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Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling.

Wang Y, Branicky R, Noë A, Hekimi S.

J Cell Biol. 2018 Jun 4;217(6):1915-1928. doi: 10.1083/jcb.201708007. Epub 2018 Apr 18. Review.


Estimating the occurrence of primary ubiquinone deficiency by analysis of large-scale sequencing data.

Hughes BG, Harrison PM, Hekimi S.

Sci Rep. 2017 Dec 18;7(1):17744. doi: 10.1038/s41598-017-17564-y.


Many possible maximum lifespan trajectories.

Hughes BG, Hekimi S.

Nature. 2017 Jun 28;546(7660):E8-E9. doi: 10.1038/nature22786. No abstract available.


Proteostasis or Aging: Let the CHIPs Fall Where They May.

Branicky R, Hekimi S.

Dev Cell. 2017 Apr 24;41(2):126-128. doi: 10.1016/j.devcel.2017.04.006. Review.


Pathogenicity of two COQ7 mutations and responses to 2,4-dihydroxybenzoate bypass treatment.

Wang Y, Smith C, Parboosingh JS, Khan A, Innes M, Hekimi S.

J Cell Mol Med. 2017 Oct;21(10):2329-2343. doi: 10.1111/jcmm.13154. Epub 2017 Apr 13.


A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1.

Liu JL, Yee C, Wang Y, Hekimi S.

Sci Rep. 2017 Apr 12;7(1):859. doi: 10.1038/s41598-017-00754-z.


Making a splash with splicing.

Branicky R, Hekimi S.

Cell Res. 2017 Apr;27(4):457-458. doi: 10.1038/cr.2017.24. Epub 2017 Feb 24.


Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans.

Blanchette CR, Thackeray A, Perrat PN, Hekimi S, Bénard CY.

PLoS Genet. 2017 Jan 9;13(1):e1006525. doi: 10.1371/journal.pgen.1006525. eCollection 2017 Jan.


Mitochondrial ROS and the Effectors of the Intrinsic Apoptotic Pathway in Aging Cells: The Discerning Killers!

Hekimi S, Wang Y, Noë A.

Front Genet. 2016 Sep 14;7:161. doi: 10.3389/fgene.2016.00161. eCollection 2016. Review.


Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans.

Desjardins D, Cacho-Valadez B, Liu JL, Wang Y, Yee C, Bernard K, Khaki A, Breton L, Hekimi S.

Aging Cell. 2017 Feb;16(1):104-112. doi: 10.1111/acel.12528. Epub 2016 Sep 28.


Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates.

Hughes BG, Hekimi S.

Genetics. 2016 Nov;204(3):905-920. doi: 10.1534/genetics.116.192369. Epub 2016 Sep 16.


Understanding Ubiquinone.

Wang Y, Hekimi S.

Trends Cell Biol. 2016 May;26(5):367-378. doi: 10.1016/j.tcb.2015.12.007. Epub 2016 Jan 27. Review.


Mitochondrial dysfunction and longevity in animals: Untangling the knot.

Wang Y, Hekimi S.

Science. 2015 Dec 4;350(6265):1204-7. doi: 10.1126/science.aac4357. Review.


Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.

Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A.

Aging Cell. 2015 Oct;14(5):887-95. doi: 10.1111/acel.12368. Epub 2015 Jun 26.


Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis.

Wang Y, Oxer D, Hekimi S.

Nat Commun. 2015 Mar 6;6:6393. doi: 10.1038/ncomms7393.


A microfluidic device for efficient chemical testing using Caenorhabditis elegans.

Song P, Zhang W, Sobolevski A, Bernard K, Hekimi S, Liu X.

Biomed Microdevices. 2015 Apr;17(2):38. doi: 10.1007/s10544-015-9939-8.


Mitochondrial and cytoplasmic ROS have opposing effects on lifespan.

Schaar CE, Dues DJ, Spielbauer KK, Machiela E, Cooper JF, Senchuk M, Hekimi S, Van Raamsdonk JM.

PLoS Genet. 2015 Feb 11;11(2):e1004972. doi: 10.1371/journal.pgen.1004972. eCollection 2015 Feb.


Compensatory elevation of voluntary activity in mouse mutants with impaired mitochondrial energy metabolism.

Lapointe J, Hughes BG, Bigras E, Hekimi S.

Physiol Rep. 2014 Nov 20;2(11). pii: e12214. doi: 10.14814/phy2.12214. Print 2014 Nov 1.


The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans.

Yee C, Yang W, Hekimi S.

Cell. 2014 May 8;157(4):897-909. doi: 10.1016/j.cell.2014.02.055.


CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants.

Baruah A, Chang H, Hall M, Yuan J, Gordon S, Johnson E, Shtessel LL, Yee C, Hekimi S, Derry WB, Lee SS.

PLoS Genet. 2014 Feb 27;10(2):e1004097. doi: 10.1371/journal.pgen.1004097. eCollection 2014 Feb.


Mitochondrial respiration without ubiquinone biosynthesis.

Wang Y, Hekimi S.

Hum Mol Genet. 2013 Dec 1;22(23):4768-83. doi: 10.1093/hmg/ddt330. Epub 2013 Jul 11.


Molecular genetics of ubiquinone biosynthesis in animals.

Wang Y, Hekimi S.

Crit Rev Biochem Mol Biol. 2013 Jan-Feb;48(1):69-88. doi: 10.3109/10409238.2012.741564. Epub 2012 Nov 29. Review.


An enhanced immune response of Mclk1⁺/⁻ mutant mice is associated with partial protection from fibrosis, cancer and the development of biomarkers of aging.

Wang D, Wang Y, Argyriou C, Carrière A, Malo D, Hekimi S.

PLoS One. 2012;7(11):e49606. doi: 10.1371/journal.pone.0049606. Epub 2012 Nov 14.


The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/- mice.

Lapointe J, Wang Y, Bigras E, Hekimi S.

J Cell Biol. 2012 Oct 15;199(2):215-24. doi: 10.1083/jcb.201203090. Epub 2012 Oct 8.


Superoxide dismutase is dispensable for normal animal lifespan.

Van Raamsdonk JM, Hekimi S.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5785-90. doi: 10.1073/pnas.1116158109. Epub 2012 Mar 26.


Mitochondrial oxidative stress alters a pathway in Caenorhabditis elegans strongly resembling that of bile acid biosynthesis and secretion in vertebrates.

Liu JL, Desjardins D, Branicky R, Agellon LB, Hekimi S.

PLoS Genet. 2012;8(3):e1002553. doi: 10.1371/journal.pgen.1002553. Epub 2012 Mar 15.


Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival.

Robert F, Mills JR, Agenor A, Wang D, DiMarco S, Cencic R, Tremblay ML, Gallouzi IE, Hekimi S, Wing SS, Pelletier J.

Cancer Res. 2012 Feb 1;72(3):747-56. doi: 10.1158/0008-5472.CAN-11-2739. Epub 2011 Dec 12.


A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice.

Hughes BG, Hekimi S.

PLoS One. 2011;6(10):e26116. doi: 10.1371/journal.pone.0026116. Epub 2011 Oct 10.


FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1.

Van Raamsdonk JM, Hekimi S.

Mech Ageing Dev. 2011 Oct;132(10):519-21. doi: 10.1016/j.mad.2011.08.006. Epub 2011 Aug 27.


Taking a "good" look at free radicals in the aging process.

Hekimi S, Lapointe J, Wen Y.

Trends Cell Biol. 2011 Oct;21(10):569-76. doi: 10.1016/j.tcb.2011.06.008. Epub 2011 Aug 6. Review.


Phylogenetic ubiquity of the effects of altered ubiquinone biosynthesis on survival.

Hekimi S, Hughes B.

Aging (Albany NY). 2011 Mar;3(3):184-5. No abstract available.


A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.

Yang W, Hekimi S.

PLoS Biol. 2010 Dec 7;8(12):e1000556. doi: 10.1371/journal.pbio.1000556.


Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.

Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS.

Am J Respir Crit Care Med. 2011 Apr 15;183(8):1043-54. doi: 10.1164/rccm.201002-0181OC. Epub 2010 Oct 19.


Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?

Van Raamsdonk JM, Hekimi S.

Antioxid Redox Signal. 2010 Dec 15;13(12):1911-53. doi: 10.1089/ars.2010.3215. Epub 2010 Sep 13. Review.


Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage.

Van Raamsdonk JM, Meng Y, Camp D, Yang W, Jia X, Bénard C, Hekimi S.

Genetics. 2010 Jun;185(2):559-71. doi: 10.1534/genetics.110.115378. Epub 2010 Apr 9.


Impact papers on aging in 2009.

Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM Jr, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J.

Aging (Albany NY). 2010 Mar;2(3):111-21. Epub 2010 Mar 23. Review.


Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans.

Yang W, Hekimi S.

Aging Cell. 2010 Jun;9(3):433-47. doi: 10.1111/j.1474-9726.2010.00571.x. Epub 2010 Mar 19.


Lifelong protection from global cerebral ischemia and reperfusion in long-lived Mclk1(+/)(-) mutants.

Zheng H, Lapointe J, Hekimi S.

Exp Neurol. 2010 Jun;223(2):557-65. doi: 10.1016/j.expneurol.2010.02.002. Epub 2010 Feb 17.


Lipid transport and signaling in Caenorhabditis elegans.

Branicky R, Desjardins D, Liu JL, Hekimi S.

Dev Dyn. 2010 May;239(5):1365-77. doi: 10.1002/dvdy.22234. Review.


Elevated mitochondrial reactive oxygen species generation affects the immune response via hypoxia-inducible factor-1alpha in long-lived Mclk1+/- mouse mutants.

Wang D, Malo D, Hekimi S.

J Immunol. 2010 Jan 15;184(2):582-90. doi: 10.4049/jimmunol.0902352. Epub 2009 Dec 9.


When a theory of aging ages badly.

Lapointe J, Hekimi S.

Cell Mol Life Sci. 2010 Jan;67(1):1-8. doi: 10.1007/s00018-009-0138-8. Review.


Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice.

Lapointe J, Stepanyan Z, Bigras E, Hekimi S.

J Biol Chem. 2009 Jul 24;284(30):20364-74. doi: 10.1074/jbc.M109.006569. Epub 2009 May 28.


Mclk1+/- mice are not resistant to the development of atherosclerosis.

Hughes BG, Hekimi S.

Lipids Health Dis. 2009 May 5;8:16. doi: 10.1186/1476-511X-8-16.


Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.

Van Raamsdonk JM, Hekimi S.

PLoS Genet. 2009 Feb;5(2):e1000361. doi: 10.1371/journal.pgen.1000361. Epub 2009 Feb 6.


The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.

Wang Y, Branicky R, Stepanyan Z, Carroll M, Guimond MP, Hihi A, Hayes S, McBride K, Hekimi S.

J Biol Chem. 2009 Jan 2;284(1):314-23. doi: 10.1074/jbc.M807579200. Epub 2008 Oct 15.


Early mitochondrial dysfunction in long-lived Mclk1+/- mice.

Lapointe J, Hekimi S.

J Biol Chem. 2008 Sep 19;283(38):26217-27. doi: 10.1074/jbc.M803287200. Epub 2008 Jul 17.


Evolutionary conservation of drug action on lipoprotein metabolism-related targets.

Hihi AK, Beauchamp MC, Branicky R, Desjardins A, Casanova I, Guimond MP, Carroll M, Ethier M, Kianicka I, McBride K, Hekimi S.

J Lipid Res. 2008 Jan;49(1):74-83. Epub 2007 Sep 27.

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