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Items: 12


Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.

Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM.

Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5.


Determination of Structural Ensembles of Proteins: Restraining vs Reweighting.

Rangan R, Bonomi M, Heller GT, Cesari A, Bussi G, Vendruscolo M.

J Chem Theory Comput. 2018 Dec 11;14(12):6632-6641. doi: 10.1021/acs.jctc.8b00738. Epub 2018 Nov 28.


Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Aug 17;13(8):2308-2319. doi: 10.1021/acschembio.8b00466. Epub 2018 Jun 28.


Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins.

Heller GT, Bonomi M, Vendruscolo M.

J Mol Biol. 2018 Aug 3;430(16):2288-2292. doi: 10.1016/j.jmb.2018.03.015. Epub 2018 Mar 26. Review.


Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide.

Heller GT, Aprile FA, Bonomi M, Camilloni C, De Simone A, Vendruscolo M.

J Mol Biol. 2017 Sep 1;429(18):2772-2779. doi: 10.1016/j.jmb.2017.07.016. Epub 2017 Jul 22.


Methods of probing the interactions between small molecules and disordered proteins.

Heller GT, Aprile FA, Vendruscolo M.

Cell Mol Life Sci. 2017 Sep;74(17):3225-3243. doi: 10.1007/s00018-017-2563-4. Epub 2017 Jun 19. Review.


Simultaneous quantification of protein order and disorder.

Sormanni P, Piovesan D, Heller GT, Bonomi M, Kukic P, Camilloni C, Fuxreiter M, Dosztanyi Z, Pappu RV, Babu MM, Longhi S, Tompa P, Dunker AK, Uversky VN, Tosatto SC, Vendruscolo M.

Nat Chem Biol. 2017 Mar 22;13(4):339-342. doi: 10.1038/nchembio.2331. No abstract available.


A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.

Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limbocker R, Sormanni P, Heller GT, Aprile FA, Cremades N, Cecchi C, Chiti F, Nollen EA, Knowles TP, Vendruscolo M, Bax A, Zasloff M, Dobson CM.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1009-E1017. doi: 10.1073/pnas.1610586114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Mar 21;114(12 ):E2543. Limboker, Ryan [corrected to Limbocker, Ryan].


Principles of protein structural ensemble determination.

Bonomi M, Heller GT, Camilloni C, Vendruscolo M.

Curr Opin Struct Biol. 2017 Feb;42:106-116. doi: 10.1016/ Epub 2017 Jan 5. Review.


Targeting disordered proteins with small molecules using entropy.

Heller GT, Sormanni P, Vendruscolo M.

Trends Biochem Sci. 2015 Sep;40(9):491-6. doi: 10.1016/j.tibs.2015.07.004. Epub 2015 Aug 11. Review.


Quartz microbalance technology for probing biomolecular interactions.

Heller GT, Mercer-Smith AR, Johal MS.

Methods Mol Biol. 2015;1278:153-64. doi: 10.1007/978-1-4939-2425-7_9.


Accounting for unintended binding events in the analysis of quartz crystal microbalance kinetic data.

Heller GT, Zwang TJ, Sarapata EA, Haber MA, Sazinsky MH, Radunskaya AE, Johal MS.

Colloids Surf B Biointerfaces. 2014 May 1;117:425-31. doi: 10.1016/j.colsurfb.2014.02.044. Epub 2014 Mar 12.


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