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Influenza virus uses transportin 1 for vRNP debundling during cell entry.

Miyake Y, Keusch JJ, Decamps L, Ho-Xuan H, Iketani S, Gut H, Kutay U, Helenius A, Yamauchi Y.

Nat Microbiol. 2019 Jan 28. doi: 10.1038/s41564-018-0332-2. [Epub ahead of print]


Virus Entry: Looking Back and Moving Forward.

Helenius A.

J Mol Biol. 2018 Jun 22;430(13):1853-1862. doi: 10.1016/j.jmb.2018.03.034. Epub 2018 Apr 28. Review.


Correction for Engel et al., "Role of Endosomes in Simian Virus 40 Entry and Infection".

Engel S, Heger T, Mancini R, Herzog F, Kartenbeck J, Hayer A, Helenius A.

J Virol. 2017 Sep 27;91(20). pii: e01059-17. doi: 10.1128/JVI.01059-17. Print 2017 Oct 15. No abstract available.


Model for the architecture of caveolae based on a flexible, net-like assembly of Cavin1 and Caveolin discs.

Stoeber M, Schellenberger P, Siebert CA, Leyrat C, Helenius A, Grünewald K.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8069-E8078. Epub 2016 Nov 10.


Cargo Capture and Bulk Flow in the Early Secretory Pathway.

Barlowe C, Helenius A.

Annu Rev Cell Dev Biol. 2016 Oct 6;32:197-222. Epub 2016 Jun 8. Review.


In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation.

Stauffer S, Nebioglu F, Helenius A.

J Vis Exp. 2016 Mar 27;(109):e53909. doi: 10.3791/53909.


PI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus Infection.

Nobs SP, Schneider C, Heer AK, Huotari J, Helenius A, Kopf M.

PLoS Pathog. 2016 Mar 31;12(3):e1005508. doi: 10.1371/journal.ppat.1005508. eCollection 2016 Mar.


A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes.

Gschweitl M, Ulbricht A, Barnes CA, Enchev RI, Stoffel-Studer I, Meyer-Schaller N, Huotari J, Yamauchi Y, Greber UF, Helenius A, Peter M.

Elife. 2016 Mar 23;5:e13841. doi: 10.7554/eLife.13841.


HCMV Induces Macropinocytosis for Host Cell Entry in Fibroblasts.

Hetzenecker S, Helenius A, Krzyzaniak MA.

Traffic. 2016 Apr;17(4):351-68. doi: 10.1111/tra.12355. Epub 2016 Feb 11.


Vaccinia Virus Infection Requires Maturation of Macropinosomes.

Rizopoulos Z, Balistreri G, Kilcher S, Martin CK, Syedbasha M, Helenius A, Mercer J.

Traffic. 2015 Aug;16(8):814-31. doi: 10.1111/tra.12290. Epub 2015 May 6.


Simultaneous analysis of large-scale RNAi screens for pathogen entry.

Rämö P, Drewek A, Arrieumerlou C, Beerenwinkel N, Ben-Tekaya H, Cardel B, Casanova A, Conde-Alvarez R, Cossart P, Csúcs G, Eicher S, Emmenlauer M, Greber U, Hardt WD, Helenius A, Kasper C, Kaufmann A, Kreibich S, Kühbacher A, Kunszt P, Low SH, Mercer J, Mudrak D, Muntwiler S, Pelkmans L, Pizarro-Cerdá J, Podvinec M, Pujadas E, Rinn B, Rouilly V, Schmich F, Siebourg-Polster J, Snijder B, Stebler M, Studer G, Szczurek E, Truttmann M, von Mering C, Vonderheit A, Yakimovich A, Bühlmann P, Dehio C.

BMC Genomics. 2014 Dec 22;15:1162. doi: 10.1186/1471-2164-15-1162.


Influenza A virus uses the aggresome processing machinery for host cell entry.

Banerjee I, Miyake Y, Nobs SP, Schneider C, Horvath P, Kopf M, Matthias P, Helenius A, Yamauchi Y.

Science. 2014 Oct 24;346(6208):473-7. doi: 10.1126/science.1257037.


The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.

Balistreri G, Horvath P, Schweingruber C, Zünd D, McInerney G, Merits A, Mühlemann O, Azzalin C, Helenius A.

Cell Host Microbe. 2014 Sep 10;16(3):403-11. doi: 10.1016/j.chom.2014.08.007.


Stepwise priming by acidic pH and a high K+ concentration is required for efficient uncoating of influenza A virus cores after penetration.

Stauffer S, Feng Y, Nebioglu F, Heilig R, Picotti P, Helenius A.

J Virol. 2014 Nov;88(22):13029-46. doi: 10.1128/JVI.01430-14. Epub 2014 Aug 27.


Endocytosis of viruses and bacteria.

Cossart P, Helenius A.

Cold Spring Harb Perspect Biol. 2014 Aug 1;6(8). pii: a016972. doi: 10.1101/cshperspect.a016972. Review.


Large scale RNAi reveals the requirement of nuclear envelope breakdown for nuclear import of human papillomaviruses.

Aydin I, Weber S, Snijder B, Samperio Ventayol P, Kühbacher A, Becker M, Day PM, Schiller JT, Kann M, Pelkmans L, Helenius A, Schelhaas M.

PLoS Pathog. 2014 May 29;10(5):e1004162. doi: 10.1371/journal.ppat.1004162. eCollection 2014 May.


Genome-wide small interfering RNA screens reveal VAMP3 as a novel host factor required for Uukuniemi virus late penetration.

Meier R, Franceschini A, Horvath P, Tetard M, Mancini R, von Mering C, Helenius A, Lozach PY.

J Virol. 2014 Aug;88(15):8565-78. doi: 10.1128/JVI.00388-14. Epub 2014 May 21.


Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens.

Franceschini A, Meier R, Casanova A, Kreibich S, Daga N, Andritschke D, Dilling S, Rämö P, Emmenlauer M, Kaufmann A, Conde-Álvarez R, Low SH, Pelkmans L, Helenius A, Hardt WD, Dehio C, von Mering C.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4548-53. doi: 10.1073/pnas.1402353111. Epub 2014 Mar 10.


siRNA screen of early poxvirus genes identifies the AAA+ ATPase D5 as the virus genome-uncoating factor.

Kilcher S, Schmidt FI, Schneider C, Kopf M, Helenius A, Mercer J.

Cell Host Microbe. 2014 Jan 15;15(1):103-12. doi: 10.1016/j.chom.2013.12.008.


Receptor concentration and diffusivity control multivalent binding of Sv40 to membrane bilayers.

Szklarczyk OM, González-Segredo N, Kukura P, Oppenheim A, Choquet D, Sandoghdar V, Helenius A, Sbalzarini IF, Ewers H.

PLoS Comput Biol. 2013;9(11):e1003310. doi: 10.1371/journal.pcbi.1003310. Epub 2013 Nov 14.


Role of DC-SIGN in Lassa virus entry into human dendritic cells.

Goncalves AR, Moraz ML, Pasquato A, Helenius A, Lozach PY, Kunz S.

J Virol. 2013 Nov;87(21):11504-15. doi: 10.1128/JVI.01893-13. Epub 2013 Aug 21.


Vaccinia virus entry is followed by core activation and proteasome-mediated release of the immunomodulatory effector VH1 from lateral bodies.

Schmidt FI, Bleck CK, Reh L, Novy K, Wollscheid B, Helenius A, Stahlberg H, Mercer J.

Cell Rep. 2013 Aug 15;4(3):464-76. doi: 10.1016/j.celrep.2013.06.028. Epub 2013 Jul 25.


High-content analysis of sequential events during the early phase of influenza A virus infection.

Banerjee I, Yamauchi Y, Helenius A, Horvath P.

PLoS One. 2013 Jul 12;8(7):e68450. doi: 10.1371/journal.pone.0068450. Print 2013.


Architecture of respiratory syncytial virus revealed by electron cryotomography.

Liljeroos L, Krzyzaniak MA, Helenius A, Butcher SJ.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11133-8. doi: 10.1073/pnas.1309070110. Epub 2013 Jun 17.


Virus entry at a glance.

Yamauchi Y, Helenius A.

J Cell Sci. 2013 Mar 15;126(Pt 6):1289-95. doi: 10.1242/jcs.119685. Epub 2013 May 2. Review. No abstract available.


Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein.

Krzyzaniak MA, Zumstein MT, Gerez JA, Picotti P, Helenius A.

PLoS Pathog. 2013;9(4):e1003309. doi: 10.1371/journal.ppat.1003309. Epub 2013 Apr 11.


Virus entry--an unwilling collaboration by the cell.

Helenius A, Moss B.

Curr Opin Virol. 2013 Feb;3(1):1-2. doi: 10.1016/j.coviro.2013.01.003. Epub 2013 Feb 8. No abstract available.


Virus entry: what has pH got to do with it?

Helenius A.

Nat Cell Biol. 2013 Feb;15(2):125. doi: 10.1038/ncb2678. No abstract available.


Membranes, viruses, detergents, and endosomes.

Helenius A.

Mol Biol Cell. 2012 Nov;23(21):4157-9. doi: 10.1091/mbc.E12-05-0383.


[Control of arthropods].

Lozach PY, Helenius A.

Duodecim. 2012;128(18):1929-35. Review. Finnish.


RNAi screening reveals proteasome- and Cullin3-dependent stages in vaccinia virus infection.

Mercer J, Snijder B, Sacher R, Burkard C, Bleck CK, Stahlberg H, Pelkmans L, Helenius A.

Cell Rep. 2012 Oct 25;2(4):1036-47. doi: 10.1016/j.celrep.2012.09.003. Epub 2012 Oct 19.


Investigating endocytic pathways to the endoplasmic reticulum and to the cytosol using SNAP-trap.

Geiger R, Luisoni S, Johnsson K, Greber UF, Helenius A.

Traffic. 2013 Jan;14(1):36-46. doi: 10.1111/tra.12018. Epub 2012 Nov 12.


Gulping rather than sipping: macropinocytosis as a way of virus entry.

Mercer J, Helenius A.

Curr Opin Microbiol. 2012 Aug;15(4):490-9. doi: 10.1016/j.mib.2012.05.016. Epub 2012 Jun 29. Review.


Entry of human papillomavirus type 16 by actin-dependent, clathrin- and lipid raft-independent endocytosis.

Schelhaas M, Shah B, Holzer M, Blattmann P, Kühling L, Day PM, Schiller JT, Helenius A.

PLoS Pathog. 2012;8(4):e1002657. doi: 10.1371/journal.ppat.1002657. Epub 2012 Apr 19.


Single-cell analysis of population context advances RNAi screening at multiple levels.

Snijder B, Sacher R, Rämö P, Liberali P, Mench K, Wolfrum N, Burleigh L, Scott CC, Verheije MH, Mercer J, Moese S, Heger T, Theusner K, Jurgeit A, Lamparter D, Balistreri G, Schelhaas M, De Haan CA, Marjomäki V, Hyypiä T, Rottier PJ, Sodeik B, Marsh M, Gruenberg J, Amara A, Greber U, Helenius A, Pelkmans L.

Mol Syst Biol. 2012 Apr 24;8:579. doi: 10.1038/msb.2012.9.


Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin.

Stoeber M, Stoeck IK, Hänni C, Bleck CK, Balistreri G, Helenius A.

EMBO J. 2012 May 16;31(10):2350-64. doi: 10.1038/emboj.2012.98. Epub 2012 Apr 13.


Late-penetrating viruses.

Lozach PY, Huotari J, Helenius A.

Curr Opin Virol. 2011 Jul;1(1):35-43. doi: 10.1016/j.coviro.2011.05.004. Epub 2011 Jun 12. Review.


[DC-SIGN, a receptor for phlebovirus].

Meier R, Helenius A, Lozach PY.

Med Sci (Paris). 2012 Jan;28(1):16-8. doi: 10.1051/medsci/2012281005. Epub 2012 Jan 27. French. No abstract available.


Cullin-3 regulates late endosome maturation.

Huotari J, Meyer-Schaller N, Hubner M, Stauffer S, Katheder N, Horvath P, Mancini R, Helenius A, Peter M.

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):823-8. doi: 10.1073/pnas.1118744109. Epub 2012 Jan 4.


Histone deacetylase 8 is required for centrosome cohesion and influenza A virus entry.

Yamauchi Y, Boukari H, Banerjee I, Sbalzarini IF, Horvath P, Helenius A.

PLoS Pathog. 2011 Oct;7(10):e1002316. doi: 10.1371/journal.ppat.1002316. Epub 2011 Oct 27.


BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol.

Geiger R, Andritschke D, Friebe S, Herzog F, Luisoni S, Heger T, Helenius A.

Nat Cell Biol. 2011 Sep 25;13(11):1305-14. doi: 10.1038/ncb2339.


Endosome maturation.

Huotari J, Helenius A.

EMBO J. 2011 Aug 31;30(17):3481-500. doi: 10.1038/emboj.2011.286. Review.


Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture.

Schmidt FI, Bleck CK, Helenius A, Mercer J.

EMBO J. 2011 Jul 26;30(17):3647-61. doi: 10.1038/emboj.2011.245.


DC-SIGN as a receptor for phleboviruses.

Lozach PY, Kühbacher A, Meier R, Mancini R, Bitto D, Bouloy M, Helenius A.

Cell Host Microbe. 2011 Jul 21;10(1):75-88. doi: 10.1016/j.chom.2011.06.007.


Lipid-mediated endocytosis.

Ewers H, Helenius A.

Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a004721. doi: 10.1101/cshperspect.a004721. Review.


Role of endosomes in simian virus 40 entry and infection.

Engel S, Heger T, Mancini R, Herzog F, Kartenbeck J, Hayer A, Helenius A.

J Virol. 2011 May;85(9):4198-211. doi: 10.1128/JVI.02179-10. Epub 2011 Feb 23. Erratum in: J Virol. 2017 Sep 27;91(20):.


Folding, quality control, and secretion of pancreatic ribonuclease in live cells.

Geiger R, Gautschi M, Thor F, Hayer A, Helenius A.

J Biol Chem. 2011 Feb 18;286(7):5813-22. doi: 10.1074/jbc.M110.171694. Epub 2010 Dec 14.


Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation.

Hayer A, Stoeber M, Ritz D, Engel S, Meyer HH, Helenius A.

J Cell Biol. 2010 Nov 1;191(3):615-29. doi: 10.1083/jcb.201003086.


Apoptotic mimicry: phosphatidylserine-mediated macropinocytosis of vaccinia virus.

Mercer J, Helenius A.

Ann N Y Acad Sci. 2010 Oct;1209:49-55. doi: 10.1111/j.1749-6632.2010.05772.x.


Entry of bunyaviruses into mammalian cells.

Lozach PY, Mancini R, Bitto D, Meier R, Oestereich L, Overby AK, Pettersson RF, Helenius A.

Cell Host Microbe. 2010 Jun 25;7(6):488-99. doi: 10.1016/j.chom.2010.05.007.

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