Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 190

1.

Intratumoral CD8+ T cells with stem cell-like properties: Implications for cancer immunotherapy.

Held W, Siddiqui I, Schaeuble K, Speiser DE.

Sci Transl Med. 2019 Oct 23;11(515). pii: eaay6863. doi: 10.1126/scitranslmed.aay6863. Review.

PMID:
31645454
2.

Defining 'T cell exhaustion'.

Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, Wherry EJ, Youngblood BA, Zehn D.

Nat Rev Immunol. 2019 Nov;19(11):665-674. doi: 10.1038/s41577-019-0221-9. Epub 2019 Sep 30. Review.

PMID:
31570879
3.

γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia.

Luong-Gardiol N, Siddiqui I, Pizzitola I, Jeevan-Raj B, Charmoy M, Huang Y, Irmisch A, Curtet S, Angelov GS, Danilo M, Juilland M, Bornhauser B, Thome M, Hantschel O, Chalandon Y, Cazzaniga G, Bourquin JP, Huelsken J, Held W.

Cancer Cell. 2019 Apr 15;35(4):649-663.e10. doi: 10.1016/j.ccell.2019.03.005.

PMID:
30991025
4.

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.

Niogret C, Miah SMS, Rota G, Fonta NP, Wang H, Held W, Birchmeier W, Sexl V, Yang W, Vivier E, Ho PC, Brossay L, Guarda G.

Nat Commun. 2019 Mar 29;10(1):1444. doi: 10.1038/s41467-019-09431-3.

5.

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.

Siddiqui I, Schaeuble K, Chennupati V, Fuertes Marraco SA, Calderon-Copete S, Pais Ferreira D, Carmona SJ, Scarpellino L, Gfeller D, Pradervand S, Luther SA, Speiser DE, Held W.

Immunity. 2019 Jan 15;50(1):195-211.e10. doi: 10.1016/j.immuni.2018.12.021. Epub 2019 Jan 8.

6.

Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer.

Lan Q, Peyvandi S, Duffey N, Huang YT, Barras D, Held W, Richard F, Delorenzi M, Sotiriou C, Desmedt C, Lorusso G, Rüegg C.

Oncogene. 2019 Apr;38(15):2814-2829. doi: 10.1038/s41388-018-0624-2. Epub 2018 Dec 13.

7.

Transcriptional regulation of murine natural killer cell development, differentiation and maturation.

Held W, Jeevan-Raj B, Charmoy M.

Cell Mol Life Sci. 2018 Sep;75(18):3371-3379. doi: 10.1007/s00018-018-2865-1. Epub 2018 Jun 29. Review.

PMID:
29959459
8.

Suppression of Tcf1 by Inflammatory Cytokines Facilitates Effector CD8 T Cell Differentiation.

Danilo M, Chennupati V, Silva JG, Siegert S, Held W.

Cell Rep. 2018 Feb 20;22(8):2107-2117. doi: 10.1016/j.celrep.2018.01.072.

9.

Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells.

Chennupati V, Held W.

Immunity. 2017 Dec 19;47(6):1009-1011. doi: 10.1016/j.immuni.2017.11.028.

10.

Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation.

Abbuehl JP, Tatarova Z, Held W, Huelsken J.

Cell Stem Cell. 2017 Aug 3;21(2):241-255.e6. doi: 10.1016/j.stem.2017.07.004.

11.

The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of Granzymes.

Jeevan-Raj B, Gehrig J, Charmoy M, Chennupati V, Grandclément C, Angelino P, Delorenzi M, Held W.

Cell Rep. 2017 Jul 18;20(3):613-626. doi: 10.1016/j.celrep.2017.06.071.

12.

TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation.

Wieland D, Kemming J, Schuch A, Emmerich F, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M, Thimme R.

Nat Commun. 2017 May 3;8:15050. doi: 10.1038/ncomms15050.

13.

T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections.

Utzschneider DT, Charmoy M, Chennupati V, Pousse L, Ferreira DP, Calderon-Copete S, Danilo M, Alfei F, Hofmann M, Wieland D, Pradervand S, Thimme R, Zehn D, Held W.

Immunity. 2016 Aug 16;45(2):415-27. doi: 10.1016/j.immuni.2016.07.021.

14.

Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition.

Alari-Pahissa E, Grandclément C, Jeevan-Raj B, Leclercq G, Veillette A, Held W.

PLoS One. 2016 Apr 7;11(4):e0153236. doi: 10.1371/journal.pone.0153236. eCollection 2016.

15.

Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells.

Scholz G, Jandus C, Zhang L, Grandclément C, Lopez-Mejia IC, Soneson C, Delorenzi M, Fajas L, Held W, Dormond O, Romero P.

EBioMedicine. 2016 Jan 16;4:50-61. doi: 10.1016/j.ebiom.2016.01.019. eCollection 2016 Feb.

16.

NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels.

Grandclément C, Pick H, Vogel H, Held W.

PLoS One. 2016 Mar 10;11(3):e0151031. doi: 10.1371/journal.pone.0151031. eCollection 2016.

17.

Phage Selection of Chemically Stabilized α-Helical Peptide Ligands.

Diderich P, Bertoldo D, Dessen P, Khan MM, Pizzitola I, Held W, Huelsken J, Heinis C.

ACS Chem Biol. 2016 May 20;11(5):1422-7. doi: 10.1021/acschembio.5b00963. Epub 2016 Mar 11.

PMID:
26929989
18.

NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions.

Ludigs K, Jandus C, Utzschneider DT, Staehli F, Bessoles S, Dang AT, Rota G, Castro W, Zehn D, Vivier E, Held W, Romero P, Guarda G.

Nat Commun. 2016 Feb 10;7:10554. doi: 10.1038/ncomms10554.

19.

Phage Selection of Peptide Macrocycles against β-Catenin To Interfere with Wnt Signaling.

Bertoldo D, Khan MM, Dessen P, Held W, Huelsken J, Heinis C.

ChemMedChem. 2016 Apr 19;11(8):834-9. doi: 10.1002/cmdc.201500557. Epub 2016 Jan 26.

PMID:
26812578
20.

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion.

Hurrell BP, Schuster S, Grün E, Coutaz M, Williams RA, Held W, Malissen B, Malissen M, Yousefi S, Simon HU, Müller AJ, Tacchini-Cottier F.

PLoS Pathog. 2015 May 28;11(5):e1004929. doi: 10.1371/journal.ppat.1004929. eCollection 2015 May.

21.

Inhibitory receptor-mediated regulation of natural killer cells.

Alari-Pahissa E, Grandclément C, Jeevan-Raj B, Held W.

Crit Rev Immunol. 2014;34(6):455-65. Review.

PMID:
25597309
22.

Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.

Jaworski M, Marsland BJ, Gehrig J, Held W, Favre S, Luther SA, Perroud M, Golshayan D, Gaide O, Thome M.

EMBO J. 2014 Dec 1;33(23):2765-81. doi: 10.15252/embj.201488987. Epub 2014 Oct 15.

23.

Differences in the transduction of canonical Wnt signals demarcate effector and memory CD8 T cells with distinct recall proliferation capacity.

Boudousquié C, Danilo M, Pousse L, Jeevan-Raj B, Angelov GS, Chennupati V, Zehn D, Held W.

J Immunol. 2014 Sep 15;193(6):2784-91. doi: 10.4049/jimmunol.1400465. Epub 2014 Aug 15.

24.

Adaptations of Natural Killer Cells to Self-MHC Class I.

Bessoles S, Grandclément C, Alari-Pahissa E, Gehrig J, Jeevan-Raj B, Held W.

Front Immunol. 2014 Jul 22;5:349. doi: 10.3389/fimmu.2014.00349. eCollection 2014.

25.

Education of murine NK cells requires both cis and trans recognition of MHC class I molecules.

Bessoles S, Angelov GS, Back J, Leclercq G, Vivier E, Held W.

J Immunol. 2013 Nov 15;191(10):5044-51. doi: 10.4049/jimmunol.1301971. Epub 2013 Oct 4.

26.

Inhibitory receptors and their mode of action: key insights from NK cells.

Held W.

J Immunol. 2013 Oct 1;191(7):3489-90. doi: 10.4049/jimmunol.1302158. No abstract available.

27.

MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.

Dudda JC, Salaun B, Ji Y, Palmer DC, Monnot GC, Merck E, Boudousquie C, Utzschneider DT, Escobar TM, Perret R, Muljo SA, Hebeisen M, Rufer N, Zehn D, Donda A, Restifo NP, Held W, Gattinoni L, Romero P.

Immunity. 2013 Apr 18;38(4):742-53. doi: 10.1016/j.immuni.2012.12.006.

28.

Non-promoter DNA hypermethylation of Zygote Arrest 1 (ZAR1) in neuroblastomas.

Sugito K, Kawashima H, Yoshizawa S, Uekusa S, Hoshi R, Furuya T, Kaneda H, Hosoda T, Konuma N, Masuko T, Ohashi K, Ikeda T, Koshinaga T, Tomita R, Shinojima Y, Fujiwara K, Watanabe T, Held WA, Nagase H.

J Pediatr Surg. 2013 Apr;48(4):782-8. doi: 10.1016/j.jpedsurg.2012.08.008.

PMID:
23583134
29.

Nonclassical NK cell education.

Held W.

Nat Immunol. 2012 Dec;13(12):1135-7. doi: 10.1038/ni.2470. No abstract available.

PMID:
23160207
30.

Caspase-3 protects stressed organs against cell death.

Khalil H, Peltzer N, Walicki J, Yang JY, Dubuis G, Gardiol N, Held W, Bigliardi P, Marsland B, Liaudet L, Widmann C.

Mol Cell Biol. 2012 Nov;32(22):4523-33. doi: 10.1128/MCB.00774-12. Epub 2012 Sep 4.

31.

Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions.

Sugito K, Kawashima H, Uekusa S, Yoshizawa S, Hoshi R, Furuya T, Kaneda H, Hosoda T, Masuko T, Ohashi K, Ikeda T, Koshinaga T, Fujiwara K, Igarashi J, Ghosh S, Held WA, Nagase H.

Pediatr Blood Cancer. 2013 Mar;60(3):383-9. doi: 10.1002/pbc.24282. Epub 2012 Aug 21.

PMID:
22911660
32.

Natural killer cell mediated missing-self recognition can protect mice from primary chronic myeloid leukemia in vivo.

Kijima M, Gardiol N, Held W.

PLoS One. 2011;6(11):e27639. doi: 10.1371/journal.pone.0027639. Epub 2011 Nov 23.

33.

Cis-trans interactions of cell surface receptors: biological roles and structural basis.

Held W, Mariuzza RA.

Cell Mol Life Sci. 2011 Nov;68(21):3469-78. doi: 10.1007/s00018-011-0798-z. Epub 2011 Aug 24. Review.

PMID:
21863376
34.

Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint.

Merck E, Lees RK, Voyle RB, Held W, MacDonald HR.

J Immunol. 2011 Jul 1;187(1):110-7. doi: 10.4049/jimmunol.1002755. Epub 2011 Jun 1.

35.

Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes.

Taveirne S, Filtjens J, Van Ammel E, De Colvenaer V, Kerre T, Taghon T, Vandekerckhove B, Plum J, Held W, Leclercq G.

Blood. 2011 Jul 14;118(2):339-47. doi: 10.1182/blood-2011-01-331124. Epub 2011 May 25.

PMID:
21613250
36.

Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development.

Liang P, Song F, Ghosh S, Morien E, Qin M, Mahmood S, Fujiwara K, Igarashi J, Nagase H, Held WA.

BMC Genomics. 2011 May 11;12(1):231. doi: 10.1186/1471-2164-12-231.

37.

The interaction with H-2D(d) in cis is associated with a conformational change in the Ly49A NK cell receptor.

Back J, Angelov GS, Mariuzza RA, Held W.

Front Immunol. 2011 Oct 11;2:55. doi: 10.3389/fimmu.2011.00055. eCollection 2011.

38.

The function of natural killer cells: education, reminders and some good memories.

Held W, Kijima M, Angelov G, Bessoles S.

Curr Opin Immunol. 2011 Apr;23(2):228-33. doi: 10.1016/j.coi.2010.11.008. Epub 2010 Dec 13. Review.

PMID:
21159498
39.

A KIR-TLR connection.

Held W.

Blood. 2010 Sep 9;116(10):1629-30. doi: 10.1182/blood-2010-03-272203. No abstract available.

PMID:
20829375
40.

Identification and analysis of an early diagnostic marker for malignant melanoma: ZAR1 intra-genic differential methylation.

Shinojima Y, Terui T, Hara H, Kimura M, Igarashi J, Wang X, Kawashima H, Kobayashi Y, Muroi S, Hayakawa S, Esumi M, Fujiwara K, Ghosh S, Yamamoto T, Held W, Nagase H.

J Dermatol Sci. 2010 Aug;59(2):98-106. doi: 10.1016/j.jdermsci.2010.04.016. Epub 2010 May 20.

41.

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory.

Jeannet G, Boudousquié C, Gardiol N, Kang J, Huelsken J, Held W.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9777-82. doi: 10.1073/pnas.0914127107. Epub 2010 May 10.

42.

Probing the interactions of NK cell receptors with ligand expressed in trans and cis.

Back J, Scarpellino L, Held W.

Methods Mol Biol. 2010;612:313-23. doi: 10.1007/978-1-60761-362-6_21.

PMID:
20033650
43.

Constitutive activation of Wnt signaling favors generation of memory CD8 T cells.

Zhao DM, Yu S, Zhou X, Haring JS, Held W, Badovinac VP, Harty JT, Xue HH.

J Immunol. 2010 Feb 1;184(3):1191-9. doi: 10.4049/jimmunol.0901199. Epub 2009 Dec 21.

44.

Canonical Wnt signalling plays essential roles.

Huelsken J, Held W.

Eur J Immunol. 2009 Dec;39(12):3582-3; author reply 3583-4. doi: 10.1002/eji.200838982. No abstract available.

45.

Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis.

Back J, Malchiodi EL, Cho S, Scarpellino L, Schneider P, Kerzic MC, Mariuzza RA, Held W.

Immunity. 2009 Oct 16;31(4):598-608. doi: 10.1016/j.immuni.2009.07.007. Epub 2009 Oct 8.

46.

A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.

Chalifour A, Scarpellino L, Back J, Brodin P, Devèvre E, Gros F, Lévy F, Leclercq G, Höglund P, Beermann F, Held W.

Immunity. 2009 Mar 20;30(3):337-47. doi: 10.1016/j.immuni.2008.12.019.

47.

Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.

Jun P, Hong C, Lal A, Wong JM, McDermott MW, Bollen AW, Plass C, Held WA, Smiraglia DJ, Costello JF.

Neuro Oncol. 2009 Aug;11(4):414-22. doi: 10.1215/15228517-2008-096. Epub 2008 Nov 11.

48.

Tolerance and reactivity of NK cells: two sides of the same coin?

Held W.

Eur J Immunol. 2008 Nov;38(11):2930-3. doi: 10.1002/eji.200838755. Review.

49.

Tissue specific differentially methylated regions (TDMR): Changes in DNA methylation during development.

Song F, Mahmood S, Ghosh S, Liang P, Smiraglia DJ, Nagase H, Held WA.

Genomics. 2009 Feb;93(2):130-9. doi: 10.1016/j.ygeno.2008.09.003. Epub 2008 Nov 13.

50.

Quantitative analysis of human tissue-specific differences in methylation.

Igarashi J, Muroi S, Kawashima H, Wang X, Shinojima Y, Kitamura E, Oinuma T, Nemoto N, Song F, Ghosh S, Held WA, Nagase H.

Biochem Biophys Res Commun. 2008 Nov 28;376(4):658-64. doi: 10.1016/j.bbrc.2008.09.044. Epub 2008 Sep 19.

Supplemental Content

Support Center