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Items: 41


Go go gadget glycoprotein!: HSV-1 draws on its sizeable glycoprotein tool kit to customize its diverse entry routes.

Hilterbrand AT, Heldwein EE.

PLoS Pathog. 2019 May 9;15(5):e1007660. doi: 10.1371/journal.ppat.1007660. eCollection 2019 May. No abstract available.


The dynamic nature of the conserved tegument protein UL37 of herpesviruses.

Koenigsberg AL, Heldwein EE.

J Biol Chem. 2018 Oct 12;293(41):15827-15839. doi: 10.1074/jbc.RA118.004481. Epub 2018 Aug 30.


Structural basis for membrane anchoring and fusion regulation of the herpes simplex virus fusogen gB.

Cooper RS, Georgieva ER, Borbat PP, Freed JH, Heldwein EE.

Nat Struct Mol Biol. 2018 May;25(5):416-424. doi: 10.1038/s41594-018-0060-6. Epub 2018 May 4.


Up close with herpesviruses.

Heldwein EE.

Science. 2018 Apr 6;360(6384):34-35. doi: 10.1126/science.aat3990. No abstract available.


The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion.

Richards AL, Sollars PJ, Pitts JD, Stults AM, Heldwein EE, Pickard GE, Smith GA.

PLoS Pathog. 2017 Dec 7;13(12):e1006741. doi: 10.1371/journal.ppat.1006741. eCollection 2017 Dec.


Crystal Structure of the N-Terminal Half of the Traffic Controller UL37 from Herpes Simplex Virus 1.

Koenigsberg AL, Heldwein EE.

J Virol. 2017 Sep 27;91(20). pii: e01244-17. doi: 10.1128/JVI.01244-17. Print 2017 Oct 15.


Have NEC Coat, Will Travel: Structural Basis of Membrane Budding During Nuclear Egress in Herpesviruses.

Bigalke JM, Heldwein EE.

Adv Virus Res. 2017;97:107-141. doi: 10.1016/bs.aivir.2016.07.002. Epub 2016 Sep 1. Review.


Expression, Purification and Crystallization of the Herpesvirus Nuclear Egress Complex (NEC).

Bigalke JM, Heldwein EE.

Bio Protoc. 2016 Jul 20;6(14). pii: e1872. doi: 10.21769/BioProtoc.1872.


Characterization of Vesicular Stomatitis Virus Pseudotypes Bearing Essential Entry Glycoproteins gB, gD, gH, and gL of Herpes Simplex Virus 1.

Rogalin HB, Heldwein EE.

J Virol. 2016 Oct 28;90(22):10321-10328. doi: 10.1128/JVI.01714-16. Print 2016 Nov 15.


Nuclear Exodus: Herpesviruses Lead the Way.

Bigalke JM, Heldwein EE.

Annu Rev Virol. 2016 Sep 29;3(1):387-409. Epub 2016 Jul 22.


Erratum for Metrick and Heldwein, Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21.

Metrick CM, Heldwein EE.

J Virol. 2016 Jul 11;90(15):7007-7008. doi: 10.1128/JVI.00992-16. Print 2016 Aug 1. No abstract available.


Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21.

Metrick CM, Heldwein EE.

J Virol. 2016 May 27;90(12):5759-69. doi: 10.1128/JVI.00475-16. Print 2016 Jun 15. Erratum in: J Virol. 2016 Jul 11;90(15):7007-8.


Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.


gH/gL supercomplexes at early stages of herpesvirus entry.

Heldwein EE.

Curr Opin Virol. 2016 Jun;18:1-8. doi: 10.1016/j.coviro.2016.01.010. Epub 2016 Feb 2. Review.


Herpesvirus gB: A Finely Tuned Fusion Machine.

Cooper RS, Heldwein EE.

Viruses. 2015 Dec 11;7(12):6552-69. doi: 10.3390/v7122957. Review.


Correction: Crystal Structure of the Human Cytomegalovirus Glycoprotein B.

Burke HG, Heldwein EE.

PLoS Pathog. 2015 Nov 17;11(11):e1005300. doi: 10.1371/journal.ppat.1005300. eCollection 2015 Nov. No abstract available.


Structural basis of membrane budding by the nuclear egress complex of herpesviruses.

Bigalke JM, Heldwein EE.

EMBO J. 2015 Dec 2;34(23):2921-36. doi: 10.15252/embj.201592359. Epub 2015 Oct 28.


Crystal Structure of the Human Cytomegalovirus Glycoprotein B.

Burke HG, Heldwein EE.

PLoS Pathog. 2015 Oct 20;11(10):e1005227. doi: 10.1371/journal.ppat.1005227. eCollection 2015 Oct. Erratum in: PLoS Pathog. 2015 Nov;11(11):e1005300.


Interplay between the Herpes Simplex Virus 1 gB Cytodomain and the gH Cytotail during Cell-Cell Fusion.

Rogalin HB, Heldwein EE.

J Virol. 2015 Dec;89(24):12262-72. doi: 10.1128/JVI.02391-15. Epub 2015 Sep 23.


The Great (Nuclear) Escape: New Insights into the Role of the Nuclear Egress Complex of Herpesviruses.

Bigalke JM, Heldwein EE.

J Virol. 2015 Sep;89(18):9150-3. doi: 10.1128/JVI.02530-14. Epub 2015 Jun 24. Review.


The unusual fold of herpes simplex virus 1 UL21, a multifunctional tegument protein.

Metrick CM, Chadha P, Heldwein EE.

J Virol. 2015 Mar;89(5):2979-84. doi: 10.1128/JVI.03516-14. Epub 2014 Dec 24.


Membrane deformation and scission by the HSV-1 nuclear egress complex.

Bigalke JM, Heuser T, Nicastro D, Heldwein EE.

Nat Commun. 2014 Jun 11;5:4131. doi: 10.1038/ncomms5131.


Expression, purification, and crystallization of HSV-1 glycoproteins for structure determination.

Stampfer SD, Heldwein EE.

Methods Mol Biol. 2014;1144:249-63. doi: 10.1007/978-1-4939-0428-0_17.


Crystal structure of the herpesvirus inner tegument protein UL37 supports its essential role in control of viral trafficking.

Pitts JD, Klabis J, Richards AL, Smith GA, Heldwein EE.

J Virol. 2014 May;88(10):5462-73. doi: 10.1128/JVI.00163-14. Epub 2014 Mar 5.


Mutations in the cytoplasmic tail of herpes simplex virus 1 gH reduce the fusogenicity of gB in transfected cells.

Silverman JL, Heldwein EE.

J Virol. 2013 Sep;87(18):10139-47. doi: 10.1128/JVI.01760-13. Epub 2013 Jul 10.


Extensive mutagenesis of the HSV-1 gB ectodomain reveals remarkable stability of its postfusion form.

Vitu E, Sharma S, Stampfer SD, Heldwein EE.

J Mol Biol. 2013 Jun 12;425(11):2056-2071. doi: 10.1016/j.jmb.2013.03.001. Epub 2013 Mar 13.


Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry.

Stampfer SD, Heldwein EE.

Curr Opin Virol. 2013 Feb;3(1):13-9. doi: 10.1016/j.coviro.2012.10.005. Epub 2012 Oct 26. Review.


HCMV gB shares structural and functional properties with gB proteins from other herpesviruses.

Sharma S, Wisner TW, Johnson DC, Heldwein EE.

Virology. 2013 Jan 20;435(2):239-49. doi: 10.1016/j.virol.2012.09.024. Epub 2012 Oct 22.


Membrane requirement for folding of the herpes simplex virus 1 gB cytodomain suggests a unique mechanism of fusion regulation.

Silverman JL, Greene NG, King DS, Heldwein EE.

J Virol. 2012 Aug;86(15):8171-84. doi: 10.1128/JVI.00932-12. Epub 2012 May 23.


Capturing the herpes simplex virus core fusion complex (gB-gH/gL) in an acidic environment.

Cairns TM, Whitbeck JC, Lou H, Heldwein EE, Chowdary TK, Eisenberg RJ, Cohen GH.

J Virol. 2011 Jul;85(13):6175-84. doi: 10.1128/JVI.00119-11. Epub 2011 Apr 20.


Structural basis of local, pH-dependent conformational changes in glycoprotein B from herpes simplex virus type 1.

Stampfer SD, Lou H, Cohen GH, Eisenberg RJ, Heldwein EE.

J Virol. 2010 Dec;84(24):12924-33. doi: 10.1128/JVI.01750-10. Epub 2010 Oct 13.


Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL.

Chowdary TK, Cairns TM, Atanasiu D, Cohen GH, Eisenberg RJ, Heldwein EE.

Nat Struct Mol Biol. 2010 Jul;17(7):882-8. doi: 10.1038/nsmb.1837. Epub 2010 Jul 4.


Syncytial phenotype of C-terminally truncated herpes simplex virus type 1 gB is associated with diminished membrane interactions.

Chowdary TK, Heldwein EE.

J Virol. 2010 May;84(10):4923-35. doi: 10.1128/JVI.00206-10. Epub 2010 Mar 3.


Fusion-deficient insertion mutants of herpes simplex virus type 1 glycoprotein B adopt the trimeric postfusion conformation.

Silverman JL, Sharma S, Cairns TM, Heldwein EE.

J Virol. 2010 Feb;84(4):2001-12. doi: 10.1128/JVI.01791-09. Epub 2009 Nov 25.


Entry of herpesviruses into cells: more than one way to pull the trigger.

Heldwein EE.

Structure. 2009 Feb 13;17(2):147-9. doi: 10.1016/j.str.2009.01.003.


Entry of herpesviruses into mammalian cells.

Heldwein EE, Krummenacher C.

Cell Mol Life Sci. 2008 Jun;65(11):1653-68. doi: 10.1007/s00018-008-7570-z. Review.


Mutational evidence of internal fusion loops in herpes simplex virus glycoprotein B.

Hannah BP, Heldwein EE, Bender FC, Cohen GH, Eisenberg RJ.

J Virol. 2007 May;81(9):4858-65. Epub 2007 Feb 21. Erratum in: J Virol. 2008 Jul;82(14):7249.


Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions.

Bender FC, Samanta M, Heldwein EE, de Leon MP, Bilman E, Lou H, Whitbeck JC, Eisenberg RJ, Cohen GH.

J Virol. 2007 Apr;81(8):3827-41. Epub 2007 Jan 31.


Crystal structure of glycoprotein B from herpes simplex virus 1.

Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC.

Science. 2006 Jul 14;313(5784):217-20.


Crystal structure of the clathrin adaptor protein 1 core.

Heldwein EE, Macia E, Wang J, Yin HL, Kirchhausen T, Harrison SC.

Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14108-13. Epub 2004 Sep 17.


Crystal structure of the transcription activator BmrR bound to DNA and a drug.

Heldwein EE, Brennan RG.

Nature. 2001 Jan 18;409(6818):378-82.


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