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Items: 1 to 50 of 116

1.

Dimorphism throughout the European eel's life cycle: are ontogenetic changes in head shape related to dietary differences?

De Meyer J, Goethals T, Van Wassenbergh S, Augustijns T, Habraken J, Hellemans J, Vandewiele V, Dhaene J, Bouillart M, Adriaens D.

J Anat. 2018 May 31. doi: 10.1111/joa.12836. [Epub ahead of print]

PMID:
29855043
2.

High-throughput PCR assay design for targeted resequencing using primerXL.

Lefever S, Pattyn F, De Wilde B, Coppieters F, De Keulenaer S, Hellemans J, Vandesompele J.

BMC Bioinformatics. 2017 Sep 6;18(1):400. doi: 10.1186/s12859-017-1809-3.

3.

A unified censored normal regression model for qPCR differential gene expression analysis.

Pipelers P, Clement L, Vynck M, Hellemans J, Vandesompele J, Thas O.

PLoS One. 2017 Aug 17;12(8):e0182832. doi: 10.1371/journal.pone.0182832. eCollection 2017.

4.

Benchmarking of RNA-sequencing analysis workflows using whole-transcriptome RT-qPCR expression data.

Everaert C, Luypaert M, Maag JLV, Cheng QX, Dinger ME, Hellemans J, Mestdagh P.

Sci Rep. 2017 May 8;7(1):1559. doi: 10.1038/s41598-017-01617-3.

5.

Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR.

Mestdagh P, Lefever S, Volders PJ, Derveaux S, Hellemans J, Vandesompele J.

Sci Data. 2016 Jul 5;3:160052. doi: 10.1038/sdata.2016.52.

6.

Removal of between-run variation in a multi-plate qPCR experiment.

Ruijter JM, Ruiz Villalba A, Hellemans J, Untergasser A, van den Hoff MJ.

Biomol Detect Quantif. 2015 Jul 30;5:10-4. doi: 10.1016/j.bdq.2015.07.001. eCollection 2015 Sep.

7.

The effect of short-term intermittent hypoxic exposure on heart rate variability in a sedentary population.

Lizamore CA, Kathiravel Y, Elliott J, Hellemans J, Hamlin MJ.

Physiol Int. 2016 Mar;103(1):75-85. doi: 10.1556/036.103.2016.1.7.

PMID:
27030629
8.

RDML-Ninja and RDMLdb for standardized exchange of qPCR data.

Ruijter JM, Lefever S, Anckaert J, Hellemans J, Pfaffl MW, Benes V, Bustin SA, Vandesompele J, Untergasser A; RDML consortium.

BMC Bioinformatics. 2015 Jun 20;16:197. doi: 10.1186/s12859-015-0637-6.

9.

Flexible, scalable, and efficient targeted resequencing on a benchtop sequencer for variant detection in clinical practice.

De Leeneer K, Hellemans J, Steyaert W, Lefever S, Vereecke I, Debals E, Crombez B, Baetens M, Van Heetvelde M, Coppieters F, Vandesompele J, De Jaegher A, De Baere E, Coucke P, Claes K.

Hum Mutat. 2015 Mar;36(3):379-87. doi: 10.1002/humu.22739.

PMID:
25504618
10.

mRNA levels of BACE1 and its interacting proteins, RTN3 and PPIL2, correlate in human post mortem brain tissue.

Beyer N, Coulson DT, Quinn JG, Brockbank S, Hellemans J, Irvine GB, Ravid R, Johnston JA.

Neuroscience. 2014 Aug 22;274:44-52. doi: 10.1016/j.neuroscience.2014.05.020. Epub 2014 May 20.

PMID:
24853053
11.

Selection of reliable reference genes for RT-qPCR analysis.

Hellemans J, Vandesompele J.

Methods Mol Biol. 2014;1160:19-26. doi: 10.1007/978-1-4939-0733-5_3.

PMID:
24740218
12.

Target enrichment using parallel nanoliter quantitative PCR amplification.

De Wilde B, Lefever S, Dong W, Dunne J, Husain S, Derveaux S, Hellemans J, Vandesompele J.

BMC Genomics. 2014 Mar 10;15:184. doi: 10.1186/1471-2164-15-184.

13.

The need for transparency and good practices in the qPCR literature.

Bustin SA, Benes V, Garson J, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley G, Wittwer CT, Schjerling P, Day PJ, Abreu M, Aguado B, Beaulieu JF, Beckers A, Bogaert S, Browne JA, Carrasco-Ramiro F, Ceelen L, Ciborowski K, Cornillie P, Coulon S, Cuypers A, De Brouwer S, De Ceuninck L, De Craene J, De Naeyer H, De Spiegelaere W, Deckers K, Dheedene A, Durinck K, Ferreira-Teixeira M, Fieuw A, Gallup JM, Gonzalo-Flores S, Goossens K, Heindryckx F, Herring E, Hoenicka H, Icardi L, Jaggi R, Javad F, Karampelias M, Kibenge F, Kibenge M, Kumps C, Lambertz I, Lammens T, Markey A, Messiaen P, Mets E, Morais S, Mudarra-Rubio A, Nakiwala J, Nelis H, Olsvik PA, Pérez-Novo C, Plusquin M, Remans T, Rihani A, Rodrigues-Santos P, Rondou P, Sanders R, Schmidt-Bleek K, Skovgaard K, Smeets K, Tabera L, Toegel S, Van Acker T, Van den Broeck W, Van der Meulen J, Van Gele M, Van Peer G, Van Poucke M, Van Roy N, Vergult S, Wauman J, Tshuikina-Wiklander M, Willems E, Zaccara S, Zeka F, Vandesompele J.

Nat Methods. 2013 Nov;10(11):1063-7. doi: 10.1038/nmeth.2697.

PMID:
24173381
14.

Single-nucleotide polymorphisms and other mismatches reduce performance of quantitative PCR assays.

Lefever S, Pattyn F, Hellemans J, Vandesompele J.

Clin Chem. 2013 Oct;59(10):1470-80. doi: 10.1373/clinchem.2013.203653. Epub 2013 Sep 6.

15.

The digital MIQE guidelines: Minimum Information for Publication of Quantitative Digital PCR Experiments.

Huggett JF, Foy CA, Benes V, Emslie K, Garson JA, Haynes R, Hellemans J, Kubista M, Mueller RD, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT, Bustin SA.

Clin Chem. 2013 Jun;59(6):892-902. doi: 10.1373/clinchem.2013.206375. Epub 2013 Apr 9.

16.

Evaluation of qPCR curve analysis methods for reliable biomarker discovery: bias, resolution, precision, and implications.

Ruijter JM, Pfaffl MW, Zhao S, Spiess AN, Boggy G, Blom J, Rutledge RG, Sisti D, Lievens A, De Preter K, Derveaux S, Hellemans J, Vandesompele J.

Methods. 2013 Jan;59(1):32-46. doi: 10.1016/j.ymeth.2012.08.011. Epub 2012 Sep 3.

PMID:
22975077
17.

Molecular diagnostics for congenital hearing loss including 15 deafness genes using a next generation sequencing platform.

De Keulenaer S, Hellemans J, Lefever S, Renard JP, De Schrijver J, Van de Voorde H, Tabatabaiefar MA, Van Nieuwerburgh F, Flamez D, Pattyn F, Scharlaken B, Deforce D, Bekaert S, Van Criekinge W, Vandesompele J, Van Camp G, Coucke P.

BMC Med Genomics. 2012 May 18;5:17. doi: 10.1186/1755-8794-5-17.

18.

α-Synuclein mRNA and soluble α-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease.

Quinn JG, Coulson DT, Brockbank S, Beyer N, Ravid R, Hellemans J, Irvine GB, Johnston JA.

Brain Res. 2012 Jun 12;1459:71-80. doi: 10.1016/j.brainres.2012.04.018. Epub 2012 Apr 17.

PMID:
22560502
19.

Zinc transporter mRNA levels in Alzheimer's disease postmortem brain.

Beyer N, Coulson DT, Heggarty S, Ravid R, Hellemans J, Irvine GB, Johnston JA.

J Alzheimers Dis. 2012;29(4):863-73. doi: 10.3233/JAD-2012-112105.

PMID:
22349685
20.

Massively parallel sequencing for early molecular diagnosis in Leber congenital amaurosis.

Coppieters F, De Wilde B, Lefever S, De Meester E, De Rocker N, Van Cauwenbergh C, Pattyn F, Meire F, Leroy BP, Hellemans J, Vandesompele J, De Baere E.

Genet Med. 2012 Jun;14(6):576-85. doi: 10.1038/gim.2011.51. Epub 2012 Jan 26.

PMID:
22261762
21.

miRNA expression profiling: from reference genes to global mean normalization.

D'haene B, Mestdagh P, Hellemans J, Vandesompele J.

Methods Mol Biol. 2012;822:261-72. doi: 10.1007/978-1-61779-427-8_18.

PMID:
22144205
22.

Practical tools to implement massive parallel pyrosequencing of PCR products in next generation molecular diagnostics.

De Leeneer K, De Schrijver J, Clement L, Baetens M, Lefever S, De Keulenaer S, Van Criekinge W, Deforce D, Van Nieuwerburgh F, Bekaert S, Pattyn F, De Wilde B, Coucke P, Vandesompele J, Claes K, Hellemans J.

PLoS One. 2011;6(9):e25531. doi: 10.1371/journal.pone.0025531. Epub 2011 Sep 30.

23.

Applying massive parallel sequencing to molecular diagnosis of Marfan and Loeys-Dietz syndromes.

Baetens M, Van Laer L, De Leeneer K, Hellemans J, De Schrijver J, Van De Voorde H, Renard M, Dietz H, Lacro RV, Menten B, Van Criekinge W, De Backer J, De Paepe A, Loeys B, Coucke PJ.

Hum Mutat. 2011 Sep;32(9):1053-62. doi: 10.1002/humu.21525. Epub 2011 Jul 20.

PMID:
21542060
24.

Primer sequence disclosure: a clarification of the MIQE guidelines.

Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT.

Clin Chem. 2011 Jun;57(6):919-21. doi: 10.1373/clinchem.2011.162958. Epub 2011 Mar 18. No abstract available.

25.

Measurable impact of RNA quality on gene expression results from quantitative PCR.

Vermeulen J, De Preter K, Lefever S, Nuytens J, De Vloed F, Derveaux S, Hellemans J, Speleman F, Vandesompele J.

Nucleic Acids Res. 2011 May;39(9):e63. doi: 10.1093/nar/gkr065. Epub 2011 Feb 11.

26.

Massive parallel amplicon sequencing of the breast cancer genes BRCA1 and BRCA2: opportunities, challenges, and limitations.

De Leeneer K, Hellemans J, De Schrijver J, Baetens M, Poppe B, Van Criekinge W, De Paepe A, Coucke P, Claes K.

Hum Mutat. 2011 Mar;32(3):335-44. doi: 10.1002/humu.21428. Epub 2011 Feb 8.

PMID:
21305653
27.

Meeting Report from the Second "Minimum Information for Biological and Biomedical Investigations" (MIBBI) workshop.

Kettner C, Field D, Sansone SA, Taylor C, Aerts J, Binns N, Blake A, Britten CM, de Marco A, Fostel J, Gaudet P, González-Beltrán A, Hardy N, Hellemans J, Hermjakob H, Juty N, Leebens-Mack J, Maguire E, Neumann S, Orchard S, Parkinson H, Piel W, Ranganathan S, Rocca-Serra P, Santarsiero A, Shotton D, Sterk P, Untergasser A, Whetzel PL.

Stand Genomic Sci. 2010 Dec 25;3(3):259-66. doi: 10.4056/sigs.147362.

28.

BACE1 mRNA expression in Alzheimer's disease postmortem brain tissue.

Coulson DT, Beyer N, Quinn JG, Brockbank S, Hellemans J, Irvine GB, Ravid R, Johnston JA.

J Alzheimers Dis. 2010;22(4):1111-22. doi: 10.3233/JAD-2010-101254.

PMID:
20930286
29.

Effect of intermittent hypoxia on muscle and cerebral oxygenation during a 20-km time trial in elite athletes: a preliminary report.

Hamlin MJ, Marshall HC, Hellemans J, Ainslie PN.

Appl Physiol Nutr Metab. 2010 Aug;35(4):548-59. doi: 10.1139/H10-044.

PMID:
20725123
30.

Analysing 454 amplicon resequencing experiments using the modular and database oriented Variant Identification Pipeline.

De Schrijver JM, De Leeneer K, Lefever S, Sabbe N, Pattyn F, Van Nieuwerburgh F, Coucke P, Deforce D, Vandesompele J, Bekaert S, Hellemans J, Van Criekinge W.

BMC Bioinformatics. 2010 May 20;11:269. doi: 10.1186/1471-2105-11-269.

31.

The RIN2 syndrome: a new autosomal recessive connective tissue disorder caused by deficiency of Ras and Rab interactor 2 (RIN2).

Syx D, Malfait F, Van Laer L, Hellemans J, Hermanns-Lê T, Willaert A, Benmansour A, De Paepe A, Verloes A.

Hum Genet. 2010 Jul;128(1):79-88. doi: 10.1007/s00439-010-0829-0. Epub 2010 Apr 28.

PMID:
20424861
32.

Improved molecular diagnostics of idiopathic short stature and allied disorders: quantitative polymerase chain reaction-based copy number profiling of SHOX and pseudoautosomal region 1.

D'haene B, Hellemans J, Craen M, De Schepper J, Devriendt K, Fryns JP, Keymolen K, Debals E, de Klein A, de Jong EM, Segers K, De Paepe A, Mortier G, Vandesompele J, De Baere E.

J Clin Endocrinol Metab. 2010 Jun;95(6):3010-8. doi: 10.1210/jc.2009-2218. Epub 2010 Apr 7.

PMID:
20375215
33.

Accurate and objective copy number profiling using real-time quantitative PCR.

D'haene B, Vandesompele J, Hellemans J.

Methods. 2010 Apr;50(4):262-70. doi: 10.1016/j.ymeth.2009.12.007. Epub 2010 Jan 6. Review. Erratum in: Methods. 2011 Mar;53(3):325.

PMID:
20060046
34.

ZnT3 mRNA levels are reduced in Alzheimer's disease post-mortem brain.

Beyer N, Coulson DT, Heggarty S, Ravid R, Irvine GB, Hellemans J, Johnston JA.

Mol Neurodegener. 2009 Dec 23;4:53. doi: 10.1186/1750-1326-4-53.

35.

Homozygous inactivating mutations in the NKX3-2 gene result in spondylo-megaepiphyseal-metaphyseal dysplasia.

Hellemans J, Simon M, Dheedene A, Alanay Y, Mihci E, Rifai L, Sefiani A, van Bever Y, Meradji M, Superti-Furga A, Mortier G.

Am J Hum Genet. 2009 Dec;85(6):916-22. doi: 10.1016/j.ajhg.2009.11.005.

36.

How to do successful gene expression analysis using real-time PCR.

Derveaux S, Vandesompele J, Hellemans J.

Methods. 2010 Apr;50(4):227-30. doi: 10.1016/j.ymeth.2009.11.001. Epub 2009 Dec 5.

PMID:
19969088
37.

The heterozygous Lemd3 +/GT mouse is not a murine model for osteopoikilosis in humans.

Dheedene A, Deleye S, Hellemans J, Staelens S, Vandenberghe S, Mortier G.

Calcif Tissue Int. 2009 Dec;85(6):546-51. doi: 10.1007/s00223-009-9305-z. Epub 2009 Oct 28.

PMID:
19862465
38.

Effect of intermittent hypoxic training on 20 km time trial and 30 s anaerobic performance.

Hamlin MJ, Marshall HC, Hellemans J, Ainslie PN, Anglem N.

Scand J Med Sci Sports. 2010 Aug;20(4):651-61. doi: 10.1111/j.1600-0838.2009.00946.x. Epub 2009 Sep 28.

PMID:
19793215
39.

External oligonucleotide standards enable cross laboratory comparison and exchange of real-time quantitative PCR data.

Vermeulen J, Pattyn F, De Preter K, Vercruysse L, Derveaux S, Mestdagh P, Lefever S, Hellemans J, Speleman F, Vandesompele J.

Nucleic Acids Res. 2009 Nov;37(21):e138. doi: 10.1093/nar/gkp721.

40.

Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study.

Vermeulen J, De Preter K, Naranjo A, Vercruysse L, Van Roy N, Hellemans J, Swerts K, Bravo S, Scaruffi P, Tonini GP, De Bernardi B, Noguera R, Piqueras M, Cañete A, Castel V, Janoueix-Lerosey I, Delattre O, Schleiermacher G, Michon J, Combaret V, Fischer M, Oberthuer A, Ambros PF, Beiske K, Bénard J, Marques B, Rubie H, Kohler J, Pötschger U, Ladenstein R, Hogarty MD, McGrady P, London WB, Laureys G, Speleman F, Vandesompele J.

Lancet Oncol. 2009 Jul;10(7):663-71. doi: 10.1016/S1470-2045(09)70154-8. Epub 2009 Jun 8.

41.

The 12q14 microdeletion syndrome: additional patients and further evidence that HMGA2 is an important genetic determinant for human height.

Buysse K, Reardon W, Mehta L, Costa T, Fagerstrom C, Kingsbury DJ, Anadiotis G, McGillivray BC, Hellemans J, de Leeuw N, de Vries BB, Speleman F, Menten B, Mortier G.

Eur J Med Genet. 2009 Mar-Jun;52(2-3):101-7. doi: 10.1016/j.ejmg.2009.03.001. Epub 2009 Mar 17.

PMID:
19298872
42.

The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments.

Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT.

Clin Chem. 2009 Apr;55(4):611-22. doi: 10.1373/clinchem.2008.112797. Epub 2009 Feb 26.

43.

RDML: structured language and reporting guidelines for real-time quantitative PCR data.

Lefever S, Hellemans J, Pattyn F, Przybylski DR, Taylor C, Geurts R, Untergasser A, Vandesompele J; RDML consortium.

Nucleic Acids Res. 2009 Apr;37(7):2065-9. doi: 10.1093/nar/gkp056. Epub 2009 Feb 17.

44.

Cerebral hypoperfusion during hypoxic exercise following two different hypoxic exposures: independence from changes in dynamic autoregulation and reactivity.

Ainslie PN, Hamlin M, Hellemans J, Rasmussen P, Ogoh S.

Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1613-22. doi: 10.1152/ajpregu.90420.2008. Epub 2008 Sep 3.

45.

Buschke-Ollendorff syndrome: a manifestation of a heterozygous nonsense mutation in the LEMD3 gene.

Gass JK, Hellemans J, Mortier G, Griffiths M, Burrows NP.

J Am Acad Dermatol. 2008 May;58(5 Suppl 1):S103-4. doi: 10.1016/j.jaad.2007.03.031. No abstract available.

PMID:
18489034
46.

Effects of intermittent hypoxia on SaO(2), cerebral and muscle oxygenation during maximal exercise in athletes with exercise-induced hypoxemia.

Marshall HC, Hamlin MJ, Hellemans J, Murrell C, Beattie N, Hellemans I, Perry T, Burns A, Ainslie PN.

Eur J Appl Physiol. 2008 Sep;104(2):383-93. Epub 2007 Nov 21.

PMID:
18030490
47.

Recurrent mutation in the first zinc finger of the orphan nuclear receptor NR2E3 causes autosomal dominant retinitis pigmentosa.

Coppieters F, Leroy BP, Beysen D, Hellemans J, De Bosscher K, Haegeman G, Robberecht K, Wuyts W, Coucke PJ, De Baere E.

Am J Hum Genet. 2007 Jul;81(1):147-57. Epub 2007 May 24.

49.

qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data.

Hellemans J, Mortier G, De Paepe A, Speleman F, Vandesompele J.

Genome Biol. 2007;8(2):R19.

50.

Cardiorespiratory and cerebrovascular responses to acute poikilocapnic hypoxia following intermittent and continuous exposure to hypoxia in humans.

Ainslie PN, Barach A, Cummings KJ, Murrell C, Hamlin M, Hellemans J.

J Appl Physiol (1985). 2007 May;102(5):1953-61. Epub 2007 Jan 18.

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