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Items: 1 to 50 of 97

1.

Tropomyosin isoform Tpm2.1 regulates collective and amoeboid cell migration and cell aggregation in breast epithelial cells.

Shin H, Kim D, Helfman DM.

Oncotarget. 2017 Jul 12;8(56):95192-95205. doi: 10.18632/oncotarget.19182. eCollection 2017 Nov 10.

2.

Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling.

Jeong S, Lim S, Schevzov G, Gunning PW, Helfman DM.

Oncotarget. 2017 May 16;8(20):33544-33559. doi: 10.18632/oncotarget.16825.

3.
4.

Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling.

Kim DY, Helfman DM.

Oncogene. 2016 Aug 25;35(34):4495-508. doi: 10.1038/onc.2015.508. Epub 2016 Feb 15.

PMID:
26876209
5.

Modeling of Menkes disease via human induced pluripotent stem cells.

Suh JH, Kim D, Kim H, Helfman DM, Choi JH, Lee BH, Yoo HW, Han YM.

Biochem Biophys Res Commun. 2014 Feb 14;444(3):311-8. doi: 10.1016/j.bbrc.2014.01.038. Epub 2014 Jan 24.

PMID:
24468087
6.

The Ras-ERK pathway modulates cytoskeleton organization, cell motility and lung metastasis signature genes in MDA-MB-231 LM2.

Choi C, Helfman DM.

Oncogene. 2014 Jul 10;33(28):3668-76. doi: 10.1038/onc.2013.341. Epub 2013 Sep 2.

PMID:
23995792
7.

From skeletal muscle to cancer: insights learned elucidating the function of tropomyosin.

Choi C, Kim D, Kim S, Jeong S, Song E, Helfman DM.

J Struct Biol. 2012 Jan;177(1):63-9. doi: 10.1016/j.jsb.2011.11.016. Epub 2011 Nov 18.

PMID:
22119848
8.

Niclosamide: an established antihelminthic drug as a potential therapy against S100A4-mediated metastatic colon tumors.

Helfman DM.

J Natl Cancer Inst. 2011 Jul 6;103(13):991-2. doi: 10.1093/jnci/djr221. Epub 2011 Jun 17. No abstract available.

PMID:
21685360
9.

Germinal center-specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin.

Lu X, Kazmierczak K, Jiang X, Jones M, Watt J, Helfman DM, Moore JR, Szczesna-Cordary D, Lossos IS.

FEBS J. 2011 Jun;278(11):1922-31. doi: 10.1111/j.1742-4658.2011.08109.x. Epub 2011 Apr 20.

10.

HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway.

Jiang X, Lu X, McNamara G, Liu X, Cubedo E, Sarosiek KA, Sánchez-García I, Helfman DM, Lossos IS.

Blood. 2010 Dec 9;116(24):5217-27. doi: 10.1182/blood-2010-04-281568. Epub 2010 Sep 15.

11.

Non-muscle myosin IIB helps mediate TNF cell death signaling independent of actomyosin contractility (AMC).

Flynn PG, Helfman DM.

J Cell Biochem. 2010 Aug 15;110(6):1365-75. doi: 10.1002/jcb.22653.

PMID:
20564232
12.

Tropomyosin as a regulator of cancer cell transformation.

Helfman DM, Flynn P, Khan P, Saeed A.

Adv Exp Med Biol. 2008;644:124-31. Review.

PMID:
19209818
13.

HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration.

Lu X, Chen J, Malumbres R, Cubedo Gil E, Helfman DM, Lossos IS.

Blood. 2007 Dec 15;110(13):4268-77. Epub 2007 Sep 6.

14.

Myosin light chain kinase plays a role in the regulation of epithelial cell survival.

Connell LE, Helfman DM.

J Cell Sci. 2006 Jun 1;119(Pt 11):2269-81.

15.

Myosin light chain kinase and acto-myosin contractility modulate activation of the ERK cascade downstream of oncogenic Ras.

Helfman DM, Pawlak G.

J Cell Biochem. 2005 Aug 1;95(5):1069-80. Erratum in: J Cell Biochem. 2011 Nov;112(11):3489.

PMID:
15962288
16.

The metastasis associated protein S100A4: role in tumour progression and metastasis.

Helfman DM, Kim EJ, Lukanidin E, Grigorian M.

Br J Cancer. 2005 Jun 6;92(11):1955-8. Review.

17.

A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells.

Bakin AV, Safina A, Rinehart C, Daroqui C, Darbary H, Helfman DM.

Mol Biol Cell. 2004 Oct;15(10):4682-94. Epub 2004 Aug 18.

18.

Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation.

Dhawan J, Helfman DM.

J Cell Sci. 2004 Aug 1;117(Pt 17):3735-48. Epub 2004 Jul 13.

19.

Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder.

Pawlak G, McGarvey TW, Nguyen TB, Tomaszewski JE, Puthiyaveettil R, Malkowicz SB, Helfman DM.

Int J Cancer. 2004 Jun 20;110(3):368-73.

20.

Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway.

Lee S, Helfman DM.

J Biol Chem. 2004 Jan 16;279(3):1885-91. Epub 2003 Oct 14.

22.

Regulation of coiled-coil assembly in tropomyosins.

Araya E, Berthier C, Kim E, Yeung T, Wang X, Helfman DM.

J Struct Biol. 2002 Jan-Feb;137(1-2):176-83.

PMID:
12064944
23.

MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway.

Pawlak G, Helfman DM.

J Biol Chem. 2002 Jul 26;277(30):26927-33. Epub 2002 May 14.

25.

Cytoskeletal changes in cell transformation and tumorigenesis.

Pawlak G, Helfman DM.

Curr Opin Genet Dev. 2001 Feb;11(1):41-7. Review.

PMID:
11163149
26.
27.

Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions.

Helfman DM, Levy ET, Berthier C, Shtutman M, Riveline D, Grosheva I, Lachish-Zalait A, Elbaum M, Bershadsky AD.

Mol Biol Cell. 1999 Oct;10(10):3097-112.

31.

Regulation of the neuron-specific exon of clathrin light chain B.

Stamm S, Casper D, Hanson V, Helfman DM.

Brain Res Mol Brain Res. 1999 Jan 22;64(1):108-18.

PMID:
9889339
32.

Nonmuscle tropomyosin-4 requires coexpression with other low molecular weight isoforms for binding to thin filaments in cardiomyocytes.

Helfman DM, Berthier C, Grossman J, Leu M, Ehler E, Perriard E, Perriard JC.

J Cell Sci. 1999 Feb;112 ( Pt 3):371-80.

33.

Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon.

Lou H, Helfman DM, Gagel RF, Berget SM.

Mol Cell Biol. 1999 Jan;19(1):78-85.

34.

Distinct localizations of tropomyosin isoforms in LLC-PK1 epithelial cells suggests specialized function at cell-cell adhesions.

Temm-Grove CJ, Jockusch BM, Weinberger RP, Schevzov G, Helfman DM.

Cell Motil Cytoskeleton. 1998;40(4):393-407.

PMID:
9712268
36.

Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins.

Gimona M, Lando Z, Dolginov Y, Vandekerckhove J, Kobayashi R, Sobieszek A, Helfman DM.

J Cell Sci. 1997 Mar;110 ( Pt 5):611-21.

37.

Tropomyosin localization reveals distinct populations of microfilaments in neurites and growth cones.

Schevzov G, Gunning P, Jeffrey PL, Temm-Grove C, Helfman DM, Lin JJ, Weinberger RP.

Mol Cell Neurosci. 1997;8(6):439-54.

PMID:
9143561
38.

Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects.

Gimona M, Kazzaz JA, Helfman DM.

Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9618-23.

39.

N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin.

Watakabe A, Kobayashi R, Helfman DM.

J Cell Sci. 1996 Sep;109 ( Pt 9):2299-310.

40.
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43.

Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors.

Cáceres JF, Stamm S, Helfman DM, Krainer AR.

Science. 1994 Sep 16;265(5179):1706-9.

PMID:
8085156
44.

Splicing of the alternative exons of the chicken, rat, and Xenopus beta tropomyosin transcripts requires class-specific elements.

Balvay L, Pret AM, Libri D, Helfman DM, Fiszman MY.

J Biol Chem. 1994 Aug 5;269(31):19675-8.

46.

A sequence compilation and comparison of exons that are alternatively spliced in neurons.

Stamm S, Zhang MQ, Marr TG, Helfman DM.

Nucleic Acids Res. 1994 May 11;22(9):1515-26.

47.

Functional properties of non-muscle tropomyosin isoforms.

Pittenger MF, Kazzaz JA, Helfman DM.

Curr Opin Cell Biol. 1994 Feb;6(1):96-104. Review.

PMID:
8167032
48.

Non-radioactive detection of m3G capped RNAs by immunoblotting.

Stamm S, Mulligan GJ, Krainer AR, Helfman DM.

Nucleic Acids Res. 1994 Jan 25;22(2):252-3. No abstract available.

49.

The generation of protein isoform diversity by alternative RNA splicing.

Helfman DM.

Soc Gen Physiol Ser. 1994;49:105-15. Review. No abstract available.

PMID:
7939889
50.

Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain.

Stamm S, Casper D, Lees-Miller JP, Helfman DM.

Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):9857-61.

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