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Items: 1 to 50 of 125

1.

Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.

Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF.

J Clin Invest. 2019 Jun 4;130. pii: 124705. doi: 10.1172/JCI124705.

2.

Ca2+/Calmodulin Binding to PSD-95 Downregulates Its Palmitoylation and AMPARs in Long-Term Depression.

Chowdhury D, Hell JW.

Front Synaptic Neurosci. 2019 Mar 12;11:6. doi: 10.3389/fnsyn.2019.00006. eCollection 2019.

3.

A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia.

Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF.

Elife. 2019 Mar 1;8. pii: e42214. doi: 10.7554/eLife.42214.

4.

Chemical shift assignments of a calmodulin intermediate with two Ca2+ bound in complex with the IQ-motif of voltage-gated Ca2+ channels (CaV1.2).

Salveson I, Anderson DE, Hell JW, Ames JB.

Biomol NMR Assign. 2019 Apr;13(1):233-237. doi: 10.1007/s12104-019-09883-0. Epub 2019 Feb 20.

PMID:
30788773
5.

Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity.

Matt L, Kim K, Chowdhury D, Hell JW.

Front Mol Neurosci. 2019 Jan 31;12:8. doi: 10.3389/fnmol.2019.00008. eCollection 2019. Review.

6.

Cardiomyocyte substructure reverts to an immature phenotype during heart failure.

Lipsett DB, Frisk M, Aronsen JM, Nordén ES, Buonarati OR, Cataliotti A, Hell JW, Sjaastad I, Christensen G, Louch WE.

J Physiol. 2019 Apr;597(7):1833-1853. doi: 10.1113/JP277273. Epub 2019 Feb 27.

7.

Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation.

Buonarati OR, Hammes EA, Watson JF, Greger IH, Hell JW.

Sci Signal. 2019 Jan 1;12(562). pii: eaar6889. doi: 10.1126/scisignal.aar6889. Review.

PMID:
30600260
8.

Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by β2 adrenergic receptor/PKA and Ca2+/CaMKII signaling.

Patriarchi T, Buonarati OR, Hell JW.

EMBO J. 2018 Oct 15;37(20). pii: e99771. doi: 10.15252/embj.201899771. Epub 2018 Sep 24. Review.

PMID:
30249603
9.

Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating.

Ghosh D, Nieves-Cintrón M, Tajada S, Brust-Mascher I, Horne MC, Hell JW, Dixon RE, Santana LF, Navedo MF.

Biochim Biophys Acta Mol Cell Res. 2018 Sep;1865(9):1341-1355. doi: 10.1016/j.bbamcr.2018.06.013. Epub 2018 Jun 28.

10.

Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains.

Zhang L, Zhang P, Wang G, Zhang H, Zhang Y, Yu Y, Zhang M, Xiao J, Crespo P, Hell JW, Lin L, Huganir RL, Zhu JJ.

Neuron. 2018 May 16;98(4):783-800.e4. doi: 10.1016/j.neuron.2018.03.049. Epub 2018 Apr 26.

11.

Cascades of Homeostatic Dysregulation Promote Incubation of Cocaine Craving.

Wang J, Ishikawa M, Yang Y, Otaka M, Kim JY, Gardner GR, Stefanik MT, Milovanovic M, Huang YH, Hell JW, Wolf ME, Schlüter OM, Dong Y.

J Neurosci. 2018 May 2;38(18):4316-4328. doi: 10.1523/JNEUROSCI.3291-17.2018. Epub 2018 Apr 6.

12.

Homeostatic synaptic scaling: molecular regulators of synaptic AMPA-type glutamate receptors.

Chowdhury D, Hell JW.

F1000Res. 2018 Feb 28;7:234. doi: 10.12688/f1000research.13561.1. eCollection 2018. Review.

13.

Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell.

Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK.

Nat Commun. 2018 Mar 13;9(1):1050. doi: 10.1038/s41467-018-03459-7.

14.

SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function.

Matt L, Kirk LM, Chenaux G, Speca DJ, Puhger KR, Pride MC, Qneibi M, Haham T, Plambeck KE, Stern-Bach Y, Silverman JL, Crawley JN, Hell JW, Díaz E.

Cell Rep. 2018 Feb 27;22(9):2246-2253. doi: 10.1016/j.celrep.2018.02.026.

15.

α-Actinin Anchors PSD-95 at Postsynaptic Sites.

Matt L, Kim K, Hergarden AC, Patriarchi T, Malik ZA, Park DK, Chowdhury D, Buonarati OR, Henderson PB, Gökçek Saraç Ç, Zhang Y, Mohapatra D, Horne MC, Ames JB, Hell JW.

Neuron. 2018 Mar 7;97(5):1094-1109.e9. doi: 10.1016/j.neuron.2018.01.036. Epub 2018 Feb 8.

16.

Molecular mimicking of C-terminal phosphorylation tunes the surface dynamics of CaV1.2 calcium channels in hippocampal neurons.

Folci A, Steinberger A, Lee B, Stanika R, Scheruebel S, Campiglio M, Ramprecht C, Pelzmann B, Hell JW, Obermair GJ, Heine M, Di Biase V.

J Biol Chem. 2018 Jan 19;293(3):1040-1053. doi: 10.1074/jbc.M117.799585. Epub 2017 Nov 27.

17.

The genetics of PKMζ and memory maintenance.

Sacktor TC, Hell JW.

Sci Signal. 2017 Nov 14;10(505). pii: eaao2327. doi: 10.1126/scisignal.aao2327. Review.

18.

Ca2+/calmodulin binding to PSD-95 mediates homeostatic synaptic scaling down.

Chowdhury D, Turner M, Patriarchi T, Hergarden AC, Anderson D, Zhang Y, Sun J, Chen CY, Ames JB, Hell JW.

EMBO J. 2018 Jan 4;37(1):122-138. doi: 10.15252/embj.201695829. Epub 2017 Nov 8.

19.

Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes.

Nieves-Cintrón M, Syed AU, Buonarati OR, Rigor RR, Nystoriak MA, Ghosh D, Sasse KC, Ward SM, Santana LF, Hell JW, Navedo MF.

Sci Rep. 2017 Oct 25;7(1):14058. doi: 10.1038/s41598-017-14565-9.

20.

Proteolytic processing of the L-type Ca 2+ channel alpha 11.2 subunit in neurons.

Buonarati OR, Henderson PB, Murphy GG, Horne MC, Hell JW.

Version 2. F1000Res. 2017 Jul 21 [revised 2018 Jan 1];6:1166. doi: 10.12688/f1000research.11808.2. eCollection 2017.

21.

DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific.

Goodell DJ, Zaegel V, Coultrap SJ, Hell JW, Bayer KU.

Cell Rep. 2017 Jun 13;19(11):2231-2243. doi: 10.1016/j.celrep.2017.05.068.

22.

α-Actinin Promotes Surface Localization and Current Density of the Ca2+ Channel CaV1.2 by Binding to the IQ Region of the α1 Subunit.

Tseng PY, Henderson PB, Hergarden AC, Patriarchi T, Coleman AM, Lillya MW, Montagut-Bordas C, Lee B, Hell JW, Horne MC.

Biochemistry. 2017 Jul 18;56(28):3669-3681. doi: 10.1021/acs.biochem.7b00359. Epub 2017 Jul 3.

23.

Angiotensin II signalling kicks out p27Kip1 : casein kinase 2 augmentation of Cav 1.2 L-type Ca2+ channel activity in immature ventricular cardiomyocytes.

Horne MC, Hell JW.

J Physiol. 2017 Jul 1;595(13):4131-4132. doi: 10.1113/JP274260. Epub 2017 May 26. No abstract available.

24.

Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis.

Schampel A, Volovitch O, Koeniger T, Scholz CJ, Jörg S, Linker RA, Wischmeyer E, Wunsch M, Hell JW, Ergün S, Kuerten S.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3295-E3304. doi: 10.1073/pnas.1620052114. Epub 2017 Apr 5.

25.

Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.

Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo MF, Hell JW.

Sci Signal. 2017 Jan 24;10(463). pii: eaaf9659. doi: 10.1126/scisignal.aaf9659.

26.

Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.

Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF.

Sci Signal. 2017 Jan 24;10(463). pii: eaaf9647. doi: 10.1126/scisignal.aaf9647.

27.

Science Signaling Podcast for 24 January 2017: Tissue-specific regulation of L-type calcium channels.

Hell JW, Navedo MF, VanHook AM.

Sci Signal. 2017 Jan 24;10(463). pii: eaam6582. doi: 10.1126/scisignal.aam6582.

28.

Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo.

Chenaux G, Matt L, Hill TC, Kaur I, Liu XB, Kirk LM, Speca DJ, McMahon SA, Zito K, Hell JW, Díaz E.

eNeuro. 2016 Oct 21;3(5). pii: ENEURO.0130-16.2016. eCollection 2016 Sep-Oct.

29.

Non-ionotropic signaling by the NMDA receptor: controversy and opportunity.

Gray JA, Zito K, Hell JW.

F1000Res. 2016 May 26;5. pii: F1000 Faculty Rev-1010. doi: 10.12688/f1000research.8366.1. eCollection 2016. Review.

30.

The CaMKII/GluN2B Protein Interaction Maintains Synaptic Strength.

Barcomb K, Hell JW, Benke TA, Bayer KU.

J Biol Chem. 2016 Jul 29;291(31):16082-9. doi: 10.1074/jbc.M116.734822. Epub 2016 May 31.

31.

How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD.

Hell JW.

Sci Signal. 2016 Apr 26;9(425):e2. doi: 10.1126/scisignal.aaf7067. Review.

PMID:
27117250
32.

Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.

Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW.

EMBO J. 2016 Jun 15;35(12):1330-45. doi: 10.15252/embj.201593409. Epub 2016 Apr 21.

33.

Chemical shift assignments of the C-terminal EF-hand domain of α-actinin-1.

Turner M, Anderson DE, Rajan S, Hell JW, Ames JB.

Biomol NMR Assign. 2016 Apr;10(1):219-22. doi: 10.1007/s12104-016-9670-2. Epub 2016 Feb 10.

34.

Distinct Eligibility Traces for LTP and LTD in Cortical Synapses.

He K, Huertas M, Hong SZ, Tie X, Hell JW, Shouval H, Kirkwood A.

Neuron. 2015 Nov 4;88(3):528-38. doi: 10.1016/j.neuron.2015.09.037. Epub 2015 Oct 22.

35.

Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity.

Atkin G, Moore S, Lu Y, Nelson RF, Tipper N, Rajpal G, Hunt J, Tennant W, Hell JW, Murphy GG, Paulson H.

J Neurosci. 2015 Apr 15;35(15):6165-78. doi: 10.1523/JNEUROSCI.3013-14.2015.

36.

Mission CaMKIIγ: shuttle calmodulin from membrane to nucleus.

Malik ZA, Stein IS, Navedo MF, Hell JW.

Cell. 2014 Oct 9;159(2):235-7. doi: 10.1016/j.cell.2014.09.023.

37.

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons.

Chen CY, Matt L, Hell JW, Rogawski MA.

PLoS One. 2014 Sep 17;9(9):e108021. doi: 10.1371/journal.pone.0108021. eCollection 2014.

38.

CaMKII binding to GluN2B is important for massed spatial learning in the Morris water maze.

Stein IS, Donaldson MS, Hell JW.

F1000Res. 2014 Aug 12;3:193. doi: 10.12688/f1000research.4660.1. eCollection 2014.

39.

AKAP5 keeps L-type channels and NFAT on their toes.

Navedo MF, Hell JW.

Cell Rep. 2014 Jun 12;7(5):1341-1342. doi: 10.1016/j.celrep.2014.05.052.

40.

GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells.

Livide G, Patriarchi T, Amenduni M, Amabile S, Yasui D, Calcagno E, Lo Rizzo C, De Falco G, Ulivieri C, Ariani F, Mari F, Mencarelli MA, Hell JW, Renieri A, Meloni I.

Eur J Hum Genet. 2015 Feb;23(2):195-201. doi: 10.1038/ejhg.2014.81. Epub 2014 Jun 11.

41.

Capping of the N-terminus of PSD-95 by calmodulin triggers its postsynaptic release.

Zhang Y, Matt L, Patriarchi T, Malik ZA, Chowdhury D, Park DK, Renieri A, Ames JB, Hell JW.

EMBO J. 2014 Jun 17;33(12):1341-53. doi: 10.1002/embj.201488126. Epub 2014 Apr 4.

42.

LTP: GluN2B on the go.

Matt L, Hell JW.

EMBO J. 2014 Apr 16;33(8):781-2. doi: 10.1002/embj.201487958. Epub 2014 Mar 5.

43.

Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.

Speca DJ, Ogata G, Mandikian D, Bishop HI, Wiler SW, Eum K, Wenzel HJ, Doisy ET, Matt L, Campi KL, Golub MS, Nerbonne JM, Hell JW, Trainor BC, Sack JT, Schwartzkroin PA, Trimmer JS.

Genes Brain Behav. 2014 Apr;13(4):394-408. doi: 10.1111/gbb.12120. Epub 2014 Mar 7.

44.

CaMKII: claiming center stage in postsynaptic function and organization.

Hell JW.

Neuron. 2014 Jan 22;81(2):249-65. doi: 10.1016/j.neuron.2013.12.024. Review.

45.

Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2+ signaling in spines.

Murphy JA, Stein IS, Lau CG, Peixoto RT, Aman TK, Kaneko N, Aromolaran K, Saulnier JL, Popescu GK, Sabatini BL, Hell JW, Zukin RS.

J Neurosci. 2014 Jan 15;34(3):869-79. doi: 10.1523/JNEUROSCI.4538-13.2014.

46.

Surface L-type Ca2+ channel expression levels are increased in aged hippocampus.

Núñez-Santana FL, Oh MM, Antion MD, Lee A, Hell JW, Disterhoft JF.

Aging Cell. 2014 Feb;13(1):111-20. doi: 10.1111/acel.12157. Epub 2013 Oct 1.

47.

L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2-mediated control of cochlear BDNF expression.

Zuccotti A, Lee SC, Campanelli D, Singer W, Satheesh SV, Patriarchi T, Geisler HS, Köpschall I, Rohbock K, Nothwang HG, Hu J, Hell JW, Schimmang T, Rüttiger L, Knipper M.

Front Mol Neurosci. 2013 Aug 9;6:20. doi: 10.3389/fnmol.2013.00020. eCollection 2013.

48.

Competition between α-actinin and Ca²⁺-calmodulin controls surface retention of the L-type Ca²⁺ channel Ca(V)1.2.

Hall DD, Dai S, Tseng PY, Malik Z, Nguyen M, Matt L, Schnizler K, Shephard A, Mohapatra DP, Tsuruta F, Dolmetsch RE, Christel CJ, Lee A, Burette A, Weinberg RJ, Hell JW.

Neuron. 2013 May 8;78(3):483-97. doi: 10.1016/j.neuron.2013.02.032.

49.

Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic β-adrenergic signaling.

Zhang M, Patriarchi T, Stein IS, Qian H, Matt L, Nguyen M, Xiang YK, Hell JW.

J Biol Chem. 2013 Jun 14;288(24):17918-31. doi: 10.1074/jbc.M112.449462. Epub 2013 May 6.

50.

PKCλ: a new player in LTP coming to the rescue of PKCζ's faltering role in LTP?

Matt L, Hell JW.

EMBO J. 2013 May 15;32(10):1348-9. doi: 10.1038/emboj.2013.81. Epub 2013 Apr 5. No abstract available.

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