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Items: 1 to 50 of 167

1.

The immune microenvironment in non-small cell lung cancer is predictive of prognosis after surgery.

Öjlert ÅK, Halvorsen AR, Nebdal D, Lund-Iversen M, Solberg S, Brustugun OT, Lingjaerde OC, Helland Å.

Mol Oncol. 2019 Mar 10. doi: 10.1002/1878-0261.12475. [Epub ahead of print]

2.

Drugs of abuse testing - in brief.

Bjånes TK, Berg JA, Helland A, Westin AA.

Tidsskr Nor Laegeforen. 2019 Feb 25;139(4). doi: 10.4045/tidsskr.18.0920. Print 2019 Feb 26. Norwegian, English. No abstract available.

3.

Immune Cell Composition in Human Non-small Cell Lung Cancer.

Stankovic B, Bjørhovde HAK, Skarshaug R, Aamodt H, Frafjord A, Müller E, Hammarström C, Beraki K, Bækkevold ES, Woldbæk PR, Helland Å, Brustugun OT, Øynebråten I, Corthay A.

Front Immunol. 2019 Feb 1;9:3101. doi: 10.3389/fimmu.2018.03101. eCollection 2018.

4.

EMT network-based feature selection improves prognosis prediction in lung adenocarcinoma.

Shao B, Bjaanæs MM, Helland Å, Schütte C, Conrad T.

PLoS One. 2019 Jan 31;14(1):e0204186. doi: 10.1371/journal.pone.0204186. eCollection 2019.

5.

EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC.

Zhang R, Lai L, He J, Chen C, You D, Duan W, Dong X, Zhu Y, Lin L, Shen S, Guo Y, Su L, Shafer A, Moran S, Fleischer T, Bjaanæs MM, Karlsson A, Planck M, Staaf J, Helland Å, Esteller M, Wei Y, Chen F, Christiani DC.

Epigenetics. 2019 Jan 21:1-12. doi: 10.1080/15592294.2019.1573066. [Epub ahead of print]

PMID:
30665327
6.

A Longitudinal Study of the Association between Mammographic Density and Gene Expression in Normal Breast Tissue.

Bergholtz H, Lien TG, Ursin G, Holmen MM, Helland Å, Sørlie T, Haakensen VD.

J Mammary Gland Biol Neoplasia. 2019 Jan 6. doi: 10.1007/s10911-018-09423-x. [Epub ahead of print]

PMID:
30613869
7.

Groundbreaking basic research.

Helland Å.

Tidsskr Nor Laegeforen. 2018 Dec 10;138(20). doi: 10.4045/tidsskr.18.0802. Print 2018 Dec 11. Norwegian. No abstract available.

8.

Brain metastases with poor vascular function are susceptible to pseudoprogression after stereotactic radiation surgery.

Digernes I, Grøvik E, Nilsen LB, Saxhaug C, Geier O, Reitan E, Sætre DO, Breivik B, Reese T, Jacobsen KD, Helland Å, Emblem KE.

Adv Radiat Oncol. 2018 May 17;3(4):559-567. doi: 10.1016/j.adro.2018.05.005. eCollection 2018 Oct-Dec.

9.

Identification of therapeutic targets in chordoma through comprehensive genomic and transcriptomic analyses.

Liang WS, Dardis C, Helland A, Sekar S, Adkins J, Cuyugan L, Enriquez D, Byron S, Little AS.

Cold Spring Harb Mol Case Stud. 2018 Dec 17;4(6). pii: a003418. doi: 10.1101/mcs.a003418. Print 2018 Dec.

10.

Atezolizumab Treatment Beyond Progression in Advanced NSCLC: Results From the Randomized, Phase III OAK Study.

Gandara DR, von Pawel J, Mazieres J, Sullivan R, Helland Å, Han JY, Ponce Aix S, Rittmeyer A, Barlesi F, Kubo T, Park K, Goldschmidt J, Gandhi M, Yun C, Yu W, Matheny C, He P, Sandler A, Ballinger M, Fehrenbacher L.

J Thorac Oncol. 2018 Dec;13(12):1906-1918. doi: 10.1016/j.jtho.2018.08.2027. Epub 2018 Sep 11.

PMID:
30217492
11.

DNA Methylation of LRRC3B: A Biomarker for Survival of Early-Stage Non-Small Cell Lung Cancer Patients.

Guo Y, Zhang R, Shen S, Wei Y, Salama SM, Fleischer T, Bjaanæs MM, Karlsson A, Planck M, Su L, Zhu Z, Staaf J, Helland Å, Esteller M, Christiani DC.

Cancer Epidemiol Biomarkers Prev. 2018 Dec;27(12):1527-1535. doi: 10.1158/1055-9965.EPI-18-0454. Epub 2018 Sep 5.

PMID:
30185536
12.

Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors.

Rye IH, Trinh A, Saetersdal AB, Nebdal D, Lingjaerde OC, Almendro V, Polyak K, Børresen-Dale AL, Helland Å, Markowetz F, Russnes HG.

Mol Oncol. 2018 Nov;12(11):1838-1855. doi: 10.1002/1878-0261.12375. Epub 2018 Sep 21.

13.

Substantial nation-wide improvement in lung cancer relative survival in Norway from 2000 to 2016.

Brustugun OT, Grønberg BH, Fjellbirkeland L, Helbekkmo N, Aanerud M, Grimsrud TK, Helland Å, Møller B, Nilssen Y, Strand TE, Solberg SK.

Lung Cancer. 2018 Aug;122:138-145. doi: 10.1016/j.lungcan.2018.06.003. Epub 2018 Jun 6.

PMID:
30032822
14.

Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease.

Berg J, Halvorsen AR, Bengtson MB, Taskén KA, Mælandsmo GM, Yndestad A, Halvorsen B, Brustugun OT, Aukrust P, Ueland T, Helland Å.

BMC Cancer. 2018 Jul 13;18(1):739. doi: 10.1186/s12885-018-4659-0.

15.

Mapping Bone Marrow Response in the Vertebral Column by Positron Emission Tomography Following Radiotherapy and Erlotinib Therapy of Lung Cancer.

Abravan A, Eide HA, Løndalen AM, Helland Å, Malinen E.

Mol Imaging Biol. 2018 Jun 18. doi: 10.1007/s11307-018-1226-7. [Epub ahead of print]

PMID:
29916117
16.

Serum cytokine profiles and metabolic tumor burden in patients with non-small cell lung cancer undergoing palliative thoracic radiation therapy.

Eide HA, Knudtsen IS, Sandhu V, Løndalen AM, Halvorsen AR, Abravan A, Kure EH, Bogsrud TV, Brustugun OT, Kyte JA, Malinen E, Helland Å.

Adv Radiat Oncol. 2018 Feb 13;3(2):130-138. doi: 10.1016/j.adro.2017.12.007. eCollection 2018 Apr-Jun.

17.

Quantification of 21 antihypertensive drugs in serum using UHPLC-MS/MS.

Gundersen POM, Helland A, Spigset O, Hegstad S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jul 1;1089:84-93. doi: 10.1016/j.jchromb.2018.04.038. Epub 2018 Apr 28.

PMID:
29783197
18.

N-glycan signatures identified in tumor interstitial fluid and serum of breast cancer patients: association with tumor biology and clinical outcome.

Terkelsen T, Haakensen VD, Saldova R, Gromov P, Hansen MK, Stöckmann H, Lingjaerde OC, Børresen-Dale AL, Papaleo E, Helland Å, Rudd PM, Gromova I.

Mol Oncol. 2018 Jun;12(6):972-990. doi: 10.1002/1878-0261.12312. Epub 2018 May 14.

19.

Circulating microRNAs associated with prolonged overall survival in lung cancer patients treated with nivolumab.

Halvorsen AR, Sandhu V, Sprauten M, Flote VG, Kure EH, Brustugun OT, Helland Å.

Acta Oncol. 2018 Sep;57(9):1225-1231. doi: 10.1080/0284186X.2018.1465585. Epub 2018 Apr 23.

PMID:
29683761
20.

Alectinib versus chemotherapy in crizotinib-pretreated anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer: results from the phase III ALUR study.

Novello S, Mazières J, Oh IJ, de Castro J, Migliorino MR, Helland Å, Dziadziuszko R, Griesinger F, Kotb A, Zeaiter A, Cardona A, Balas B, Johannsdottir HK, Das-Gupta A, Wolf J.

Ann Oncol. 2018 Jun 1;29(6):1409-1416. doi: 10.1093/annonc/mdy121.

21.

A multi-omic study reveals BTG2 as a reliable prognostic marker for early-stage non-small cell lung cancer.

Shen S, Zhang R, Guo Y, Loehrer E, Wei Y, Zhu Y, Yuan Q, Moran S, Fleischer T, Bjaanaes MM, Karlsson A, Planck M, Staaf J, Helland Å, Esteller M, Su L, Chen F, Christiani DC.

Mol Oncol. 2018 Jun;12(6):913-924. doi: 10.1002/1878-0261.12204. Epub 2018 May 4.

22.

Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC.

Wei Y, Liang J, Zhang R, Guo Y, Shen S, Su L, Lin X, Moran S, Helland Å, Bjaanæs MM, Karlsson A, Planck M, Esteller M, Fleischer T, Staaf J, Zhao Y, Chen F, Christiani DC.

Clin Epigenetics. 2018 Apr 2;10:41. doi: 10.1186/s13148-018-0474-3. eCollection 2018.

23.

Systemic Inflammation Complicates the Interpretation of Therapeutic Drug Monitoring of Risperidone.

Helland A, Habib S, Ulvestad L, Spigset O.

J Clin Psychopharmacol. 2018 Jun;38(3):263-265. doi: 10.1097/JCP.0000000000000873. No abstract available.

PMID:
29613864
24.

Assessment of pulmonary 18F-FDG-PET uptake and cytokine profiles in non-small cell lung cancer patients treated with radiotherapy and erlotinib.

Abravan A, Eide HA, Knudtsen IS, Løndalen AM, Helland Å, Malinen E.

Clin Transl Radiat Oncol. 2017 Jun 15;4:57-63. doi: 10.1016/j.ctro.2017.04.002. eCollection 2017 Jun.

25.

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.

George J, Walter V, Peifer M, Alexandrov LB, Seidel D, Leenders F, Maas L, Müller C, Dahmen I, Delhomme TM, Ardin M, Leblay N, Byrnes G, Sun R, De Reynies A, McLeer-Florin A, Bosco G, Malchers F, Menon R, Altmüller J, Becker C, Nürnberg P, Achter V, Lang U, Schneider PM, Bogus M, Soloway MG, Wilkerson MD, Cun Y, McKay JD, Moro-Sibilot D, Brambilla CG, Lantuejoul S, Lemaitre N, Soltermann A, Weder W, Tischler V, Brustugun OT, Lund-Iversen M, Helland Å, Solberg S, Ansén S, Wright G, Solomon B, Roz L, Pastorino U, Petersen I, Clement JH, Sänger J, Wolf J, Vingron M, Zander T, Perner S, Travis WD, Haas SA, Olivier M, Foll M, Büttner R, Hayes DN, Brambilla E, Fernandez-Cuesta L, Thomas RK.

Nat Commun. 2018 Mar 13;9(1):1048. doi: 10.1038/s41467-018-03099-x.

26.

Whole Exome Library Construction for Next Generation Sequencing.

Liang WS, Stephenson K, Adkins J, Christofferson A, Helland A, Cuyugan L, Keats JJ.

Methods Mol Biol. 2018;1706:163-174. doi: 10.1007/978-1-4939-7471-9_9. Review.

PMID:
29423798
27.

Enantiomeric separation and quantification of R/S-amphetamine in urine by ultra-high performance supercritical fluid chromatography tandem mass spectrometry.

Hegstad S, Havnen H, Helland A, Spigset O, Frost J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 1;1077-1078:7-12. doi: 10.1016/j.jchromb.2018.01.028. Epub 2018 Feb 3.

PMID:
29413579
28.

Serum Concentrations of Paliperidone After Administration of the Long-Acting Injectable Formulation.

Helland A, Spigset O.

Ther Drug Monit. 2017 Dec;39(6):659-662. doi: 10.1097/FTD.0000000000000457.

29.

Two Hospitalizations and One Death After Exposure to Ortho-Fluorofentanyl.

Helland A, Brede WR, Michelsen LS, Gundersen POM, Aarset H, Skjølås JE, Slørdal L.

J Anal Toxicol. 2017 Oct 1;41(8):708-709. doi: 10.1093/jat/bkx050.

PMID:
28985336
30.

Dabrafenib plus trametinib in patients with previously untreated BRAFV600E-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial.

Planchard D, Smit EF, Groen HJM, Mazieres J, Besse B, Helland Å, Giannone V, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE.

Lancet Oncol. 2017 Oct;18(10):1307-1316. doi: 10.1016/S1470-2045(17)30679-4. Epub 2017 Sep 11.

PMID:
28919011
31.

Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity.

Dannenfelser R, Nome M, Tahiri A, Ursini-Siegel J, Vollan HKM, Haakensen VD, Helland Å, Naume B, Caldas C, Børresen-Dale AL, Kristensen VN, Troyanskaya OG.

Oncotarget. 2017 Jul 7;8(34):57121-57133. doi: 10.18632/oncotarget.19078. eCollection 2017 Aug 22.

32.

A new method to assess pulmonary changes using 18F-fluoro-2-deoxyglucose positron emission tomography for lung cancer patients following radiotherapy.

Abravan A, Knudtsen IS, Eide HA, Løndalen AM, Helland Å, van Luijk P, Malinen E.

Acta Oncol. 2017 Nov;56(11):1597-1603. doi: 10.1080/0284186X.2017.1349336. Epub 2017 Aug 29.

PMID:
28849707
33.

Enantiomeric separation and quantification of citalopram in serum by ultra-high performance supercritical fluid chromatography-tandem mass spectrometry.

Hegstad S, Havnen H, Helland A, Falch BMH, Spigset O.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:103-109. doi: 10.1016/j.jchromb.2017.07.009. Epub 2017 Jul 9.

PMID:
28715684
34.

NSCLC depend upon YAP expression and nuclear localization after acquiring resistance to EGFR inhibitors.

McGowan M, Kleinberg L, Halvorsen AR, Helland Å, Brustugun OT.

Genes Cancer. 2017 Mar;8(3-4):497-504. doi: 10.18632/genesandcancer.136.

35.

High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: a randomised trial.

Helland A, Bratlie M, Hagen IV, Mjøs SA, Sørnes S, Ingvar Halstensen A, Brokstad KA, Sveier H, Rosenlund G, Mellgren G, Gudbrandsen OA.

Br J Nutr. 2017 May;117(10):1368-1378. doi: 10.1017/S0007114517001234. Epub 2017 Jun 13.

PMID:
28606215
36.

EtG/EtS in Serum by UHPLC-MS-MS in Suspected Sexual Assault Cases.

Hegstad S, Helland A, Hagemann C, Spigset O.

J Anal Toxicol. 2017 Sep 1;41(7):618-622. doi: 10.1093/jat/bkx032.

PMID:
28453638
37.

High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival.

Helland Å, Brustugun OT, Nakken S, Halvorsen AR, Dønnem T, Bremnes R, Busund LT, Sun J, Lorenz S, Solberg SK, Jørgensen LH, Vodak D, Myklebost O, Hovig E, Meza-Zepeda LA.

Int J Cancer. 2017 Jul 1;141(1):184-190. doi: 10.1002/ijc.30726. Epub 2017 Apr 21.

38.

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma.

Liang WS, Hendricks W, Kiefer J, Schmidt J, Sekar S, Carpten J, Craig DW, Adkins J, Cuyugan L, Manojlovic Z, Halperin RF, Helland A, Nasser S, Legendre C, Hurley LH, Sivaprakasam K, Johnson DB, Crandall H, Busam KJ, Zismann V, Deluca V, Lee J, Sekulic A, Ariyan CE, Sosman J, Trent J.

Genome Res. 2017 Apr;27(4):524-532. doi: 10.1101/gr.213348.116.

39.

Studier av alkoholpåvirket kjøring i kjøresimulator.

Helland A.

Tidsskr Nor Laegeforen. 2017 Mar 21;137(6):470. doi: 10.4045/tidsskr.16.1112. eCollection 2017 Mar. Norwegian. No abstract available.

PMID:
28332808
Free Article
40.

Evaluation of Prognostic and Predictive Significance of Circulating MicroRNAs in Ovarian Cancer Patients.

Halvorsen AR, Kristensen G, Embleton A, Adusei C, Barretina-Ginesta MP, Beale P, Helland Å.

Dis Markers. 2017;2017:3098542. doi: 10.1155/2017/3098542. Epub 2017 Feb 15.

41.

Profiling of microRNAs in tumor interstitial fluid of breast tumors - a novel resource to identify biomarkers for prognostic classification and detection of cancer.

Halvorsen AR, Helland Å, Gromov P, Wielenga VT, Talman MM, Brunner N, Sandhu V, Børresen-Dale AL, Gromova I, Haakensen VD.

Mol Oncol. 2017 Feb;11(2):220-234. doi: 10.1002/1878-0261.12025. Epub 2016 Dec 12.

42.

Cytokine profiling of tumor interstitial fluid of the breast and its relationship with lymphocyte infiltration and clinicopathological characteristics.

Espinoza JA, Jabeen S, Batra R, Papaleo E, Haakensen V, Timmermans Wielenga V, Møller Talman ML, Brunner N, Børresen-Dale AL, Gromov P, Helland Å, Kristensen VN, Gromova I.

Oncoimmunology. 2016 Oct 24;5(12):e1248015. doi: 10.1080/2162402X.2016.1248015. eCollection 2016.

43.

PIK3CA mutations as prognostic factor in squamous cell lung carcinoma.

McGowan M, Hoven AS, Lund-Iversen M, Solberg S, Helland Å, Hirsch FR, Brustugun OT.

Lung Cancer. 2017 Jan;103:52-57. doi: 10.1016/j.lungcan.2016.11.018. Epub 2016 Nov 28.

PMID:
28024696
44.

Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease.

Eide HA, Halvorsen AR, Sandhu V, Fåne A, Berg J, Haakensen VD, Kure EH, Brustugun OT, Kiserud CE, Kyte JA, Helland Å.

Clin Transl Immunology. 2016 Nov 2;5(11):e109. eCollection 2016 Nov.

45.

DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival.

Fleischer T, Klajic J, Aure MR, Louhimo R, Pladsen AV, Ottestad L, Touleimat N, Laakso M, Halvorsen AR, Grenaker Alnæs GI, Riis ML, Helland Å, Hautaniemi S, Lønning PE, Naume B, Børresen-Dale AL, Tost J, Kristensen VN.

Oncotarget. 2017 Jan 3;8(1):1074-1082. doi: 10.18632/oncotarget.13718.

46.

Real-world data on nivolumab treatment of non-small cell lung cancer.

Brustugun OT, Sprauten M, Helland Å.

Acta Oncol. 2017 Mar;56(3):438-440. doi: 10.1080/0284186X.2016.1253865. Epub 2016 Nov 28.

PMID:
27892773
47.

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.

Weischenfeldt J, Dubash T, Drainas AP, Mardin BR, Chen Y, Stütz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R, Peifer M, Helland A, Ball CR, Jechlinger M, Sotillo R, Glimm H, Korbel JO.

Nat Genet. 2017 Jan;49(1):65-74. doi: 10.1038/ng.3722. Epub 2016 Nov 21.

48.

[New biomarkers for assesing alcohol consumption].

Aakerøy R, Skråstad RB, Helland A, Hilberg T, Aamo T, Dyrkorn R, Spigset O.

Tidsskr Nor Laegeforen. 2016 Oct 25;136(19):1643-1647. eCollection 2016 Oct. Review. Norwegian.

49.

[Serum concentration monitoring of antihypertensive drugs in treatment resistant hypertension].

Edvardsen F, Øien CM, Helland A.

Tidsskr Nor Laegeforen. 2016 Oct 11;136(18):1514-1515. eCollection 2016 Oct. Norwegian. No abstract available.

50.

High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: a randomised trial.

Hagen IV, Helland A, Bratlie M, Brokstad KA, Rosenlund G, Sveier H, Mellgren G, Gudbrandsen OA.

Br J Nutr. 2016 Aug;116(4):648-57. doi: 10.1017/S0007114516002555. Epub 2016 Jul 1.

PMID:
27363518

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