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Items: 1 to 50 of 84

1.

Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation.

De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM.

Nature. 2019 Aug;572(7767):E5. doi: 10.1038/s41586-019-1350-9.

PMID:
31296937
2.

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.

Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V.

Cell Metab. 2019 Apr 2;29(4):871-885.e5. doi: 10.1016/j.cmet.2019.02.014. Epub 2019 Mar 7.

PMID:
30853213
3.

L1 drives IFN in senescent cells and promotes age-associated inflammation.

De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM.

Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9. Epub 2019 Feb 6. Erratum in: Nature. 2019 Aug;572(7767):E5.

4.

Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster.

Wood JG, Schwer B, Wickremesinghe PC, Hartnett DA, Burhenn L, Garcia M, Li M, Verdin E, Helfand SL.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1564-1569. doi: 10.1073/pnas.1720673115. Epub 2018 Jan 29.

5.

The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target.

Willmes DM, Kurzbach A, Henke C, Schumann T, Zahn G, Heifetz A, Jordan J, Helfand SL, Birkenfeld AL.

Pharmacol Ther. 2018 May;185:1-11. doi: 10.1016/j.pharmthera.2017.10.003. Epub 2017 Oct 5. Review.

6.

The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism.

von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm MF, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Püschel GP, Birkenfeld AL.

Hepatology. 2017 Aug;66(2):616-630. doi: 10.1002/hep.29089. Epub 2017 Jun 26.

7.

A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan.

Jones BC, Wood JG, Chang C, Tam AD, Franklin MJ, Siegel ER, Helfand SL.

Nat Commun. 2016 Dec 21;7:13856. doi: 10.1038/ncomms13856.

8.

Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila.

Wood JG, Jones BC, Jiang N, Chang C, Hosier S, Wickremesinghe P, Garcia M, Hartnett DA, Burhenn L, Neretti N, Helfand SL.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11277-11282. Epub 2016 Sep 12.

9.

The longevity transporter mIndy (Slc13a5) as a target for treating hepatic steatosis and insulin resistance.

Willmes DM, Helfand SL, Birkenfeld AL.

Aging (Albany NY). 2016 Feb;8(2):208-9. No abstract available.

10.

Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span.

Pu M, Ni Z, Wang M, Wang X, Wood JG, Helfand SL, Yu H, Lee SS.

Genes Dev. 2015 Apr 1;29(7):718-31. doi: 10.1101/gad.254144.114.

11.

Human Genomics. Sleeping dogs of the genome.

Gorbunova V, Boeke JD, Helfand SL, Sedivy JM.

Science. 2014 Dec 5;346(6214):1187-8. doi: 10.1126/science.aaa3177. No abstract available.

12.

Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster.

Whitaker R, Gil MP, Ding F, Tatar M, Helfand SL, Neretti N.

Aging (Albany NY). 2014 May;6(5):355-68.

13.

Transcriptional response to dietary restriction in Drosophila melanogaster.

Ding F, Gil MP, Franklin M, Ferreira J, Tatar M, Helfand SL, Neretti N.

J Insect Physiol. 2014 Oct;69:101-6. doi: 10.1016/j.jinsphys.2014.05.002. Epub 2014 May 10.

14.
15.

Chromatin structure and transposable elements in organismal aging.

Wood JG, Helfand SL.

Front Genet. 2013 Dec 4;4:274. doi: 10.3389/fgene.2013.00274. Review.

16.

Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging.

Jiang N, Du G, Tobias E, Wood JG, Whitaker R, Neretti N, Helfand SL.

Aging (Albany NY). 2013 Nov;5(11):813-24.

17.

RNA editing regulates transposon-mediated heterochromatic gene silencing.

Savva YA, Jepson JE, Chang YJ, Whitaker R, Jones BC, St Laurent G, Tackett MR, Kapranov P, Jiang N, Du G, Helfand SL, Reenan RA.

Nat Commun. 2013;4:2745. doi: 10.1038/ncomms3745.

18.

Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner.

Whitaker R, Faulkner S, Miyokawa R, Burhenn L, Henriksen M, Wood JG, Helfand SL.

Aging (Albany NY). 2013 Sep;5(9):682-91.

19.

Genetic and biochemical tools for investigating sirtuin function in Drosophila melanogaster.

Wood JG, Whitaker R, Helfand SL.

Methods Mol Biol. 2013;1077:57-67. doi: 10.1007/978-1-62703-637-5_4.

PMID:
24014399
20.

Indy mutations and Drosophila longevity.

Rogina B, Helfand SL.

Front Genet. 2013 Apr 8;4:47. doi: 10.3389/fgene.2013.00047. eCollection 2013.

21.

takeout-dependent longevity is associated with altered Juvenile Hormone signaling.

Chamseddin KH, Khan SQ, Nguyen ML, Antosh M, Morris SN, Kolli S, Neretti N, Helfand SL, Bauer JH.

Mech Ageing Dev. 2012 Nov-Dec;133(11-12):637-46. doi: 10.1016/j.mad.2012.08.004. Epub 2012 Aug 30.

22.

Indy knockdown in mice mimics elements of dietary restriction.

Shulman GI, Helfand SL.

Aging (Albany NY). 2011 Aug;3(8):701. No abstract available.

23.

Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice.

Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, Lieske S, Carmean CM, Frederick DW, Weismann D, Knauf F, Irusta PM, De Cabo R, Helfand SL, Samuel VT, Shulman GI.

Cell Metab. 2011 Aug 3;14(2):184-95. doi: 10.1016/j.cmet.2011.06.009. Erratum in: Cell Metab. 2011 Oct 5;14(4):567.

24.

New comparative genomics approach reveals a conserved health span signature across species.

Antosh M, Fox D, Helfand SL, Cooper LN, Neretti N.

Aging (Albany NY). 2011 Jun;3(6):576-83.

25.

Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila.

Antosh M, Whitaker R, Kroll A, Hosier S, Chang C, Bauer J, Cooper L, Neretti N, Helfand SL.

Cell Cycle. 2011 Mar 15;10(6):904-11. Epub 2011 Mar 15.

26.

Chromatin remodeling in the aging genome of Drosophila.

Wood JG, Hillenmeyer S, Lawrence C, Chang C, Hosier S, Lightfoot W, Mukherjee E, Jiang N, Schorl C, Brodsky AS, Neretti N, Helfand SL.

Aging Cell. 2010 Dec;9(6):971-8. doi: 10.1111/j.1474-9726.2010.00624.x. Epub 2010 Oct 21.

27.

Dietary restriction: standing up for sirtuins.

Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E.

Science. 2010 Aug 27;329(5995):1012-3; author reply 1013-4. doi: 10.1126/science.329.5995.1012. No abstract available.

28.

Comparative transcriptional profiling identifies takeout as a gene that regulates life span.

Bauer J, Antosh M, Chang C, Schorl C, Kolli S, Neretti N, Helfand SL.

Aging (Albany NY). 2010 May;2(5):298-310.

29.

Impact papers on aging in 2009.

Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM Jr, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J.

Aging (Albany NY). 2010 Mar;2(3):111-21. Epub 2010 Mar 23. Review.

30.

Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan.

Fridell YW, Hoh M, Kréneisz O, Hosier S, Chang C, Scantling D, Mulkey DK, Helfand SL.

Aging (Albany NY). 2009 Jul 21;1(8):699-713.

31.

Dominant-negative Dmp53 extends life span through the dTOR pathway in D. melanogaster.

Bauer JH, Chang C, Bae G, Morris SN, Helfand SL.

Mech Ageing Dev. 2010 Mar;131(3):193-201. doi: 10.1016/j.mad.2010.01.007. Epub 2010 Feb 1.

32.

dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster.

Bauer JH, Morris SN, Chang C, Flatt T, Wood JG, Helfand SL.

Aging (Albany NY). 2009 Jan;1(1):38-48.

33.

Sir2 and longevity: the p53 connection.

Bauer JH, Helfand SL.

Cell Cycle. 2009 Jun 15;8(12):1821. Epub 2009 Jun 15. No abstract available.

34.

Long-lived Indy and calorie restriction interact to extend life span.

Wang PY, Neretti N, Whitaker R, Hosier S, Chang C, Lu D, Rogina B, Helfand SL.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9262-7. doi: 10.1073/pnas.0904115106. Epub 2009 May 22.

35.

Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage.

Neretti N, Wang PY, Brodsky AS, Nyguyen HH, White KP, Rogina B, Helfand SL.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2277-82. doi: 10.1073/pnas.0812484106. Epub 2009 Jan 21.

36.

Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling.

Bauer JH, Chang C, Morris SN, Hozier S, Andersen S, Waitzman JS, Helfand SL.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13355-60. Epub 2007 Aug 8.

37.

The humble fly: what a model system can reveal about the human biology of aging.

Bauer JH, Helfand SL.

Med Health R I. 2006 Sep;89(9):314-5. No abstract available.

PMID:
17036696
38.

New tricks of an old molecule: lifespan regulation by p53.

Bauer JH, Helfand SL.

Aging Cell. 2006 Oct;5(5):437-40. Review.

39.

Involvement of Drosophila uncoupling protein 5 in metabolism and aging.

Sánchez-Blanco A, Fridell YW, Helfand SL.

Genetics. 2006 Mar;172(3):1699-710. Epub 2005 Dec 30.

40.

Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span.

Bauer JH, Poon PC, Glatt-Deeley H, Abrams JM, Helfand SL.

Curr Biol. 2005 Nov 22;15(22):2063-8.

41.
42.

Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.

Fridell YW, Sánchez-Blanco A, Silvia BA, Helfand SL.

Cell Metab. 2005 Feb;1(2):145-52.

43.

Calorie restriction delays lipid oxidative damage in Drosophila melanogaster.

Zheng J, Mutcherson R 2nd, Helfand SL.

Aging Cell. 2005 Aug;4(4):209-16.

44.

Sir2 mediates longevity in the fly through a pathway related to calorie restriction.

Rogina B, Helfand SL.

Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15998-6003. Epub 2004 Nov 1.

45.

Functional characterization of a Drosophila mitochondrial uncoupling protein.

Fridell YW, Sánchez-Blanco A, Silvia BA, Helfand SL.

J Bioenerg Biomembr. 2004 Jun;36(3):219-28.

PMID:
15337852
46.

An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster.

Bauer JH, Goupil S, Garber GB, Helfand SL.

Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12980-5. Epub 2004 Aug 24.

47.

Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D.

Nature. 2004 Aug 5;430(7000):686-9. Epub 2004 Jul 14. Erratum in: Nature. 2004 Sep 2;431(7004):107.

PMID:
15254550
48.

Genetics of aging in the fruit fly, Drosophila melanogaster.

Helfand SL, Rogina B.

Annu Rev Genet. 2003;37:329-48. Review.

PMID:
14616064
49.

From genes to aging in Drosophila.

Helfand SL, Rogina B.

Adv Genet. 2003;49:67-109. Review.

PMID:
12779251
50.

Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies.

Marden JH, Rogina B, Montooth KL, Helfand SL.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3369-73. Epub 2003 Mar 7.

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