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Items: 49

1.

Activation of toll-like receptors 2 and 4 on CD34+ cells increases human megakaryo/thrombopoiesis induced by thrombopoietin.

D'Atri LP, Rodríguez CS, Miguel CP, Pozner RG, Ortiz Wilczyñski JM, Negrotto S, Carrera-Silva EA, Heller PG, Schattner M.

J Thromb Haemost. 2019 Aug 9. doi: 10.1111/jth.14605. [Epub ahead of print]

PMID:
31397069
2.

Platelets as Mediators of Thromboinflammation in Chronic Myeloproliferative Neoplasms.

Marin Oyarzún CP, Heller PG.

Front Immunol. 2019 Jun 14;10:1373. doi: 10.3389/fimmu.2019.01373. eCollection 2019. Review.

3.

Multiple concomitant mechanisms contribute to low platelet count in patients with immune thrombocytopenia.

Grodzielski M, Goette NP, Glembotsky AC, Constanza Baroni Pietto M, Méndez-Huergo SP, Pierdominici MS, Montero VS, Rabinovich GA, Molinas FC, Heller PG, Lev PR, Marta RF.

Sci Rep. 2019 Feb 18;9(1):2208. doi: 10.1038/s41598-018-38086-1.

4.

Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia.

Glembotsky AC, Sliwa D, Bluteau D, Balayn N, Marin Oyarzún CP, Raimbault A, Bordas M, Droin N, Pirozhkova I, Washington V, Goette NP, Marta RF, Favier R, Raslova H, Heller PG.

Haematologica. 2019 Jun;104(6):1244-1255. doi: 10.3324/haematol.2018.188904. Epub 2018 Dec 13.

5.

Autoantibodies in immune thrombocytopenia affect the physiological interaction between megakaryocytes and bone marrow extracellular matrix proteins.

Grodzielski M, Di Buduo CA, Goette NP, Lev PR, Soprano PM, Heller PG, Balduini A, Marta RF.

Br J Haematol. 2018 Oct;183(2):319-323. doi: 10.1111/bjh.14977. Epub 2017 Oct 26. No abstract available.

PMID:
29076144
6.

RUNX1 deficiency (familial platelet disorder with predisposition to myeloid leukemia, FPDMM).

Schlegelberger B, Heller PG.

Semin Hematol. 2017 Apr;54(2):75-80. doi: 10.1053/j.seminhematol.2017.04.006. Epub 2017 Apr 13. Review.

PMID:
28637620
7.

Bleeding risk of surgery and its prevention in patients with inherited platelet disorders.

Orsini S, Noris P, Bury L, Heller PG, Santoro C, Kadir RA, Butta NC, Falcinelli E, Cid AR, Fabris F, Fouassier M, Miyazaki K, Lozano ML, Zúñiga P, Flaujac C, Podda GM, Bermejo N, Favier R, Henskens Y, De Maistre E, De Candia E, Mumford AD, Ozdemir GN, Eker I, Nurden P, Bayart S, Lambert MP, Bussel J, Zieger B, Tosetto A, Melazzini F, Glembotsky AC, Pecci A, Cattaneo M, Schlegel N, Gresele P; European Hematology Association - Scientific Working Group (EHA-SWG) on thrombocytopenias and platelet function disorders.

Haematologica. 2017 Jul;102(7):1192-1203. doi: 10.3324/haematol.2016.160754. Epub 2017 Apr 6.

8.

Mutations of RUNX1 in families with inherited thrombocytopenia.

De Rocco D, Melazzini F, Marconi C, Pecci A, Bottega R, Gnan C, Palombo F, Giordano P, Coccioli MS, Glembotsky AC, Heller PG, Seri M, Savoia A, Noris P.

Am J Hematol. 2017 Jun;92(6):E86-E88. doi: 10.1002/ajh.24703. Epub 2017 Mar 24. No abstract available.

9.

Differential expression of SDF-1 receptor CXCR4 in molecularly defined forms of inherited thrombocytopenias.

Salim JP, Glembotsky AC, Lev PR, Marin Oyarzún CP, Goette NP, Molinas FC, Marta RF, Heller PG.

Platelets. 2017 Sep;28(6):602-606. doi: 10.1080/09537104.2016.1254763. Epub 2016 Dec 29.

PMID:
28032520
10.

Neutrophil extracellular trap formation and circulating nucleosomes in patients with chronic myeloproliferative neoplasms.

Marin Oyarzún CP, Carestia A, Lev PR, Glembotsky AC, Castro Ríos MA, Moiraghi B, Molinas FC, Marta RF, Schattner M, Heller PG.

Sci Rep. 2016 Dec 13;6:38738. doi: 10.1038/srep38738.

11.

Gray platelet syndrome: Novel mutations of the NBEAL2 gene.

Bottega R, Nicchia E, Alfano C, Glembotsky AC, Pastore A, Bertaggia-Calderara D, Bisig B, Duchosal MA, Arbesú G, Alberio L, Heller PG, Savoia A.

Am J Hematol. 2017 Feb;92(2):E20-E22. doi: 10.1002/ajh.24610. No abstract available.

12.

Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-Antibodies.

Goette NP, Glembotsky AC, Lev PR, Grodzielski M, Contrufo G, Pierdominici MS, Espasandin YR, Riveros D, García AJ, Molinas FC, Heller PG, Marta RF.

PLoS One. 2016 Aug 5;11(8):e0160563. doi: 10.1371/journal.pone.0160563. eCollection 2016.

13.

Corrigendum: Abnormal proplatelet formation and emperipolesis in cultured human megakaryocytes from gray platelet syndrome patients.

Di Buduo CA, Alberelli MA, Glembotsky AC, Podda G, Lev PR, Cattaneo M, Landolfi R, Heller PG, Balduini A, De Candia E.

Sci Rep. 2016 Apr 29;6:25027. doi: 10.1038/srep25027. No abstract available.

14.

Abnormal proplatelet formation and emperipolesis in cultured human megakaryocytes from gray platelet syndrome patients.

Di Buduo CA, Alberelli MA, Glembostky AC, Podda G, Lev PR, Cattaneo M, Landolfi R, Heller PG, Balduini A, De Candia E.

Sci Rep. 2016 Mar 18;6:23213. doi: 10.1038/srep23213. Erratum in: Sci Rep. 2016 Apr 29;6:25027.

15.

Somatic mutations associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia.

Antony-Debré I, Duployez N, Bucci M, Geffroy S, Micol JB, Renneville A, Boissel N, Dhédin N, Réa D, Nelken B, Berthon C, Leblanc T, Mozziconacci MJ, Favier R, Heller PG, Abdel-Wahab O, Raslova H, Latger-Cannard V, Preudhomme C.

Leukemia. 2016 Apr;30(4):999-1002. doi: 10.1038/leu.2015.236. Epub 2015 Aug 28. No abstract available.

PMID:
26316320
16.

Nonmuscle Myosin Heavy Chain IIA Mutation Predicts Severity and Progression of Sensorineural Hearing Loss in Patients With MYH9-Related Disease.

Verver EJ, Topsakal V, Kunst HP, Huygen PL, Heller PG, Pujol-Moix N, Savoia A, Benazzo M, Fierro T, Grolman W, Gresele P, Pecci A.

Ear Hear. 2016 Jan-Feb;37(1):112-20. doi: 10.1097/AUD.0000000000000198.

PMID:
26226608
17.

Long-term follow-up of essential thrombocythemia patients treated with anagrelide: subgroup analysis according to JAK2/CALR/MPL mutational status.

Mela Osorio MJ, Ferrari L, Goette NP, Gutierrez MI, Glembotsky AC, Maldonado AC, Lev PR, Alvarez C, Korin L, Marta RF, Molinas FC, Heller PG.

Eur J Haematol. 2016 Apr;96(4):435-42. doi: 10.1111/ejh.12614. Epub 2015 Jul 19.

PMID:
26119186
18.

Megakaryocytic emperipolesis and platelet function abnormalities in five patients with gray platelet syndrome.

Larocca LM, Heller PG, Podda G, Pujol-Moix N, Glembotsky AC, Pecci A, Alberelli MA, Balduini CL, Landolfi R, Cattaneo M, De Candia E.

Platelets. 2015;26(8):751-7. doi: 10.3109/09537104.2014.994093. Epub 2015 Mar 25.

PMID:
25806575
19.

Anagrelide platelet-lowering effect is due to inhibition of both megakaryocyte maturation and proplatelet formation: insight into potential mechanisms.

Espasandin YR, Glembotsky AC, Grodzielski M, Lev PR, Goette NP, Molinas FC, Marta RF, Heller PG.

J Thromb Haemost. 2015 Apr;13(4):631-42. doi: 10.1111/jth.12850. Epub 2015 Feb 18.

20.

Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders.

Noris P, Biino G, Pecci A, Civaschi E, Savoia A, Seri M, Melazzini F, Loffredo G, Russo G, Bozzi V, Notarangelo LD, Gresele P, Heller PG, Pujol-Moix N, Kunishima S, Cattaneo M, Bussel J, De Candia E, Cagioni C, Ramenghi U, Barozzi S, Fabris F, Balduini CL.

Blood. 2014 Aug 7;124(6):e4-e10. doi: 10.1182/blood-2014-03-564328. Epub 2014 Jul 2.

21.

Spectrum of the mutations in Bernard-Soulier syndrome.

Savoia A, Kunishima S, De Rocco D, Zieger B, Rand ML, Pujol-Moix N, Caliskan U, Tokgoz H, Pecci A, Noris P, Srivastava A, Ward C, Morel-Kopp MC, Alessi MC, Bellucci S, Beurrier P, de Maistre E, Favier R, Hézard N, Hurtaud-Roux MF, Latger-Cannard V, Lavenu-Bombled C, Proulle V, Meunier S, Négrier C, Nurden A, Randrianaivo H, Fabris F, Platokouki H, Rosenberg N, HadjKacem B, Heller PG, Karimi M, Balduini CL, Pastore A, Lanza F.

Hum Mutat. 2014 Sep;35(9):1033-45. doi: 10.1002/humu.22607. Epub 2014 Jul 15. Review.

PMID:
24934643
22.

Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia.

Noris P, Schlegel N, Klersy C, Heller PG, Civaschi E, Pujol-Moix N, Fabris F, Favier R, Gresele P, Latger-Cannard V, Cuker A, Nurden P, Greinacher A, Cattaneo M, De Candia E, Pecci A, Hurtaud-Roux MF, Glembotsky AC, Muñiz-Diaz E, Randi ML, Trillot N, Bury L, Lecompte T, Marconi C, Savoia A, Balduini CL, Bayart S, Bauters A, Benabdallah-Guedira S, Boehlen F, Borg JY, Bottega R, Bussel J, De Rocco D, de Maistre E, Faleschini M, Falcinelli E, Ferrari S, Ferster A, Fierro T, Fleury D, Fontana P, James C, Lanza F, Le Cam Duchez V, Loffredo G, Magini P, Martin-Coignard D, Menard F, Mercier S, Mezzasoma A, Minuz P, Nichele I, Notarangelo LD, Pippucci T, Podda GM, Pouymayou C, Rigouzzo A, Royer B, Sie P, Siguret V, Trichet C, Tucci A, Saposnik B, Veneri D; European Hematology Association – Scientific Working Group on Thrombocytopenias and Platelet Function Disorders.

Haematologica. 2014 Aug;99(8):1387-94. doi: 10.3324/haematol.2014.105924. Epub 2014 Apr 24.

23.

Impaired proplatelet formation in immune thrombocytopenia: a novel mechanism contributing to decreased platelet count.

Lev PR, Grodzielski M, Goette NP, Glembotsky AC, Espasandin YR, Pierdominici MS, Contrufo G, Montero VS, Ferrari L, Molinas FC, Heller PG, Marta RF.

Br J Haematol. 2014 Jun;165(6):854-64. doi: 10.1111/bjh.12832. Epub 2014 Mar 27.

PMID:
24673454
24.

Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets.

Glembotsky AC, Bluteau D, Espasandin YR, Goette NP, Marta RF, Marin Oyarzun CP, Korin L, Lev PR, Laguens RP, Molinas FC, Raslova H, Heller PG.

J Thromb Haemost. 2014 May;12(5):761-72. doi: 10.1111/jth.12550.

25.

MYH9-related disease: a novel prognostic model to predict the clinical evolution of the disease based on genotype-phenotype correlations.

Pecci A, Klersy C, Gresele P, Lee KJ, De Rocco D, Bozzi V, Russo G, Heller PG, Loffredo G, Ballmaier M, Fabris F, Beggiato E, Kahr WH, Pujol-Moix N, Platokouki H, Van Geet C, Noris P, Yerram P, Hermans C, Gerber B, Economou M, De Groot M, Zieger B, De Candia E, Fraticelli V, Kersseboom R, Piccoli GB, Zimmermann S, Fierro T, Glembotsky AC, Vianello F, Zaninetti C, Nicchia E, Güthner C, Baronci C, Seri M, Knight PJ, Balduini CL, Savoia A.

Hum Mutat. 2014 Feb;35(2):236-47. doi: 10.1002/humu.22476. Epub 2013 Dec 12.

26.

ANKRD26-related thrombocytopenia and myeloid malignancies.

Noris P, Favier R, Alessi MC, Geddis AE, Kunishima S, Heller PG, Giordano P, Niederhoffer KY, Bussel JB, Podda GM, Vianelli N, Kersseboom R, Pecci A, Gnan C, Marconi C, Auvrignon A, Cohen W, Yu JC, Iguchi A, Miller Imahiyerobo A, Boehlen F, Ghalloussi D, De Rocco D, Magini P, Civaschi E, Biino G, Seri M, Savoia A, Balduini CL.

Blood. 2013 Sep 12;122(11):1987-9. doi: 10.1182/blood-2013-04-499319. No abstract available.

PMID:
24030261
27.

MYH9-related disease: five novel mutations expanding the spectrum of causative mutations and confirming genotype/phenotype correlations.

De Rocco D, Zieger B, Platokouki H, Heller PG, Pastore A, Bottega R, Noris P, Barozzi S, Glembotsky AC, Pergantou H, Balduini CL, Savoia A, Pecci A.

Eur J Med Genet. 2013 Jan;56(1):7-12. doi: 10.1016/j.ejmg.2012.10.009. Epub 2012 Oct 30.

28.

Correlation between platelet phenotype and NBEAL2 genotype in patients with congenital thrombocytopenia and α-granule deficiency.

Bottega R, Pecci A, De Candia E, Pujol-Moix N, Heller PG, Noris P, De Rocco D, Podda GM, Glembotsky AC, Cattaneo M, Balduini CL, Savoia A.

Haematologica. 2013 Jun;98(6):868-74. doi: 10.3324/haematol.2012.075861. Epub 2012 Oct 25.

29.

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression.

Bluteau D, Glembotsky AC, Raimbault A, Balayn N, Gilles L, Rameau P, Nurden P, Alessi MC, Debili N, Vainchenker W, Heller PG, Favier R, Raslova H.

Blood. 2012 Sep 27;120(13):2708-18. Epub 2012 Aug 16.

PMID:
22898599
30.

International collaboration as a tool for diagnosis of patients with inherited thrombocytopenia in the setting of a developing country.

Glembotsky AC, Marta RF, Pecci A, De Rocco D, Gnan C, Espasandin YR, Goette NP, Negro F, Noris P, Savoia A, Balduini CL, Molinas FC, Heller PG.

J Thromb Haemost. 2012 Aug;10(8):1653-61. doi: 10.1111/j.1538-7836.2012.04805.x.

31.

Production of functional platelet-like particles by the megakaryoblastic DAMI cell line provides a model for platelet biogenesis.

Lev PR, Goette NP, Glembotsky AC, Laguens RP, Meckert PM, Salim JP, Heller PG, Pozner RG, Marta RF, Molinas FC.

Platelets. 2011;22(1):28-38. doi: 10.3109/09537104.2010.515271. Epub 2010 Dec 14.

PMID:
21143024
32.

Abnormal regulation of soluble and anchored IL-6 receptor in monocytes from patients with essential thrombocythemia.

Goette NP, Lev PR, Heller PG, Glembotsky AC, Chazarreta CD, Salim JP, Molinas FC, Marta RF.

Exp Hematol. 2010 Oct;38(10):868-876.e1. doi: 10.1016/j.exphem.2010.06.007. Epub 2010 Jun 23.

PMID:
20600579
33.

Monocyte IL-2Ralpha expression is associated with thrombosis and the JAK2V617F mutation in myeloproliferative neoplasms.

Goette NP, Lev PR, Heller PG, Kornblihtt LI, Korin L, Molinas FC, Marta RF.

Cytokine. 2010 Jul;51(1):67-72. doi: 10.1016/j.cyto.2010.04.011. Epub 2010 May 18.

PMID:
20483636
34.

Heavy chain myosin 9-related disease (MYH9 -RD): neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder.

Savoia A, De Rocco D, Panza E, Bozzi V, Scandellari R, Loffredo G, Mumford A, Heller PG, Noris P, De Groot MR, Giani M, Freddi P, Scognamiglio F, Riondino S, Pujol-Moix N, Fabris F, Seri M, Balduini CL, Pecci A.

Thromb Haemost. 2010 Apr;103(4):826-32. doi: 10.1160/TH09-08-0593. Epub 2010 Feb 19.

PMID:
20174760
35.

Screening for MPL mutations in essential thrombocythemia and primary myelofibrosis: normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets.

Glembotsky AC, Korin L, Lev PR, Chazarreta CD, Marta RF, Molinas FC, Heller PG.

Eur J Haematol. 2010 May;84(5):398-405. doi: 10.1111/j.1600-0609.2010.01421.x. Epub 2010 Jan 22.

PMID:
20113333
36.

MYH9 related disease: a novel missense Ala95Asp mutation of the MYH9 gene.

de Rocco D, Heller PG, Girotto G, Pastore A, Glembotsky AC, Marta RF, Bozzi V, Pecci A, Molinas FC, Savoia A.

Platelets. 2009 Dec;20(8):598-602. doi: 10.3109/09537100903349620.

PMID:
19860543
37.

Dysregulation of stromal derived factor 1/CXCR4 axis in the megakaryocytic lineage in essential thrombocythemia.

Salim JP, Goette NP, Lev PR, Chazarreta CD, Heller PG, Alvarez C, Molinas FC, Marta RF.

Br J Haematol. 2009 Jan;144(1):69-77. doi: 10.1111/j.1365-2141.2008.07428.x. Epub 2008 Nov 1.

PMID:
19006565
38.

Diverse Mpl expression pattern among pedigrees with inherited thrombocytopenia: potential diagnostic and therapeutic implications.

Heller PG, Glembotsky AC, Goette NP, Marta RF, Lev PR, Molinas FC.

J Thromb Haemost. 2008 Dec;6(12):2215-7. doi: 10.1111/j.1538-7836.2008.03159.x. Epub 2008 Sep 23. No abstract available.

39.

Primary myelofibrosis in a patient who developed primary biliary cirrhosis, autoimmune hemolytic anemia and fibrillary glomerulonephritis.

Kornblihtt LI, Vassalllu PS, Heller PG, Lago NR, Alvarez CL, Molinas FC.

Ann Hematol. 2008 Dec;87(12):1019-20. doi: 10.1007/s00277-008-0516-6. Epub 2008 Jun 25. No abstract available.

PMID:
18575863
40.

Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease.

Pecci A, Panza E, Pujol-Moix N, Klersy C, Di Bari F, Bozzi V, Gresele P, Lethagen S, Fabris F, Dufour C, Granata A, Doubek M, Pecoraro C, Koivisto PA, Heller PG, Iolascon A, Alvisi P, Schwabe D, De Candia E, Rocca B, Russo U, Ramenghi U, Noris P, Seri M, Balduini CL, Savoia A.

Hum Mutat. 2008 Mar;29(3):409-17.

PMID:
18059020
41.

JAK2V617F mutation in platelets from essential thrombocythemia patients: correlation with clinical features and analysis of STAT5 phosphorylation status.

Heller PG, Lev PR, Salim JP, Kornblihtt LI, Goette NP, Chazarreta CD, Glembotsky AC, Vassallu PS, Marta RF, Molinas FC.

Eur J Haematol. 2006 Sep;77(3):210-6.

PMID:
16923108
42.

Unexplained recurrent venous thrombosis in a patient with MYH9-related disease.

Heller PG, Pecci A, Glembotsky AC, Savoia A, Negro FD, Balduini CL, Molinas FC.

Platelets. 2006 Jun;17(4):274-5. No abstract available.

PMID:
16769605
43.

Moyamoya syndrome in an adolescent with essential thrombocythemia: successful intracranial carotid stent placement.

Kornblihtt LI, Cocorullo S, Miranda C, Lylyk P, Heller PG, Molinas FC.

Stroke. 2005 Aug;36(8):E71-3. Epub 2005 Jul 14.

PMID:
16020757
44.

Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation.

Heller PG, Glembotsky AC, Gandhi MJ, Cummings CL, Pirola CJ, Marta RF, Kornblihtt LI, Drachman JG, Molinas FC.

Blood. 2005 Jun 15;105(12):4664-70. Epub 2005 Mar 1.

PMID:
15741216
45.

PDGF-A, PDGF-B, TGFbeta, and bFGF mRNA levels in patients with essential thrombocythemia treated with anagrelide.

Lev PR, Salim JP, Kornblihtt LI, Pirola CJ, Marta RF, Heller PG, Molinas FC.

Am J Hematol. 2005 Feb;78(2):155-7.

46.

The clinical course of patients with septic abortion admitted to an intensive care unit.

Finkielman JD, De Feo FD, Heller PG, Afessa B.

Intensive Care Med. 2004 Jun;30(6):1097-102. Epub 2004 Mar 9.

PMID:
15007546
47.

Associated thrombophilic defects in essential thrombocythaemia: their relationship with clinical manifestations.

Kornblihtt LI, Heller PG, Correa G, Castañón M, Genoud V, Vassallu P, Sarano J, Kordich L, Molinas FC.

Thromb Res. 2003;112(3):131-5. No abstract available.

PMID:
14967408
48.

[Catastrophic antiphospholipid syndrome. Communication of 2 forms of presentation].

Grinberg AR, Heller PG, Correa G, Sarano JF, Molinas FC, Nicastro MA, Alvarez CL.

Medicina (B Aires). 1999;59(6):743-6. Spanish.

PMID:
10752219
49.

Pulmonary hypertension in paroxysmal nocturnal hemoglobinuria.

Heller PG, Grinberg AR, Lencioni M, Molina MM, Roncoroni AJ.

Chest. 1992 Aug;102(2):642-3.

PMID:
1643968

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