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Items: 1 to 50 of 62

1.

Non-promoter DNA hypermethylation of Zygote Arrest 1 (ZAR1) in neuroblastomas.

Sugito K, Kawashima H, Yoshizawa S, Uekusa S, Hoshi R, Furuya T, Kaneda H, Hosoda T, Konuma N, Masuko T, Ohashi K, Ikeda T, Koshinaga T, Tomita R, Shinojima Y, Fujiwara K, Watanabe T, Held WA, Nagase H.

J Pediatr Surg. 2013 Apr;48(4):782-8. doi: 10.1016/j.jpedsurg.2012.08.008.

PMID:
23583134
2.

Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions.

Sugito K, Kawashima H, Uekusa S, Yoshizawa S, Hoshi R, Furuya T, Kaneda H, Hosoda T, Masuko T, Ohashi K, Ikeda T, Koshinaga T, Fujiwara K, Igarashi J, Ghosh S, Held WA, Nagase H.

Pediatr Blood Cancer. 2013 Mar;60(3):383-9. doi: 10.1002/pbc.24282. Epub 2012 Aug 21.

PMID:
22911660
3.

Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development.

Liang P, Song F, Ghosh S, Morien E, Qin M, Mahmood S, Fujiwara K, Igarashi J, Nagase H, Held WA.

BMC Genomics. 2011 May 11;12(1):231. doi: 10.1186/1471-2164-12-231.

4.

Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.

Jun P, Hong C, Lal A, Wong JM, McDermott MW, Bollen AW, Plass C, Held WA, Smiraglia DJ, Costello JF.

Neuro Oncol. 2009 Aug;11(4):414-22. doi: 10.1215/15228517-2008-096. Epub 2008 Nov 11.

5.

Tissue specific differentially methylated regions (TDMR): Changes in DNA methylation during development.

Song F, Mahmood S, Ghosh S, Liang P, Smiraglia DJ, Nagase H, Held WA.

Genomics. 2009 Feb;93(2):130-9. doi: 10.1016/j.ygeno.2008.09.003. Epub 2008 Nov 13.

6.

Quantitative analysis of human tissue-specific differences in methylation.

Igarashi J, Muroi S, Kawashima H, Wang X, Shinojima Y, Kitamura E, Oinuma T, Nemoto N, Song F, Ghosh S, Held WA, Nagase H.

Biochem Biophys Res Commun. 2008 Nov 28;376(4):658-64. doi: 10.1016/j.bbrc.2008.09.044. Epub 2008 Sep 19.

7.

Identification of DNA methylation in 3' genomic regions that are associated with upregulation of gene expression in colorectal cancer.

Smith JF, Mahmood S, Song F, Morrow A, Smiraglia D, Zhang X, Rajput A, Higgins MJ, Krumm A, Petrelli NJ, Costello JF, Nagase H, Plass C, Held WA.

Epigenetics. 2007 Sep;2(3):161-72. Epub 2007 Jul 27.

PMID:
17965620
8.

Analysis of tissue-specific differentially methylated regions (TDMs) in humans.

Kitamura E, Igarashi J, Morohashi A, Hida N, Oinuma T, Nemoto N, Song F, Ghosh S, Held WA, Yoshida-Noro C, Nagase H.

Genomics. 2007 Mar;89(3):326-37. Epub 2006 Dec 26.

9.

Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression.

Song F, Smith JF, Kimura MT, Morrow AD, Matsuyama T, Nagase H, Held WA.

Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3336-41. Epub 2005 Feb 22.

10.

DNA methylation controls the responsiveness of hepatoma cells to leukemia inhibitory factor.

Blanchard F, Tracy E, Smith J, Chattopadhyay S, Wang Y, Held WA, Baumann H.

Hepatology. 2003 Dec;38(6):1516-28.

PMID:
14647063
11.

Global methylation screening in the Arabidopsis thaliana and Mus musculus genome: applications of virtual image restriction landmark genomic scanning (Vi-RLGS).

Matsuyama T, Kimura MT, Koike K, Abe T, Nakano T, Asami T, Ebisuzaki T, Held WA, Yoshida S, Nagase H.

Nucleic Acids Res. 2003 Aug 1;31(15):4490-6.

12.

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.

Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y.

Genome Res. 2003 Jun;13(6B):1273-89.

13.

FR901228, an inhibitor of histone deacetylases, increases the cellular responsiveness to IL-6 type cytokines by enhancing the expression of receptor proteins.

Blanchard F, Kinzie E, Wang Y, Duplomb L, Godard A, Held WA, Asch BB, Baumann H.

Oncogene. 2002 Sep 12;21(41):6264-77.

14.

Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies.

Smiraglia DJ, Rush LJ, Frühwald MC, Dai Z, Held WA, Costello JF, Lang JC, Eng C, Li B, Wright FA, Caligiuri MA, Plass C.

Hum Mol Genet. 2001 Jun 15;10(13):1413-9.

PMID:
11440994
15.

Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci.

Rush LJ, Dai Z, Smiraglia DJ, Gao X, Wright FA, Frühwald M, Costello JF, Held WA, Yu L, Krahe R, Kolitz JE, Bloomfield CD, Caligiuri MA, Plass C.

Blood. 2001 May 15;97(10):3226-33.

PMID:
11342453
16.

Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice.

Tateno M, Fukunishi Y, Komatsu S, Okazaki Y, Kawai J, Shibata K, Itoh M, Muramatsu M, Held WA, Hayashizaki Y.

Cancer Res. 2001 Feb 1;61(3):1144-53.

17.

Restriction landmark genomic scanning of mouse liver tumors for gene amplification: overexpression of cyclin A2.

Haddad R, Morrow AD, Plass C, Held WA.

Biochem Biophys Res Commun. 2000 Jul 21;274(1):188-96.

PMID:
10903917
18.

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

Costello JF, Frühwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, Wright FA, Feramisco JD, Peltomäki P, Lang JC, Schuller DE, Yu L, Bloomfield CD, Caligiuri MA, Yates A, Nishikawa R, Su Huang H, Petrelli NJ, Zhang X, O'Dorisio MS, Held WA, Cavenee WK, Plass C.

Nat Genet. 2000 Feb;24(2):132-8.

PMID:
10655057
19.

Methylation and downregulated expression of mac25/insulin-like growth factor binding protein-7 is associated with liver tumorigenesis in SV40T/t antigen transgenic mice, screened by restriction landmark genomic scanning for methylation (RLGS-M).

Komatsu S, Okazaki Y, Tateno M, Kawai J, Konno H, Kusakabe M, Yoshiki A, Muramatsu M, Held WA, Hayashizaki Y.

Biochem Biophys Res Commun. 2000 Jan 7;267(1):109-17.

PMID:
10623583
20.

Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene.

Plass C, Yu F, Yu L, Strout MP, El-Rifai W, Elonen E, Knuutila S, Marcucci G, Young DC, Held WA, Bloomfield CD, Caligiuri MA.

Oncogene. 1999 May 20;18(20):3159-65.

21.

A direct repeat sequence at the Rasgrf1 locus and imprinted expression.

Pearsall RS, Plass C, Romano MA, Garrick MD, Shibata H, Hayashizaki Y, Held WA.

Genomics. 1999 Jan 15;55(2):194-201.

PMID:
9933566
22.

A methylation imprint mark in the mouse imprinted gene Grf1/Cdc25Mm locus shares a common feature with the U2afbp-rs gene: an association with a short tandem repeat and a hypermethylated region.

Shibata H, Yoda Y, Kato R, Ueda T, Kamiya M, Hiraiwa N, Yoshiki A, Plass C, Pearsall RS, Held WA, Muramatsu M, Sasaki H, Kusakabe M, Hayashizaki Y.

Genomics. 1998 Apr 1;49(1):30-7.

PMID:
9570946
23.

The Rasgrf1-repeat sequence (D9Ncvs53) maps between Mod1 and Rbp1 on mouse chromosome 9 and may define a putative imprinted region.

Pearsall RS, Imai K, Shibata H, Hayashizaki Y, Chapman VM, Held WA, Plass C.

Mamm Genome. 1998 Mar;9(3):261-2. No abstract available.

PMID:
9501318
25.

An oocyte-specific methylation imprint center in the mouse U2afbp-rs/U2af1-rs1 gene marks the establishment of allele-specific methylation during preimplantation development.

Shibata H, Ueda T, Kamiya M, Yoshiki A, Kusakabe M, Plass C, Held WA, Sunahara S, Katsuki M, Muramatsu M, Hayashizaki Y.

Genomics. 1997 Sep 1;44(2):171-8.

PMID:
9299233
26.

Restriction landmark genomic scanning (RLGS-M)-based genome-wide scanning of mouse liver tumors for alterations in DNA methylation status.

Akama TO, Okazaki Y, Ito M, Okuizumi H, Konno H, Muramatsu M, Plass C, Held WA, Hayashizaki Y.

Cancer Res. 1997 Aug 1;57(15):3294-9.

27.

An arrayed human not I-EcoRV boundary library as a tool for RLGS spot analysis.

Plass C, Weichenhan D, Catanese J, Costello JF, Yu F, Yu L, Smiraglia D, Cavenee WK, Caligiuri MA, deJong P, Held WA.

DNA Res. 1997 Jun 30;4(3):253-5. No abstract available.

PMID:
9330914
28.

Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA.

Costello JF, Plass C, Arap W, Chapman VM, Held WA, Berger MS, Su Huang HJ, Cavenee WK.

Cancer Res. 1997 Apr 1;57(7):1250-4.

29.

Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS-M.

Plass C, Shibata H, Kalcheva I, Mullins L, Kotelevtseva N, Mullins J, Kato R, Sasaki H, Hirotsune S, Okazaki Y, Held WA, Hayashizaki Y, Chapman VM.

Nat Genet. 1996 Sep;14(1):106-9.

PMID:
8782830
30.

Absence of imprinting in U2AFBPL, a human homologue of the imprinted mouse gene U2afbp-rs.

Pearsall RS, Shibata H, Brozowska A, Yoshino K, Okuda K, deJong PJ, Plass C, Chapman VM, Hayashizaki Y, Held WA.

Biochem Biophys Res Commun. 1996 May 6;222(1):171-7.

PMID:
8630064
31.

Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice.

Held WA, O'Brien JG, Kerns K, Gallagher JF, Sigmund CD, Gross KW.

Cancer Res. 1994 Dec 15;54(24):6496-9.

32.

Genetic analysis of liver tumorigenesis in SV40 T antigen transgenic mice implies a role for imprinted genes.

Held WA, Pazik J, O'Brien JG, Kerns K, Gobey M, Meis R, Kenny L, Rustum Y.

Cancer Res. 1994 Dec 15;54(24):6489-95.

33.

Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth.

Schirmacher P, Held WA, Yang D, Chisari FV, Rustum Y, Rogler CE.

Cancer Res. 1992 May 1;52(9):2549-56.

34.
35.
36.

Identification and characterization of functional genes encoding the mouse major urinary proteins.

Held WA, Gallagher JF, Hohman CM, Kuhn NJ, Sampsell BM, Hughes RG Jr.

Mol Cell Biol. 1987 Oct;7(10):3705-12.

37.

Effects of Schistosoma mansoni on androgen regulated gene expression in the mouse.

Isseroff H, Sylvester PW, Held WA.

Mol Biochem Parasitol. 1986 Mar;18(3):401-12.

PMID:
3083257
38.

Genetic variation in major urinary proteins in wild mice.

Held WA, Sampsell BM.

Curr Top Microbiol Immunol. 1986;127:124-30. No abstract available.

PMID:
3731839
39.

Rat alpha 2u-globulin mRNA expression in the preputial gland.

Held WA, Gallagher JF.

Biochem Genet. 1985 Apr;23(3-4):281-90.

PMID:
2409959
40.
41.
42.

The acute phase response of mouse liver. Genetic analysis of the major acute phase reactants.

Baumann H, Held WA, Berger FG.

J Biol Chem. 1984 Jan 10;259(1):566-73.

43.
44.

Characterization of mutants of herpes simplex viruses, types 1 and 2, that produce fragments of the thymidine kinase polypeptide.

Block TM, Kuhn NJ, Kustas KA, Held WA, Gross K, Hughes RG Jr.

Can J Microbiol. 1983 Apr;29(4):385-93.

PMID:
6303540
45.
46.

Dexamethasone regulation of alpha 1-acid glycoprotein and other acute phase reactants in rat liver and hepatoma cells.

Baumann H, Firestone GL, Burgess TL, Gross KW, Yamamoto KR, Held WA.

J Biol Chem. 1983 Jan 10;258(1):563-70. No abstract available.

48.

In vitro synthesis and characterization of precursors to the mouse major urinary proteins.

Szoka PR, Gallagher JF, Held WA.

J Biol Chem. 1980 Feb 25;255(4):1367-73. No abstract available.

49.

An abundant androgen-regulated mRNA in the mouse kidney.

Toole JJ, Hastie ND, Held WA.

Cell. 1979 Jun;17(2):441-8.

PMID:
455472
50.

Multiple genes coding for the androgen-regulated major urinary proteins of the mouse.

Hastie ND, Held WA, Toole JJ.

Cell. 1979 Jun;17(2):449-57.

PMID:
88267

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