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Items: 1 to 20 of 259

1.

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia.

Radzisheuskaya A, Shliaha PV, Grinev V, Lorenzini E, Kovalchuk S, Shlyueva D, Gorshkov V, Hendrickson RC, Jensen ON, Helin K.

Nat Struct Mol Biol. 2019 Oct 14. doi: 10.1038/s41594-019-0313-z. [Epub ahead of print]

PMID:
31611688
2.

Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity.

Højfeldt JW, Hedehus L, Laugesen A, Tatar T, Wiehle L, Helin K.

Mol Cell. 2019 Aug 31. pii: S1097-2765(19)30586-6. doi: 10.1016/j.molcel.2019.07.031. [Epub ahead of print]

PMID:
31521506
3.

BTK inhibitors synergize with 5-FU to treat drug-resistant TP53-null colon cancers.

Lavitrano M, Ianzano L, Bonomo S, Cialdella A, Cerrito MG, Pisano F, Missaglia C, Giovannoni R, Romano G, McLean CM, Voest EE, D'Amato F, Noli B, Ferri GL, Agostini M, Pucciarelli S, Helin K, Leone BE, Canzonieri V, Grassilli E.

J Pathol. 2019 Sep 13. doi: 10.1002/path.5347. [Epub ahead of print]

PMID:
31518438
4.

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis.

Backe MB, Jin C, Andreone L, Sankar A, Agger K, Helin K, Madsen AN, Poulsen SS, Bysani M, Bacos K, Ling C, Perone MJ, Holst B, Mandrup-Poulsen T.

J Diabetes Res. 2019 Jul 28;2019:5451038. doi: 10.1155/2019/5451038. eCollection 2019.

5.

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.

Agger K, Nishimura K, Miyagi S, Messling JE, Rasmussen KD, Helin K.

Blood. 2019 Oct 3;134(14):1154-1158. doi: 10.1182/blood.2019000855. Epub 2019 Aug 21.

PMID:
31434704
6.

Correction for Danovi et al., "Amplification of Mdmx (or Mdm4) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity".

Danovi D, Meulmeester E, Pasini D, Migliorini D, Capra M, Frenk R, de Graaf P, Francoz S, Gasparini P, Gobbi A, Helin K, Pelicci PG, Jochemsen AG, Marine JC.

Mol Cell Biol. 2019 Jul 16;39(15). pii: e00150-19. doi: 10.1128/MCB.00150-19. Print 2019 Aug 1. No abstract available.

7.

Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation.

Laugesen A, Højfeldt JW, Helin K.

Mol Cell. 2019 Apr 4;74(1):8-18. doi: 10.1016/j.molcel.2019.03.011. Review.

PMID:
30951652
8.

The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.

Miyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, Iwama A.

Blood. 2019 Jun 6;133(23):2495-2506. doi: 10.1182/blood.2019000468. Epub 2019 Mar 27.

PMID:
30917958
9.

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells.

Rasmussen KD, Berest I, Keβler S, Nishimura K, Simón-Carrasco L, Vassiliou GS, Pedersen MT, Christensen J, Zaugg JB, Helin K.

Genome Res. 2019 Apr;29(4):564-575. doi: 10.1101/gr.239277.118. Epub 2019 Feb 22.

10.

PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells.

Agrawal Singh S, Lerdrup M, Gomes AR, van de Werken HJ, Vilstrup Johansen J, Andersson R, Sandelin A, Helin K, Hansen K.

Elife. 2019 Jan 23;8. pii: e40364. doi: 10.7554/eLife.40364.

11.

HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases.

Paroni G, Bolis M, Zanetti A, Ubezio P, Helin K, Staller P, Gerlach LO, Fratelli M, Neve RM, Terao M, Garattini E.

Oncogene. 2019 Apr;38(15):2675-2689. doi: 10.1038/s41388-018-0620-6. Epub 2018 Dec 11.

PMID:
30538297
12.

Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity.

Bagger SO, Hopkinson BM, Pandey DP, Bak M, Brydholm AV, Villadsen R, Helin K, Rønnov-Jessen L, Petersen OW, Kim J.

Mol Cancer. 2018 Dec 10;17(1):171. doi: 10.1186/s12943-018-0918-6.

13.

Secondary hypertension in patients with saccular intracranial aneurysm disease: A population based study.

Kotikoski S, Huttunen J, Huttunen TJ, Helin K, Frösen J, Koivisto T, Kurki MI, von Und Zu Fraunberg M, Kunnamo I, Jääskeläinen JE, Lindgren AE.

PLoS One. 2018 Oct 31;13(10):e0206432. doi: 10.1371/journal.pone.0206432. eCollection 2018.

14.

The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase.

Vasconez AE, Janetzko P, Oo JA, Pflüger-Müller B, Ratiu C, Gu L, Helin K, Geisslinger G, Fleming I, Schröder K, Fork C, Brandes RP, Leisegang MS.

Acta Physiol (Oxf). 2019 Jan;225(1):e13168. doi: 10.1111/apha.13168. Epub 2018 Aug 25.

PMID:
30076673
15.

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

Weissmann S, Cloos PA, Sidoli S, Jensen ON, Pollard S, Helin K.

Cancer Res. 2018 Aug 1;78(15):4114-4125. doi: 10.1158/0008-5472.CAN-18-0342. Epub 2018 May 29.

16.

Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.

Li H, Yao Q, Mariscal AG, Wu X, Hülse J, Pedersen E, Helin K, Waisman A, Vinkel C, Thomsen SF, Avgustinova A, Benitah SA, Lovato P, Norsgaard H, Mortensen MS, Veng L, Rozell B, Brakebusch C.

Nat Commun. 2018 Apr 12;9(1):1420. doi: 10.1038/s41467-018-03704-z.

17.

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.

Højfeldt JW, Laugesen A, Willumsen BM, Damhofer H, Hedehus L, Tvardovskiy A, Mohammad F, Jensen ON, Helin K.

Nat Struct Mol Biol. 2018 Mar;25(3):225-232. doi: 10.1038/s41594-018-0036-6. Epub 2018 Feb 26.

18.

Oncohistones: drivers of pediatric cancers.

Mohammad F, Helin K.

Genes Dev. 2017 Dec 1;31(23-24):2313-2324. doi: 10.1101/gad.309013.117. Review.

19.

Polycystic kidney disease among 4,436 intracranial aneurysm patients from a defined population.

Nurmonen HJ, Huttunen T, Huttunen J, Kurki MI, Helin K, Koivisto T, von Und Zu Fraunberg M, Jääskeläinen JE, Lindgren AE.

Neurology. 2017 Oct 31;89(18):1852-1859. doi: 10.1212/WNL.0000000000004597. Epub 2017 Oct 4.

PMID:
28978659
20.

Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development.

Sankar A, Kooistra SM, Gonzalez JM, Ohlsson C, Poutanen M, Helin K.

Development. 2017 Sep 15;144(18):3264-3277. doi: 10.1242/dev.155473. Epub 2017 Aug 21.

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