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Items: 34


Size Matters: The Functional Role of the CEACAM1 Isoform Signature and Its Impact for NK Cell-Mediated Killing in Melanoma.

Helfrich I, Singer BB.

Cancers (Basel). 2019 Mar 13;11(3). pii: E356. doi: 10.3390/cancers11030356. Review.


Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers.

Schöpel M, Shkura O, Seidel J, Kock K, Zhong X, Löffek S, Helfrich I, Bachmann HS, Scherkenbeck J, Herrmann C, Stoll R.

Int J Mol Sci. 2018 Apr 10;19(4). pii: E1133. doi: 10.3390/ijms19041133.


Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.

Klein JC, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, Helfrich I, Dittmer U, Kirschning CJ, Brandau S.

Nat Commun. 2017 Mar 16;8:14600. doi: 10.1038/ncomms14600.


Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression.

Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA, Lang KS.

Nat Commun. 2017 Mar 1;8:14447. doi: 10.1038/ncomms14447.


Tension in Cancer.

Löffek S, Franzke CW, Helfrich I.

Int J Mol Sci. 2016 Nov 16;17(11). pii: E1910. Review.


Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia.

Klose R, Krzywinska E, Castells M, Gotthardt D, Putz EM, Kantari-Mimoun C, Chikdene N, Meinecke AK, Schrödter K, Helfrich I, Fandrey J, Sexl V, Stockmann C.

Nat Commun. 2016 Aug 19;7:12528. doi: 10.1038/ncomms12528.


Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma.

Roesch A, Paschen A, Landsberg J, Helfrich I, Becker JC, Schadendorf D.

Eur J Cancer. 2016 May;59:109-112. doi: 10.1016/j.ejca.2016.02.023. Epub 2016 Mar 26.


Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor Metastasis.

Carpinteiro A, Beckmann N, Seitz A, Hessler G, Wilker B, Soddemann M, Helfrich I, Edelmann B, Gulbins E, Becker KA.

Cell Physiol Biochem. 2016;38(1):1-14. doi: 10.1159/000438604. Epub 2016 Jan 8.


Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging.

Stoffels I, Morscher S, Helfrich I, Hillen U, Leyh J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J.

Sci Transl Med. 2015 Dec 9;7(317):317ra199. doi: 10.1126/scitranslmed.aad1278. Erratum in: Sci Transl Med. 2015 Dec 23;7(319):319er8. Lehy, Julia [corrected to Leyh, Julia].


CEACAM1-4L Promotes Anchorage-Independent Growth in Melanoma.

Löffek S, Ullrich N, Görgens A, Murke F, Eilebrecht M, Menne C, Giebel B, Schadendorf D, Singer BB, Helfrich I.

Front Oncol. 2015 Oct 19;5:234. doi: 10.3389/fonc.2015.00234. eCollection 2015.


MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma.

Ullrich N, Löffek S, Horn S, Ennen M, Sánchez-Del-Campo L, Zhao F, Breitenbuecher F, Davidson I, Singer BB, Schadendorf D, Goding CR, Helfrich I.

Pigment Cell Melanoma Res. 2015 Nov;28(6):736-40. doi: 10.1111/pcmr.12414.


Regulation of hematogenous tumor metastasis by acid sphingomyelinase.

Carpinteiro A, Becker KA, Japtok L, Hessler G, Keitsch S, Požgajovà M, Schmid KW, Adams C, Müller S, Kleuser B, Edwards MJ, Grassmé H, Helfrich I, Gulbins E.

EMBO Mol Med. 2015 Jun;7(6):714-34. doi: 10.15252/emmm.201404571.


CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival.

Ullrich N, Heinemann A, Nilewski E, Scheffrahn I, Klode J, Scherag A, Schadendorf D, Singer BB, Helfrich I.

Cancer Res. 2015 May 1;75(9):1897-907. doi: 10.1158/0008-5472.CAN-14-1752. Epub 2015 Mar 5.


The impact of the immune system on tumor: angiogenesis and vascular remodeling.

Stockmann C, Schadendorf D, Klose R, Helfrich I.

Front Oncol. 2014 Apr 8;4:69. doi: 10.3389/fonc.2014.00069. eCollection 2014. Review.


Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.

Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D, Kohlmeyer J, Riesenberg S, van den Boorn-Konijnenberg D, Hömig-Hölzel C, Reuten R, Schadow B, Weighardt H, Wenzel D, Helfrich I, Schadendorf D, Bloch W, Bianchi ME, Lugassy C, Barnhill RL, Koch M, Fleischmann BK, Förster I, Kastenmüller W, Kolanus W, Hölzel M, Gaffal E, Tüting T.

Nature. 2014 Mar 6;507(7490):109-13. doi: 10.1038/nature13111. Epub 2014 Feb 26.


Primary tumor versus metastasis: new experimental models for studies on cancer cell homing and metastasis in melanoma.

Helfrich I, Ullrich N, Zigrino P, Schadendorf D.

Pigment Cell Melanoma Res. 2014 Mar;27(2):309-16. doi: 10.1111/pcmr.12204. Epub 2014 Jan 6. No abstract available.


Vascular endothelial growth factor promotes pericyte coverage of brain capillaries, improves cerebral blood flow during subsequent focal cerebral ischemia, and preserves the metabolic penumbra.

Zechariah A, ElAli A, Doeppner TR, Jin F, Hasan MR, Helfrich I, Mies G, Hermann DM.

Stroke. 2013 Jun;44(6):1690-7. doi: 10.1161/STROKEAHA.111.000240. Epub 2013 Apr 30.


Hyperlipidemia attenuates vascular endothelial growth factor-induced angiogenesis, impairs cerebral blood flow, and disturbs stroke recovery via decreased pericyte coverage of brain endothelial cells.

Zechariah A, ElAli A, Hagemann N, Jin F, Doeppner TR, Helfrich I, Mies G, Hermann DM.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1561-7. doi: 10.1161/ATVBAHA.112.300749. Epub 2013 Apr 4. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):e129.


Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth.

Hansen W, Hutzler M, Abel S, Alter C, Stockmann C, Kliche S, Albert J, Sparwasser T, Sakaguchi S, Westendorf AM, Schadendorf D, Buer J, Helfrich I.

J Exp Med. 2012 Oct 22;209(11):2001-16. doi: 10.1084/jem.20111497. Epub 2012 Oct 8.


Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis.

Meinecke AK, Nagy N, Lago GD, Kirmse S, Klose R, Schrödter K, Zimmermann A, Helfrich I, Rundqvist H, Theegarten D, Anhenn O, Orian-Rousseau V, Johnson RS, Alitalo K, Fischer JW, Fandrey J, Stockmann C.

Blood. 2012 Jun 14;119(24):5931-42. doi: 10.1182/blood-2011-12-396895. Epub 2012 Apr 30.


Blood vessel maturation, vascular phenotype and angiogenic potential in malignant melanoma: one step forward for overcoming anti-angiogenic drug resistance?

Helfrich I, Schadendorf D.

Mol Oncol. 2011 Apr;5(2):137-49. doi: 10.1016/j.molonc.2011.01.003. Epub 2011 Feb 3. Review.


The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells.

Testori J, Schweighofer B, Helfrich I, Sturtzel C, Lipnik K, Gesierich S, Nasarre P, Hofer-Warbinek R, Bilban M, Augustin HG, Hofer E.

Blood. 2011 Mar 3;117(9):2735-44. doi: 10.1182/blood-2010-07-293209. Epub 2011 Jan 11.


A wound size-dependent effect of myeloid cell-derived vascular endothelial growth factor on wound healing.

Stockmann C, Kirmse S, Helfrich I, Weidemann A, Takeda N, Doedens A, Johnson RS.

J Invest Dermatol. 2011 Mar;131(3):797-801. doi: 10.1038/jid.2010.345. Epub 2010 Nov 25. No abstract available.


Drug treatment of chronic-intermittent abdominal cramping and pain: a multi-national survey on usage and attitudes.

Mueller-Lissner S, Quigley EM, Helfrich I, Schaefer E.

Aliment Pharmacol Ther. 2010 Aug;32(3):472-7. doi: 10.1111/j.1365-2036.2010.04368.x. Epub 2010 May 22.


Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma.

Helfrich I, Scheffrahn I, Bartling S, Weis J, von Felbert V, Middleton M, Kato M, Ergün S, Augustin HG, Schadendorf D.

J Exp Med. 2010 Mar 15;207(3):491-503. doi: 10.1084/jem.20091846. Epub 2010 Mar 1. Erratum in: J Exp Med. 2013 Apr 8;210(4):853. Augustin, Helmut G [added].


Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma.

Helfrich I, Edler L, Sucker A, Thomas M, Christian S, Schadendorf D, Augustin HG.

Clin Cancer Res. 2009 Feb 15;15(4):1384-92. doi: 10.1158/1078-0432.CCR-08-1615.


Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth.

Nasarre P, Thomas M, Kruse K, Helfrich I, Wolter V, Deppermann C, Schadendorf D, Thurston G, Fiedler U, Augustin HG.

Cancer Res. 2009 Feb 15;69(4):1324-33. doi: 10.1158/0008-5472.CAN-08-3030. Epub 2009 Feb 10.


A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation.

Wald A, Scarpignato C, Mueller-Lissner S, Kamm MA, Hinkel U, Helfrich I, Schuijt C, Mandel KG.

Aliment Pharmacol Ther. 2008 Oct 1;28(7):917-30. doi: 10.1111/j.1365-2036.2008.03806.x. Epub 2008 Jul 17.


Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells.

Christian S, Winkler R, Helfrich I, Boos AM, Besemfelder E, Schadendorf D, Augustin HG.

Am J Pathol. 2008 Feb;172(2):486-94. doi: 10.2353/ajpath.2008.070623. Epub 2008 Jan 10.


The burden of constipation on quality of life: results of a multinational survey.

Wald A, Scarpignato C, Kamm MA, Mueller-Lissner S, Helfrich I, Schuijt C, Bubeck J, Limoni C, Petrini O.

Aliment Pharmacol Ther. 2007 Jul 15;26(2):227-36.


Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation.

Helfrich I, Schmitz A, Zigrino P, Michels C, Haase I, le Bivic A, Leitges M, Niessen CM.

J Invest Dermatol. 2007 Apr;127(4):782-91. Epub 2006 Nov 16.


Prevalence and management of abdominal cramping and pain: a multinational survey.

Quigley EM, Locke GR, Mueller-Lissner S, Paulo LG, Tytgat GN, Helfrich I, Schaefer E.

Aliment Pharmacol Ther. 2006 Jul 15;24(2):411-9.


E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions.

Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T, Niessen CM.

EMBO J. 2005 Mar 23;24(6):1146-56. Epub 2005 Mar 3.


Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.

Helfrich I, Chen M, Schmidt R, Fürstenberger G, Kopp-Schneider A, Trick D, Gröne HJ, Zur Hausen H, Rösl F.

J Virol. 2004 May;78(9):4797-805.

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