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Items: 1 to 50 of 255

1.

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia.

Radzisheuskaya A, Shliaha PV, Grinev V, Lorenzini E, Kovalchuk S, Shlyueva D, Gorshkov V, Hendrickson RC, Jensen ON, Helin K.

Nat Struct Mol Biol. 2019 Oct 14. doi: 10.1038/s41594-019-0313-z. [Epub ahead of print]

PMID:
31611688
2.

Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity.

Højfeldt JW, Hedehus L, Laugesen A, Tatar T, Wiehle L, Helin K.

Mol Cell. 2019 Aug 31. pii: S1097-2765(19)30586-6. doi: 10.1016/j.molcel.2019.07.031. [Epub ahead of print]

PMID:
31521506
3.

BTK inhibitors synergize with 5-FU to treat drug-resistant TP53-null colon cancers.

Lavitrano M, Ianzano L, Bonomo S, Cialdella A, Cerrito MG, Pisano F, Missaglia C, Giovannoni R, Romano G, McLean CM, Voest EE, D'Amato F, Noli B, Ferri GL, Agostini M, Pucciarelli S, Helin K, Leone BE, Canzonieri V, Grassilli E.

J Pathol. 2019 Sep 13. doi: 10.1002/path.5347. [Epub ahead of print]

PMID:
31518438
4.

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis.

Backe MB, Jin C, Andreone L, Sankar A, Agger K, Helin K, Madsen AN, Poulsen SS, Bysani M, Bacos K, Ling C, Perone MJ, Holst B, Mandrup-Poulsen T.

J Diabetes Res. 2019 Jul 28;2019:5451038. doi: 10.1155/2019/5451038. eCollection 2019.

5.

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.

Agger K, Nishimura K, Miyagi S, Messling JE, Rasmussen KD, Helin K.

Blood. 2019 Oct 3;134(14):1154-1158. doi: 10.1182/blood.2019000855. Epub 2019 Aug 21.

PMID:
31434704
6.

Correction for Danovi et al., "Amplification of Mdmx (or Mdm4) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity".

Danovi D, Meulmeester E, Pasini D, Migliorini D, Capra M, Frenk R, de Graaf P, Francoz S, Gasparini P, Gobbi A, Helin K, Pelicci PG, Jochemsen AG, Marine JC.

Mol Cell Biol. 2019 Jul 16;39(15). pii: e00150-19. doi: 10.1128/MCB.00150-19. Print 2019 Aug 1. No abstract available.

7.

Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation.

Laugesen A, Højfeldt JW, Helin K.

Mol Cell. 2019 Apr 4;74(1):8-18. doi: 10.1016/j.molcel.2019.03.011. Review.

PMID:
30951652
8.

The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.

Miyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, Iwama A.

Blood. 2019 Jun 6;133(23):2495-2506. doi: 10.1182/blood.2019000468. Epub 2019 Mar 27.

PMID:
30917958
9.

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells.

Rasmussen KD, Berest I, Keβler S, Nishimura K, Simón-Carrasco L, Vassiliou GS, Pedersen MT, Christensen J, Zaugg JB, Helin K.

Genome Res. 2019 Apr;29(4):564-575. doi: 10.1101/gr.239277.118. Epub 2019 Feb 22.

10.

PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells.

Agrawal Singh S, Lerdrup M, Gomes AR, van de Werken HJ, Vilstrup Johansen J, Andersson R, Sandelin A, Helin K, Hansen K.

Elife. 2019 Jan 23;8. pii: e40364. doi: 10.7554/eLife.40364.

11.

HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases.

Paroni G, Bolis M, Zanetti A, Ubezio P, Helin K, Staller P, Gerlach LO, Fratelli M, Neve RM, Terao M, Garattini E.

Oncogene. 2019 Apr;38(15):2675-2689. doi: 10.1038/s41388-018-0620-6. Epub 2018 Dec 11.

PMID:
30538297
12.

Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity.

Bagger SO, Hopkinson BM, Pandey DP, Bak M, Brydholm AV, Villadsen R, Helin K, Rønnov-Jessen L, Petersen OW, Kim J.

Mol Cancer. 2018 Dec 10;17(1):171. doi: 10.1186/s12943-018-0918-6.

13.

Secondary hypertension in patients with saccular intracranial aneurysm disease: A population based study.

Kotikoski S, Huttunen J, Huttunen TJ, Helin K, Frösen J, Koivisto T, Kurki MI, von Und Zu Fraunberg M, Kunnamo I, Jääskeläinen JE, Lindgren AE.

PLoS One. 2018 Oct 31;13(10):e0206432. doi: 10.1371/journal.pone.0206432. eCollection 2018.

14.

The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase.

Vasconez AE, Janetzko P, Oo JA, Pflüger-Müller B, Ratiu C, Gu L, Helin K, Geisslinger G, Fleming I, Schröder K, Fork C, Brandes RP, Leisegang MS.

Acta Physiol (Oxf). 2019 Jan;225(1):e13168. doi: 10.1111/apha.13168. Epub 2018 Aug 25.

PMID:
30076673
15.

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

Weissmann S, Cloos PA, Sidoli S, Jensen ON, Pollard S, Helin K.

Cancer Res. 2018 Aug 1;78(15):4114-4125. doi: 10.1158/0008-5472.CAN-18-0342. Epub 2018 May 29.

16.

Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.

Li H, Yao Q, Mariscal AG, Wu X, Hülse J, Pedersen E, Helin K, Waisman A, Vinkel C, Thomsen SF, Avgustinova A, Benitah SA, Lovato P, Norsgaard H, Mortensen MS, Veng L, Rozell B, Brakebusch C.

Nat Commun. 2018 Apr 12;9(1):1420. doi: 10.1038/s41467-018-03704-z.

17.

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.

Højfeldt JW, Laugesen A, Willumsen BM, Damhofer H, Hedehus L, Tvardovskiy A, Mohammad F, Jensen ON, Helin K.

Nat Struct Mol Biol. 2018 Mar;25(3):225-232. doi: 10.1038/s41594-018-0036-6. Epub 2018 Feb 26.

18.

Oncohistones: drivers of pediatric cancers.

Mohammad F, Helin K.

Genes Dev. 2017 Dec 1;31(23-24):2313-2324. doi: 10.1101/gad.309013.117. Review.

19.

Polycystic kidney disease among 4,436 intracranial aneurysm patients from a defined population.

Nurmonen HJ, Huttunen T, Huttunen J, Kurki MI, Helin K, Koivisto T, von Und Zu Fraunberg M, Jääskeläinen JE, Lindgren AE.

Neurology. 2017 Oct 31;89(18):1852-1859. doi: 10.1212/WNL.0000000000004597. Epub 2017 Oct 4.

PMID:
28978659
20.

Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development.

Sankar A, Kooistra SM, Gonzalez JM, Ohlsson C, Poutanen M, Helin K.

Development. 2017 Sep 15;144(18):3264-3277. doi: 10.1242/dev.155473. Epub 2017 Aug 21.

21.

EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice.

Dong Y, Isono KI, Ohbo K, Endo TA, Ohara O, Maekawa M, Toyama Y, Ito C, Toshimori K, Helin K, Ogonuki N, Inoue K, Ogura A, Yamagata K, Kitabayashi I, Koseki H.

Mol Cell Biol. 2017 Sep 12;37(19). pii: e00082-17. doi: 10.1128/MCB.00082-17. Print 2017 Oct 1.

22.

Impact of Young Age on the Presentation of Saccular Intracranial Aneurysms: Population-Based Analysis of 4082 Patients.

Räisänen S, Frösen J, Kurki MI, Huttunen T, Huttunen J, Koivisto T, Helin K, von Und Zu Fraunberg M, Jääskeläinen JE, Lindgren AE.

Neurosurgery. 2018 Jun 1;82(6):815-823. doi: 10.1093/neuros/nyx305.

PMID:
28605505
23.

Neurofibromatosis type 1 is not associated with subarachnoid haemorrhage.

Kurtelius A, Kallionpää RA, Huttunen J, Huttunen TJ, Helin K, Koivisto T, Frösen J, von Und Zu Fraunberg M, Peltonen S, Peltonen J, Jääskeläinen JE, Lindgren AE.

PLoS One. 2017 Jun 2;12(6):e0178711. doi: 10.1371/journal.pone.0178711. eCollection 2017.

24.

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.

Mohammad F, Weissmann S, Leblanc B, Pandey DP, Højfeldt JW, Comet I, Zheng C, Johansen JV, Rapin N, Porse BT, Tvardovskiy A, Jensen ON, Olaciregui NG, Lavarino C, Suñol M, de Torres C, Mora J, Carcaboso AM, Helin K.

Nat Med. 2017 Apr;23(4):483-492. doi: 10.1038/nm.4293. Epub 2017 Feb 27.

PMID:
28263309
25.

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.

Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova TB, Anil-Kirmizitas B, Bassett A, Kooistra SM, Agger K, Helin K, Heard E, Brockdorff N.

Nat Commun. 2016 Nov 28;7:13661. doi: 10.1038/ncomms13661.

26.

Maintaining cell identity: PRC2-mediated regulation of transcription and cancer.

Comet I, Riising EM, Leblanc B, Helin K.

Nat Rev Cancer. 2016 Dec;16(12):803-810. doi: 10.1038/nrc.2016.83. Epub 2016 Sep 23. Review.

PMID:
27658528
27.

Regional tumour glutamine supply affects chromatin and cell identity.

Højfeldt JW, Helin K.

Nat Cell Biol. 2016 Sep 28;18(10):1027-9. doi: 10.1038/ncb3414. Review.

PMID:
27684506
28.

Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer.

Laugesen A, Højfeldt JW, Helin K.

Cold Spring Harb Perspect Med. 2016 Sep 1;6(9). pii: a026575. doi: 10.1101/cshperspect.a026575. Review.

29.

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression.

Radzisheuskaya A, Shlyueva D, Müller I, Helin K.

Nucleic Acids Res. 2016 Oct 14;44(18):e141. Epub 2016 Jun 28.

30.

Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation.

Schwämmle V, Sidoli S, Ruminowicz C, Wu X, Lee CF, Helin K, Jensen ON.

Mol Cell Proteomics. 2016 Aug;15(8):2715-29. doi: 10.1074/mcp.M115.054460. Epub 2016 Jun 14.

31.

Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.

Pedersen MT, Kooistra SM, Radzisheuskaya A, Laugesen A, Johansen JV, Hayward DG, Nilsson J, Agger K, Helin K.

EMBO J. 2016 Jul 15;35(14):1550-64. doi: 10.15252/embj.201593317. Epub 2016 Jun 6.

32.

Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.

Agger K, Miyagi S, Pedersen MT, Kooistra SM, Johansen JV, Helin K.

Genes Dev. 2016 Jun 1;30(11):1278-88. doi: 10.1101/gad.280495.116. Epub 2016 Jun 2.

33.

ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells.

Riso V, Cammisa M, Kukreja H, Anvar Z, Verde G, Sparago A, Acurzio B, Lad S, Lonardo E, Sankar A, Helin K, Feil R, Fico A, Angelini C, Grimaldi G, Riccio A.

Nucleic Acids Res. 2016 Sep 30;44(17):8165-78. doi: 10.1093/nar/gkw505. Epub 2016 Jun 1.

34.

Irregular Shape of Intracranial Aneurysm Indicates Rupture Risk Irrespective of Size in a Population-Based Cohort.

Lindgren AE, Koivisto T, Björkman J, von Und Zu Fraunberg M, Helin K, Jääskeläinen JE, Frösen J.

Stroke. 2016 May;47(5):1219-26. doi: 10.1161/STROKEAHA.115.012404. Epub 2016 Apr 12.

PMID:
27073241
35.

Role of TET enzymes in DNA methylation, development, and cancer.

Rasmussen KD, Helin K.

Genes Dev. 2016 Apr 1;30(7):733-50. doi: 10.1101/gad.276568.115. Review.

36.

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice.

Scourzic L, Couronné L, Pedersen MT, Della Valle V, Diop M, Mylonas E, Calvo J, Mouly E, Lopez CK, Martin N, Fontenay M, Bender A, Guibert S, Dubreuil P, Dessen P, Droin N, Pflumio F, Weber M, Gaulard P, Helin K, Mercher T, Bernard OA.

Leukemia. 2016 Jun;30(6):1388-98. doi: 10.1038/leu.2016.29. Epub 2016 Feb 15.

37.

A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation.

Grassilli E, Pisano F, Cialdella A, Bonomo S, Missaglia C, Cerrito MG, Masiero L, Ianzano L, Giordano F, Cicirelli V, Narloch R, D'Amato F, Noli B, Ferri GL, Leone BE, Stanta G, Bonin S, Helin K, Giovannoni R, Lavitrano M.

Oncogene. 2016 Aug 18;35(33):4368-78. doi: 10.1038/onc.2015.504. Epub 2016 Jan 25.

38.

SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance.

Cruickshank VA, Sroczynska P, Sankar A, Miyagi S, Rundsten CF, Johansen JV, Helin K.

PLoS One. 2015 Nov 16;10(11):e0142806. doi: 10.1371/journal.pone.0142806. eCollection 2015.

39.

H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.

Vandamme J, Sidoli S, Mariani L, Friis C, Christensen J, Helin K, Jensen ON, Salcini AE.

Nucleic Acids Res. 2015 Nov 16;43(20):9694-710. doi: 10.1093/nar/gkv1063. Epub 2015 Oct 17.

40.

Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals.

Wu X, Bekker-Jensen IH, Christensen J, Rasmussen KD, Sidoli S, Qi Y, Kong Y, Wang X, Cui Y, Xiao Z, Xu G, Williams K, Rappsilber J, Sønderby CK, Winther O, Jensen ON, Helin K.

Cell Res. 2015 Nov;25(11):1205-18. doi: 10.1038/cr.2015.121. Epub 2015 Oct 16.

41.

RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo.

Ptaschinski C, Mukherjee S, Moore ML, Albert M, Helin K, Kunkel SL, Lukacs NW.

PLoS Pathog. 2015 Jun 17;11(6):e1004978. doi: 10.1371/journal.ppat.1004978. eCollection 2015 Jun.

42.

Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5.

Fork C, Gu L, Hitzel J, Josipovic I, Hu J, SzeKa Wong M, Ponomareva Y, Albert M, Schmitz SU, Uchida S, Fleming I, Helin K, Steinhilber D, Leisegang MS, Brandes RP.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1645-52. doi: 10.1161/ATVBAHA.115.305561. Epub 2015 May 28.

PMID:
26023081
43.

TET1: an epigenetic guardian of lymphomagenesis.

Rasmussen KD, Helin K.

Nat Immunol. 2015 Jun;16(6):592-4. doi: 10.1038/ni.3176. No abstract available.

PMID:
25988898
44.

The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence.

Montes M, Nielsen MM, Maglieri G, Jacobsen A, Højfeldt J, Agrawal-Singh S, Hansen K, Helin K, van de Werken HJG, Pedersen JS, Lund AH.

Nat Commun. 2015 Apr 24;6:6967. doi: 10.1038/ncomms7967.

PMID:
25908244
45.

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis.

Rasmussen KD, Jia G, Johansen JV, Pedersen MT, Rapin N, Bagger FO, Porse BT, Bernard OA, Christensen J, Helin K.

Genes Dev. 2015 May 1;29(9):910-22. doi: 10.1101/gad.260174.115. Epub 2015 Apr 17.

46.

Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.

Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H.

Blood. 2015 May 28;125(22):3437-46. doi: 10.1182/blood-2014-03-562694. Epub 2015 Apr 14.

47.

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice.

Stewart MH, Albert M, Sroczynska P, Cruickshank VA, Guo Y, Rossi DJ, Helin K, Enver T.

Blood. 2015 Mar 26;125(13):2075-8. doi: 10.1182/blood-2014-08-596734. Epub 2015 Feb 5.

48.

Inhibition of demethylases by GSK-J1/J4.

Heinemann B, Nielsen JM, Hudlebusch HR, Lees MJ, Larsen DV, Boesen T, Labelle M, Gerlach LO, Birk P, Helin K.

Nature. 2014 Oct 2;514(7520):E1-2. doi: 10.1038/nature13688. No abstract available.

PMID:
25279926
49.

A dual program for translation regulation in cellular proliferation and differentiation.

Gingold H, Tehler D, Christoffersen NR, Nielsen MM, Asmar F, Kooistra SM, Christophersen NS, Christensen LL, Borre M, Sørensen KD, Andersen LD, Andersen CL, Hulleman E, Wurdinger T, Ralfkiær E, Helin K, Grønbæk K, Ørntoft T, Waszak SM, Dahan O, Pedersen JS, Lund AH, Pilpel Y.

Cell. 2014 Sep 11;158(6):1281-1292. doi: 10.1016/j.cell.2014.08.011.

50.

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.

De Raedt T, Beert E, Pasmant E, Luscan A, Brems H, Ortonne N, Helin K, Hornick JL, Mautner V, Kehrer-Sawatzki H, Clapp W, Bradner J, Vidaud M, Upadhyaya M, Legius E, Cichowski K.

Nature. 2014 Oct 9;514(7521):247-51. doi: 10.1038/nature13561. Epub 2014 Aug 13.

PMID:
25119042

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