM, Ansari T, Jeffery PK, Hellewell PG.

Br J Pharmacol. 1998 Nov;125(6):1228-35.

50.

Role of the mitogen-activated protein kinases and tyrosine kinases during leukotriene B4-induced eosinophil activation.

Lindsay MA, Haddad EB, Rousell J, Teixeira MM, Hellewell PG, Barnes PJ, Giembycz MA.

J Leukoc Biol. 1998 Oct;64(4):555-62.

PMID:
9766637

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