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Items: 1 to 50 of 108

1.

Two classes of EF1-family translational GTPases encoded by giant viruses.

Zinoviev A, Kuroha K, Pestova TV, Hellen CUT.

Nucleic Acids Res. 2019 Jun 20;47(11):5761-5776. doi: 10.1093/nar/gkz296.

2.

Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1.

Kuroha K, Zinoviev A, Hellen CUT, Pestova TV.

Mol Cell. 2018 Oct 18;72(2):286-302.e8. doi: 10.1016/j.molcel.2018.08.022. Epub 2018 Sep 20.

3.

Functions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2.

Zinoviev A, Goyal A, Jindal S, LaCava J, Komar AA, Rodnina MV, Hellen CUT, Pestova TV.

Genes Dev. 2018 Sep 1;32(17-18):1226-1241. doi: 10.1101/gad.314724.118. Epub 2018 Aug 14.

4.

Translation Termination and Ribosome Recycling in Eukaryotes.

Hellen CUT.

Cold Spring Harb Perspect Biol. 2018 Oct 1;10(10). pii: a032656. doi: 10.1101/cshperspect.a032656. Review.

PMID:
29735640
5.

An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation.

Imai S, Kumar P, Hellen CU, D'Souza VM, Wagner G.

Nat Struct Mol Biol. 2016 Sep;23(9):859-64. doi: 10.1038/nsmb.3280. Epub 2016 Aug 15.

6.

Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs.

Kumar P, Hellen CU, Pestova TV.

Genes Dev. 2016 Jul 1;30(13):1573-88. doi: 10.1101/gad.282418.116.

7.
8.

Initiation on the divergent Type I cadicivirus IRES: factor requirements and interactions with the translation apparatus.

Asnani M, Pestova TV, Hellen CU.

Nucleic Acids Res. 2016 Apr 20;44(7):3390-407. doi: 10.1093/nar/gkw074. Epub 2016 Feb 11.

9.

Attachment of ribosomal complexes and retrograde scanning during initiation on the Halastavi árva virus IRES.

Abaeva IS, Pestova TV, Hellen CU.

Nucleic Acids Res. 2016 Mar 18;44(5):2362-77. doi: 10.1093/nar/gkw016. Epub 2016 Jan 17.

10.

Structure of mammalian eIF3 in the context of the 43S preinitiation complex.

des Georges A, Dhote V, Kuhn L, Hellen CU, Pestova TV, Frank J, Hashem Y.

Nature. 2015 Sep 24;525(7570):491-5. doi: 10.1038/nature14891. Epub 2015 Sep 7.

11.

Multiple mechanisms of reinitiation on bicistronic calicivirus mRNAs.

Zinoviev A, Hellen CUT, Pestova TV.

Mol Cell. 2015 Mar 19;57(6):1059-1073. doi: 10.1016/j.molcel.2015.01.039.

12.

Widespread distribution and structural diversity of Type IV IRESs in members of Picornaviridae.

Asnani M, Kumar P, Hellen CU.

Virology. 2015 Apr;478:61-74. doi: 10.1016/j.virol.2015.02.016. Epub 2015 Feb 27.

13.

Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs.

Kumar P, Sweeney TR, Skabkin MA, Skabkina OV, Hellen CU, Pestova TV.

Nucleic Acids Res. 2014 Mar;42(5):3228-45. doi: 10.1093/nar/gkt1321. Epub 2013 Dec 25.

14.

The mechanism of translation initiation on Type 1 picornavirus IRESs.

Sweeney TR, Abaeva IS, Pestova TV, Hellen CU.

EMBO J. 2014 Jan 7;33(1):76-92. doi: 10.1002/embj.201386124. Epub 2013 Dec 15.

15.

Structure of the mammalian ribosomal pre-termination complex associated with eRF1.eRF3.GDPNP.

des Georges A, Hashem Y, Unbehaun A, Grassucci RA, Taylor D, Hellen CU, Pestova TV, Frank J.

Nucleic Acids Res. 2014 Mar;42(5):3409-18. doi: 10.1093/nar/gkt1279. Epub 2013 Dec 11.

16.

Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit.

Hashem Y, des Georges A, Dhote V, Langlois R, Liao HY, Grassucci RA, Pestova TV, Hellen CU, Frank J.

Nature. 2013 Nov 28;503(7477):539-43. doi: 10.1038/nature12658. Epub 2013 Nov 3.

17.

Reinitiation and other unconventional posttermination events during eukaryotic translation.

Skabkin MA, Skabkina OV, Hellen CU, Pestova TV.

Mol Cell. 2013 Jul 25;51(2):249-64. doi: 10.1016/j.molcel.2013.05.026. Epub 2013 Jun 27.

18.

Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29.

Hashem Y, des Georges A, Dhote V, Langlois R, Liao HY, Grassucci RA, Hellen CU, Pestova TV, Frank J.

Cell. 2013 May 23;153(5):1108-19. doi: 10.1016/j.cell.2013.04.036.

19.

Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs.

Dhote V, Sweeney TR, Kim N, Hellen CU, Pestova TV.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3150-9. doi: 10.1073/pnas.1208014109. Epub 2012 Oct 9.

20.

Termination and post-termination events in eukaryotic translation.

Jackson RJ, Hellen CU, Pestova TV.

Adv Protein Chem Struct Biol. 2012;86:45-93. doi: 10.1016/B978-0-12-386497-0.00002-5. Review.

PMID:
22243581
21.

A distinct class of internal ribosomal entry site in members of the Kobuvirus and proposed Salivirus and Paraturdivirus genera of the Picornaviridae.

Sweeney TR, Dhote V, Yu Y, Hellen CU.

J Virol. 2012 Feb;86(3):1468-86. doi: 10.1128/JVI.05862-11. Epub 2011 Nov 23.

22.

The mechanism of translation initiation on Aichivirus RNA mediated by a novel type of picornavirus IRES.

Yu Y, Sweeney TR, Kafasla P, Jackson RJ, Pestova TV, Hellen CU.

EMBO J. 2011 Aug 26;30(21):4423-36. doi: 10.1038/emboj.2011.306.

23.

Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.

Pisareva VP, Skabkin MA, Hellen CU, Pestova TV, Pisarev AV.

EMBO J. 2011 May 4;30(9):1804-17. doi: 10.1038/emboj.2011.93. Epub 2011 Mar 29.

24.

Common conformational changes induced in type 2 picornavirus IRESs by cognate trans-acting factors.

Yu Y, Abaeva IS, Marintchev A, Pestova TV, Hellen CU.

Nucleic Acids Res. 2011 Jun;39(11):4851-65. doi: 10.1093/nar/gkr045. Epub 2011 Feb 8.

25.

Bypassing of stems versus linear base-by-base inspection of mammalian mRNAs during ribosomal scanning.

Abaeva IS, Marintchev A, Pisareva VP, Hellen CU, Pestova TV.

EMBO J. 2011 Jan 5;30(1):115-29. doi: 10.1038/emboj.2010.302. Epub 2010 Nov 26.

26.

Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling.

Skabkin MA, Skabkina OV, Dhote V, Komar AA, Hellen CU, Pestova TV.

Genes Dev. 2010 Aug 15;24(16):1787-801. doi: 10.1101/gad.1957510.

27.

The role of ABCE1 in eukaryotic posttermination ribosomal recycling.

Pisarev AV, Skabkin MA, Pisareva VP, Skabkina OV, Rakotondrafara AM, Hentze MW, Hellen CU, Pestova TV.

Mol Cell. 2010 Jan 29;37(2):196-210. doi: 10.1016/j.molcel.2009.12.034.

28.

The mechanism of eukaryotic translation initiation and principles of its regulation.

Jackson RJ, Hellen CU, Pestova TV.

Nat Rev Mol Cell Biol. 2010 Feb;11(2):113-27. doi: 10.1038/nrm2838. Review.

29.

The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis.

Parsyan A, Shahbazian D, Martineau Y, Petroulakis E, Alain T, Larsson O, Mathonnet G, Tettweiler G, Hellen CU, Pestova TV, Svitkin YV, Sonenberg N.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22217-22. doi: 10.1073/pnas.0909773106. Epub 2009 Dec 11.

30.

Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing.

Yu Y, Marintchev A, Kolupaeva VG, Unbehaun A, Veryasova T, Lai SC, Hong P, Wagner G, Hellen CU, Pestova TV.

Nucleic Acids Res. 2009 Aug;37(15):5167-82. doi: 10.1093/nar/gkp519. Epub 2009 Jun 26.

31.

IRES-induced conformational changes in the ribosome and the mechanism of translation initiation by internal ribosomal entry.

Hellen CU.

Biochim Biophys Acta. 2009 Sep-Oct;1789(9-10):558-70. doi: 10.1016/j.bbagrm.2009.06.001. Epub 2009 Jun 17. Review.

32.

Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites.

de Breyne S, Yu Y, Unbehaun A, Pestova TV, Hellen CU.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9197-202. doi: 10.1073/pnas.0900153106. Epub 2009 May 22.

33.

Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29.

Pisareva VP, Pisarev AV, Komar AA, Hellen CU, Pestova TV.

Cell. 2008 Dec 26;135(7):1237-50. doi: 10.1016/j.cell.2008.10.037.

34.

Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases.

de Breyne S, Bonderoff JM, Chumakov KM, Lloyd RE, Hellen CU.

Virology. 2008 Aug 15;378(1):118-22. doi: 10.1016/j.virol.2008.05.019. Epub 2008 Jun 24.

35.

Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes.

Pisarev AV, Kolupaeva VG, Yusupov MM, Hellen CU, Pestova TV.

EMBO J. 2008 Jun 4;27(11):1609-21. doi: 10.1038/emboj.2008.90. Epub 2008 May 8.

36.

eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II.

Pestova TV, de Breyne S, Pisarev AV, Abaeva IS, Hellen CU.

EMBO J. 2008 Apr 9;27(7):1060-72. doi: 10.1038/emboj.2008.49. Epub 2008 Mar 13.

37.

Translational control by a small RNA: dendritic BC1 RNA targets the eukaryotic initiation factor 4A helicase mechanism.

Lin D, Pestova TV, Hellen CU, Tiedge H.

Mol Cell Biol. 2008 May;28(9):3008-19. doi: 10.1128/MCB.01800-07. Epub 2008 Mar 3.

38.

Factor requirements for translation initiation on the Simian picornavirus internal ribosomal entry site.

de Breyne S, Yu Y, Pestova TV, Hellen CU.

RNA. 2008 Feb;14(2):367-80. Epub 2007 Dec 19.

39.

Recycling of eukaryotic posttermination ribosomal complexes.

Pisarev AV, Hellen CU, Pestova TV.

Cell. 2007 Oct 19;131(2):286-99.

40.

In vitro reconstitution and biochemical characterization of translation initiation by internal ribosomal entry.

Kolupaeva VG, de Breyne S, Pestova TV, Hellen CU.

Methods Enzymol. 2007;430:409-39.

PMID:
17913647
41.

Assembly and analysis of eukaryotic translation initiation complexes.

Pisarev AV, Unbehaun A, Hellen CU, Pestova TV.

Methods Enzymol. 2007;430:147-77.

PMID:
17913638
42.

Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5.

Galkin O, Bentley AA, Gupta S, Compton BA, Mazumder B, Kinzy TG, Merrick WC, Hatzoglou M, Pestova TV, Hellen CU, Komar AA.

RNA. 2007 Dec;13(12):2116-28. Epub 2007 Sep 27.

43.

Position of eukaryotic initiation factor eIF5B on the 80S ribosome mapped by directed hydroxyl radical probing.

Unbehaun A, Marintchev A, Lomakin IB, Didenko T, Wagner G, Hellen CU, Pestova TV.

EMBO J. 2007 Jul 11;26(13):3109-23. Epub 2007 Jun 14.

45.

Kinetic analysis of the interaction of guanine nucleotides with eukaryotic translation initiation factor eIF5B.

Pisareva VP, Hellen CU, Pestova TV.

Biochemistry. 2007 Mar 13;46(10):2622-9. Epub 2007 Feb 13.

PMID:
17297921
46.

Bypassing translation initiation.

Hellen CU.

Structure. 2007 Jan;15(1):4-6.

47.

Kinetic analysis of interaction of eukaryotic release factor 3 with guanine nucleotides.

Pisareva VP, Pisarev AV, Hellen CU, Rodnina MV, Pestova TV.

J Biol Chem. 2006 Dec 29;281(52):40224-35. Epub 2006 Oct 24.

48.

Small molecule derails translation initiation.

Pestova TV, Hellen CU.

Nat Chem Biol. 2006 Apr;2(4):176-7. No abstract available.

PMID:
16547475
49.
50.

Translation, interrupted.

Pestova TV, Hellen CU.

Nat Struct Mol Biol. 2006 Feb;13(2):98-9. No abstract available.

PMID:
16462810

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