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MINFLUX nanoscopy delivers 3D multicolor nanometer resolution in cells.

Gwosch KC, Pape JK, Balzarotti F, Hoess P, Ellenberg J, Ries J, Hell SW.

Nat Methods. 2020 Jan 13. doi: 10.1038/s41592-019-0688-0. [Epub ahead of print]


Negatively charged yellow-emitting 1-aminopyrene dyes for reductive amination and fluorescence detection of glycans.

Belov VN, Savicheva EA, Mitronova GY, Thomas L, Böhm MJ, Seikowski J, Hell SW.

Angew Chem Int Ed Engl. 2020 Jan 2. doi: 10.1002/anie.201908063. [Epub ahead of print]


Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes.

Hell SM, Meyer CF, Laudadio G, Misale A, Willis MC, Noël T, Trabanco AA, Gouverneur V.

J Am Chem Soc. 2020 Jan 15;142(2):720-725. doi: 10.1021/jacs.9b13071. Epub 2020 Jan 3.


Autonomous bioluminescence imaging of single mammalian cells with the bacterial bioluminescence system.

Gregor C, Pape JK, Gwosch KC, Gilat T, Sahl SJ, Hell SW.

Proc Natl Acad Sci U S A. 2019 Dec 2. pii: 201913616. doi: 10.1073/pnas.1913616116. [Epub ahead of print]


Author Correction: Chimeric peptidomimetic antibiotics against Gram-negative bacteria.

Luther A, Urfer M, Zahn M, Müller M, Wang SY, Mondal M, Vitale A, Hartmann JB, Sharpe T, Monte FL, Kocherla H, Cline E, Pessi G, Rath P, Modaresi SM, Chiquet P, Stiegeler S, Verbree C, Remus T, Schmitt M, Kolopp C, Westwood MA, Desjonquères N, Brabet E, Hell S, LePoupon K, Vermeulen A, Jaisson R, Rithié V, Upert G, Lederer A, Zbinden P, Wach A, Moehle K, Zerbe K, Locher HH, Bernardini F, Dale GE, Eberl L, Wollscheid B, Hiller S, Robinson JA, Obrecht D.

Nature. 2019 Dec;576(7786):E5. doi: 10.1038/s41586-019-1810-2.


Correction to "Triarylmethane Fluorophores Resistant to Oxidative Photobluing".

Butkevich AN, Bossi ML, Lukinavičius G, Hell SW.

J Am Chem Soc. 2019 Nov 27;141(47):18917. doi: 10.1021/jacs.9b11892. Epub 2019 Nov 14. No abstract available.


Mono- and bithiophene-substituted diarylethene photoswitches with emissive open or closed forms.

Schleper AL, Bossi ML, Belov VN, Hell SW.

Beilstein J Org Chem. 2019 Oct 1;15:2344-2354. doi: 10.3762/bjoc.15.227. eCollection 2019.


Chimeric peptidomimetic antibiotics against Gram-negative bacteria.

Luther A, Urfer M, Zahn M, Müller M, Wang SY, Mondal M, Vitale A, Hartmann JB, Sharpe T, Monte FL, Kocherla H, Cline E, Pessi G, Rath P, Modaresi SM, Chiquet P, Stiegeler S, Verbree C, Remus T, Schmitt M, Kolopp C, Westwood MA, Desjonquères N, Brabet E, Hell S, LePoupon K, Vermeulen A, Jaisson R, Rithié V, Upert G, Lederer A, Zbinden P, Wach A, Moehle K, Zerbe K, Locher HH, Bernardini F, Dale GE, Eberl L, Wollscheid B, Hiller S, Robinson JA, Obrecht D.

Nature. 2019 Dec;576(7787):452-458. doi: 10.1038/s41586-019-1665-6. Epub 2019 Oct 23. Erratum in: Nature. 2019 Nov 23;:.


Voices in methods development.

Anikeeva P, Boyden E, Brangwynne C, Cissé II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman E, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW Jr, Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M, Zhuang X.

Nat Methods. 2019 Oct;16(10):945-951. doi: 10.1038/s41592-019-0585-6. No abstract available.


Reversibly Photoswitchable Fluorescent Diarylethenes Resistant against Photobleaching in Aqueous Solutions.

Uno K, Bossi ML, Irie M, Belov VN, Hell SW.

J Am Chem Soc. 2019 Oct 16;141(41):16471-16478. doi: 10.1021/jacs.9b08748. Epub 2019 Oct 4.


Molecular contribution function in RESOLFT nanoscopy.

Frahm L, Keller-Findeisen J, Alt P, Schnorrenberg S, Del Álamo Ruiz M, Aspelmeier T, Munk A, Jakobs S, Hell SW.

Opt Express. 2019 Jul 22;27(15):21956-21987. doi: 10.1364/OE.27.021956.


Mic60 exhibits a coordinated clustered distribution along and across yeast and mammalian mitochondria.

Stoldt S, Stephan T, Jans DC, Brüser C, Lange F, Keller-Findeisen J, Riedel D, Hell SW, Jakobs S.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):9853-9858. doi: 10.1073/pnas.1820364116. Epub 2019 Apr 26.


Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid.

Meyer CF, Hell SM, Misale A, Trabanco AA, Gouverneur V.

Angew Chem Int Ed Engl. 2019 Jun 24;58(26):8829-8833. doi: 10.1002/anie.201903801. Epub 2019 May 24.


Rhodamine-Hoechst positional isomers for highly efficient staining of heterochromatin.

Bucevičius J, Keller-Findeisen J, Gilat T, Hell SW, Lukinavičius G.

Chem Sci. 2018 Dec 12;10(7):1962-1970. doi: 10.1039/c8sc05082a. eCollection 2019 Feb 21.


Rapid active zone remodeling consolidates presynaptic potentiation.

Böhme MA, McCarthy AW, Grasskamp AT, Beuschel CB, Goel P, Jusyte M, Laber D, Huang S, Rey U, Petzoldt AG, Lehmann M, Göttfert F, Haghighi P, Hell SW, Owald D, Dickman D, Sigrist SJ, Walter AM.

Nat Commun. 2019 Mar 6;10(1):1085. doi: 10.1038/s41467-019-08977-6.


Triarylmethane Fluorophores Resistant to Oxidative Photobluing.

Butkevich AN, Bossi ML, Lukinavičius G, Hell SW.

J Am Chem Soc. 2019 Jan 16;141(2):981-989. doi: 10.1021/jacs.8b11036. Epub 2019 Jan 2. Erratum in: J Am Chem Soc. 2019 Nov 27;141(47):18917.


Near-infrared STED nanoscopy with an engineered bacterial phytochrome.

Kamper M, Ta H, Jensen NA, Hell SW, Jakobs S.

Nat Commun. 2018 Nov 12;9(1):4762. doi: 10.1038/s41467-018-07246-2.


Incidence of notified Lyme borreliosis in Germany, 2013-2017.

Enkelmann J, Böhmer M, Fingerle V, Siffczyk C, Werber D, Littmann M, Merbecks SS, Helmeke C, Schroeder S, Hell S, Schlotthauer U, Burckhardt F, Stark K, Schielke A, Wilking H.

Sci Rep. 2018 Oct 8;8(1):14976. doi: 10.1038/s41598-018-33136-0.


Robust nanoscopy of a synaptic protein in living mice by organic-fluorophore labeling.

Masch JM, Steffens H, Fischer J, Engelhardt J, Hubrich J, Keller-Findeisen J, D'Este E, Urban NT, Grant SGN, Sahl SJ, Kamin D, Hell SW.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8047-E8056. doi: 10.1073/pnas.1807104115. Epub 2018 Aug 6.


MINFLUX monitors rapid molecular jumps with superior spatiotemporal resolution.

Eilers Y, Ta H, Gwosch KC, Balzarotti F, Hell SW.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6117-6122. doi: 10.1073/pnas.1801672115. Epub 2018 May 29.


Fluorescent dyes and probes for super-resolution microscopy of microtubules and tracheoles in living cells and tissues.

Lukinavičius G, Mitronova GY, Schnorrenberg S, Butkevich AN, Barthel H, Belov VN, Hell SW.

Chem Sci. 2018 Feb 26;9(13):3324-3334. doi: 10.1039/c7sc05334g. eCollection 2018 Apr 7.


Photoactivatable Rhodamine Spiroamides and Diazoketones Decorated with "Universal Hydrophilizer" or Hydroxyl Groups.

Roubinet B, Bischoff M, Nizamov S, Yan S, Geisler C, Stoldt S, Mitronova GY, Belov VN, Bossi ML, Hell SW.

J Org Chem. 2018 Jun 15;83(12):6466-6476. doi: 10.1021/acs.joc.8b00756. Epub 2018 May 30.


STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles.

Vlijm R, Li X, Panic M, Rüthnick D, Hata S, Herrmannsdörfer F, Kuner T, Heilemann M, Engelhardt J, Hell SW, Schiebel E.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2246-E2253. doi: 10.1073/pnas.1716840115. Epub 2018 Feb 20.


Novel reversibly switchable fluorescent proteins for RESOLFT and STED nanoscopy engineered from the bacterial photoreceptor YtvA.

Gregor C, Sidenstein SC, Andresen M, Sahl SJ, Danzl JG, Hell SW.

Sci Rep. 2018 Feb 9;8(1):2724. doi: 10.1038/s41598-018-19947-1.


PONy Dyes: Direct Addition of P(III) Nucleophiles to Organic Fluorophores.

Butkevich AN, Sednev MV, Shojaei H, Belov VN, Hell SW.

Org Lett. 2018 Feb 16;20(4):1261-1264. doi: 10.1021/acs.orglett.8b00270. Epub 2018 Feb 6.


Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones.

Neef J, Urban NT, Ohn TL, Frank T, Jean P, Hell SW, Willig KI, Moser T.

Nat Commun. 2018 Jan 18;9(1):290. doi: 10.1038/s41467-017-02612-y.


Strongly enhanced bacterial bioluminescence with the ilux operon for single-cell imaging.

Gregor C, Gwosch KC, Sahl SJ, Hell SW.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):962-967. doi: 10.1073/pnas.1715946115. Epub 2018 Jan 16.


Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.

Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO.

EMBO J. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16.


Assessing the Clinical Benefit of Systemic Adjuvant Therapies for Early Breast Cancer.

Möbus V, Hell S, Schmidt M.

Geburtshilfe Frauenheilkd. 2017 Oct;77(10):1079-1087. doi: 10.1055/s-0043-119542. Epub 2017 Oct 26.


High-Affinity Functional Fluorescent Ligands for Human β-Adrenoceptors.

Mitronova GY, Lukinavičius G, Butkevich AN, Kohl T, Belov VN, Lehnart SE, Hell SW.

Sci Rep. 2017 Sep 26;7(1):12319. doi: 10.1038/s41598-017-12468-3.


Two-Color 810 nm STED Nanoscopy of Living Cells with Endogenous SNAP-Tagged Fusion Proteins.

Butkevich AN, Ta H, Ratz M, Stoldt S, Jakobs S, Belov VN, Hell SW.

ACS Chem Biol. 2018 Feb 16;13(2):475-480. doi: 10.1021/acschembio.7b00616. Epub 2017 Oct 2.


SRpHi ratiometric pH biosensors for super-resolution microscopy.

Richardson DS, Gregor C, Winter FR, Urban NT, Sahl SJ, Willig KI, Hell SW.

Nat Commun. 2017 Sep 18;8(1):577. doi: 10.1038/s41467-017-00606-4.


Photobleaching in STED nanoscopy and its dependence on the photon flux applied for reversible silencing of the fluorophore.

Oracz J, Westphal V, Radzewicz C, Sahl SJ, Hell SW.

Sci Rep. 2017 Sep 12;7(1):11354. doi: 10.1038/s41598-017-09902-x.


Fluorescence nanoscopy in cell biology.

Sahl SJ, Hell SW, Jakobs S.

Nat Rev Mol Cell Biol. 2017 Nov;18(11):685-701. doi: 10.1038/nrm.2017.71. Epub 2017 Sep 6. Review.


Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission.

Reddy-Alla S, Böhme MA, Reynolds E, Beis C, Grasskamp AT, Mampell MM, Maglione M, Jusyte M, Rey U, Babikir H, McCarthy AW, Quentin C, Matkovic T, Bergeron DD, Mushtaq Z, Göttfert F, Owald D, Mielke T, Hell SW, Sigrist SJ, Walter AM.

Neuron. 2017 Sep 13;95(6):1350-1364.e12. doi: 10.1016/j.neuron.2017.08.016. Epub 2017 Aug 31.


Adaptive-illumination STED nanoscopy.

Heine J, Reuss M, Harke B, D'Este E, Sahl SJ, Hell SW.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9797-9802. doi: 10.1073/pnas.1708304114. Epub 2017 Aug 28.


Cell-Permeant Large Stokes Shift Dyes for Transfection-Free Multicolor Nanoscopy.

Butkevich AN, Lukinavičius G, D'Este E, Hell SW.

J Am Chem Soc. 2017 Sep 13;139(36):12378-12381. doi: 10.1021/jacs.7b06412. Epub 2017 Aug 30.


Superresolution optical magnetic imaging and spectroscopy using individual electronic spins in diamond.

Jaskula JC, Bauch E, Arroyo-Camejo S, Lukin MD, Hell SW, Trifonov AS, Walsworth RL.

Opt Express. 2017 May 15;25(10):11048-11064. doi: 10.1364/OE.25.011048.


Fluorescent Photoswitchable Diarylethenes for Biolabeling and Single-Molecule Localization Microscopies with Optical Superresolution.

Roubinet B, Weber M, Shojaei H, Bates M, Bossi ML, Belov VN, Irie M, Hell SW.

J Am Chem Soc. 2017 May 17;139(19):6611-6620. doi: 10.1021/jacs.7b00274. Epub 2017 May 4.


Multicolour nanoscopy of fixed and living cells with a single STED beam and hyperspectral detection.

Winter FR, Loidolt M, Westphal V, Butkevich AN, Gregor C, Sahl SJ, Hell SW.

Sci Rep. 2017 Apr 18;7:46492. doi: 10.1038/srep46492.


Hydroxylated Fluorescent Dyes for Live-Cell Labeling: Synthesis, Spectra and Super-Resolution STED.

Butkevich AN, Belov VN, Kolmakov K, Sokolov VV, Shojaei H, Sidenstein SC, Kamin D, Matthias J, Vlijm R, Engelhardt J, Hell SW.

Chemistry. 2017 Sep 7;23(50):12114-12119. doi: 10.1002/chem.201701216. Epub 2017 May 2.


Achromatic light patterning and improved image reconstruction for parallelized RESOLFT nanoscopy.

Chmyrov A, Leutenegger M, Grotjohann T, Schönle A, Keller-Findeisen J, Kastrup L, Jakobs S, Donnert G, Sahl SJ, Hell SW.

Sci Rep. 2017 Mar 20;7:44619. doi: 10.1038/srep44619.


Ground State Depletion Nanoscopy Resolves Semiconductor Nanowire Barcode Segments at Room Temperature.

Oracz J, Adolfsson K, Westphal V, Radzewicz C, Borgström MT, Sahl SJ, Prinz CN, Hell SW.

Nano Lett. 2017 Apr 12;17(4):2652-2659. doi: 10.1021/acs.nanolett.7b00468. Epub 2017 Mar 9.


Strong signal increase in STED fluorescence microscopy by imaging regions of subdiffraction extent.

Göttfert F, Pleiner T, Heine J, Westphal V, Görlich D, Sahl SJ, Hell SW.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2125-2130. doi: 10.1073/pnas.1621495114. Epub 2017 Feb 13.


Adenosine receptors regulate gap junction coupling of the human cerebral microvascular endothelial cells hCMEC/D3 by Ca2+ influx through cyclic nucleotide-gated channels.

Bader A, Bintig W, Begandt D, Klett A, Siller IG, Gregor C, Schaarschmidt F, Weksler B, Romero I, Couraud PO, Hell SW, Ngezahayo A.

J Physiol. 2017 Apr 15;595(8):2497-2517. doi: 10.1113/JP273150. Epub 2017 Feb 14.


Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes.

Balzarotti F, Eilers Y, Gwosch KC, Gynnå AH, Westphal V, Stefani FD, Elf J, Hell SW.

Science. 2017 Feb 10;355(6325):606-612. doi: 10.1126/science.aak9913. Epub 2016 Dec 22.


Ultrastructural anatomy of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy.

D'Este E, Kamin D, Balzarotti F, Hell SW.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E191-E199. doi: 10.1073/pnas.1619553114. Epub 2016 Dec 21.


Bichromophoric Compounds with Orthogonally and Parallelly Arranged Chromophores Separated by Rigid Spacers.

Meineke DN, Bossi ML, Ta H, Belov VN, Hell SW.

Chemistry. 2017 Feb 16;23(10):2469-2475. doi: 10.1002/chem.201605587. Epub 2017 Jan 20.


Carboxylated Photoswitchable Diarylethenes for Biolabeling and Super-Resolution RESOLFT Microscopy.

Roubinet B, Bossi ML, Alt P, Leutenegger M, Shojaei H, Schnorrenberg S, Nizamov S, Irie M, Belov VN, Hell SW.

Angew Chem Int Ed Engl. 2016 Dec 5;55(49):15429-15433. doi: 10.1002/anie.201607940. Epub 2016 Oct 21.


Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.

Böhme MA, Beis C, Reddy-Alla S, Reynolds E, Mampell MM, Grasskamp AT, Lützkendorf J, Bergeron DD, Driller JH, Babikir H, Göttfert F, Robinson IM, O'Kane CJ, Hell SW, Wahl MC, Stelzl U, Loll B, Walter AM, Sigrist SJ.

Nat Neurosci. 2016 Oct;19(10):1311-20. doi: 10.1038/nn.4364. Epub 2016 Aug 15.


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