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Items: 1 to 50 of 92

1.

Association between mid-life marital status and cognitive function in later life: population based cohort study.

Håkansson K, Rovio S, Helkala EL, Vilska AR, Winblad B, Soininen H, Nissinen A, Mohammed AH, Kivipelto M.

BMJ. 2009 Jul 2;339:b2462. doi: 10.1136/bmj.b2462.

2.

Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study.

Hämäläinen A, Grau-Olivares M, Tervo S, Niskanen E, Pennanen C, Huuskonen J, Kivipelto M, Hänninen T, Tapiola M, Vanhanen M, Hallikainen M, Helkala EL, Nissinen A, Vanninen RL, Soininen H.

Neurodegener Dis. 2008;5(3-4):186-9. doi: 10.1159/000113698. Epub 2008 Mar 6.

PMID:
18322386
3.

Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study.

Eskelinen MH, Ngandu T, Helkala EL, Tuomilehto J, Nissinen A, Soininen H, Kivipelto M.

Int J Geriatr Psychiatry. 2008 Jul;23(7):741-7. doi: 10.1002/gps.1969.

PMID:
18188871
4.

Education and dementia: what lies behind the association?

Ngandu T, von Strauss E, Helkala EL, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M.

Neurology. 2007 Oct 2;69(14):1442-50.

PMID:
17909157
5.

Carotid intima-media thickness and cognitive function in elderly women: a population-based study.

Komulainen P, Kivipelto M, Lakka TA, Hassinen M, Helkala EL, Patja K, Nissinen A, Rauramaa R.

Neuroepidemiology. 2007;28(4):207-13. Epub 2007 Sep 11.

PMID:
17851259
6.

Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment.

Hämäläinen A, Tervo S, Grau-Olivares M, Niskanen E, Pennanen C, Huuskonen J, Kivipelto M, Hänninen T, Tapiola M, Vanhanen M, Hallikainen M, Helkala EL, Nissinen A, Vanninen R, Soininen H.

Neuroimage. 2007 Oct 1;37(4):1122-31. Epub 2007 Jun 29.

PMID:
17683950
7.

Serum high sensitivity C-reactive protein and cognitive function in elderly women.

Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala EL, Gylling H, Nissinen A, Rauramaa R.

Age Ageing. 2007 Jul;36(4):443-8. Epub 2007 May 30.

PMID:
17537742
8.

Alcohol drinking and cognitive functions: findings from the Cardiovascular Risk Factors Aging and Dementia (CAIDE) Study.

Ngandu T, Helkala EL, Soininen H, Winblad B, Tuomilehto J, Nissinen A, Kivipelto M.

Dement Geriatr Cogn Disord. 2007;23(3):140-9. Epub 2006 Dec 14.

9.

MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study.

Tapiola T, Pennanen C, Tapiola M, Tervo S, Kivipelto M, Hänninen T, Pihlajamäki M, Laakso MP, Hallikainen M, Hämäläinen A, Vanhanen M, Helkala EL, Vanninen R, Nissinen A, Rossi R, Frisoni GB, Soininen H.

Neurobiol Aging. 2008 Jan;29(1):31-8. Epub 2006 Nov 13.

PMID:
17097769
10.

Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women.

Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Helkala EL, Haapala I, Nissinen A, Rauramaa R.

Dement Geriatr Cogn Disord. 2007;23(1):29-34. Epub 2006 Oct 27.

PMID:
17068394
11.

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.

Koivisto AM, Helisalmi S, Pihlajamaki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala EL, Hanninen T, Kervinen K, Kesaniemi YA, Laakso M, Soininen H.

Dement Geriatr Cogn Disord. 2006;22(5-6):449-53. Epub 2006 Sep 21.

PMID:
16988505
12.

Association of metabolic syndrome with Alzheimer disease: a population-based study.

Vanhanen M, Koivisto K, Moilanen L, Helkala EL, Hänninen T, Soininen H, Kervinen K, Kesäniemi YA, Laakso M, Kuusisto J.

Neurology. 2006 Sep 12;67(5):843-7.

PMID:
16966548
13.

Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study.

Laitinen MH, Ngandu T, Rovio S, Helkala EL, Uusitalo U, Viitanen M, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M.

Dement Geriatr Cogn Disord. 2006;22(1):99-107. Epub 2006 May 19.

PMID:
16710090
14.

The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study.

Pennanen C, Testa C, Boccardi M, Laakso MP, Hallikainen M, Helkala EL, Hänninen T, Kivipelto M, Könönen M, Nissinen A, Tervo S, Vanhanen M, Vanninen R, Frisoni GB, Soininen H.

Dement Geriatr Cogn Disord. 2006;22(1):60-6. Epub 2006 May 8.

PMID:
16682795
15.

Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population.

Koivisto AM, Helisalmi S, Pihlajamäki J, Moilanen L, Kuusisto J, Laakso M, Hiltunen M, Keijo K, Hänninen T, Helkala EL, Kervinen K, Kesäniemi YA, Soininen H.

J Neurogenet. 2005 Jul-Dec;19(3-4):155-61.

PMID:
16540406
16.

Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease.

Rovio S, Kåreholt I, Helkala EL, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M.

Lancet Neurol. 2005 Nov;4(11):705-11.

PMID:
16239176
17.

Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease.

Kivipelto M, Ngandu T, Fratiglioni L, Viitanen M, Kåreholt I, Winblad B, Helkala EL, Tuomilehto J, Soininen H, Nissinen A.

Arch Neurol. 2005 Oct;62(10):1556-60.

PMID:
16216938
18.

Growth patterns at distal radius and tibial shaft in pubertal girls: a 2-year longitudinal study.

Wang Q, Alén M, Nicholson P, Lyytikäinen A, Suuriniemi M, Helkala E, Suominen H, Cheng S.

J Bone Miner Res. 2005 Jun;20(6):954-61. Epub 2005 Jan 24.

19.

A voxel based morphometry study on mild cognitive impairment.

Pennanen C, Testa C, Laakso MP, Hallikainen M, Helkala EL, Hänninen T, Kivipelto M, Könönen M, Nissinen A, Tervo S, Vanhanen M, Vanninen R, Frisoni GB, Soininen H.

J Neurol Neurosurg Psychiatry. 2005 Jan;76(1):11-4.

20.

Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study.

Anttila T, Helkala EL, Viitanen M, Kåreholt I, Fratiglioni L, Winblad B, Soininen H, Tuomilehto J, Nissinen A, Kivipelto M.

BMJ. 2004 Sep 4;329(7465):539. Epub 2004 Aug 10.

21.

Hippocampus and entorhinal cortex in mild cognitive impairment and early AD.

Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Hänninen T, Laakso MP, Hallikainen M, Vanhanen M, Nissinen A, Helkala EL, Vainio P, Vanninen R, Partanen K, Soininen H.

Neurobiol Aging. 2004 Mar;25(3):303-10.

PMID:
15123335
22.

Relationship of sex hormones to bone geometric properties and mineral density in early pubertal girls.

Wang Q, Nicholson PH, Suuriniemi M, Lyytikäinen A, Helkala E, Alen M, Suominen H, Cheng S.

J Clin Endocrinol Metab. 2004 Apr;89(4):1698-703.

PMID:
15070933
23.

Usefulness of repeated presentation of Mini-Mental State Examination as a diagnostic procedure--a population-based study.

Helkala EL, Kivipelto M, Hallikainen M, Alhainen K, Heinonen H, Tuomilehto J, Soininen H, Nissinen A.

Acta Neurol Scand. 2002 Dec;106(6):341-6.

PMID:
12460138
24.

Midlife income, occupation, APOE status, and dementia: a population-based study.

Anttila T, Helkala EL, Kivipelto M, Hallikainen M, Alhainen K, Heinonen H, Mannermaa A, Tuomilehto J, Soininen H, Nissinen A.

Neurology. 2002 Sep 24;59(6):887-93.

PMID:
12297572
25.

Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease.

Kivipelto M, Helkala EL, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Iivonen S, Mannermaa A, Tuomilehto J, Nissinen A, Soininen H.

Ann Intern Med. 2002 Aug 6;137(3):149-55.

PMID:
12160362
26.

Serum cholesterol and depressive symptoms in elderly Finnish men.

Aijänseppä S, Kivinen P, Helkala EL, Kivelä SL, Tuomilehto J, Nissinen A.

Int J Geriatr Psychiatry. 2002 Jul;17(7):629-34.

PMID:
12112160
27.

Associations between apolipoprotein E phenotype, glucose metabolism and cognitive function in men. An explorative study in a population sample.

Helkala EL, Lakka T, Vanhanen M, Tuomainen TP, Ehnholm C, Kaplan GA, Salonen JT.

Diabet Med. 2001 Dec;18(12):991-7.

28.

Socioeconomic position across the lifecourse and cognitive function in late middle age.

Turrell G, Lynch JW, Kaplan GA, Everson SA, Helkala EL, Kauhanen J, Salonen JT.

J Gerontol B Psychol Sci Soc Sci. 2002 Jan;57(1):S43-51.

PMID:
11773232
29.

Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study.

Kivipelto M, Helkala EL, Hänninen T, Laakso MP, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A.

Neurology. 2001 Jun 26;56(12):1683-9.

PMID:
11425934
30.

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.

Kivipelto M, Helkala EL, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A.

BMJ. 2001 Jun 16;322(7300):1447-51.

31.

Childhood socioeconomic position and cognitive function in adulthood.

Kaplan GA, Turrell G, Lynch JW, Everson SA, Helkala EL, Salonen JT.

Int J Epidemiol. 2001 Apr;30(2):256-63.

PMID:
11369724
32.

APOE-epsilon4 is associated with weight loss in women with AD: a population-based study.

Vanhanen M, Kivipelto M, Koivisto K, Kuusisto J, Mykkänen L, Helkala EL, Hänninen T, Kervinen K, Kesäniemi YA, Laakso MP, Soininen H, Laakso M.

Neurology. 2001 Mar 13;56(5):655-9.

PMID:
11245719
33.

Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study.

Koivisto AM, Lempiäinen P, Koivisto K, Helkala EL, Mykkänen L, Kuusisto J, Kervinen K, Kesäniemi YA, Laakso M, Soininen H.

Neuroepidemiology. 2000 Nov-Dec;19(6):327-32.

PMID:
11060507
34.

Type-2 diabetes and cognitive function in a non-demented population.

Vanhanen M, Kuusisto J, Koivisto K, Mykkänen L, Helkala EL, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M.

Acta Neurol Scand. 1999 Aug;100(2):97-101.

PMID:
10442450
35.

MRI of the hippocampus in Alzheimer's disease: sensitivity, specificity, and analysis of the incorrectly classified subjects.

Laakso MP, Soininen H, Partanen K, Lehtovirta M, Hallikainen M, Hänninen T, Helkala EL, Vainio P, Riekkinen PJ Sr.

Neurobiol Aging. 1998 Jan-Feb;19(1):23-31.

PMID:
9562499
36.

Cognitive function in an elderly population with persistent impaired glucose tolerance.

Vanhanen M, Koivisto K, Kuusisto J, Mykkänen L, Helkala EL, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M.

Diabetes Care. 1998 Mar;21(3):398-402.

PMID:
9540022
37.

Tetrahydroaminoacridine improves the recency effect in Alzheimer's disease.

Riekkinen M, Soininen H, Riekkinen P Sr, Kuikka J, Laakso M, Helkala EL, Partanen J, Riekkinen P Jr.

Neuroscience. 1998 Mar;83(2):471-9.

PMID:
9460755
38.

Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study.

Kuusisto J, Koivisto K, Mykkänen L, Helkala EL, Vanhanen M, Hänninen T, Kervinen K, Kesäniemi YA, Riekkinen PJ, Laakso M.

BMJ. 1997 Oct 25;315(7115):1045-9.

39.

Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function.

Vanhanen M, Koivisto K, Karjalainen L, Helkala EL, Laakso M, Soininen H, Riekkinen P Sr.

Neuroreport. 1997 Apr 14;8(6):1527-30.

PMID:
9172168
40.

Relationship between EEG reactivity and neuropsychological tests in vascular dementia.

Partanen J, Soininen H, Helkala EL, Könönen M, Kilpeläinen R, Riekkinen P.

J Neural Transm (Vienna). 1997;104(8-9):905-12.

PMID:
9451722
41.

Stability of age-associated memory impairment during a longitudinal population-based study.

Helkala EL, Koivisto K, Hanninen T, Vanhanen M, Kuusisto J, Mykkanen L, Laakso M, Riekkinen P Sr.

J Am Geriatr Soc. 1997 Jan;45(1):120-2. No abstract available.

PMID:
8994504
42.

Slow-wave activity in the spectral analysis of the electroencephalogram and volumes of hippocampus in subgroups of Alzheimer's disease patients.

Helkala EL, Hänninen T, Hallikainen M, Könönen M, Laakso MP, Hartikainen P, Soininen H, Partanen J, Partanen K, Vainio P, Riekkinen P Sr.

Behav Neurosci. 1996 Dec;110(6):1235-43.

PMID:
8986328
43.

EEG reactivity correlates with neuropsychological test scores in Down's syndrome.

Partanen J, Soininen H, Könönen M, Kilpeläinen R, Helkala EL, Riekkinen P Sr.

Acta Neurol Scand. 1996 Oct;94(4):242-6.

PMID:
8937534
44.

MR T2 relaxometry in Alzheimer's disease and age-associated memory impairment.

Laakso MP, Partanen K, Soininen H, Lehtovirta M, Hallikainen M, Hänninen T, Helkala EL, Vainio P, Riekkinen PJ Sr.

Neurobiol Aging. 1996 Jul-Aug;17(4):535-40.

PMID:
8832627
45.

Prevalence of ageing-associated cognitive decline in an elderly population.

Hanninen T, Koivisto K, Reinikainen KJ, Helkala EL, Soininen H, Mykkänen L, Laakso M, Riekkinen PJ.

Age Ageing. 1996 May;25(3):201-5.

PMID:
8670552
46.

Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia: An MRI study.

Laakso MP, Partanen K, Riekkinen P, Lehtovirta M, Helkala EL, Hallikainen M, Hanninen T, Vainio P, Soininen H.

Neurology. 1996 Mar;46(3):678-81.

PMID:
8618666
47.

Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study.

Helkala EL, Koivisto K, Hanninen T, Vanhanen M, Kervinen K, Kuusisto J, Mykkanen L, Kesaniemi YA, Laakso M, Riekkinen P Sr.

Neurosci Lett. 1996 Feb 9;204(3):177-80.

PMID:
8938259
48.

Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism.

Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Helkala EL, Hartikainen P, Hänninen T, Ryynänen M, Riekkinen PJ.

Neurology. 1996 Feb;46(2):413-9.

PMID:
8614504
49.

A follow-up study of age-associated memory impairment: neuropsychological predictors of dementia.

Hänninen T, Hallikainen M, Koivisto K, Helkala EL, Reinikainen KJ, Soininen H, Mykkänen L, Laakso M, Pyörälä K, Riekkinen PJ Sr.

J Am Geriatr Soc. 1995 Sep;43(9):1007-15.

PMID:
7657916
50.

Tetrahydroaminoacridine modulates technetium-99m labelled ethylene dicysteinate retention in Alzheimer's disease measured with single photon emission computed tomography imaging.

Riekkinen P Jr, Kuikka J, Soininen H, Helkala EL, Hallikainen M, Riekkinen P.

Neurosci Lett. 1995 Jul 28;195(1):53-6.

PMID:
7478254

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